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Protein

Zinc finger protein 536

Gene

ZNF536

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 15223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri158 – 18023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29724C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32324C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri631 – 65323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri751 – 77323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri779 – 80123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 536
Gene namesi
Name:ZNF536
Synonyms:KIAA0390
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29025. ZNF536.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134920047.

Polymorphism and mutation databases

BioMutaiZNF536.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13001300Zinc finger protein 536PRO_0000271041Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei826 – 8261PhosphoserineCombined sources
Modified residuei827 – 8271PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15090.
MaxQBiO15090.
PaxDbiO15090.
PRIDEiO15090.

PTM databases

iPTMnetiO15090.
PhosphoSiteiO15090.

Expressioni

Gene expression databases

BgeeiO15090.
CleanExiHS_ZNF536.
ExpressionAtlasiO15090. baseline and differential.
GenevisibleiO15090. HS.

Interactioni

Protein-protein interaction databases

BioGridi115093. 4 interactions.
IntActiO15090. 3 interactions.
STRINGi9606.ENSP00000347730.

Structurei

3D structure databases

ProteinModelPortaliO15090.
SMRiO15090. Positions 751-802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 15223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri158 – 18023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29724C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32324C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri631 – 65323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri751 – 77323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri779 – 80123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000155801.
HOVERGENiHBG080712.
InParanoidiO15090.
OMAiQSANEFR.
PhylomeDBiO15090.
TreeFamiTF332241.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEASLCLGV SSAEPEAEPH LSGPVLNGQY AMSQKLHQIT SQLSHAFPEL
60 70 80 90 100
HPRPNPEEKP PASLEEKAHV PMSGQPMGSQ MALLANQLGR EVDTSLNGRV
110 120 130 140 150
DLQQFLNGQN LGIMSQMSDI EDDARKNRKY PCPLCGKRFR FNSILSLHMR
160 170 180 190 200
THTGEKPFKC PYCDHRAAQK GNLKIHLRTH KLGNLGKGRG RVREENRLLH
210 220 230 240 250
ELEERAILRD KQLKGSLLQP RPDLKPPPHA QQAPLAACTL ALQANHSVPD
260 270 280 290 300
VAHPVPSPKP ASVQEDAVAP AAGFRCTFCK GKFKKREELD RHIRILHKPY
310 320 330 340 350
KCTLCDFAAS QEEELISHVE KAHITAESAQ GQGPNGGGEQ SANEFRCEVC
360 370 380 390 400
GQVFSQAWFL KGHMRKHKDS FEHCCQICGR RFKEPWFLKN HMKVHLNKLS
410 420 430 440 450
VKNKSPSDPE VPVPMGGMSQ EAHANLYSRY LSCLQSGFMT PDKAGLSEPS
460 470 480 490 500
QLYGKGELPM KEKEALGKLL SPISSMAHGV PEGDKHSLLG CLNLVPPLKS
510 520 530 540 550
SCIERLQAAA KAAEMDPVNS YQAWQLMARG MAMEHGFLSK EHPLQRNHED
560 570 580 590 600
TLANAGVLFD KEKREYVLVG ADGSKQKMPA DLVHSTKVGS QRDLPSKLDP
610 620 630 640 650
LESSRDFLSH GLNQTLEYNL QGPGNMKEKP TECPDCGRVF RTYHQVVVHS
660 670 680 690 700
RVHKRDRKGE EDGLHVGLDE RRGSGSDQES QSVSRSTTPG SSNVTEESGV
710 720 730 740 750
GGGLSQTGSA QEDSPHPSSP SSSDIGEEAG RSAGVQQPAL LRDRSLGSAM
760 770 780 790 800
KDCPYCGKTF RTSHHLKVHL RIHTGEKPYK CPHCDYAGTQ SASLKYHLER
810 820 830 840 850
HHRERQNGAG PLSGQPPNQD HKDEMSSKAS LFIRPDILRG AFKGLPGIDF
860 870 880 890 900
RGGPASQQWT SGVLSSGDHS GQATGMSSEV PSDALKGTDL PSKSTHFSEI
910 920 930 940 950
GRAYQSIVSN GVNFQGSLQA FMDSFVLSSL KKEKDMKDKA LADPPSMKVH
960 970 980 990 1000
GVDGGEEKPS GKSSQRKSEK SQYEPLDLSV RPDAASLPGS SVTVQDSIAW
1010 1020 1030 1040 1050
HGCLFCAFTT SSMELMALHL QANHLGKAKR KDNTIGVTVN CKDQAREASK
1060 1070 1080 1090 1100
MALLPSLQSN KDLGLSNMIS SLDSASEKMA QGQLKETLGE QKSGAWTGHV
1110 1120 1130 1140 1150
DPAFCNFPSD FYKQFGVYPG MVGSGASSSC PNKEPDGKAH SEEDVPILIP
1160 1170 1180 1190 1200
ETTSKNTTDD LSDIASSEDM DSSKGENNDE EDVETEPEMM TKPLSALSKD
1210 1220 1230 1240 1250
SSSDGGDSLQ PTGTSQPVQG LVSPLSQAPE KQWHSQGLLQ AQDPLAGLPK
1260 1270 1280 1290 1300
PERGPQSLDK PMNMLSVLRA YSSDGLAAFN GLASSTANSG CIKRPDLCGK
Length:1,300
Mass (Da):141,417
Last modified:January 9, 2007 - v3
Checksum:i858B5B7047653664
GO

