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Protein

Syntaphilin

Gene

SNPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits SNARE complex formation by absorbing free syntaxin-1.1 Publication

GO - Molecular functioni

  • syntaxin-1 binding Source: UniProtKB

GO - Biological processi

  • brain development Source: Ensembl
  • neuron differentiation Source: Ensembl
  • neurotransmitter secretion Source: UniProtKB
  • synaptic vesicle docking Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaphilin
Gene namesi
Name:SNPH
Synonyms:KIAA0374
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15931. SNPH.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei425 – 44420HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • cytoplasmic microtubule Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial membrane Source: Ensembl
  • neuronal cell body Source: Ensembl
  • neuron projection Source: UniProtKB-SubCell
  • presynaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38053.

Polymorphism and mutation databases

BioMutaiSNPH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494SyntaphilinPRO_0000072030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei200 – 2001PhosphoserineBy similarity
Modified residuei204 – 2041PhosphoserineBy similarity
Modified residuei214 – 2141PhosphothreonineBy similarity
Modified residuei219 – 2191PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15079.
MaxQBiO15079.
PaxDbiO15079.
PeptideAtlasiO15079.
PRIDEiO15079.

PTM databases

iPTMnetiO15079.
PhosphoSiteiO15079.

Expressioni

Tissue specificityi

Brain specific. Found in synapses.1 Publication

Gene expression databases

BgeeiENSG00000101298.
CleanExiHS_SNPH.
GenevisibleiO15079. HS.

Organism-specific databases

HPAiHPA049393.

Interactioni

Subunit structurei

Binds to syntaxin-1.

GO - Molecular functioni

  • syntaxin-1 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115099. 1 interaction.
STRINGi9606.ENSP00000371297.

Structurei

3D structure databases

ProteinModelPortaliO15079.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili79 – 16183Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 4211Poly-SerAdd
BLAST
Compositional biasi405 – 4095Poly-Glu

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGP3. Eukaryota.
ENOG410XQEB. LUCA.
GeneTreeiENSGT00520000055634.
HOGENOMiHOG000148964.
HOVERGENiHBG006785.
InParanoidiO15079.
OMAiQNGMAKE.
OrthoDBiEOG091G07I1.
PhylomeDBiO15079.
TreeFamiTF332407.

Family and domain databases

InterProiIPR026196. Syntaphilin.
IPR028197. Syntaphilin/Syntabulin.
[Graphical view]
PANTHERiPTHR16208. PTHR16208. 1 hit.
PTHR16208:SF1. PTHR16208:SF1. 1 hit.
PfamiPF15290. Syntaphilin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15079-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMSLPGSRR TSAGSRRRTS PPVSVRDAYG TSSLSSSSNS GSYKGSDSSP
60 70 80 90 100
TPRRSMKYTL CSDNHGIKPP TPEQYLTPLQ QKEVCIRHLK ARLKDTQDRL
110 120 130 140 150
QDRDTEIDDL KTQLSRMQED WIEEECHRVE AQLALKEARK EIKQLKQVID
160 170 180 190 200
TVKNNLIDKD KGLQKYFVDI NIQNKKLETL LHSMEVAQNG MAKEDGTGES
210 220 230 240 250
AGGSPARSLT RSSTYTKLSD PAVCGDRQPG DPSSGSAEDG ADSGFAAADD
260 270 280 290 300
TLSRTDALEA SSLLSSGVDC GTEETSLHSS FGLGPRFPAS NTYEKLLCGM
310 320 330 340 350
EAGVQASCMQ ERAIQTDFVQ YQPDLDTILE KVTQAQVCGT DPESGDRCPE
360 370 380 390 400
LDAHPSGPRD PNSAVVVTVG DELEAPEPIT RGPTPQRPGA NPNPGQSVSV
410 420 430 440 450
VCPMEEEEEA AVAEKEPKSY WSRHYIVDLL AVVVPAVPTV AWLCRSQRRQ
460 470 480 490
GQPIYNISSL LRGCCTVALH SIRRISCRSL SQPSPSPAGG GSQL
Length:494
Mass (Da):53,537
Last modified:June 16, 2009 - v2
Checksum:iCD6269CB66792D2C
GO
Isoform 2 (identifier: O15079-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGSGPSERMTWPGPALSAGPPTRPLSSAPGIPPIPPLTRTHSLM

