O15084 (ANR28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
Short name=PP6-ARS-A
Short name=Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A

Alternative name(s):
Ankyrin repeat domain-containing protein 28
Phosphatase interactor targeting protein hnRNP K
Short name=PITK

Gene names

Name:	ANKRD28
Synonyms:	KIAA0379

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1053 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. Ref.6 Ref.7
Subunit structure	Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3. Ref.6 Ref.7
Subcellular location	Nucleus › nucleoplasm. Note: Seems to be excluded from nucleoli. Ref.6
Sequence similarities	Contains 27 ANK repeats.
Sequence caution	The sequence AAQ72374.1 differs from that shown. Reason: Frameshift at position 408. The sequence BAA20833.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAC86737.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative promoter usage Alternative splicing
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PPP6C	O00743	3	EBI-359567,EBI-359751
PPP6R1	Q9UPN7	4	EBI-359567,EBI-359745
PPP6R3	Q5H9R7	3	EBI-359567,EBI-355498
TNKS2	Q9H2K2	3	EBI-359567,EBI-4398527

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15084-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15084-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.

Note: Produced by alternative promoter usage.

Isoform 3 (identifier: O15084-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAFLKLRDQ → MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVLVRY

Isoform 4 (identifier: O15084-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAFLKLRDQ → MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1053	1053	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A		PRO_0000066919
Regions
	Repeat	40 – 69	30	ANK 1
	Repeat	73 – 102	30	ANK 2
	Repeat	106 – 135	30	ANK 3
	Repeat	139 – 168	30	ANK 4
	Repeat	172 – 201	30	ANK 5
	Repeat	205 – 234	30	ANK 6
	Repeat	238 – 267	30	ANK 7
	Repeat	271 – 301	31	ANK 8
	Repeat	305 – 334	30	ANK 9
	Repeat	338 – 367	30	ANK 10
	Repeat	371 – 400	30	ANK 11
	Repeat	404 – 433	30	ANK 12
	Repeat	437 – 466	30	ANK 13
	Repeat	470 – 500	31	ANK 14
	Repeat	504 – 534	31	ANK 15
	Repeat	549 – 578	30	ANK 16
	Repeat	582 – 611	30	ANK 17
	Repeat	616 – 645	30	ANK 18
	Repeat	652 – 681	30	ANK 19
	Repeat	685 – 714	30	ANK 20
	Repeat	718 – 747	30	ANK 21
	Repeat	755 – 784	30	ANK 22
	Repeat	787 – 817	31	ANK 23
	Repeat	822 – 851	30	ANK 24
	Repeat	855 – 885	31	ANK 25
	Repeat	889 – 918	30	ANK 26
	Repeat	925 – 954	30	ANK 27
Amino acid modifications
	Modified residue	84	1	Phosphoserine By similarity
	Modified residue	1007	1	Phosphoserine Ref.6
