O15083 (ERC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ERC protein 2

Gene names

Name:	ERC2
Synonyms:	KIAA0378

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	957 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.
Subunit structure	Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its C-terminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A. Ref.4
Subcellular location	Cytoplasm. Cell junction › synapse. Cell junction › synapse › synaptosome. Cytoplasm › cytoskeleton. Note: In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density By similarity. Ref.4
Sequence caution	The sequence BAA20832.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasm Cytoskeleton Synapse Synaptosome
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell growth cone Inferred from sequence or structural similarity. Source: UniProtKB presynaptic membrane Inferred from sequence or structural similarity. Source: UniProtKB synaptosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction Ref.4. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MYB	P10242	2	EBI-2684336,EBI-298355

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 957	957	ERC protein 2		PRO_0000087002
Regions
	Coiled coil	140 – 917	778	Potential
	Compositional bias	35 – 41	7	Poly-Gly
	Compositional bias	129 – 133	5	Poly-His
	Compositional bias	879 – 882	4	Poly-Lys
	Compositional bias	920 – 932	13	Poly-His
Amino acid modifications
	Modified residue	14	1	Phosphoserine By similarity
	Modified residue	187	1	Phosphoserine Ref.5
Natural variations
	Natural variant	542	1	N → S. Corresponds to variant rs12488237 [ dbSNP | Ensembl ].		VAR_050973

Sequences

	Sequence		Length	Mass (Da)
	O15083 [UniParc]. Last modified August 31, 2004. Version 3. Checksum: ACE9310F27C6079D	FASTA	957	110,558
	10 20 30 40 50 60 MYGSARTITN LEGSPSRSPR LPRSPRLGHR RTSSGGGGGT GKTLSMENIQ SLNAAYATSG 70 80 90 100 110 120 PMYLSDHEGV ASTTYPKGTM TLGRATNRAV YGGRVTAMGS SPNIASAGLS HTDVLSYTDQ 130 140 150 160 170 180 HGGLTGSSHH HHHQVPSMLR QVRDSTMLDL QAQLKELQRE NDLLRKELDI KDSKLGSSMN 190 200 210 220 230 240 SIKTFWSPEL KKERVLRKEE AARMSVLKEQ MRVSHEENQH LQLTIQALQD ELRTQRDLNH 250 260 270 280 290 300 LLQQESGNRG AEHFTIELTE ENFRRLQAEH DRQAKELFLL RKTLEEMELR IETQKQTLNA 310 320 330 340 350 360 RDESIKKLLE MLQSKGLPSK SLEDDNERTR RMAEAESQVS HLEVILDQKE KENIHLREEL 370 380 390 400 410 420 HRRSQLQPEP AKTKALQTVI EMKDTKIASL ERNIRDLEDE IQMLKANGVL NTEDREEEIK 430 440 450 460 470 480 QIEVYKSHSK FMKTKIDQLK QELSKKESEL LALQTKLETL SNQNSDCKQH IEVLKESLTA 490 500 510 520 530 540 KEQRAAILQT EVDALRLRLE EKESFLNKKT KQLQDLTEEK GTLAGEIRDM KDMLEVKERK 550 560 570 580 590 600 INVLQKKIEN LQEQLRDKDK QLTNLKDRVK SLQTDSSNTD TALATLEEAL SEKERIIERL 610 620 630 640 650 660 KEQRERDDRE RLEEIESFRK ENKDLKEKVN ALQAELTEKE SSLIDLKEHA SSLASAGLKR 670 680 690 700 710 720 DSKLKSLEIA IEQKKEECSK LEAQLKKAHN IEDDSRMNPE FADQIKQLDK EASYYRDECG 730 740 750 760 770 780 KAQAEVDRLL EILKEVENEK NDKDKKIAEL ESLTLRHMKD QNKKVANLKH NQQLEKKKNA 790 800 810 820 830 840 QLLEEVRRRE DSMADNSQHL QIEELMNALE KTRQELDATK ARLASTQQSL AEKEAHLANL 850 860 870 880 890 900 RIERRKQLEE ILEMKQEALL AAISEKDANI ALLELSASKK KKTQEEVMAL KREKDRLVHQ 910 920 930 940 950 LKQQTQNRMK LMADNYDDDH HHYHHHHHHH HHRSPGRSQH SNHRPSPDQD DEEGIWA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PNS.
[4]	"Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins." Ko J., Na M., Kim S., Lee J.R., Kim E. J. Biol. Chem. 278:42377-42385(2003) [PubMed: 12923177] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PPFIA1; PPFIA2; PPFIA3 AND PPFIA4.
[5]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB002376 mRNA. Translation: BAA20832.2. Different initiation. BC046212 mRNA. No translation available. BC111550 mRNA. Translation: AAI11551.1. BC112391 mRNA. Translation: AAI12392.1.
IPI	IPI00472614.
RefSeq	NP_056391.1. NM_015576.1.
UniGene	Hs.476389.
3D structure databases
ProteinModelPortal	O15083.
SMR	O15083. Positions 138-169.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15083. 2 interactions.
STRING	O15083.
PTM databases
PhosphoSite	O15083.
Proteomic databases
PRIDE	O15083.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000288221; ENSP00000288221; ENSG00000187672. ENST00000460849; ENSP00000417445; ENSG00000187672.
GeneID	26059.
KEGG	hsa:26059.
UCSC	uc003dhr.1. human.
Organism-specific databases
CTD	26059.
GeneCards	GC03M055542.
H-InvDB	HIX0023054.
HGNC	HGNC:31922. ERC2.
HPA	CAB012344.
neXtProt	NX_O15083.
PharmGKB	PA162385249.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10233.
GeneTree	ENSGT00390000015969.
HOGENOM	HBG446371.
HOVERGEN	HBG051496.
InParanoid	O15083.
OMA	MYNPAHN.
OrthoDB	EOG4FTW00.
PhylomeDB	O15083.
Gene expression databases
ArrayExpress	O15083.
Bgee	O15083.
CleanEx	HS_ERC2.
Genevestigator	O15083.
GermOnline	ENSG00000187672. Homo sapiens.
Family and domain databases
InterPro	IPR019323. CAZ_cplx_RIM-bd_prot. [Graphical view]
Pfam	PF10174. Cast. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	47950.

Entry information

Entry name

ERC2_HUMAN

Accession

Primary (citable) accession number: O15083
Secondary accession number(s): Q2T9F6, Q86TK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	November 16, 2011
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.