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Protein

Angiopoietin-2

Gene

ANGPT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi429CalciumCombined sources2 Publications1
Metal bindingi431CalciumCombined sources2 Publications1
Metal bindingi433Calcium; via carbonyl oxygenCombined sources2 Publications1
Metal bindingi435Calcium; via carbonyl oxygenCombined sources2 Publications1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • receptor tyrosine kinase binding Source: UniProtKB
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-210993 Tie2 Signaling
SignaLinkiO15123
SIGNORiO15123

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-2
Short name:
ANG-2
Gene namesi
Name:ANGPT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000091879.13
HGNCiHGNC:485 ANGPT2
MIMi601922 gene
neXtProtiNX_O15123

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi285
OpenTargetsiENSG00000091879
PharmGKBiPA24792

Chemistry databases

ChEMBLiCHEMBL3580489

Polymorphism and mutation databases

BioMutaiANGPT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000911319 – 496Angiopoietin-2Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi284 ↔ 313Combined sources2 Publications
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi433 ↔ 435Combined sources2 Publications
Disulfide bondi437 ↔ 450Combined sources2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO15123
PaxDbiO15123
PeptideAtlasiO15123
PRIDEiO15123
ProteomicsDBi48460
48461 [O15123-2]
48462 [O15123-3]

PTM databases

GlyConnecti664
iPTMnetiO15123
PhosphoSitePlusiO15123
SwissPalmiO15123
UniCarbKBiO15123

Expressioni

Gene expression databases

BgeeiENSG00000091879
CleanExiHS_ANGPT2
ExpressionAtlasiO15123 baseline and differential
GenevisibleiO15123 HS

Organism-specific databases

HPAiCAB011437
CAB017626

Interactioni

Subunit structurei

Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TEKQ027635EBI-15552475,EBI-2257090

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB
  • signaling receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi106782, 13 interactors
DIPiDIP-6048N
IntActiO15123, 6 interactors
MINTiO15123
STRINGi9606.ENSP00000314897

Structurei

Secondary structure

1496
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi281 – 283Combined sources3
Helixi284 – 289Combined sources6
Beta strandi296 – 301Combined sources6
Beta strandi308 – 314Combined sources7
Helixi317 – 319Combined sources3
Beta strandi322 – 331Combined sources10
Helixi339 – 344Combined sources6
Beta strandi351 – 354Combined sources4
Helixi357 – 364Combined sources8
Beta strandi369 – 376Combined sources8
Beta strandi378 – 380Combined sources3
Beta strandi382 – 392Combined sources11
Helixi395 – 397Combined sources3
Beta strandi401 – 410Combined sources10
Beta strandi431 – 435Combined sources5
Helixi437 – 441Combined sources5
Beta strandi448 – 450Combined sources3
Beta strandi452 – 454Combined sources3
Beta strandi471 – 474Combined sources4
Helixi475 – 478Combined sources4
Beta strandi485 – 493Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z3SX-ray2.35A/B281-496[»]
1Z3UX-ray2.25A/B/C/D281-496[»]
2GY7X-ray3.70A281-495[»]
4JZCX-ray1.90A279-496[»]
4ZFGX-ray2.27A277-496[»]
ProteinModelPortaliO15123
SMRiO15123
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15123

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini275 – 495Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili166 – 248Sequence analysisAdd BLAST83

Domaini

The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00920000148944
HOGENOMiHOG000037128
HOVERGENiHBG001644
InParanoidiO15123
KOiK05466
OMAiYWKGSGY
OrthoDBiEOG091G03M1
PhylomeDBiO15123
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 2 hits
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR028844 Ang-2
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF199 PTHR19143:SF199, 1 hit
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15123-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWQIVFFTLS CDLVLAAAYN NFRKSMDSIG KKQYQVQHGS CSYTFLLPEM
60 70 80 90 100
DNCRSSSSPY VSNAVQRDAP LEYDDSVQRL QVLENIMENN TQWLMKLENY
110 120 130 140 150
IQDNMKKEMV EIQQNAVQNQ TAVMIEIGTN LLNQTAEQTR KLTDVEAQVL
160 170 180 190 200
NQTTRLELQL LEHSLSTNKL EKQILDQTSE INKLQDKNSF LEKKVLAMED
210 220 230 240 250
KHIIQLQSIK EEKDQLQVLV SKQNSIIEEL EKKIVTATVN NSVLQKQQHD
260 270 280 290 300
LMETVNNLLT MMSTSNSAKD PTVAKEEQIS FRDCAEVFKS GHTTNGIYTL
310 320 330 340 350
TFPNSTEEIK AYCDMEAGGG GWTIIQRRED GSVDFQRTWK EYKVGFGNPS
360 370 380 390 400
GEYWLGNEFV SQLTNQQRYV LKIHLKDWEG NEAYSLYEHF YLSSEELNYR
410 420 430 440 450
IHLKGLTGTA GKISSISQPG NDFSTKDGDN DKCICKCSQM LTGGWWFDAC
460 470 480 490
GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF
Length:496
Mass (Da):56,919
Last modified:January 1, 1998 - v1
Checksum:i5642A58847A7385C
GO
Isoform 3 (identifier: O15123-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-148: Missing.

Show »
Length:444
Mass (Da):50,958
Checksum:iE512409CE73987A1
GO
Isoform 2 (identifier: O15123-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-268: Missing.

Note: No experimental confirmation available.
Show »
Length:495
Mass (Da):56,848
Checksum:iEBFAC35ABF1F08F6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049069333V → I. Corresponds to variant dbSNP:rs7813215EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00154097 – 148Missing in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_040096268Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004327 mRNA Translation: AAB63190.1
AB009865 mRNA Translation: BAA95590.1
AF187858 mRNA Translation: AAF76526.1
AK290070 mRNA Translation: BAF82759.1
AC018398 Genomic DNA No translation available.
CH471153 Genomic DNA Translation: EAW80474.1
BC126200 mRNA Translation: AAI26201.1
BC126202 mRNA Translation: AAI26203.1
BC143902 mRNA Translation: AAI43903.1
CCDSiCCDS47761.1 [O15123-2]
CCDS47762.1 [O15123-3]
CCDS5958.1 [O15123-1]
RefSeqiNP_001112359.1, NM_001118887.1 [O15123-3]
NP_001112360.1, NM_001118888.1 [O15123-2]
NP_001138.1, NM_001147.2 [O15123-1]
UniGeneiHs.583870

Genome annotation databases

EnsembliENST00000325203; ENSP00000314897; ENSG00000091879 [O15123-1]
ENST00000338312; ENSP00000343517; ENSG00000091879 [O15123-2]
ENST00000629816; ENSP00000486858; ENSG00000091879 [O15123-3]
GeneIDi285
KEGGihsa:285
UCSCiuc003wqj.6 human [O15123-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANGP2_HUMAN
AccessioniPrimary (citable) accession number: O15123
Secondary accession number(s): A0AV38
, A8K205, B7ZLM7, Q9NRR7, Q9P2Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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