	Modified residue	1011	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 154	154	Missing in isoform 2.		VSP_012433
	Alternative sequence	1 – 9	9	MAFLKLRDQ → MSRVCIVVLEEVEDESPAFI SKLPQENKSLHSPPSGNVLV RY in isoform 3.		VSP_041013
	Alternative sequence	1 – 9	9	MAFLKLRDQ → MSRVCIVVLEEVEDESPAFI SKLPQENKSLHSPPSGNVL in isoform 4.		VSP_041014
Experimental info
	Mutagenesis	1007 – 1011	5	SKTVS → AKTVA: Marked decrease in phosphorylation. Increased PPP1C-binding. No effect on HNRPK-binding. Ref.6
	Sequence conflict	293	1	V → A in AAQ72374. Ref.1
	Sequence conflict	500	1	I → V in AAQ72374. Ref.1
	Sequence conflict	500	1	I → V in BAC86737. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 3, 2011. Version 5. Checksum: BDB4855193364585	FASTA	1,053	112,966
	10 20 30 40 50 60 MAFLKLRDQP SLVQAIFNGD PDEVRALIFK KEDVNFQDNE KRTPLHAAAY LGDAEIIELL 70 80 90 100 110 120 ILSGARVNAK DSKWLTPLHR AVASCSEEAV QVLLKHSADV NARDKNWQTP LHIAAANKAV 130 140 150 160 170 180 KCAEALVPLL SNVNVSDRAG RTALHHAAFS GHGEMVKLLL SRGANINAFD KKDRRAIHWA 190 200 210 220 230 240 AYMGHIEVVK LLVSHGAEVT CKDKKSYTPL HAAASSGMIS VVKYLLDLGV DMNEPNAYGN 250 260 270 280 290 300 TPLHVACYNG QDVVVNELID CGAIVNQKNE KGFTPLHFAA ASTHGALCLE LLVGNGADVN 310 320 330 340 350 360 MKSKDGKTPL HMTALHGRFS RSQTIIQSGA VIDCEDKNGN TPLHIAARYG HELLINTLIT 370 380 390 400 410 420 SGADTAKRGI HGMFPLHLAA LSGFSDCCRK LLSSGFDIDT PDDFGRTCLH AAAAGGNLEC 430 440 450 460 470 480 LNLLLNTGAD FNKKDKFGRS PLHYAAANCN YQCLFALVGS GASVNDLDER GCTPLHYAAT 490 500 510 520 530 540 SDTDGKCLEY LLRNDANPGI RDKQGYNAVH YSAAYGHRLC LQLIASETPL DVLMETSGTD 550 560 570 580 590 600 MLSDSDNRAT ISPLHLAAYH GHHQALEVLV QSLLDLDVRN SSGRTPLDLA AFKGHVECVD 610 620 630 640 650 660 VLINQGASIL VKDYILKRTP IHAAATNGHS ECLRLLIGNA EPQNAVDIQD GNGQTPLMLS 670 680 690 700 710 720 VLNGHTDCVY SLLNKGANVD AKDKWGRTAL HRGAVTGHEE CVDALLQHGA KCLLRDSRGR 730 740 750 760 770 780 TPIHLSAACG HIGVLGALLQ SAASMDANPA TADNHGYTAL HWACYNGHET CVELLLEQEV 790 800 810 820 830 840 FQKTEGNAFS PLHCAVINDN EGAAEMLIDT LGASIVNATD SKGRTPLHAA AFTDHVECLQ 850 860 870 880 890 900 LLLSHNAQVN SVDSTGKTPL MMAAENGQTN TVEMLVSSAS AELTLQDNSK NTALHLACSK 910 920 930 940 950 960 GHETSALLIL EKITDRNLIN ATNAALQTPL HVAARNGLTM VVQELLGKGA SVLAVDENGY 970 980 990 1000 1010 1020 TPALACAPNK DVADCLALIL ATMMPVSSSS PLSSLTFNAI NRYTNTSKTV SFEALPIMRN 1030 1040 1050 EPSSYCSFNN IGGEQEYLYT DVDELNDSDS ETY
	Isoform 2 [UniParc]. Checksum: E06723898ABF4B08	FASTA	899	96,161
