Reviewed, UniProtKB/Swiss-Prot O15116 (LSM1_HUMAN)

Names and origin

Protein names

Recommended name:
    U6 snRNA-associated Sm-like protein LSm1
Alternative name(s):
    Cancer-associated Sm-like
    Small nuclear ribonuclear CaSm

Gene names

Name:	LSM1
Synonyms:	CASM

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subunit structure	LSm subunits form a heteromer with a donut shape.
Subcellular location	Nucleus Potential.
Tissue specificity	Has elevated expression in pancreatic cancer and in several cancer-derived cell lines.
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
Gene Ontology (GO)
Biological process	RNA splicing Ref.2 Traceable author statement. Source: ProtInc mRNA processing Ref.2 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from direct assay. Source: MGI nucleus Ref.2 Inferred from direct assay. Source: MGI ribonucleoprotein complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA splicing factor activity, transesterification mechanism Ref.2 Traceable author statement. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CLIC1	O00299	1	EBI-347619,EBI-347404
EXOSC8	Q96B26	1	EBI-347619,EBI-371922
FAM136A	Q96C01	1	EBI-347619,EBI-373319
GRHPR	Q9UBQ7	1	EBI-347619,EBI-372445
HSP90AA1	P07900	1	EBI-347619,EBI-296047
LSM2	Q9Y333	2	EBI-347619,EBI-347416
LSM3	P62310	2	EBI-347619,EBI-348239
LSM4	Q9Y4Z0	1	EBI-347619,EBI-372521
LSM6	P62312	1	EBI-347619,EBI-373310
NARS	O43776	1	EBI-347619,EBI-373505
PSMB5	P28074	1	EBI-347619,EBI-357828
PSMB8	P28062	1	EBI-347619,EBI-372294
RRP1B	Q14684	1	EBI-347619,EBI-372051
TMEM214	Q6NUQ4	1	EBI-347619,EBI-372318
UPF2	Q9HAU5	1	EBI-347619,EBI-372073
UXT	Q9UBK9	1	EBI-347619,EBI-357355
VPS11	Q9H270	1	EBI-347619,EBI-373380

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 133	133	U6 snRNA-associated Sm-like protein LSm1		PRO_0000125554

Sequences

	Sequence		Length	Mass (Da)
	O15116-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: FF798CDA9447037A	FASTA	133	15,179
	10 20 30 40 50 60 MNYMPGTASL IEDIDKKHLV LLRDGRTLIG FLRSIDQFAN LVLHQTVERI HVGKKYGDIP 70 80 90 100 110 120 RGIFVVRGEN VVLLGEIDLE KESDTPLQQV SIEEILEEQR VEQQTKLEAE KLKVQALKDR 130 GLSIPRADTL DEY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CaSm: an Sm-like protein that contributes to the transformed state in cancer cells." Schweinfest C.W., Graber M.W., Chapman J.M., Papas T.S., Baron P.L., Watson D.K. Cancer Res. 57:2961-2965(1997) [PubMed: 9230209] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin." Salgado-Garrido J., Bragado-Nilsson E., Kandels-Lewis S., Seraphin B. EMBO J. 18:3451-3462(1999) [PubMed: 10369684] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymph node.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF000177 mRNA. Translation: AAB62189.1. AJ238094 mRNA. Translation: CAB45865.1. BC001767 mRNA. Translation: AAH01767.1.
IPI	IPI00004436.
RefSeq	NP_055277.1.
UniGene	Hs.425311
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O15116. 18 interactions.
Proteomic databases
PeptideAtlas	O15116.
PRIDE	O15116.
Genome annotation databases
Ensembl	ENSG00000175324. Homo sapiens. [Contig view]
GeneID	27257.
KEGG	hsa:27257.
Organism-specific databases
GeneCards	GC08M038140.
H-InvDB	HIX0007457.
HGNC	HGNC:20472. LSM1.
MIM	607281. gene.
PharmGKB	PA134864226.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O15116.
HOVERGEN	O15116.
OMA	O15116. TASLIDD.
Gene expression databases
ArrayExpress	O15116.
Bgee	O15116.
CleanEx	HS_LSM1.
GermOnline	ENSG00000175324. Homo sapiens.
Family and domain databases
InterPro	IPR006649. Euk_arc_LSM_core. IPR001163. LSM_snRNP_core. [Graphical view]
Pfam	PF01423. LSM. 1 hit. [Graphical view]
ProDom	PD020287. snRNP. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00651. Sm. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	50202.
SOURCE	Search...

Entry information

Entry name

LSM1_HUMAN

Accession

Primary (citable) accession number: O15116

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)