Reviewed, UniProtKB/Swiss-Prot O15146 (MUSK_HUMAN)

Names and origin

Protein names

Recommended name:
    Muscle, skeletal receptor tyrosine protein kinase
    EC=2.7.10.1
Alternative name(s):
    Muscle-specific tyrosine protein kinase receptor
      Short name=Muscle-specific kinase receptor
      Short name=MuSK

Gene names

Name:

MUSK

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	869 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit structure	Interacts with DOK7, which probably regulates its activity By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Involvement in disease	Defects in MUSK is a cause of autosomal recessive congenital myasthenic syndrome (CMS) [MIM:608931]. Congenital myasthenic syndromes are inherited disorders of neuromuscular transmission that stem from mutations in presynaptic, synaptic, or postsynaptic proteins. MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 FZ (frizzled) domain. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.
Sequence caution	The sequence CAH69977.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAH69978.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI17349.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI17350.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	muscle organ development Ref.1 Traceable author statement. Source: ProtInc protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15146-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15146-2)

The sequence of this isoform differs from the canonical sequence as follows:
     209-209: E → EEESEPEQDTK
     307-394: Missing.
     454-462: DYNKENLKT → A

Isoform 3 (identifier: O15146-3)

The sequence of this isoform differs from the canonical sequence as follows:
     307-394: Missing.
     454-462: DYNKENLKT → A

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 869	846	Muscle, skeletal receptor tyrosine protein kinase		PRO_0000024446
Regions
	Topological domain	24 – 495	472	Extracellular Potential
	Transmembrane	496 – 516	21	Potential
	Topological domain	517 – 869	353	Cytoplasmic Potential
	Domain	28 – 116	89	Ig-like 1
	Domain	121 – 205	85	Ig-like 2
	Domain	212 – 302	91	Ig-like 3
	Domain	312 – 450	139	FZ
	Domain	575 – 856	282	Protein kinase
	Nucleotide binding	581 – 589	9	ATP By similarity
Sites
	Active site	725	1	Proton acceptor By similarity
	Binding site	609	1	ATP By similarity
Amino acid modifications
	Modified residue	755	1	Phosphotyrosine; by autocatalysis By similarity
	Glycosylation	222	1	N-linked (GlcNAc...) Potential
	Glycosylation	338	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 99		By similarity
	Disulfide bond	142 ↔ 190		By similarity
	Disulfide bond	233 ↔ 282		By similarity
	Disulfide bond	317 ↔ 382		By similarity
	Disulfide bond	325 ↔ 375		By similarity
	Disulfide bond	366 ↔ 406		By similarity
	Disulfide bond	394 ↔ 447		By similarity
	Disulfide bond	398 ↔ 434		By similarity
Natural variations
	Alternative sequence	209	1	E → EEESEPEQDTK in isoform 2.		VSP_035958
	Alternative sequence	307 – 394	88	Missing in isoform 2 and isoform 3.		VSP_035959
	Alternative sequence	454 – 462	9	DYNKENLKT → A in isoform 2 and isoform 3.		VSP_035960
	Natural variant	27	1	A → G		VAR_041748
	Natural variant	100	1	T → M		VAR_041749
	Natural variant	107	1	G → E		VAR_041750
	Natural variant	159	1	S → G: dbSNP rs35176182. Ref.6		VAR_041751
	Natural variant	222	1	N → S		VAR_041752
	Natural variant	413	1	M → I: dbSNP rs2274419. Ref.6		VAR_021930
	Natural variant	629	1	L → F		VAR_041753
	Natural variant	644	1	V → A		VAR_041754
	Natural variant	664	1	N → S		VAR_041755
	Natural variant	696	1	P → L		VAR_041756
	Natural variant	782	1	E → D		VAR_041757
	Natural variant	790	1	V → M in a case of congenital myasthenic syndrome; does not affect catalytic kinase activity; reduces protein expression and stability. Ref.5		VAR_023046
	Natural variant	819	1	N → S in a lung neuroendocrine carcinoma sample; somatic mutation. Ref.6		VAR_041758
	Natural variant	829	1	V → L: dbSNP rs578430. Ref.6		VAR_033837
	Natural variant	858	1	R → H		VAR_041759

