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Protein

Angiopoietin-2

Gene

ANGPT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi429CalciumCombined sources2 Publications1
Metal bindingi431CalciumCombined sources2 Publications1
Metal bindingi433Calcium; via carbonyl oxygenCombined sources2 Publications1
Metal bindingi435Calcium; via carbonyl oxygenCombined sources2 Publications1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • receptor binding Source: ProtInc
  • receptor tyrosine kinase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000091879-MONOMER.
ReactomeiR-HSA-210993. Tie2 Signaling.
SignaLinkiO15123.
SIGNORiO15123.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-2
Short name:
ANG-2
Gene namesi
Name:ANGPT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:485. ANGPT2.

Subcellular locationi

GO - Cellular componenti

  • cell projection Source: Ensembl
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • nucleus Source: Ensembl
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi285.
OpenTargetsiENSG00000091879.
PharmGKBiPA24792.

Polymorphism and mutation databases

BioMutaiANGPT2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000911319 – 496Angiopoietin-2Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi133N-linked (GlcNAc...)Sequence analysis1
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Glycosylationi240N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi284 ↔ 313Combined sources2 Publications
Glycosylationi304N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi433 ↔ 435Combined sources2 Publications
Disulfide bondi437 ↔ 450Combined sources2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO15123.
PaxDbiO15123.
PeptideAtlasiO15123.
PRIDEiO15123.

PTM databases

iPTMnetiO15123.
PhosphoSitePlusiO15123.
SwissPalmiO15123.
UniCarbKBiO15123.

Expressioni

Gene expression databases

BgeeiENSG00000091879.
CleanExiHS_ANGPT2.
ExpressionAtlasiO15123. baseline and differential.
GenevisibleiO15123. HS.

Organism-specific databases

HPAiCAB011437.
CAB017626.

Interactioni

Subunit structurei

Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TEKQ027634EBI-2912111,EBI-2257090

GO - Molecular functioni

  • receptor binding Source: ProtInc
  • receptor tyrosine kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi106782. 9 interactors.
DIPiDIP-6048N.
IntActiO15123. 6 interactors.
MINTiMINT-8247351.
STRINGi9606.ENSP00000314897.

Structurei

Secondary structure

1496
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi281 – 283Combined sources3
Helixi284 – 289Combined sources6
Beta strandi296 – 301Combined sources6
Beta strandi308 – 314Combined sources7
Helixi317 – 319Combined sources3
Beta strandi322 – 331Combined sources10
Helixi339 – 344Combined sources6
Beta strandi351 – 354Combined sources4
Helixi357 – 364Combined sources8
Beta strandi369 – 376Combined sources8
Beta strandi378 – 380Combined sources3
Beta strandi382 – 392Combined sources11
Helixi395 – 397Combined sources3
Beta strandi401 – 410Combined sources10
Beta strandi431 – 435Combined sources5
Helixi437 – 441Combined sources5
Beta strandi448 – 450Combined sources3
Beta strandi452 – 454Combined sources3
Beta strandi471 – 474Combined sources4
Helixi475 – 478Combined sources4
Beta strandi485 – 493Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z3SX-ray2.35A/B281-496[»]
1Z3UX-ray2.25A/B/C/D281-496[»]
2GY7X-ray3.70A281-495[»]
4JZCX-ray1.90A279-496[»]
4ZFGX-ray2.27A277-496[»]
ProteinModelPortaliO15123.
SMRiO15123.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15123.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini275 – 495Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili166 – 248Sequence analysisAdd BLAST83

Domaini

The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037128.
HOVERGENiHBG001644.
InParanoidiO15123.
KOiK05466.
OMAiTWKEYKV.
OrthoDBiEOG091G03M1.
PhylomeDBiO15123.
TreeFamiTF336658.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028844. Ang-2.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF199. PTHR19143:SF199. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15123-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWQIVFFTLS CDLVLAAAYN NFRKSMDSIG KKQYQVQHGS CSYTFLLPEM
60 70 80 90 100
DNCRSSSSPY VSNAVQRDAP LEYDDSVQRL QVLENIMENN TQWLMKLENY
110 120 130 140 150
IQDNMKKEMV EIQQNAVQNQ TAVMIEIGTN LLNQTAEQTR KLTDVEAQVL
160 170 180 190 200
NQTTRLELQL LEHSLSTNKL EKQILDQTSE INKLQDKNSF LEKKVLAMED
210 220 230 240 250
KHIIQLQSIK EEKDQLQVLV SKQNSIIEEL EKKIVTATVN NSVLQKQQHD
260 270 280 290 300
LMETVNNLLT MMSTSNSAKD PTVAKEEQIS FRDCAEVFKS GHTTNGIYTL
310 320 330 340 350
TFPNSTEEIK AYCDMEAGGG GWTIIQRRED GSVDFQRTWK EYKVGFGNPS
360 370 380 390 400
GEYWLGNEFV SQLTNQQRYV LKIHLKDWEG NEAYSLYEHF YLSSEELNYR
410 420 430 440 450
IHLKGLTGTA GKISSISQPG NDFSTKDGDN DKCICKCSQM LTGGWWFDAC
460 470 480 490
GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF
Length:496
Mass (Da):56,919
Last modified:January 1, 1998 - v1
Checksum:i5642A58847A7385C
GO
Isoform 3 (identifier: O15123-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-148: Missing.

