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O15075

- DCLK1_HUMAN

UniProt

O15075 - DCLK1_HUMAN

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Protein

Serine/threonine-protein kinase DCLK1

Gene

DCLK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei419 – 4191ATPPROSITE-ProRule annotation
Active sitei511 – 5111Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi396 – 4049ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: ProtInc
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
  4. receptor signaling protein activity Source: ProtInc

GO - Biological processi

  1. axon extension Source: Ensembl
  2. central nervous system development Source: ProtInc
  3. central nervous system projection neuron axonogenesis Source: Ensembl
  4. dendrite morphogenesis Source: Ensembl
  5. endosomal transport Source: UniProtKB
  6. forebrain development Source: Ensembl
  7. nervous system development Source: ProtInc
  8. neuron migration Source: Ensembl
  9. protein phosphorylation Source: ProtInc
  10. response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 2681.
SignaLinkiO15075.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK1 (EC:2.7.11.1)
Alternative name(s):
Doublecortin domain-containing protein 3A
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1
Gene namesi
Name:DCLK1
Synonyms:DCAMKL1, DCDC3A, KIAA0369
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:2700. DCLK1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 740740Serine/threonine-protein kinase DCLK1PRO_0000085919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei307 – 3071PhosphoserineBy similarity
Modified residuei330 – 3301PhosphoserineBy similarity
Modified residuei332 – 3321PhosphoserineBy similarity
Modified residuei337 – 3371PhosphoserineBy similarity
Modified residuei352 – 3521Phosphoserine1 Publication
Modified residuei376 – 3761PhosphoserineBy similarity
Modified residuei520 – 5201PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15075.
PaxDbiO15075.
PRIDEiO15075.

PTM databases

PhosphoSiteiO15075.

Expressioni

Tissue specificityi

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.1 Publication

Inductioni

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

Gene expression databases

BgeeiO15075.
CleanExiHS_DCLK1.
ExpressionAtlasiO15075. baseline and differential.
GenevestigatoriO15075.

Organism-specific databases

HPAiCAB012405.
HPA015655.

Interactioni

Protein-protein interaction databases

BioGridi114635. 8 interactions.
IntActiO15075. 1 interaction.
STRINGi9606.ENSP00000255448.

Structurei

Secondary structure

1
740
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi53 – 553Combined sources
Beta strandi56 – 638Combined sources
Beta strandi72 – 765Combined sources
Turni78 – 803Combined sources
Helixi84 – 9512Combined sources
Beta strandi98 – 1014Combined sources
Beta strandi107 – 1104Combined sources
Helixi120 – 1223Combined sources
Beta strandi128 – 1358Combined sources
Turni142 – 1454Combined sources
Helixi148 – 1514Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MFWX-ray1.60A49-154[»]
1MG4X-ray1.50A49-154[»]
1UF0NMR-A54-156[»]
ProteinModelPortaliO15075.
SMRiO15075. Positions 54-154, 340-711.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15075.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 14387Doublecortin 1PROSITE-ProRule annotationAdd
BLAST
Domaini186 – 26984Doublecortin 2PROSITE-ProRule annotationAdd
BLAST
Domaini390 – 647258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi288 – 34053Pro/Ser-richAdd
BLAST
Compositional biasi698 – 7014Poly-Arg

Sequence similaritiesi

Contains 2 doublecortin domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120480.
HOGENOMiHOG000233016.
HOVERGENiHBG003790.
InParanoidiO15075.
KOiK08805.
OMAiFLLDESX.
OrthoDBiEOG7M98FQ.
PhylomeDBiO15075.
TreeFamiTF318770.

Family and domain databases

Gene3Di3.10.20.230. 2 hits.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533. Doublecortin_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF03607. DCX. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50309. DC. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist. Type A (AS and AL) and type B (BS and BL) isoforms differ respectively by the presence or absence of the doublecortin domain. An alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms.

Isoform 2 (identifier: O15075-1) [UniParc]FASTAAdd to Basket

Also known as: AL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL
60 70 80 90 100
SSEKKAKKVR FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN
110 120 130 140 150
LPQGVRTIYT IDGLKKISSL DQLVEGESYV CGSIEPFKKL EYTKNVNPNW
160 170 180 190 200
SVNVKTTSAS RAVSSLATAK GSPSEVRENK DFIRPKLVTI IRSGVKPRKA
210 220 230 240 250
VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK QVMCLQDFFG
260 270 280 290 300
DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG
310 320 330 340 350
PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG
360 370 380 390 400
GSSTSLASTK VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN
410 420 430 440 450
FAVVKECVER STAREYALKI IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL
460 470 480 490 500
LIEEMDVPTE LYLVMELVKG GDLFDAITST NKYTERDASG MLYNLASAIK
510 520 530 540 550
YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV DGPLYTVCGT
560 570 580 590 600
PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ
610 620 630 640 650
ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD
660 670 680 690 700
GLPENEHQLS VAGKIKKHFN TGPKPNSTAA GVSVIATTAL DKERQVFRRR
710 720 730 740
RNQDVRSRYK AQPAPPELNS ESEDYSPSSS ETVRSPNSPF
Length:740
Mass (Da):82,224
Last modified:May 30, 2000 - v2
Checksum:iD7B6D855099A315C
GO
Isoform 1 (identifier: O15075-2) [UniParc]FASTAAdd to Basket