	10 20 30 40 50 60 MVKLLLSRGA NINAFDKKDR RAIHWAAYMG HIEVVKLLVS HGAEVTCKDK KSYTPLHAAA 70 80 90 100 110 120 SSGMISVVKY LLDLGVDMNE PNAYGNTPLH VACYNGQDVV VNELIDCGAI VNQKNEKGFT 130 140 150 160 170 180 PLHFAAASTH GALCLELLVG NGADVNMKSK DGKTPLHMTA LHGRFSRSQT IIQSGAVIDC 190 200 210 220 230 240 EDKNGNTPLH IAARYGHELL INTLITSGAD TAKRGIHGMF PLHLAALSGF SDCCRKLLSS 250 260 270 280 290 300 GFDIDTPDDF GRTCLHAAAA GGNLECLNLL LNTGADFNKK DKFGRSPLHY AAANCNYQCL 310 320 330 340 350 360 FALVGSGASV NDLDERGCTP LHYAATSDTD GKCLEYLLRN DANPGIRDKQ GYNAVHYSAA 370 380 390 400 410 420 YGHRLCLQLI ASETPLDVLM ETSGTDMLSD SDNRATISPL HLAAYHGHHQ ALEVLVQSLL 430 440 450 460 470 480 DLDVRNSSGR TPLDLAAFKG HVECVDVLIN QGASILVKDY ILKRTPIHAA ATNGHSECLR 490 500 510 520 530 540 LLIGNAEPQN AVDIQDGNGQ TPLMLSVLNG HTDCVYSLLN KGANVDAKDK WGRTALHRGA 550 560 570 580 590 600 VTGHEECVDA LLQHGAKCLL RDSRGRTPIH LSAACGHIGV LGALLQSAAS MDANPATADN 610 620 630 640 650 660 HGYTALHWAC YNGHETCVEL LLEQEVFQKT EGNAFSPLHC AVINDNEGAA EMLIDTLGAS 670 680 690 700 710 720 IVNATDSKGR TPLHAAAFTD HVECLQLLLS HNAQVNSVDS TGKTPLMMAA ENGQTNTVEM 730 740 750 760 770 780 LVSSASAELT LQDNSKNTAL HLACSKGHET SALLILEKIT DRNLINATNA ALQTPLHVAA 790 800 810 820 830 840 RNGLTMVVQE LLGKGASVLA VDENGYTPAL ACAPNKDVAD CLALILATMM PVSSSSPLSS 850 860 870 880 890 LTFNAINRYT NTSKTVSFEA LPIMRNEPSS YCSFNNIGGE QEYLYTDVDE LNDSDSETY
	Isoform 3 [UniParc]. Checksum: 47A3F97E5C72F0E8	FASTA	1,086	116,543
	10 20 30 40 50 60 MSRVCIVVLE EVEDESPAFI SKLPQENKSL HSPPSGNVLV RYPSLVQAIF NGDPDEVRAL 70 80 90 100 110 120 IFKKEDVNFQ DNEKRTPLHA AAYLGDAEII ELLILSGARV NAKDSKWLTP LHRAVASCSE 130 140 150 160 170 180 EAVQVLLKHS ADVNARDKNW QTPLHIAAAN KAVKCAEALV PLLSNVNVSD RAGRTALHHA 190 200 210 220 230 240 AFSGHGEMVK LLLSRGANIN AFDKKDRRAI HWAAYMGHIE VVKLLVSHGA EVTCKDKKSY 250 260 270 280 290 300 TPLHAAASSG MISVVKYLLD LGVDMNEPNA YGNTPLHVAC YNGQDVVVNE LIDCGAIVNQ 310 320 330 340 350 360 KNEKGFTPLH FAAASTHGAL CLELLVGNGA DVNMKSKDGK TPLHMTALHG RFSRSQTIIQ 370 380 390 400 410 420 SGAVIDCEDK NGNTPLHIAA RYGHELLINT LITSGADTAK RGIHGMFPLH LAALSGFSDC 430 440 450 460 470 480 CRKLLSSGFD IDTPDDFGRT CLHAAAAGGN LECLNLLLNT GADFNKKDKF GRSPLHYAAA 490 500 510 520 530 540 NCNYQCLFAL VGSGASVNDL DERGCTPLHY AATSDTDGKC LEYLLRNDAN PGIRDKQGYN 550 560 570 580 590 600 AVHYSAAYGH RLCLQLIASE TPLDVLMETS GTDMLSDSDN RATISPLHLA AYHGHHQALE 610 620 630 640 650 660 VLVQSLLDLD VRNSSGRTPL DLAAFKGHVE CVDVLINQGA SILVKDYILK RTPIHAAATN 670 680 690 700 710 720 GHSECLRLLI GNAEPQNAVD IQDGNGQTPL MLSVLNGHTD CVYSLLNKGA NVDAKDKWGR 730 740 750 760 770 780 TALHRGAVTG HEECVDALLQ HGAKCLLRDS RGRTPIHLSA ACGHIGVLGA LLQSAASMDA 790 800 810 820 830 840 NPATADNHGY TALHWACYNG HETCVELLLE QEVFQKTEGN AFSPLHCAVI NDNEGAAEML 850 860 870 880 890 900 IDTLGASIVN ATDSKGRTPL HAAAFTDHVE CLQLLLSHNA QVNSVDSTGK TPLMMAAENG 910 920 930 940 950 960 QTNTVEMLVS SASAELTLQD NSKNTALHLA CSKGHETSAL LILEKITDRN LINATNAALQ 970 980 990 1000 1010 1020 TPLHVAARNG LTMVVQELLG KGASVLAVDE NGYTPALACA PNKDVADCLA LILATMMPVS 1030 1040 1050 1060 1070 1080 SSSPLSSLTF NAINRYTNTS KTVSFEALPI MRNEPSSYCS FNNIGGEQEY LYTDVDELND SDSETY