Show »
Length:444
Mass (Da):50,958
Checksum:iE512409CE73987A1
GO
Isoform 2 (identifier: O15123-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-268: Missing.

Note: No experimental confirmation available.
Show »
Length:495
Mass (Da):56,848
Checksum:iEBFAC35ABF1F08F6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049069333V → I.Corresponds to variant rs7813215dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00154097 – 148Missing in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_040096268Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004327 mRNA. Translation: AAB63190.1.
AB009865 mRNA. Translation: BAA95590.1.
AF187858 mRNA. Translation: AAF76526.1.
AK290070 mRNA. Translation: BAF82759.1.
AC018398 Genomic DNA. No translation available.
CH471153 Genomic DNA. Translation: EAW80474.1.
BC126200 mRNA. Translation: AAI26201.1.
BC126202 mRNA. Translation: AAI26203.1.
BC143902 mRNA. Translation: AAI43903.1.
CCDSiCCDS47761.1. [O15123-2]
CCDS47762.1. [O15123-3]
CCDS5958.1. [O15123-1]
RefSeqiNP_001112359.1. NM_001118887.1. [O15123-3]
NP_001112360.1. NM_001118888.1. [O15123-2]
NP_001138.1. NM_001147.2. [O15123-1]
UniGeneiHs.583870.

Genome annotation databases

EnsembliENST00000325203; ENSP00000314897; ENSG00000091879. [O15123-1]
ENST00000338312; ENSP00000343517; ENSG00000091879. [O15123-2]
ENST00000629816; ENSP00000486858; ENSG00000091879. [O15123-3]
GeneIDi285.
KEGGihsa:285.
UCSCiuc003wqj.6. human. [O15123-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Angiopoietin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004327 mRNA. Translation: AAB63190.1.
AB009865 mRNA. Translation: BAA95590.1.
AF187858 mRNA. Translation: AAF76526.1.
AK290070 mRNA. Translation: BAF82759.1.
AC018398 Genomic DNA. No translation available.
CH471153 Genomic DNA. Translation: EAW80474.1.
BC126200 mRNA. Translation: AAI26201.1.
BC126202 mRNA. Translation: AAI26203.1.
BC143902 mRNA. Translation: AAI43903.1.
CCDSiCCDS47761.1. [O15123-2]
CCDS47762.1. [O15123-3]
CCDS5958.1. [O15123-1]
RefSeqiNP_001112359.1. NM_001118887.1. [O15123-3]
NP_001112360.1. NM_001118888.1. [O15123-2]
NP_001138.1. NM_001147.2. [O15123-1]
UniGeneiHs.583870.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z3SX-ray2.35A/B281-496[»]
1Z3UX-ray2.25A/B/C/D281-496[»]
2GY7X-ray3.70A281-495[»]
4JZCX-ray1.90A279-496[»]
4ZFGX-ray2.27A277-496[»]
ProteinModelPortaliO15123.
SMRiO15123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106782. 9 interactors.
DIPiDIP-6048N.
IntActiO15123. 6 interactors.
MINTiMINT-8247351.
STRINGi9606.ENSP00000314897.

PTM databases

iPTMnetiO15123.
PhosphoSitePlusiO15123.
SwissPalmiO15123.
UniCarbKBiO15123.

Polymorphism and mutation databases

BioMutaiANGPT2.

Proteomic databases

EPDiO15123.
PaxDbiO15123.
PeptideAtlasiO15123.
PRIDEiO15123.

Protocols and materials databases

DNASUi285.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325203; ENSP00000314897; ENSG00000091879. [O15123-1]
ENST00000338312; ENSP00000343517; ENSG00000091879. [O15123-2]
ENST00000629816; ENSP00000486858; ENSG00000091879. [O15123-3]
GeneIDi285.
KEGGihsa:285.
UCSCiuc003wqj.6. human. [O15123-1]

Organism-specific databases

CTDi285.
DisGeNETi285.
GeneCardsiANGPT2.
HGNCiHGNC:485. ANGPT2.
HPAiCAB011437.
CAB017626.
MIMi601922. gene.
neXtProtiNX_O15123.
OpenTargetsiENSG00000091879.
PharmGKBiPA24792.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037128.
HOVERGENiHBG001644.
InParanoidiO15123.
KOiK05466.
OMAiTWKEYKV.
OrthoDBiEOG091G03M1.
PhylomeDBiO15123.
TreeFamiTF336658.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000091879-MONOMER.
ReactomeiR-HSA-210993. Tie2 Signaling.
SignaLinkiO15123.
SIGNORiO15123.

Miscellaneous databases

EvolutionaryTraceiO15123.
GeneWikiiANGPT2.
GenomeRNAii285.
PROiO15123.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091879.
CleanExiHS_ANGPT2.
ExpressionAtlasiO15123. baseline and differential.
GenevisibleiO15123. HS.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028844. Ang-2.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF199. PTHR19143:SF199. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANGP2_HUMAN
AccessioniPrimary (citable) accession number: O15123
Secondary accession number(s): A0AV38
, A8K205, B7ZLM7, Q9NRR7, Q9P2Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.