Sequence cautioni

The sequence BAA20844.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002388 mRNA. Translation: BAA20844.2. Different initiation.
BC132720 mRNA. Translation: AAI32721.1.
BC132722 mRNA. Translation: AAI32723.1.
BC146757 mRNA. Translation: AAI46758.1.
CCDSiCCDS32984.1.
RefSeqiNP_055532.1. NM_014717.2.
UniGeneiHs.378901.

Genome annotation databases

EnsembliENST00000355537; ENSP00000347730; ENSG00000198597.
GeneIDi9745.
KEGGihsa:9745.
UCSCiuc002nsu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002388 mRNA. Translation: BAA20844.2. Different initiation.
BC132720 mRNA. Translation: AAI32721.1.
BC132722 mRNA. Translation: AAI32723.1.
BC146757 mRNA. Translation: AAI46758.1.
CCDSiCCDS32984.1.
RefSeqiNP_055532.1. NM_014717.2.
UniGeneiHs.378901.

3D structure databases

ProteinModelPortaliO15090.
SMRiO15090. Positions 751-802.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115093. 4 interactions.
IntActiO15090. 3 interactions.
STRINGi9606.ENSP00000347730.

PTM databases

iPTMnetiO15090.
PhosphoSiteiO15090.

Polymorphism and mutation databases

BioMutaiZNF536.

Proteomic databases

EPDiO15090.
MaxQBiO15090.
PaxDbiO15090.
PRIDEiO15090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355537; ENSP00000347730; ENSG00000198597.
GeneIDi9745.
KEGGihsa:9745.
UCSCiuc002nsu.2. human.

Organism-specific databases

CTDi9745.
GeneCardsiZNF536.
HGNCiHGNC:29025. ZNF536.
neXtProtiNX_O15090.
PharmGKBiPA134920047.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000155801.
HOVERGENiHBG080712.
InParanoidiO15090.
OMAiQSANEFR.
PhylomeDBiO15090.
TreeFamiTF332241.

Miscellaneous databases

ChiTaRSiZNF536. human.
GenomeRNAii9745.
NextBioi36670.
PROiO15090.

Gene expression databases

BgeeiO15090.
CleanExiHS_ZNF536.
ExpressionAtlasiO15090. baseline and differential.
GenevisibleiO15090. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Ohara O., Nagase T., Kikuno R., Nomura N.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor."
    Sakai T., Hino K., Wada S., Maeda H.
    DNA Res. 10:155-165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826 AND SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiZN536_HUMAN
AccessioniPrimary (citable) accession number: O15090
Secondary accession number(s): A2RU18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 11, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.