	Isoform 4 [UniParc]. Checksum: 349BC9338F251E08	FASTA	1,083	116,124
	10 20 30 40 50 60 MSRVCIVVLE EVEDESPAFI SKLPQENKSL HSPPSGNVLP SLVQAIFNGD PDEVRALIFK 70 80 90 100 110 120 KEDVNFQDNE KRTPLHAAAY LGDAEIIELL ILSGARVNAK DSKWLTPLHR AVASCSEEAV 130 140 150 160 170 180 QVLLKHSADV NARDKNWQTP LHIAAANKAV KCAEALVPLL SNVNVSDRAG RTALHHAAFS 190 200 210 220 230 240 GHGEMVKLLL SRGANINAFD KKDRRAIHWA AYMGHIEVVK LLVSHGAEVT CKDKKSYTPL 250 260 270 280 290 300 HAAASSGMIS VVKYLLDLGV DMNEPNAYGN TPLHVACYNG QDVVVNELID CGAIVNQKNE 310 320 330 340 350 360 KGFTPLHFAA ASTHGALCLE LLVGNGADVN MKSKDGKTPL HMTALHGRFS RSQTIIQSGA 370 380 390 400 410 420 VIDCEDKNGN TPLHIAARYG HELLINTLIT SGADTAKRGI HGMFPLHLAA LSGFSDCCRK 430 440 450 460 470 480 LLSSGFDIDT PDDFGRTCLH AAAAGGNLEC LNLLLNTGAD FNKKDKFGRS PLHYAAANCN 490 500 510 520 530 540 YQCLFALVGS GASVNDLDER GCTPLHYAAT SDTDGKCLEY LLRNDANPGI RDKQGYNAVH 550 560 570 580 590 600 YSAAYGHRLC LQLIASETPL DVLMETSGTD MLSDSDNRAT ISPLHLAAYH GHHQALEVLV 610 620 630 640 650 660 QSLLDLDVRN SSGRTPLDLA AFKGHVECVD VLINQGASIL VKDYILKRTP IHAAATNGHS 670 680 690 700 710 720 ECLRLLIGNA EPQNAVDIQD GNGQTPLMLS VLNGHTDCVY SLLNKGANVD AKDKWGRTAL 730 740 750 760 770 780 HRGAVTGHEE CVDALLQHGA KCLLRDSRGR TPIHLSAACG HIGVLGALLQ SAASMDANPA 790 800 810 820 830 840 TADNHGYTAL HWACYNGHET CVELLLEQEV FQKTEGNAFS PLHCAVINDN EGAAEMLIDT 850 860 870 880 890 900 LGASIVNATD SKGRTPLHAA AFTDHVECLQ LLLSHNAQVN SVDSTGKTPL MMAAENGQTN 910 920 930 940 950 960 TVEMLVSSAS AELTLQDNSK NTALHLACSK GHETSALLIL EKITDRNLIN ATNAALQTPL 970 980 990 1000 1010 1020 HVAARNGLTM VVQELLGKGA SVLAVDENGY TPALACAPNK DVADCLALIL ATMMPVSSSS 1030 1040 1050 1060 1070 1080 PLSSLTFNAI NRYTNTSKTV SFEALPIMRN EPSSYCSFNN IGGEQEYLYT DVDELNDSDS ETY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning a new transcript of KIAA0379 protein in testis." Lu L., Huang X.Y., Yin L.L., Xu M., Li J.M., Zhou Z.M., Sha J.H. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Testis.
[2]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-767 (ISOFORM 3). Tissue: Amygdala and Cerebellum.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-752 (ISOFORMS 3 AND 4).
[6]	"PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K." Kwiek N.C., Thacker D.F., Datto M.B., Megosh H.B., Haystead T.A.J. Cell. Signal. 18:1769-1778(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PPP1C AND HNRPK, PHOSPHORYLATION AT SER-1007 AND SER-1011, MUTAGENESIS OF 1007-SER--SER-1011.
