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O15127

- SCAM2_HUMAN

UniProt

O15127 - SCAM2_HUMAN

Protein

Secretory carrier-associated membrane protein 2

Gene

SCAMP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (11 Jul 2001)
      Previous versions | rss
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    Functioni

    Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. post-Golgi vesicle-mediated transport Source: ProtInc
    2. protein transport Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secretory carrier-associated membrane protein 2
    Short name:
    Secretory carrier membrane protein 2
    Gene namesi
    Name:SCAMP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:10564. SCAMP2.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication. Recycling endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi apparatus Source: HPA
    3. integral component of membrane Source: UniProtKB
    4. intracellular membrane-bounded organelle Source: HPA
    5. nucleus Source: HPA
    6. recycling endosome membrane Source: UniProtKB
    7. trans-Golgi network membrane Source: UniProtKB
    8. transport vesicle Source: Ensembl

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34977.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Secretory carrier-associated membrane protein 2PRO_0000191254Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei319 – 3191Phosphoserine1 Publication
    Modified residuei320 – 3201Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO15127.
    PaxDbiO15127.
    PeptideAtlasiO15127.
    PRIDEiO15127.

    PTM databases

    PhosphoSiteiO15127.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiO15127.
    BgeeiO15127.
    CleanExiHS_SCAMP2.
    GenevestigatoriO15127.

    Organism-specific databases

    HPAiHPA014699.
    HPA019194.

    Interactioni

    Subunit structurei

    Interacts with SLC6A4 and SLC9A7.2 Publications

    Protein-protein interaction databases

    BioGridi115377. 6 interactions.
    IntActiO15127. 4 interactions.
    MINTiMINT-5003778.
    STRINGi9606.ENSP00000268099.

    Structurei

    3D structure databases

    ProteinModelPortaliO15127.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 153153CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 1817LumenalSequence Analysis
    Topological domaini203 – 21816CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini240 – 26223LumenalSequence AnalysisAdd
    BLAST
    Topological domaini284 – 32946CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni203 – 21816Interaction with SLC9A7Add
    BLAST

    Sequence similaritiesi

    Belongs to the SCAMP family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285953.
    HOGENOMiHOG000294221.
    HOVERGENiHBG071938.
    InParanoidiO15127.
    OMAiSIIMMVV.
    OrthoDBiEOG7FZ009.
    PhylomeDBiO15127.
    TreeFamiTF313797.

    Family and domain databases

    InterProiIPR007273. SCAMP.
    [Graphical view]
    PANTHERiPTHR10687. PTHR10687. 1 hit.
    PfamiPF04144. SCAMP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15127-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAFDTNPFA DPVDVNPFQD PSVTQLTNAP QGGLAEFNPF SETNAATTVP    50
    VTQLPGSSQP AVLQPSVEPT QPTPQAVVSA AQAGLLRQQE ELDRKAAELE 100
    RKERELQNTV ANLHVRQNNW PPLPSWCPVK PCFYQDFSTE IPADYQRICK 150
    MLYYLWMLHS VTLFLNLLAC LAWFSGNSSK GVDFGLSILW FLIFTPCAFL 200
    CWYRPIYKAF RSDNSFSFFV FFFVFFCQIG IYIIQLVGIP GLGDSGWIAA 250
    LSTLDNHSLA ISVIMMVVAG FFTLCAVLSV FLLQRVHSLY RRTGASFQQA 300
    QEEFSQGIFS SRTFHRAASS AAQGAFQGN 329
    Length:329
    Mass (Da):36,649
    Last modified:July 11, 2001 - v2
    Checksum:i046ACB926FD951DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF005038 mRNA. Translation: AAB62723.2.
    AK315516 mRNA. Translation: BAG37897.1.
    CH471136 Genomic DNA. Translation: EAW99300.1.
    BC001376 mRNA. Translation: AAH01376.1.
    BC004385 mRNA. Translation: AAH04385.1.
    CCDSiCCDS10271.1.
    RefSeqiNP_005688.2. NM_005697.3.
    UniGeneiHs.458917.

    Genome annotation databases

    EnsembliENST00000268099; ENSP00000268099; ENSG00000140497.
    GeneIDi10066.
    KEGGihsa:10066.
    UCSCiuc002azb.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF005038 mRNA. Translation: AAB62723.2 .
    AK315516 mRNA. Translation: BAG37897.1 .
    CH471136 Genomic DNA. Translation: EAW99300.1 .
    BC001376 mRNA. Translation: AAH01376.1 .
    BC004385 mRNA. Translation: AAH04385.1 .
    CCDSi CCDS10271.1.
    RefSeqi NP_005688.2. NM_005697.3.
    UniGenei Hs.458917.

    3D structure databases

    ProteinModelPortali O15127.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115377. 6 interactions.
    IntActi O15127. 4 interactions.
    MINTi MINT-5003778.
    STRINGi 9606.ENSP00000268099.

    PTM databases

    PhosphoSitei O15127.

    Proteomic databases

    MaxQBi O15127.
    PaxDbi O15127.
    PeptideAtlasi O15127.
    PRIDEi O15127.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268099 ; ENSP00000268099 ; ENSG00000140497 .
    GeneIDi 10066.
    KEGGi hsa:10066.
    UCSCi uc002azb.1. human.

    Organism-specific databases

    CTDi 10066.
    GeneCardsi GC15M075136.
    HGNCi HGNC:10564. SCAMP2.
    HPAi HPA014699.
    HPA019194.
    MIMi 606912. gene.
    neXtProti NX_O15127.
    PharmGKBi PA34977.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285953.
    HOGENOMi HOG000294221.
    HOVERGENi HBG071938.
    InParanoidi O15127.
    OMAi SIIMMVV.
    OrthoDBi EOG7FZ009.
    PhylomeDBi O15127.
    TreeFami TF313797.

    Miscellaneous databases

    ChiTaRSi SCAMP2. human.
    GeneWikii SCAMP2.
    GenomeRNAii 10066.
    NextBioi 38041.
    PROi O15127.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15127.
    Bgeei O15127.
    CleanExi HS_SCAMP2.
    Genevestigatori O15127.

    Family and domain databases

    InterProi IPR007273. SCAMP.
    [Graphical view ]
    PANTHERi PTHR10687. PTHR10687. 1 hit.
    Pfami PF04144. SCAMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions."
      Singleton D.R., Wu T.T., Castle J.D.
      J. Cell Sci. 110:2099-2107(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Singleton D.R., Wu T.T., Castle J.D.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    6. "Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7."
      Lin P.J., Williams W.P., Luu Y., Molday R.S., Orlowski J., Numata M.
      J. Cell Sci. 118:1885-1897(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SLC9A7.
    7. "Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2."
      Mueller H.K., Wiborg O., Haase J.
      J. Biol. Chem. 281:28901-28909(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SLC6A4.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSCAM2_HUMAN
    AccessioniPrimary (citable) accession number: O15127
    Secondary accession number(s): B2RDF0, Q9BQE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 11, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3