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O15127

- SCAM2_HUMAN

UniProt

O15127 - SCAM2_HUMAN

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Protein

Secretory carrier-associated membrane protein 2

Gene

SCAMP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

GO - Biological processi

  1. post-Golgi vesicle-mediated transport Source: ProtInc
  2. protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 2
Short name:
Secretory carrier membrane protein 2
Gene namesi
Name:SCAMP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:10564. SCAMP2.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication. Recycling endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 153153CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Topological domaini175 – 1817LumenalSequence Analysis
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Topological domaini203 – 21816CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence AnalysisAdd
BLAST
Topological domaini240 – 26223LumenalSequence AnalysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence AnalysisAdd
BLAST
Topological domaini284 – 32946CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. Golgi apparatus Source: HPA
  3. integral component of membrane Source: UniProtKB
  4. intracellular membrane-bounded organelle Source: HPA
  5. nucleus Source: HPA
  6. recycling endosome membrane Source: UniProtKB
  7. trans-Golgi network membrane Source: UniProtKB
  8. transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34977.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Secretory carrier-associated membrane protein 2PRO_0000191254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei319 – 3191Phosphoserine1 Publication
Modified residuei320 – 3201Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15127.
PaxDbiO15127.
PeptideAtlasiO15127.
PRIDEiO15127.

PTM databases

PhosphoSiteiO15127.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiO15127.
CleanExiHS_SCAMP2.
ExpressionAtlasiO15127. baseline and differential.
GenevestigatoriO15127.

Organism-specific databases

HPAiHPA014699.
HPA019194.

Interactioni

Subunit structurei

Interacts with SLC6A4 and SLC9A7.2 Publications

Protein-protein interaction databases

BioGridi115377. 14 interactions.
IntActiO15127. 4 interactions.
MINTiMINT-5003778.
STRINGi9606.ENSP00000268099.

Structurei

3D structure databases

ProteinModelPortaliO15127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni203 – 21816Interaction with SLC9A7Add
BLAST

Sequence similaritiesi

Belongs to the SCAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285953.
GeneTreeiENSGT00390000014393.
HOGENOMiHOG000294221.
HOVERGENiHBG071938.
InParanoidiO15127.
OMAiSIIMMVV.
OrthoDBiEOG7FZ009.
PhylomeDBiO15127.
TreeFamiTF313797.

Family and domain databases

InterProiIPR007273. SCAMP.
[Graphical view]
PANTHERiPTHR10687. PTHR10687. 1 hit.
PfamiPF04144. SCAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15127-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAFDTNPFA DPVDVNPFQD PSVTQLTNAP QGGLAEFNPF SETNAATTVP
60 70 80 90 100
VTQLPGSSQP AVLQPSVEPT QPTPQAVVSA AQAGLLRQQE ELDRKAAELE
110 120 130 140 150
RKERELQNTV ANLHVRQNNW PPLPSWCPVK PCFYQDFSTE IPADYQRICK
160 170 180 190 200
MLYYLWMLHS VTLFLNLLAC LAWFSGNSSK GVDFGLSILW FLIFTPCAFL
210 220 230 240 250
CWYRPIYKAF RSDNSFSFFV FFFVFFCQIG IYIIQLVGIP GLGDSGWIAA
260 270 280 290 300
LSTLDNHSLA ISVIMMVVAG FFTLCAVLSV FLLQRVHSLY RRTGASFQQA
310 320
QEEFSQGIFS SRTFHRAASS AAQGAFQGN
Length:329
Mass (Da):36,649
Last modified:July 11, 2001 - v2
Checksum:i046ACB926FD951DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005038 mRNA. Translation: AAB62723.2.
AK315516 mRNA. Translation: BAG37897.1.
CH471136 Genomic DNA. Translation: EAW99300.1.
BC001376 mRNA. Translation: AAH01376.1.
BC004385 mRNA. Translation: AAH04385.1.
CCDSiCCDS10271.1.
RefSeqiNP_005688.2. NM_005697.3.
UniGeneiHs.458917.

Genome annotation databases

EnsembliENST00000268099; ENSP00000268099; ENSG00000140497.
GeneIDi10066.
KEGGihsa:10066.
UCSCiuc002azb.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005038 mRNA. Translation: AAB62723.2 .
AK315516 mRNA. Translation: BAG37897.1 .
CH471136 Genomic DNA. Translation: EAW99300.1 .
BC001376 mRNA. Translation: AAH01376.1 .
BC004385 mRNA. Translation: AAH04385.1 .
CCDSi CCDS10271.1.
RefSeqi NP_005688.2. NM_005697.3.
UniGenei Hs.458917.

3D structure databases

ProteinModelPortali O15127.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115377. 14 interactions.
IntActi O15127. 4 interactions.
MINTi MINT-5003778.
STRINGi 9606.ENSP00000268099.

PTM databases

PhosphoSitei O15127.

Proteomic databases

MaxQBi O15127.
PaxDbi O15127.
PeptideAtlasi O15127.
PRIDEi O15127.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268099 ; ENSP00000268099 ; ENSG00000140497 .
GeneIDi 10066.
KEGGi hsa:10066.
UCSCi uc002azb.1. human.

Organism-specific databases

CTDi 10066.
GeneCardsi GC15M075136.
HGNCi HGNC:10564. SCAMP2.
HPAi HPA014699.
HPA019194.
MIMi 606912. gene.
neXtProti NX_O15127.
PharmGKBi PA34977.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285953.
GeneTreei ENSGT00390000014393.
HOGENOMi HOG000294221.
HOVERGENi HBG071938.
InParanoidi O15127.
OMAi SIIMMVV.
OrthoDBi EOG7FZ009.
PhylomeDBi O15127.
TreeFami TF313797.

Miscellaneous databases

ChiTaRSi SCAMP2. human.
GeneWikii SCAMP2.
GenomeRNAii 10066.
NextBioi 38041.
PROi O15127.
SOURCEi Search...

Gene expression databases

Bgeei O15127.
CleanExi HS_SCAMP2.
ExpressionAtlasi O15127. baseline and differential.
Genevestigatori O15127.

Family and domain databases

InterProi IPR007273. SCAMP.
[Graphical view ]
PANTHERi PTHR10687. PTHR10687. 1 hit.
Pfami PF04144. SCAMP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions."
    Singleton D.R., Wu T.T., Castle J.D.
    J. Cell Sci. 110:2099-2107(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Singleton D.R., Wu T.T., Castle J.D.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7."
    Lin P.J., Williams W.P., Luu Y., Molday R.S., Orlowski J., Numata M.
    J. Cell Sci. 118:1885-1897(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SLC9A7.
  7. "Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2."
    Mueller H.K., Wiborg O., Haase J.
    J. Biol. Chem. 281:28901-28909(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SLC6A4.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSCAM2_HUMAN
AccessioniPrimary (citable) accession number: O15127
Secondary accession number(s): B2RDF0, Q9BQE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 11, 2001
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3