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 3DDC20E179FA010C	FASTA	869	97,056
	10 20 30 40 50 60 MRELVNIPLV HILTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 70 80 90 100 110 120 WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT ANNGVGGAVE SCGALQVKMK 130 140 150 160 170 180 PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSP LRENSRIAVL ESGSLRIHNV 190 200 210 220 230 240 QKEDAGQYRC VAKNSLGTAY SKVVKLEVEV FARILRAPES HNVTFGSFVT LHCTATGIPV 250 260 270 280 290 300 PTITWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT 310 320 330 340 350 360 ISIAEWSKPQ KDNKGYCAQY RGEVCNAVLA KDALVFLNTS YADPEEAQEL LVHTAWNELK 370 380 390 400 410 420 VVSPVCRPAA EALLCNHIFQ ECSPGVVPTP IPICREYCLA VKELFCAKEW LVMEEKTHRG 430 440 450 460 470 480 LYRSEMHLLS VPECSKLPSM HWDPTACARL PHLDYNKENL KTFPPMTSSK PSVDIPNLPS 490 500 510 520 530 540 SSSSSFSVSP TYSMTVIISI MSSFAIFVLL TITTLYCCRR RKQWKNKKRE SAAVTLTTLP 550 560 570 580 590 600 SELLLDRLHP NPMYQRMPLL LNPKLLSLEY PRNNIEYVRD IGEGAFGRVF QARAPGLLPY 610 620 630 640 650 660 EPFTMVAVKM LKEEASADMQ ADFQREAALM AEFDNPNIVK LLGVCAVGKP MCLLFEYMAY 670 680 690 700 710 720 GDLNEFLRSM SPHTVCSLSH SDLSMRAQVS SPGPPPLSCA EQLCIARQVA AGMAYLSERK 730 740 750 760 770 780 FVHRDLATRN CLVGENMVVK IADFGLSRNI YSADYYKANE NDAIPIRWMP PESIFYNRYT 790 800 810 820 830 840 TESDVWAYGV VLWEIFSYGL QPYYGMAHEE VIYYVRDGNI LSCPENCPVE LYNLMRLCWS 850 860 KLPADRPSFT SIHRILERMC ERAEGTVSV
	Isoform 2. Checksum: 695BD37016C0D980	FASTA	783	87,598
	10 20 30 40 50 60 MRELVNIPLV HILTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 70 80 90 100 110 120 WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT ANNGVGGAVE SCGALQVKMK 130 140 150 160 170 180 PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSP LRENSRIAVL ESGSLRIHNV 190 200 210 220 230 240 QKEDAGQYRC VAKNSLGTAY SKVVKLEVEE ESEPEQDTKV FARILRAPES HNVTFGSFVT 250 260 270 280 290 300 LHCTATGIPV PTITWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE 310 320 330 340 350 360 KFSTAKAAAT ISIAEWREYC LAVKELFCAK EWLVMEEKTH RGLYRSEMHL LSVPECSKLP 370 380 390 400 410 420 SMHWDPTACA RLPHLAFPPM TSSKPSVDIP NLPSSSSSSF SVSPTYSMTV IISIMSSFAI 430 440 450 460 470 480 FVLLTITTLY CCRRRKQWKN KKRESAAVTL TTLPSELLLD RLHPNPMYQR MPLLLNPKLL 490 500 510 520 530 540 SLEYPRNNIE YVRDIGEGAF GRVFQARAPG LLPYEPFTMV AVKMLKEEAS ADMQADFQRE 550 560 570 580 590 600 AALMAEFDNP NIVKLLGVCA VGKPMCLLFE YMAYGDLNEF LRSMSPHTVC SLSHSDLSMR 610 620 630 640 650 660 AQVSSPGPPP LSCAEQLCIA RQVAAGMAYL SERKFVHRDL ATRNCLVGEN MVVKIADFGL 670 680 690 700 710 720 SRNIYSADYY KANENDAIPI RWMPPESIFY NRYTTESDVW AYGVVLWEIF SYGLQPYYGM 730 740 750 760 770 780 AHEEVIYYVR DGNILSCPEN CPVELYNLMR LCWSKLPADR PSFTSIHRIL ERMCERAEGT VSV
	Isoform 3. Checksum: 3BEA481E3C84D000	FASTA	773	86,425
	10 20 30 40 50 60 MRELVNIPLV HILTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 70 80 90 100 110 120 WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT ANNGVGGAVE SCGALQVKMK 130 140 150 160 170 180 PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSP LRENSRIAVL ESGSLRIHNV 190 200 210 220 230 240 QKEDAGQYRC VAKNSLGTAY SKVVKLEVEV FARILRAPES HNVTFGSFVT LHCTATGIPV 250 260 270 280 290 300 PTITWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT 310 320 330 340 350 360 ISIAEWREYC LAVKELFCAK EWLVMEEKTH RGLYRSEMHL LSVPECSKLP SMHWDPTACA 370 380 390 400 410 420 RLPHLAFPPM TSSKPSVDIP NLPSSSSSSF SVSPTYSMTV IISIMSSFAI FVLLTITTLY 430 440 450 460 470 480 CCRRRKQWKN KKRESAAVTL TTLPSELLLD RLHPNPMYQR MPLLLNPKLL SLEYPRNNIE 490 500 510 520 530 540 YVRDIGEGAF GRVFQARAPG LLPYEPFTMV AVKMLKEEAS ADMQADFQRE AALMAEFDNP 550 560 570 580 590 600 NIVKLLGVCA VGKPMCLLFE YMAYGDLNEF LRSMSPHTVC SLSHSDLSMR AQVSSPGPPP 610 620 630 640 650 660 LSCAEQLCIA RQVAAGMAYL SERKFVHRDL ATRNCLVGEN MVVKIADFGL SRNIYSADYY 670 680 690 700 710 720 KANENDAIPI RWMPPESIFY NRYTTESDVW AYGVVLWEIF SYGLQPYYGM AHEEVIYYVR 730 740 750 760 770 DGNILSCPEN CPVELYNLMR LCWSKLPADR PSFTSIHRIL ERMCERAEGT VSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury." Valenzuela D.M., Stitt T.N., DiStefano P.S., Rojas E., Mattsson K., Compton D.L., Nunez L., Park J.S., Stark J.L., Gies D.R., Thomas S., LeBeau M.M., Fernald A.A., Copeland N.G., Jenkins N.A., Burden S.J., Glass D.J., Yancopoulos G.D. Neuron 15:573-584(1995) [PubMed: 7546737] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	Valenzuela D.M., Rojas E., Yancopoulos G.D. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
[5]	"MUSK, a new target for mutations causing congenital myasthenic syndrome." Chevessier F., Faraut B., Ravel-Chapuis A., Richard P., Gaudon K., Bauche S., Prioleau C., Herbst R., Goillot E., Ioos C., Azulay J.-P., Attarian S., Leroy J.-P., Fournier E., Legay C., Schaeffer L., Koenig J., Fardeau M. , Eymard B., Pouget J., Hantai D. Hum. Mol. Genet. 13:3229-3240(2004) [PubMed: 15496425] [Abstract] Cited for: VARIANT CONGENITAL MYASTHENIC SYNDROME MET-790.
[6]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-27; MET-100; GLU-107; GLY-159; SER-222; ILE-413; PHE-629; ALA-644; SER-664; LEU-696; ASP-782; SER-819; LEU-829 AND HIS-858.
+	Additional computationally mapped references.

