Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O15123

- ANGP2_HUMAN

UniProt

O15123 - ANGP2_HUMAN

Protein

Angiopoietin-2

Gene

ANGPT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.4 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi429 – 4291Calcium
    Metal bindingi431 – 4311Calcium
    Metal bindingi433 – 4331Calcium; via carbonyl oxygen
    Metal bindingi435 – 4351Calcium; via carbonyl oxygen

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. receptor binding Source: ProtInc
    4. receptor tyrosine kinase binding Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. blood coagulation Source: Reactome
    3. cellular response to growth factor stimulus Source: Ensembl
    4. germ cell development Source: Ensembl
    5. glomerulus vasculature development Source: UniProtKB
    6. leukocyte migration Source: Reactome
    7. maternal process involved in female pregnancy Source: Ensembl
    8. negative regulation of angiogenesis Source: Ensembl
    9. negative regulation of blood vessel endothelial cell migration Source: UniProtKB
    10. negative regulation of cell-substrate adhesion Source: Ensembl
    11. negative regulation of positive chemotaxis Source: UniProtKB
    12. organ regeneration Source: Ensembl
    13. positive regulation of angiogenesis Source: Ensembl
    14. response to activity Source: Ensembl
    15. response to glucose Source: Ensembl
    16. response to hypoxia Source: Ensembl
    17. response to mechanical stimulus Source: Ensembl
    18. response to organic cyclic compound Source: Ensembl
    19. response to radiation Source: Ensembl
    20. signal transduction Source: ProtInc
    21. Tie signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_12621. Tie2 Signaling.
    SignaLinkiO15123.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiopoietin-2
    Short name:
    ANG-2
    Gene namesi
    Name:ANGPT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:485. ANGPT2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell projection Source: Ensembl
    2. extracellular region Source: Reactome
    3. extracellular space Source: UniProtKB
    4. nucleus Source: Ensembl
    5. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24792.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 496478Angiopoietin-2PRO_0000009113Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi284 ↔ 313
    Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi433 ↔ 435
    Disulfide bondi437 ↔ 450

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO15123.
    PRIDEiO15123.

    PTM databases

    PhosphoSiteiO15123.

    Expressioni

    Gene expression databases

    ArrayExpressiO15123.
    BgeeiO15123.
    CleanExiHS_ANGPT2.
    GenevestigatoriO15123.

    Organism-specific databases

    HPAiCAB011437.
    CAB017626.

    Interactioni

    Subunit structurei

    Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TEKQ027634EBI-2912111,EBI-2257090

    Protein-protein interaction databases

    BioGridi106782. 7 interactions.
    DIPiDIP-6048N.
    IntActiO15123. 6 interactions.
    MINTiMINT-8247351.
    STRINGi9606.ENSP00000314897.

    Structurei

    Secondary structure

    1
    496
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi281 – 2833
    Helixi284 – 2896
    Beta strandi296 – 3016
    Beta strandi308 – 3147
    Beta strandi322 – 33110
    Helixi339 – 3446
    Beta strandi351 – 3544
    Helixi357 – 3648
    Beta strandi369 – 3768
    Beta strandi378 – 3803
    Beta strandi382 – 39211
    Helixi395 – 3973
    Beta strandi401 – 41010
    Beta strandi431 – 4355
    Helixi437 – 4415
    Beta strandi448 – 4503
    Beta strandi452 – 4543
    Helixi475 – 4784
    Beta strandi485 – 4939

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Z3SX-ray2.35A/B281-496[»]
    1Z3UX-ray2.25A/B/C/D281-496[»]
    2GY7X-ray3.70A281-495[»]
    4JZCX-ray1.90A279-496[»]
    ProteinModelPortaliO15123.
    SMRiO15123. Positions 165-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO15123.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini275 – 495221Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili166 – 24883Sequence AnalysisAdd
    BLAST

    Domaini

    The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.

