Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O15143

- ARC1B_HUMAN

UniProt

O15143 - ARC1B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Actin-related protein 2/3 complex subunit 1B

Gene

ARPC1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

  1. Arp2/3 complex-mediated actin nucleation Source: FlyBase
  2. cellular component movement Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

SignaLinkiO15143.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1B
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:ARPC1B
Synonyms:ARC41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:704. ARPC1B.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: ProtInc
  2. Arp2/3 protein complex Source: FlyBase
  3. cytoplasm Source: UniProtKB-KW
  4. extracellular vesicular exosome Source: UniProt
  5. focal adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 372371Actin-related protein 2/3 complex subunit 1BPRO_0000050855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO15143.
PaxDbiO15143.
PRIDEiO15143.

PTM databases

PhosphoSiteiO15143.

Expressioni

Gene expression databases

BgeeiO15143.
CleanExiHS_ARPC1B.
ExpressionAtlasiO15143. baseline and differential.
GenevestigatoriO15143.

Organism-specific databases

HPAiHPA004832.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Protein-protein interaction databases

BioGridi115402. 45 interactions.
DIPiDIP-41254N.
IntActiO15143. 5 interactions.
MINTiMINT-5003785.
STRINGi9606.ENSP00000252725.

Structurei

3D structure databases

ProteinModelPortaliO15143.
SMRiO15143. Positions 2-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 4540WD 1Add
BLAST
Repeati50 – 8940WD 2Add
BLAST
Repeati94 – 13542WD 3Add
BLAST
Repeati140 – 17940WD 4Add
BLAST
Repeati242 – 28039WD 5Add
BLAST
Repeati324 – 36744WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiO15143.
KOiK05757.
OMAiKWVKVHE.
PhylomeDBiO15143.
TreeFamiTF315041.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR017383. ARPC2/3_su1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15143-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWTKVHELKE
60 70 80 90 100
HNGQVTGIDW APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR
110 120 130 140 150
CVRWAPNENK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNNVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS
210 220 230 240 250
SCGWVHGVCF SASGSRVAWV SHDSTVCLAD ADKKMAVATL ASETLPLLAL
260 270 280 290 300
TFITDNSLVA AGHDCFPVLF TYDAAAGMLS FGGRLDVPKQ SSQRGLTARE
310 320 330 340 350
RFQNLDKKAS SEGGTAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM
360 370
DGGMSIWDVK SLESALKDLK IK
Length:372
Mass (Da):40,950
Last modified:January 23, 2007 - v3
Checksum:i1939F5B63D40BD27
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371K → N.
Corresponds to variant rs1045012 [ dbSNP | Ensembl ].
VAR_014477

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006084 mRNA. Translation: AAB64189.1.
AC004922 Genomic DNA. No translation available.
BC002562 mRNA. Translation: AAH02562.1.
BC002988 mRNA. Translation: AAH02988.2.
BC007555 mRNA. Translation: AAH07555.1.
CCDSiCCDS5661.1.
RefSeqiNP_005711.1. NM_005720.3.
XP_006715888.1. XM_006715825.1.
XP_006715889.1. XM_006715826.1.
UniGeneiHs.489284.

Genome annotation databases

EnsembliENST00000252725; ENSP00000252725; ENSG00000130429.
ENST00000451682; ENSP00000389631; ENSG00000130429.
GeneIDi10095.
KEGGihsa:10095.
UCSCiuc003upz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006084 mRNA. Translation: AAB64189.1 .
AC004922 Genomic DNA. No translation available.
BC002562 mRNA. Translation: AAH02562.1 .
BC002988 mRNA. Translation: AAH02988.2 .
BC007555 mRNA. Translation: AAH07555.1 .
CCDSi CCDS5661.1.
RefSeqi NP_005711.1. NM_005720.3.
XP_006715888.1. XM_006715825.1.
XP_006715889.1. XM_006715826.1.
UniGenei Hs.489284.

3D structure databases

ProteinModelPortali O15143.
SMRi O15143. Positions 2-371.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115402. 45 interactions.
DIPi DIP-41254N.
IntActi O15143. 5 interactions.
MINTi MINT-5003785.
STRINGi 9606.ENSP00000252725.

PTM databases

PhosphoSitei O15143.

Proteomic databases

MaxQBi O15143.
PaxDbi O15143.
PRIDEi O15143.

Protocols and materials databases

DNASUi 10095.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252725 ; ENSP00000252725 ; ENSG00000130429 .
ENST00000451682 ; ENSP00000389631 ; ENSG00000130429 .
GeneIDi 10095.
KEGGi hsa:10095.
UCSCi uc003upz.3. human.

Organism-specific databases

CTDi 10095.
GeneCardsi GC07P098971.
HGNCi HGNC:704. ARPC1B.
HPAi HPA004832.
MIMi 604223. gene.
neXtProti NX_O15143.
PharmGKBi PA24998.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00390000008339.
HOGENOMi HOG000181752.
HOVERGENi HBG050560.
InParanoidi O15143.
KOi K05757.
OMAi KWVKVHE.
PhylomeDBi O15143.
TreeFami TF315041.

Enzyme and pathway databases

SignaLinki O15143.

Miscellaneous databases

ChiTaRSi ARPC1B. human.
GeneWikii ARPC1B.
GenomeRNAii 10095.
NextBioi 38181.
PROi O15143.
SOURCEi Search...

Gene expression databases

Bgeei O15143.
CleanExi HS_ARPC1B.
ExpressionAtlasi O15143. baseline and differential.
Genevestigatori O15143.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR017383. ARPC2/3_su1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR10709. PTHR10709. 1 hit.
Pfami PF00400. WD40. 3 hits.
[Graphical view ]
PIRSFi PIRSF038093. ARP2/3_su1. 1 hit.
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly."
    Welch M.D., Depace A.H., Verma S., Iwamatsu A., Mitchison T.J.
    J. Cell Biol. 138:375-384(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung, Placenta and Skin.
  4. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-20.
    Tissue: Platelet.
  5. "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity."
    Gournier H., Goley E.D., Niederstrasser H., Trinh T., Welch M.D.
    Mol. Cell 8:1041-1052(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECONSTITUTION OF THE ARP2/3 COMPLEX.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARC1B_HUMAN
AccessioniPrimary (citable) accession number: O15143
Secondary accession number(s): Q9BU00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3