Web resources

GeneReviews

Wikipedia

MuSK entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF006464 mRNA. Translation: AAB63044.1. AL157881, AL513328 Genomic DNA. Translation: CAH69977.1. Sequence problems. AL513328, AL157881 Genomic DNA. Translation: CAI17349.1. Sequence problems. AL157881, AL513328 Genomic DNA. Translation: CAH69978.1. Sequence problems. AL513328, AL157881 Genomic DNA. Translation: CAI17350.1. Sequence problems. BC109098 mRNA. Translation: AAI09099.1. BC109099 mRNA. Translation: AAI09100.1.
IPI	IPI00289243. IPI00655599. IPI00915471.
RefSeq	NP_005583.1.
UniGene	Hs.521653
3D structure databases
HSSP	HSSP built from PDB template 1LUF based on UniProtKB Q62838.
SMR	O15146. Positions 25-211.
ModBase	Search...
Protein-protein interaction databases
STRING	O15146.
PTM databases
PhosphoSite	O15146.
Proteomic databases
PRIDE	O15146.
Genome annotation databases
Ensembl	ENST00000189978; ENSP00000189978; ENSG00000030304; Homo sapiens. [Genome view] ENST00000374438; ENSP00000363561; ENSG00000030304; Homo sapiens. [Genome view] ENST00000374439; ENSP00000363562; ENSG00000030304; Homo sapiens. [Genome view] ENST00000374440; ENSP00000363563; ENSG00000030304; Homo sapiens. [Genome view] ENST00000374441; ENSP00000363564; ENSG00000030304; Homo sapiens. [Genome view] ENST00000374447; ENSP00000363570; ENSG00000030304; Homo sapiens. [Genome view] ENST00000374448; ENSP00000363571; ENSG00000030304; Homo sapiens. [Genome view] ENST00000416899; ENSP00000393608; ENSG00000030304; Homo sapiens. [Genome view]
GeneID	4593.
KEGG	hsa:4593.
UCSC	uc004bey.2. human.
Organism-specific databases
CTD	4593.
GeneCards	GC09P112470.
H-InvDB	HIX0034744.
HGNC	HGNC:7525. MUSK.
MIM	600878. gene. 601296. gene. 608931. phenotype.
Orphanet	590. Congenital myasthenic syndromes. 98913. Postsynaptic congenital myasthenic syndromes.
PharmGKB	PA31326.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O15146.
Enzyme and pathway databases
BRENDA	2.7.10.1. 247.
Gene expression databases
ArrayExpress	O15146.
Bgee	O15146.
CleanEx	HS_MUSK.
Genevestigator	O15146.
GermOnline	ENSG00000030304. Homo sapiens.
Family and domain databases
InterPro	IPR020067. Frizzled-like_dom. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 3 hits.
Pfam	PF01392. Fz. 1 hit. PF07679. I-set. 3 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00408. IGc2. 3 hits. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS50038. FZ. 1 hit. PS50835. IG_LIKE. 3 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	17656.
SOURCE	Search...

Entry information

Entry name

MUSK_HUMAN

Accession

Primary (citable) accession number: O15146
Secondary accession number(s): Q32MJ8 , Q32MJ9, Q5VZW7, Q5VZW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	January 1, 1998
Last modified:	October 13, 2009
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.