[7]	"Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains." Stefansson B., Ohama T., Daugherty A.E., Brautigan D.L. Biochemistry 47:1442-1451(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PPP6C; PPP6R1 AND PPP6R3.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY367056 mRNA. Translation: AAQ72374.1. Frameshift. AB002377 mRNA. Translation: BAA20833.2. Different initiation. AK126888 mRNA. Translation: BAC86737.1. Sequence problems. AK293770 mRNA. Translation: BAG57186.1. BC106948 mRNA. Translation: AAI06949.2. BC113868 mRNA. Translation: AAI13869.1. BC114476 mRNA. Translation: AAI14477.1.
IPI	IPI00477505. IPI00514769. IPI00981632. IPI01009712.
RefSeq	NP_001182027.1. NM_001195098.1. NP_001182028.1. NM_001195099.1. NP_056014.2. NM_015199.3.
UniGene	Hs.335239.
3D structure databases
ProteinModelPortal	O15084.
SMR	O15084. Positions 8-1022.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-27583N.
IntAct	O15084. 32 interactions.
MINT	MINT-1150737.
STRING	9606.ENSP00000382379.
PTM databases
PhosphoSite	O15084.
Proteomic databases
PaxDb	O15084.
PRIDE	O15084.
Protocols and materials databases
DNASU	23243.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000383777; ENSP00000373287; ENSG00000206560. ENST00000399451; ENSP00000382379; ENSG00000206560. ENST00000412318; ENSP00000397341; ENSG00000206560.
GeneID	23243.
KEGG	hsa:23243.
UCSC	uc003cai.1. human. uc003cal.1. human. uc003cam.2. human.
Organism-specific databases
CTD	23243.
GeneCards	GC03M015708.
H-InvDB	HIX0003106.
HGNC	HGNC:29024. ANKRD28.
MIM	611122. gene.
neXtProt	NX_O15084.
PharmGKB	PA134880251.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0666.
HOGENOM	HOG000033959.
HOVERGEN	HBG067697.
InParanoid	O15084.
KO	K15502.
OMA	DMLNDSD.
OrthoDB	EOG4NCMCR.
Gene expression databases
ArrayExpress	O15084.
Bgee	O15084.
CleanEx	HS_ANKRD28.
Genevestigator	O15084.
GermOnline	ENSG00000206560. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 4 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Pfam	PF00023. Ank. 22 hits. PF12796. Ank_2. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 28 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 3 hits.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 24 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23243.
NextBio	44912.
SOURCE	Search...

Entry information

Entry name

ANR28_HUMAN

Accession

Primary (citable) accession number: O15084
Secondary accession number(s): B4DES5 , Q1WWL4, Q29RW6, Q3B857, Q6ULS0, Q6ZT57

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 3, 2011
Last modified:	May 1, 2013
This is version 117 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.