    Sequence similaritiesi

    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG298026.
    HOGENOMiHOG000037128.
    HOVERGENiHBG001644.
    InParanoidiO15123.
    KOiK05466.
    OMAiIKAYCDM.
    OrthoDBiEOG7X9G60.
    PhylomeDBiO15123.
    TreeFamiTF336658.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR028844. Ang-2.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view]
    PANTHERiPTHR19143:SF199. PTHR19143:SF199. 1 hit.
    PfamiPF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15123-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWQIVFFTLS CDLVLAAAYN NFRKSMDSIG KKQYQVQHGS CSYTFLLPEM    50
    DNCRSSSSPY VSNAVQRDAP LEYDDSVQRL QVLENIMENN TQWLMKLENY 100
    IQDNMKKEMV EIQQNAVQNQ TAVMIEIGTN LLNQTAEQTR KLTDVEAQVL 150
    NQTTRLELQL LEHSLSTNKL EKQILDQTSE INKLQDKNSF LEKKVLAMED 200
    KHIIQLQSIK EEKDQLQVLV SKQNSIIEEL EKKIVTATVN NSVLQKQQHD 250
    LMETVNNLLT MMSTSNSAKD PTVAKEEQIS FRDCAEVFKS GHTTNGIYTL 300
    TFPNSTEEIK AYCDMEAGGG GWTIIQRRED GSVDFQRTWK EYKVGFGNPS 350
    GEYWLGNEFV SQLTNQQRYV LKIHLKDWEG NEAYSLYEHF YLSSEELNYR 400
    IHLKGLTGTA GKISSISQPG NDFSTKDGDN DKCICKCSQM LTGGWWFDAC 450
    GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF 496
    Length:496
    Mass (Da):56,919
    Last modified:January 1, 1998 - v1
    Checksum:i5642A58847A7385C
    GO
    Isoform 3 (identifier: O15123-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         97-148: Missing.

    Show »
    Length:444
    Mass (Da):50,958
    Checksum:iE512409CE73987A1
    GO
    Isoform 2 (identifier: O15123-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         268-268: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:495
    Mass (Da):56,848
    Checksum:iEBFAC35ABF1F08F6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti333 – 3331V → I.
    Corresponds to variant rs7813215 [ dbSNP | Ensembl ].
    VAR_049069

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei97 – 14852Missing in isoform 3. 1 PublicationVSP_001540Add
    BLAST
    Alternative sequencei268 – 2681Missing in isoform 2. 2 PublicationsVSP_040096

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004327 mRNA. Translation: AAB63190.1.
    AB009865 mRNA. Translation: BAA95590.1.
    AF187858 mRNA. Translation: AAF76526.1.
    AK290070 mRNA. Translation: BAF82759.1.
    AC018398 Genomic DNA. No translation available.
    CH471153 Genomic DNA. Translation: EAW80474.1.
    BC126200 mRNA. Translation: AAI26201.1.
    BC126202 mRNA. Translation: AAI26203.1.
    BC143902 mRNA. Translation: AAI43903.1.
    CCDSiCCDS47761.1. [O15123-2]
    CCDS47762.1. [O15123-3]
    CCDS5958.1. [O15123-1]
    RefSeqiNP_001112359.1. NM_001118887.1. [O15123-3]
    NP_001112360.1. NM_001118888.1. [O15123-2]
    NP_001138.1. NM_001147.2. [O15123-1]
    UniGeneiHs.583870.

    Genome annotation databases

    EnsembliENST00000325203; ENSP00000314897; ENSG00000091879. [O15123-1]
    ENST00000338312; ENSP00000343517; ENSG00000091879. [O15123-2]
    GeneIDi285.
    KEGGihsa:285.
    UCSCiuc003wqj.4. human. [O15123-1]
    uc003wqk.4. human. [O15123-3]
    uc010lri.3. human. [O15123-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Angiopoietin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004327 mRNA. Translation: AAB63190.1 .
    AB009865 mRNA. Translation: BAA95590.1 .
    AF187858 mRNA. Translation: AAF76526.1 .
    AK290070 mRNA. Translation: BAF82759.1 .
    AC018398 Genomic DNA. No translation available.
    CH471153 Genomic DNA. Translation: EAW80474.1 .
    BC126200 mRNA. Translation: AAI26201.1 .
    BC126202 mRNA. Translation: AAI26203.1 .
    BC143902 mRNA. Translation: AAI43903.1 .
    CCDSi CCDS47761.1. [O15123-2 ]
    CCDS47762.1. [O15123-3 ]
    CCDS5958.1. [O15123-1 ]
    RefSeqi NP_001112359.1. NM_001118887.1. [O15123-3 ]
    NP_001112360.1. NM_001118888.1. [O15123-2 ]
    NP_001138.1. NM_001147.2. [O15123-1 ]
    UniGenei Hs.583870.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Z3S X-ray 2.35 A/B 281-496 [» ]
    1Z3U X-ray 2.25 A/B/C/D 281-496 [» ]
    2GY7 X-ray 3.70 A 281-495 [» ]
    4JZC X-ray 1.90 A 279-496 [» ]
    ProteinModelPortali O15123.
    SMRi O15123. Positions 165-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106782. 7 interactions.
    DIPi DIP-6048N.
    IntActi O15123. 6 interactions.
    MINTi MINT-8247351.
    STRINGi 9606.ENSP00000314897.

