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Protein

ERC protein 2

Gene

ERC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.

Names & Taxonomyi

Protein namesi
Recommended name:
ERC protein 2
Gene namesi
Name:ERC2
Synonyms:KIAA0378
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31922. ERC2.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell junctionsynapse 1 Publication
  • Cell junctionsynapsesynaptosome 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity).By similarity

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB-SubCell
  • cytoskeleton Source: UniProtKB-SubCell
  • growth cone Source: UniProtKB
  • presynaptic active zone Source: ParkinsonsUK-UCL
  • presynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385249.

Polymorphism and mutation databases

BioMutaiERC2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957ERC protein 2PRO_0000087002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651PhosphoserineBy similarity
Modified residuei666 – 6661PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15083.
MaxQBiO15083.
PaxDbiO15083.
PRIDEiO15083.

PTM databases

iPTMnetiO15083.
PhosphoSiteiO15083.

Expressioni

Gene expression databases

BgeeiO15083.
CleanExiHS_ERC2.
ExpressionAtlasiO15083. baseline and differential.
GenevisibleiO15083. HS.

Organism-specific databases

HPAiCAB012344.

Interactioni

Subunit structurei

Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its C-terminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYBP102422EBI-2684336,EBI-298355

Protein-protein interaction databases

BioGridi117521. 16 interactions.
IntActiO15083. 3 interactions.
MINTiMINT-2795549.
STRINGi9606.ENSP00000288221.

Structurei

3D structure databases

ProteinModelPortaliO15083.
SMRiO15083. Positions 148-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili140 – 917778Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 417Poly-Gly
Compositional biasi129 – 1335Poly-His
Compositional biasi879 – 8824Poly-Lys
Compositional biasi920 – 93213Poly-HisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4809. Eukaryota.
ENOG410Y4GU. LUCA.
GeneTreeiENSGT00650000093320.
HOGENOMiHOG000236353.
HOVERGENiHBG051496.
InParanoidiO15083.
KOiK19878.
OMAiIIEMKDT.
OrthoDBiEOG7CZK4T.
PhylomeDBiO15083.
TreeFamiTF324969.

Family and domain databases

InterProiIPR019323. ELKS/CAST.
[Graphical view]
PANTHERiPTHR18861. PTHR18861. 1 hit.
PfamiPF10174. Cast. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGSARTITN LEGSPSRSPR LPRSPRLGHR RTSSGGGGGT GKTLSMENIQ
60 70 80 90 100
SLNAAYATSG PMYLSDHEGV ASTTYPKGTM TLGRATNRAV YGGRVTAMGS
110 120 130 140 150
SPNIASAGLS HTDVLSYTDQ HGGLTGSSHH HHHQVPSMLR QVRDSTMLDL
160 170 180 190 200
QAQLKELQRE NDLLRKELDI KDSKLGSSMN SIKTFWSPEL KKERVLRKEE
210 220 230 240 250
AARMSVLKEQ MRVSHEENQH LQLTIQALQD ELRTQRDLNH LLQQESGNRG
260 270 280 290 300
AEHFTIELTE ENFRRLQAEH DRQAKELFLL RKTLEEMELR IETQKQTLNA
310 320 330 340 350
RDESIKKLLE MLQSKGLPSK SLEDDNERTR RMAEAESQVS HLEVILDQKE
360 370 380 390 400
KENIHLREEL HRRSQLQPEP AKTKALQTVI EMKDTKIASL ERNIRDLEDE
410 420 430 440 450
IQMLKANGVL NTEDREEEIK QIEVYKSHSK FMKTKIDQLK QELSKKESEL
460 470 480 490 500
LALQTKLETL SNQNSDCKQH IEVLKESLTA KEQRAAILQT EVDALRLRLE
510 520 530 540 550
EKESFLNKKT KQLQDLTEEK GTLAGEIRDM KDMLEVKERK INVLQKKIEN
560 570 580 590 600
LQEQLRDKDK QLTNLKDRVK SLQTDSSNTD TALATLEEAL SEKERIIERL
610 620 630 640 650
KEQRERDDRE RLEEIESFRK ENKDLKEKVN ALQAELTEKE SSLIDLKEHA
660 670 680 690 700
SSLASAGLKR DSKLKSLEIA IEQKKEECSK LEAQLKKAHN IEDDSRMNPE
710 720 730 740 750
FADQIKQLDK EASYYRDECG KAQAEVDRLL EILKEVENEK NDKDKKIAEL
760 770 780 790 800
ESLTLRHMKD QNKKVANLKH NQQLEKKKNA QLLEEVRRRE DSMADNSQHL
810 820 830 840 850
QIEELMNALE KTRQELDATK ARLASTQQSL AEKEAHLANL RIERRKQLEE
860 870 880 890 900
ILEMKQEALL AAISEKDANI ALLELSASKK KKTQEEVMAL KREKDRLVHQ
910 920 930 940 950
LKQQTQNRMK LMADNYDDDH HHYHHHHHHH HHRSPGRSQH SNHRPSPDQD

