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Protein

Actin-related protein 2/3 complex subunit 3

Gene

ARPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-HSA-8856828. Clathrin-mediated endocytosis.
SIGNORiO15145.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 3
Alternative name(s):
Arp2/3 complex 21 kDa subunit
Short name:
p21-ARC
Gene namesi
Name:ARPC3
Synonyms:ARC21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111229.15.
HGNCiHGNC:706. ARPC3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi10094.
OpenTargetsiENSG00000111229.
PharmGKBiPA25000.

Chemistry databases

DrugBankiDB08235. N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001240422 – 178Actin-related protein 2/3 complex subunit 3Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei47PhosphotyrosineCombined sources1
Modified residuei56N6-acetyllysineCombined sources1
Modified residuei61N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO15145.
MaxQBiO15145.
PaxDbiO15145.
PeptideAtlasiO15145.
PRIDEiO15145.
TopDownProteomicsiO15145.

2D gel databases

OGPiO15145.

PTM databases

iPTMnetiO15145.
PhosphoSitePlusiO15145.
SwissPalmiO15145.

Expressioni

Gene expression databases

BgeeiENSG00000111229.
ExpressionAtlasiO15145. baseline and differential.
GenevisibleiO15145. HS.

Organism-specific databases

HPAiHPA006550.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115401. 83 interactors.
CORUMiO15145.
DIPiDIP-33187N.
IntActiO15145. 65 interactors.
MINTiMINT-156243.
STRINGi9606.ENSP00000228825.

Structurei

3D structure databases

ProteinModelPortaliO15145.
SMRiO15145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC3 family.Curated

Phylogenomic databases

eggNOGiKOG3155. Eukaryota.
ENOG4111FTG. LUCA.
GeneTreeiENSGT00390000018018.
HOGENOMiHOG000161465.
HOVERGENiHBG050581.
InParanoidiO15145.
KOiK05756.
OMAiKWWLSFT.
OrthoDBiEOG091G0OUM.
PhylomeDBiO15145.
TreeFamiTF314598.

Family and domain databases

Gene3Di1.10.1760.10. 1 hit.
InterProiView protein in InterPro
IPR007204. ARPC3.
PANTHERiPTHR12391. PTHR12391. 1 hit.
PfamiView protein in Pfam
PF04062. P21-Arc. 1 hit.
PIRSFiPIRSF016315. ARP2/3_P21-Arc. 1 hit.
SUPFAMiSSF69060. SSF69060. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK
60 70 80 90 100
ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI
110 120 130 140 150
TNFPIPGEPG FPLNAIYAKP ANKQEDEVMR AYLQQLRQET GLRLCEKVFD
160 170
PQNDKPSKWW TCFVKRQFMN KSLSGPGQ
Length:178
Mass (Da):20,547
Last modified:January 23, 2007 - v3
Checksum:i7149F598B48F0EAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134Q → P in AAB61466 (PubMed:9359840).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004561 mRNA. Translation: AAB61466.1.
AF006086 mRNA. Translation: AAB64191.1.
CR407667 mRNA. Translation: CAG28595.1.
BC067747 mRNA. Translation: AAH67747.1.
BC078162 mRNA. Translation: AAH78162.1.
CCDSiCCDS9146.1.
RefSeqiNP_001265485.1. NM_001278556.1.
NP_001274151.1. NM_001287222.1.
UniGeneiHs.524741.

Genome annotation databases

EnsembliENST00000228825; ENSP00000228825; ENSG00000111229.
GeneIDi10094.
KEGGihsa:10094.
UCSCiuc001tqq.5. human.

Similar proteinsi

Entry informationi

Entry nameiARPC3_HUMAN
AccessioniPrimary (citable) accession number: O15145
Secondary accession number(s): O00554
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families