O15130 (NPFF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FMRFamide-related peptides

Cleaved into the following 3 chains:

1. Neuropeptide SF
   Short name=NPSF
2. Neuropeptide FF
   Short name=NPFF
3. Neuropeptide AF
   Short name=NPAF

Gene names

Name:

NPFF

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	113 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. Ref.2
Subcellular location	Secreted.
Sequence similarities	Belongs to the FARP (FMRFamide related peptide) family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Neuropeptide
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acute inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara maternal process involved in female pregnancy Inferred from electronic annotation. Source: Compara negative regulation of appetite Inferred from electronic annotation. Source: Compara negative regulation of heart rate Inferred from electronic annotation. Source: Compara negative regulation of insulin secretion Inferred from electronic annotation. Source: Compara neuropeptide signaling pathway Traceable author statement PubMed 10851242. Source: ProtInc positive regulation of blood pressure Inferred from electronic annotation. Source: Compara regulation of excitatory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara regulation of sensory perception of pain Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to morphine Inferred from electronic annotation. Source: Compara somatostatin secretion Inferred from electronic annotation. Source: Compara spinal cord development Inferred from electronic annotation. Source: Compara synaptic transmission Traceable author statement Ref.1. Source: ProtInc vasopressin secretion Inferred from electronic annotation. Source: Compara
Cellular_component	axon terminus Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: Compara perikaryon Inferred from electronic annotation. Source: Compara vesicle Inferred from electronic annotation. Source: Compara
Molecular_function	receptor binding Traceable author statement PubMed 10851242Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 65	45			PRO_0000009898
	Peptide	66 – 76	11	Neuropeptide SF		PRO_0000009899
	Peptide	69 – 76	8	Neuropeptide FF		PRO_0000009900
	Propeptide	79 – 92	14			PRO_0000009901
	Peptide	93 – 110	18	Neuropeptide AF		PRO_0000009902
Amino acid modifications
	Modified residue	76	1	Phenylalanine amide By similarity
	Modified residue	110	1	Phenylalanine amide By similarity
Natural variations
	Natural variant	88	1	W → R. Corresponds to variant rs35822762 [ dbSNP | Ensembl ].		VAR_049183

Sequences

	Sequence		Length	Mass (Da)
	O15130 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 1E9D4ED2A69238E3	FASTA	113	12,440
	10 20 30 40 50 60 MDSRQAAALL VLLLLIDGGC AEGPGGQQED QLSAEEDSEP LPPQDAQTSG SLLHYLLQAM 70 80 90 100 110 ERPGRSQAFL FQPQRFGRNT QGSWRNEWLS PRAGEGLNSQ FWSLAAPQRF GKK

References

[1]	"A human gene encoding morphine modulating peptides related to NPFF and FMRFamide." Perry S.J., Yi-Kung Huang E., Cronk D., Bagust J., Sharma R., Walker R.J., Wilson S., Burke J.F. FEBS Lett. 409:426-430(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF." Catarsi S., Babinski K., Seguela P. Neuropharmacology 41:592-600(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF005271 mRNA. Translation: AAB64288.1.
IPI	IPI00005140.
RefSeq	NP_003708.1. NM_003717.2.
UniGene	Hs.733076.
3D structure databases
ProteinModelPortal	O15130.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000267017.
Proteomic databases
PaxDb	O15130.
PRIDE	O15130.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000267017; ENSP00000267017; ENSG00000139574.
GeneID	8620.
KEGG	hsa:8620.
UCSC	uc001sdw.1. human.
Organism-specific databases
CTD	8620.
GeneCards	GC12M053896.
HGNC	HGNC:7901. NPFF.
MIM	604643. gene.
neXtProt	NX_O15130.
PharmGKB	PA31704.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44970.
HOGENOM	HOG000113843.
HOVERGEN	HBG006519.
InParanoid	O15130.
KO	K05247.
OMA	MDSRQAA.
OrthoDB	EOG49PB16.
PhylomeDB	O15130.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	O15130.
CleanEx	HS_NPFF.
Genevestigator	O15130.
GermOnline	ENSG00000139574. Homo sapiens.
Family and domain databases
InterPro	IPR008065. FMRFamid-related_peptide. [Graphical view]
PANTHER	PTHR15044. PTHR15044. 1 hit.
PIRSF	PIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTS	PR01682. FMRFAMIDEPEP.
ProtoNet	Search...
Other
GenomeRNAi	8620.
NextBio	32299.
SOURCE	Search...

Entry information

Entry name

NPFF_HUMAN

Accession

Primary (citable) accession number: O15130

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.