Also known as: AS

The sequence of this isoform differs from the canonical sequence as follows:
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

Show »
Length:729
Mass (Da):81,100
Checksum:i32C685F6B308A6BD
GO
Isoform 3 (identifier: O15075-3) [UniParc]FASTAAdd to Basket

Also known as: BS

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

Show »
Length:422
Mass (Da):46,557
Checksum:i945DC91D48ECDB3A
GO
Isoform 4 (identifier: O15075-4) [UniParc]FASTAAdd to Basket

Also known as: BL

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE

Show »
Length:433
Mass (Da):47,681
Checksum:i7EA1B5E565ADFC9A
GO

Sequence cautioni

The sequence BAA20824.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291G → C in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
VAR_045673
Natural varianti46 – 461T → M in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
VAR_045674
Natural varianti93 – 931R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
VAR_045675
Natural varianti291 – 2911S → F in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
VAR_045676
Natural varianti292 – 2921R → H.1 Publication
Corresponds to variant rs56185003 [ dbSNP | Ensembl ].
VAR_045677

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 307307Missing in isoform 3 and isoform 4. 2 PublicationsVSP_004905Add
BLAST
Alternative sequencei308 – 3136PASTSS → MLELIE in isoform 3 and isoform 4. 2 PublicationsVSP_004906
Alternative sequencei687 – 74054TTALD…PNSPF → LDHGFTIKRSGSLDYYQQPG MYWIRPPLLIRRGRFSDEDA TRM in isoform 1 and isoform 3. 5 PublicationsVSP_004907Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002367 mRNA. Translation: BAA20824.2. Different initiation.
AL157760
, AL157694, AL160392, AL390029 Genomic DNA. Translation: CAH70167.1.
AL157760 Genomic DNA. Translation: CAH70170.1.
AK295777 mRNA. Translation: BAH12185.1.
AL157760
, AL157694, AL160392, AL390029 Genomic DNA. Translation: CAH70168.1.
AL160392
, AL157694, AL157760, AL390029 Genomic DNA. Translation: CAH70261.1.
AL160392
, AL157694, AL157760, AL390029 Genomic DNA. Translation: CAH70262.1.
AL157694
, AL157760, AL160392, AL390029 Genomic DNA. Translation: CAH70656.1.
AL157694
, AL157760, AL160392, AL390029 Genomic DNA. Translation: CAH70657.1.
AL390029
, AL157694, AL157760, AL160392 Genomic DNA. Translation: CAI15720.1.
AL390029
, AL157694, AL157760, AL160392 Genomic DNA. Translation: CAI15721.1.
CH471075 Genomic DNA. Translation: EAX08550.1.
CH471075 Genomic DNA. Translation: EAX08551.1.
BC152456 mRNA. Translation: AAI52457.1.
CCDSiCCDS55895.1. [O15075-4]
CCDS73561.1. [O15075-3]
CCDS9354.1. [O15075-2]
RefSeqiNP_001182344.1. NM_001195415.1. [O15075-3]
NP_001182345.1. NM_001195416.1. [O15075-4]
NP_004725.1. NM_004734.4. [O15075-2]
XP_005266649.1. XM_005266592.1. [O15075-1]
XP_006719956.1. XM_006719893.1. [O15075-1]
UniGeneiHs.507755.
Hs.728619.