Show »
Length:538
Mass (Da):57,990
Checksum:i9A22618F39049E07
GO

Sequence cautioni

The sequence BAA20829 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MPGSGPSERMTWPGPALSAG PPTRPLSSAPGIPPIPPLTR THSLM in isoform 2. 2 PublicationsVSP_037438

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187733 mRNA. Translation: AAF29901.1.
AB002372 mRNA. Translation: BAA20829.2. Different initiation.
AL136531 Genomic DNA. Translation: CAC16177.1.
AL136531 Genomic DNA. Translation: CAI95140.1.
CH471133 Genomic DNA. Translation: EAX10643.1.
BC035788 mRNA. Translation: AAH35788.1.
CCDSiCCDS13012.1. [O15079-1]
RefSeqiNP_001305163.1. NM_001318234.1. [O15079-2]
NP_055538.2. NM_014723.3. [O15079-1]
UniGeneiHs.323833.

Genome annotation databases

EnsembliENST00000381867; ENSP00000371291; ENSG00000101298. [O15079-2]
ENST00000381873; ENSP00000371297; ENSG00000101298. [O15079-1]
ENST00000614659; ENSP00000479696; ENSG00000101298. [O15079-2]
GeneIDi9751.
KEGGihsa:9751.
UCSCiuc002wes.4. human. [O15079-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187733 mRNA. Translation: AAF29901.1.
AB002372 mRNA. Translation: BAA20829.2. Different initiation.
AL136531 Genomic DNA. Translation: CAC16177.1.
AL136531 Genomic DNA. Translation: CAI95140.1.
CH471133 Genomic DNA. Translation: EAX10643.1.
BC035788 mRNA. Translation: AAH35788.1.
CCDSiCCDS13012.1. [O15079-1]
RefSeqiNP_001305163.1. NM_001318234.1. [O15079-2]
NP_055538.2. NM_014723.3. [O15079-1]
UniGeneiHs.323833.

3D structure databases

ProteinModelPortaliO15079.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115099. 1 interaction.
STRINGi9606.ENSP00000371297.

PTM databases

iPTMnetiO15079.
PhosphoSiteiO15079.

Polymorphism and mutation databases

BioMutaiSNPH.

Proteomic databases

EPDiO15079.
MaxQBiO15079.
PaxDbiO15079.
PeptideAtlasiO15079.
PRIDEiO15079.

Protocols and materials databases

DNASUi9751.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381867; ENSP00000371291; ENSG00000101298. [O15079-2]
ENST00000381873; ENSP00000371297; ENSG00000101298. [O15079-1]
ENST00000614659; ENSP00000479696; ENSG00000101298. [O15079-2]
GeneIDi9751.
KEGGihsa:9751.
UCSCiuc002wes.4. human. [O15079-1]

Organism-specific databases

CTDi9751.
GeneCardsiSNPH.
HGNCiHGNC:15931. SNPH.
HPAiHPA049393.
MIMi604942. gene.
neXtProtiNX_O15079.
PharmGKBiPA38053.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGP3. Eukaryota.
ENOG410XQEB. LUCA.
GeneTreeiENSGT00520000055634.
HOGENOMiHOG000148964.
HOVERGENiHBG006785.
InParanoidiO15079.
OMAiQNGMAKE.
OrthoDBiEOG091G07I1.
PhylomeDBiO15079.
TreeFamiTF332407.

Miscellaneous databases

ChiTaRSiSNPH. human.
GenomeRNAii9751.
PROiO15079.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101298.
CleanExiHS_SNPH.
GenevisibleiO15079. HS.

Family and domain databases

InterProiIPR026196. Syntaphilin.
IPR028197. Syntaphilin/Syntabulin.
[Graphical view]
PANTHERiPTHR16208. PTHR16208. 1 hit.
PTHR16208:SF1. PTHR16208:SF1. 1 hit.
PfamiPF15290. Syntaphilin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNPH_HUMAN
AccessioniPrimary (citable) accession number: O15079
Secondary accession number(s): Q8IYI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 16, 2009
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.