Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O15130 (NPFF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pro-FMRFamide-related neuropeptide FF
Alternative name(s):
FMRFamide-related peptides

Cleaved into the following 3 chains:

  1. Neuropeptide SF
    Short name=NPSF
  2. Neuropeptide FF
    Short name=NPFF
  3. Neuropeptide AF
    Short name=NPAF
Gene names
Name:NPFF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. Ref.2

Subcellular location

Secreted.

Sequence similarities

Belongs to the FARP (FMRFamide related peptide) family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionNeuropeptide
   PTMAmidation
Cleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacute inflammatory response to antigenic stimulus

Inferred from electronic annotation. Source: Ensembl

maternal process involved in female pregnancy

Inferred from electronic annotation. Source: Ensembl

negative regulation of appetite

Inferred from electronic annotation. Source: Ensembl

negative regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

negative regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Traceable author statement PubMed 10851242. Source: ProtInc

positive regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

regulation of excitatory postsynaptic membrane potential

Inferred from electronic annotation. Source: Ensembl

regulation of membrane depolarization

Inferred from electronic annotation. Source: Ensembl

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to morphine

Inferred from electronic annotation. Source: Ensembl

somatostatin secretion

Inferred from electronic annotation. Source: Ensembl

spinal cord development

Inferred from electronic annotation. Source: Ensembl

synaptic transmission

Traceable author statement Ref.1. Source: ProtInc

vasopressin secretion

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon terminus

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: Ensembl

perikaryon

Inferred from electronic annotation. Source: Ensembl

vesicle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionreceptor binding

Traceable author statement PubMed 10851242Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 6545
PRO_0000009898
Peptide66 – 7611Neuropeptide SF
PRO_0000009899
Peptide69 – 768Neuropeptide FF
PRO_0000009900
Propeptide79 – 9214
PRO_0000009901
Peptide93 – 11018Neuropeptide AF
PRO_0000009902

Amino acid modifications

Modified residue761Phenylalanine amide By similarity
Modified residue1101Phenylalanine amide By similarity

Natural variations

Natural variant881W → R.
Corresponds to variant rs35822762 [ dbSNP | Ensembl ].
VAR_049183

Sequences

Sequence LengthMass (Da)Tools
O15130 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 1E9D4ED2A69238E3

FASTA11312,440
        10         20         30         40         50         60 
MDSRQAAALL VLLLLIDGGC AEGPGGQQED QLSAEEDSEP LPPQDAQTSG SLLHYLLQAM 

        70         80         90        100        110 
ERPGRSQAFL FQPQRFGRNT QGSWRNEWLS PRAGEGLNSQ FWSLAAPQRF GKK 

« Hide

References

[1]"A human gene encoding morphine modulating peptides related to NPFF and FMRFamide."
Perry S.J., Yi-Kung Huang E., Cronk D., Bagust J., Sharma R., Walker R.J., Wilson S., Burke J.F.
FEBS Lett. 409:426-430(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF."
Catarsi S., Babinski K., Seguela P.
Neuropharmacology 41:592-600(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF005271 mRNA. Translation: AAB64288.1.
CCDSCCDS8862.1.
RefSeqNP_003708.1. NM_003717.2.
UniGeneHs.733076.

3D structure databases

ProteinModelPortalO15130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000267017.

Proteomic databases

PaxDbO15130.
PRIDEO15130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267017; ENSP00000267017; ENSG00000139574.
GeneID8620.
KEGGhsa:8620.
UCSCuc001sdw.1. human.

Organism-specific databases

CTD8620.
GeneCardsGC12M053896.
HGNCHGNC:7901. NPFF.
MIM604643. gene.
neXtProtNX_O15130.
PharmGKBPA31704.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44970.
HOGENOMHOG000113843.
HOVERGENHBG006519.
InParanoidO15130.
KOK05247.
OMADSHERWG.
OrthoDBEOG75B87K.
PhylomeDBO15130.
TreeFamTF330924.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO15130.
CleanExHS_NPFF.
GenevestigatorO15130.

Family and domain databases

InterProIPR008065. FMRFamid-related_peptide.
[Graphical view]
PANTHERPTHR15044. PTHR15044. 1 hit.
PfamPF15085. NPFF. 1 hit.
[Graphical view]
PIRSFPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSPR01682. FMRFAMIDEPEP.
ProtoNetSearch...

Other

GeneWikiNPFF.
GenomeRNAi8620.
NextBio32299.
PROO15130.
SOURCESearch...

Entry information

Entry nameNPFF_HUMAN
AccessionPrimary (citable) accession number: O15130
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM