O15125 (O15125_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Alternative spliced form of p15 CDK inhibitor EMBL AAB69989.1

Submitted name:
Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4) EMBL CAH70602.1
Submitted name:
Uncharacterized protein Ensembl ENSP00000445136 Ensembl ENSP00000369487

Gene names

Name:	CDKN2B EMBL CAH70602.1 Ensembl ENSP00000445136 Ensembl ENSP00000369487
ORF Names:	RP11-149I2.1-002 EMBL CAH70602.1

Organism

Homo sapiens (Human) EMBL AAB69989.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Kinase EMBL CAH70602.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	cyclin-dependent protein kinase inhibitor activity Non-traceable author statement Ref.1. Source: UniProtKB kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O15125 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 3EB74DDEC36E674D	FASTA	78	8,078
	10 20 30 40 50 60 MREENKGMPS GGGSDEGLAS AAARGLVEKV RQLLEAGADP NGVNRFGRRA IQVAGAPGPR 70 RQGARERGAR PRRIGAGT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor." Tsubari M., Tiihonen E., Laiho M. Cancer Res. 57:2966-2973(1997) [PubMed: 9230210] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Babbage A. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF004819 mRNA. Translation: AAB69989.1. AL449423 Genomic DNA. Translation: CAH70602.1.
IPI	IPI00010054.
RefSeq	NP_511042.1. NM_078487.2.
UniGene	Hs.72901.
3D structure databases
HSSP	HSSP built from PDB template 1D9S based on UniProtKB P55271.
ProteinModelPortal	O15125.
SMR	O15125. Positions 11-53.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1377924.
STRING	O15125.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380142; ENSP00000369487; ENSG00000147883. ENST00000539462; ENSP00000445136; ENSG00000147883.
GeneID	1030.
KEGG	hsa:1030.
UCSC	uc003zpn.1. human.
Organism-specific databases
CTD	1030.
HGNC	HGNC:1788. CDKN2B.
PharmGKB	PA26321.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06503.
HOVERGEN	HBG052822.
Gene expression databases
ArrayExpress	O15125.
Bgee	O15125.
Family and domain databases
InterPro	IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
KO	K04685.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	4331.

Entry information

Entry name

O15125_HUMAN

Accession

Primary (citable) accession number: O15125

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.