DEEGIWA
Length:957
Mass (Da):110,558
Last modified:August 31, 2004 - v3
Checksum:iACE9310F27C6079D
GO

Sequence cautioni

The sequence BAA20832.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti542 – 5421N → S.
Corresponds to variant rs12488237 [ dbSNP | Ensembl ].
VAR_050973

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002376 mRNA. Translation: BAA20832.2. Different initiation.
BC046212 mRNA. No translation available.
BC111550 mRNA. Translation: AAI11551.1.
BC112391 mRNA. Translation: AAI12392.1.
CCDSiCCDS46851.1.
RefSeqiNP_056391.1. NM_015576.2.
UniGeneiHs.476389.

Genome annotation databases

EnsembliENST00000288221; ENSP00000288221; ENSG00000187672.
ENST00000460849; ENSP00000417445; ENSG00000187672.
ENST00000612797; ENSP00000483127; ENSG00000187672.
GeneIDi26059.
KEGGihsa:26059.
UCSCiuc062kue.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002376 mRNA. Translation: BAA20832.2. Different initiation.
BC046212 mRNA. No translation available.
BC111550 mRNA. Translation: AAI11551.1.
BC112391 mRNA. Translation: AAI12392.1.
CCDSiCCDS46851.1.
RefSeqiNP_056391.1. NM_015576.2.
UniGeneiHs.476389.

3D structure databases

ProteinModelPortaliO15083.
SMRiO15083. Positions 148-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117521. 16 interactions.
IntActiO15083. 3 interactions.
MINTiMINT-2795549.
STRINGi9606.ENSP00000288221.

PTM databases

iPTMnetiO15083.
PhosphoSiteiO15083.

Polymorphism and mutation databases

BioMutaiERC2.

Proteomic databases

EPDiO15083.
MaxQBiO15083.
PaxDbiO15083.
PRIDEiO15083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288221; ENSP00000288221; ENSG00000187672.
ENST00000460849; ENSP00000417445; ENSG00000187672.
ENST00000612797; ENSP00000483127; ENSG00000187672.
GeneIDi26059.
KEGGihsa:26059.
UCSCiuc062kue.1. human.

Organism-specific databases

CTDi26059.
GeneCardsiERC2.
HGNCiHGNC:31922. ERC2.
HPAiCAB012344.
neXtProtiNX_O15083.
PharmGKBiPA162385249.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4809. Eukaryota.
ENOG410Y4GU. LUCA.
GeneTreeiENSGT00650000093320.
HOGENOMiHOG000236353.
HOVERGENiHBG051496.
InParanoidiO15083.
KOiK19878.
OMAiIIEMKDT.
OrthoDBiEOG7CZK4T.
PhylomeDBiO15083.
TreeFamiTF324969.

Miscellaneous databases

ChiTaRSiERC2. human.
GeneWikiiERC2_(gene).
GenomeRNAii26059.
PROiO15083.

Gene expression databases

BgeeiO15083.
CleanExiHS_ERC2.
ExpressionAtlasiO15083. baseline and differential.
GenevisibleiO15083. HS.

Family and domain databases

InterProiIPR019323. ELKS/CAST.
[Graphical view]
PANTHERiPTHR18861. PTHR18861. 1 hit.
PfamiPF10174. Cast. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  4. "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins."
    Ko J., Na M., Kim S., Lee J.R., Kim E.
    J. Biol. Chem. 278:42377-42385(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PPFIA1; PPFIA2; PPFIA3 AND PPFIA4.

Entry informationi

Entry nameiERC2_HUMAN
AccessioniPrimary (citable) accession number: O15083
Secondary accession number(s): Q2T9F6, Q86TK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: June 8, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.