Genome annotation databases

EnsembliENST00000255448; ENSP00000255448; ENSG00000133083. [O15075-2]
ENST00000360631; ENSP00000353846; ENSG00000133083. [O15075-1]
ENST00000379893; ENSP00000369223; ENSG00000133083. [O15075-4]
ENST00000615680; ENSP00000484452; ENSG00000133083. [O15075-3]
GeneIDi9201.
KEGGihsa:9201.
UCSCiuc001uve.4. human. [O15075-3]
uc001uvf.3. human. [O15075-2]
uc010teh.2. human. [O15075-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002367 mRNA. Translation: BAA20824.2 . Different initiation.
AL157760
, AL157694 , AL160392 , AL390029 Genomic DNA. Translation: CAH70167.1 .
AL157760 Genomic DNA. Translation: CAH70170.1 .
AK295777 mRNA. Translation: BAH12185.1 .
AL157760
, AL157694 , AL160392 , AL390029 Genomic DNA. Translation: CAH70168.1 .
AL160392
, AL157694 , AL157760 , AL390029 Genomic DNA. Translation: CAH70261.1 .
AL160392
, AL157694 , AL157760 , AL390029 Genomic DNA. Translation: CAH70262.1 .
AL157694
, AL157760 , AL160392 , AL390029 Genomic DNA. Translation: CAH70656.1 .
AL157694
, AL157760 , AL160392 , AL390029 Genomic DNA. Translation: CAH70657.1 .
AL390029
, AL157694 , AL157760 , AL160392 Genomic DNA. Translation: CAI15720.1 .
AL390029
, AL157694 , AL157760 , AL160392 Genomic DNA. Translation: CAI15721.1 .
CH471075 Genomic DNA. Translation: EAX08550.1 .
CH471075 Genomic DNA. Translation: EAX08551.1 .
BC152456 mRNA. Translation: AAI52457.1 .
CCDSi CCDS55895.1. [O15075-4 ]
CCDS73561.1. [O15075-3 ]
CCDS9354.1. [O15075-2 ]
RefSeqi NP_001182344.1. NM_001195415.1. [O15075-3 ]
NP_001182345.1. NM_001195416.1. [O15075-4 ]
NP_004725.1. NM_004734.4. [O15075-2 ]
XP_005266649.1. XM_005266592.1. [O15075-1 ]
XP_006719956.1. XM_006719893.1. [O15075-1 ]
UniGenei Hs.507755.
Hs.728619.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MFW X-ray 1.60 A 49-154 [» ]
1MG4 X-ray 1.50 A 49-154 [» ]
1UF0 NMR - A 54-156 [» ]
ProteinModelPortali O15075.
SMRi O15075. Positions 54-154, 340-711.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114635. 8 interactions.
IntActi O15075. 1 interaction.
STRINGi 9606.ENSP00000255448.

Chemistry

BindingDBi O15075.
ChEMBLi CHEMBL5683.
GuidetoPHARMACOLOGYi 2005.

PTM databases

PhosphoSitei O15075.

Proteomic databases

MaxQBi O15075.
PaxDbi O15075.
PRIDEi O15075.

Protocols and materials databases

DNASUi 9201.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255448 ; ENSP00000255448 ; ENSG00000133083 . [O15075-2 ]
ENST00000360631 ; ENSP00000353846 ; ENSG00000133083 . [O15075-1 ]
ENST00000379893 ; ENSP00000369223 ; ENSG00000133083 . [O15075-4 ]
ENST00000615680 ; ENSP00000484452 ; ENSG00000133083 . [O15075-3 ]
GeneIDi 9201.
KEGGi hsa:9201.
UCSCi uc001uve.4. human. [O15075-3 ]
uc001uvf.3. human. [O15075-2 ]
uc010teh.2. human. [O15075-4 ]

Organism-specific databases

CTDi 9201.
GeneCardsi GC13M036343.
HGNCi HGNC:2700. DCLK1.
HPAi CAB012405.
HPA015655.
MIMi 604742. gene.
neXtProti NX_O15075.
PharmGKBi PA162383325.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00770000120480.
HOGENOMi HOG000233016.
HOVERGENi HBG003790.
InParanoidi O15075.
KOi K08805.
OMAi FLLDESX.
OrthoDBi EOG7M98FQ.
PhylomeDBi O15075.
TreeFami TF318770.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 2681.
SignaLinki O15075.

Miscellaneous databases

ChiTaRSi DCLK1. human.
EvolutionaryTracei O15075.
GeneWikii DCLK1.
GenomeRNAii 9201.
NextBioi 34489.
PROi O15075.
SOURCEi Search...

Gene expression databases

Bgeei O15075.
CleanExi HS_DCLK1.
ExpressionAtlasi O15075. baseline and differential.
Genevestigatori O15075.

Family and domain databases

Gene3Di 3.10.20.230. 2 hits.
InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533. Doublecortin_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24347. PTHR24347. 1 hit.
Pfami PF03607. DCX. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00537. DCX. 2 hits.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50309. DC. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin."
    Omori Y., Suzuki M., Ozaki K., Harada Y., Nakamura Y., Takahashi E., Fujiwara T.
    J. Hum. Genet. 43:169-177(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
  2. "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)."
    Sossey-Alaoui K., Srivastava A.K.
    Genomics 56:121-126(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Fetal brain.
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Hippocampus.
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS)."
    Matsumoto N., Pilz D.T., Ledbetter D.H.
    Genomics 56:179-183(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
    Leong W.F., Chow V.T.
    Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Solution structure of the N-terminal DCX domain of human doublecortin-like kinase."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2003) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 51-156.
  12. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-29; MET-46; GLN-93; PHE-291 AND HIS-292.

Entry informationi

Entry nameiDCLK1_HUMAN
AccessioniPrimary (citable) accession number: O15075
Secondary accession number(s): B7Z3E9
, Q5VZY8, Q5VZZ0, Q5VZZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 26, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3