    PTM databases

    PhosphoSitei O15123.

    Proteomic databases

    PaxDbi O15123.
    PRIDEi O15123.

    Protocols and materials databases

    DNASUi 285.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325203 ; ENSP00000314897 ; ENSG00000091879 . [O15123-1 ]
    ENST00000338312 ; ENSP00000343517 ; ENSG00000091879 . [O15123-2 ]
    GeneIDi 285.
    KEGGi hsa:285.
    UCSCi uc003wqj.4. human. [O15123-1 ]
    uc003wqk.4. human. [O15123-3 ]
    uc010lri.3. human. [O15123-2 ]

    Organism-specific databases

    CTDi 285.
    GeneCardsi GC08M006347.
    HGNCi HGNC:485. ANGPT2.
    HPAi CAB011437.
    CAB017626.
    MIMi 601922. gene.
    neXtProti NX_O15123.
    PharmGKBi PA24792.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG298026.
    HOGENOMi HOG000037128.
    HOVERGENi HBG001644.
    InParanoidi O15123.
    KOi K05466.
    OMAi IKAYCDM.
    OrthoDBi EOG7X9G60.
    PhylomeDBi O15123.
    TreeFami TF336658.

    Enzyme and pathway databases

    Reactomei REACT_12621. Tie2 Signaling.
    SignaLinki O15123.

    Miscellaneous databases

    EvolutionaryTracei O15123.
    GeneWikii ANGPT2.
    GenomeRNAii 285.
    NextBioi 1151.
    PROi O15123.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15123.
    Bgeei O15123.
    CleanExi HS_ANGPT2.
    Genevestigatori O15123.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR028844. Ang-2.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view ]
    PANTHERi PTHR19143:SF199. PTHR19143:SF199. 1 hit.
    Pfami PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TEK/TIE2, FUNCTION.
      Tissue: Lung.
    2. "Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma."
      Tanaka S., Mori M., Sakamoto Y., Makuuchi M., Sugimachi K., Wands J.R.
      J. Clin. Invest. 103:341-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Characterization and expression of a novel alternatively spliced human angiopoietin-2."
      Kim I., Kim J.-H., Ryu Y.S., Jung S.H., Nah J.J., Koh G.Y.
      J. Biol. Chem. 275:18550-18556(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Umbilical vein endothelial cell.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Substantia nigra.
    5. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Colon.
    8. "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats."
      Fiedler U., Krissl T., Koidl S., Weiss C., Koblizek T., Deutsch U., Martiny-Baron G., Marme D., Augustin H.G.
      J. Biol. Chem. 278:1721-1727(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TEK/TIE2.
    9. "Biological characterization of angiopoietin-3 and angiopoietin-4."
      Lee H.J., Cho C.H., Hwang S.J., Choi H.H., Kim K.T., Ahn S.Y., Kim J.H., Oh J.L., Lee G.M., Koh G.Y.
      FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1, INTERACTION WITH TEK/TIE2.
    10. "Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells."
      Yacyshyn O.K., Lai P.F.H., Forse K., Teichert-Kuliszewska K., Jurasz P., Stewart D.J.
      Angiogenesis 12:25-33(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium."
      Yuan H.T., Khankin E.V., Karumanchi S.A., Parikh S.M.
      Mol. Cell. Biol. 29:2011-2022(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TEK/TIE2.
    12. "Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system."
      Augustin H.G., Koh G.Y., Thurston G., Alitalo K.
      Nat. Rev. Mol. Cell Biol. 10:165-177(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    13. "Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition."
      Barton W.A., Tzvetkova D., Nikolov D.B.
      Structure 13:825-832(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 281-496, DISULFIDE BONDS, CALCIUM-BINDING SITES.
    14. "Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex."
      Barton W.A., Tzvetkova-Robev D., Miranda E.P., Kolev M.V., Rajashankar K.R., Himanen J.P., Nikolov D.B.
      Nat. Struct. Mol. Biol. 13:524-532(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.7 ANGSTROMS) OF 281-495 IN COMPLEX WITH TEK, DISULFIDE BONDS, CALCIUM-BINDING SITES.

    Entry informationi

    Entry nameiANGP2_HUMAN
    AccessioniPrimary (citable) accession number: O15123
    Secondary accession number(s): A0AV38
    , A8K205, B7ZLM7, Q9NRR7, Q9P2Y7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3