Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase DCLK1

Gene

DCLK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei419ATPPROSITE-ProRule annotation1
Active sitei511Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi396 – 404ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: UniProtKB-KW
  • signal transducer activity, downstream of receptor Source: ProtInc

GO - Biological processi

  • axon extension Source: Ensembl
  • central nervous system development Source: ProtInc
  • central nervous system projection neuron axonogenesis Source: Ensembl
  • dendrite morphogenesis Source: Ensembl
  • endosomal transport Source: UniProtKB
  • forebrain development Source: Ensembl
  • intracellular signal transduction Source: InterPro
  • negative regulation of protein localization to nucleus Source: Ensembl
  • nervous system development Source: ProtInc
  • neuron migration Source: Ensembl
  • peptidyl-serine phosphorylation Source: Ensembl
  • protein phosphorylation Source: ProtInc
  • response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS05730-MONOMER.
BRENDAi2.7.11.1. 2681.
SignaLinkiO15075.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK1 (EC:2.7.11.1)
Alternative name(s):
Doublecortin domain-containing protein 3A
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1
Gene namesi
Name:DCLK1
Synonyms:DCAMKL1, DCDC3A, KIAA0369
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:2700. DCLK1.

Subcellular locationi

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • postsynaptic density Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9201.
OpenTargetsiENSG00000133083.
PharmGKBiPA162383325.

Chemistry databases

ChEMBLiCHEMBL5683.
GuidetoPHARMACOLOGYi2005.

Polymorphism and mutation databases

BioMutaiDCLK1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859191 – 740Serine/threonine-protein kinase DCLK1Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei46PhosphothreonineBy similarity1
Modified residuei305PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei334PhosphoserineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei353PhosphoserineBy similarity1
Modified residuei355PhosphoserineBy similarity1
Modified residuei364PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1
Modified residuei520PhosphotyrosineBy similarity1
Modified residuei726PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1
Modified residuei738PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15075.
PaxDbiO15075.
PeptideAtlasiO15075.
PRIDEiO15075.

PTM databases

iPTMnetiO15075.
PhosphoSitePlusiO15075.
SwissPalmiO15075.

Expressioni

Tissue specificityi

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.1 Publication

Inductioni

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000133083.
CleanExiHS_DCLK1.
ExpressionAtlasiO15075. baseline and differential.
GenevisibleiO15075. HS.

Organism-specific databases

HPAiCAB012405.
HPA015655.

Interactioni

Protein-protein interaction databases

BioGridi114635. 14 interactors.
IntActiO15075. 8 interactors.
STRINGi9606.ENSP00000255448.

Chemistry databases

BindingDBiO15075.

Structurei

Secondary structure

1740
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi53 – 55Combined sources3
Beta strandi56 – 63Combined sources8
Beta strandi72 – 76Combined sources5
Turni78 – 80Combined sources3
Helixi84 – 95Combined sources12
Beta strandi98 – 101Combined sources4
Beta strandi107 – 110Combined sources4
Helixi120 – 122Combined sources3
Beta strandi128 – 135Combined sources8
Turni142 – 145Combined sources4
Helixi148 – 151Combined sources4
Helixi384 – 389Combined sources6
Beta strandi390 – 398Combined sources9
Beta strandi400 – 409Combined sources10
Turni410 – 412Combined sources3
Beta strandi415 – 422Combined sources8
Beta strandi427 – 429Combined sources3
Helixi436 – 440Combined sources5
Beta strandi451 – 456Combined sources6
Beta strandi458 – 466Combined sources9
Helixi473 – 480Combined sources8
Helixi485 – 504Combined sources20
Helixi514 – 516Combined sources3
Beta strandi517 – 521Combined sources5
Beta strandi527 – 531Combined sources5
Turni551 – 553Combined sources3
Helixi556 – 560Combined sources5
Helixi568 – 582Combined sources15
Helixi596 – 603Combined sources8
Turni610 – 615Combined sources6
Helixi618 – 627Combined sources10
Turni632 – 634Combined sources3
Helixi638 – 643Combined sources6
Helixi645 – 647Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MFWX-ray1.60A49-154[»]
1MG4X-ray1.50A49-154[»]
1UF0NMR-A54-156[»]
5JZJX-ray1.71A/B372-649[»]
5JZNX-ray2.85A/B372-649[»]
ProteinModelPortaliO15075.
SMRiO15075.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15075.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 143Doublecortin 1PROSITE-ProRule annotationAdd BLAST87
Domaini186 – 269Doublecortin 2PROSITE-ProRule annotationAdd BLAST84
Domaini390 – 647Protein kinasePROSITE-ProRule annotationAdd BLAST258

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi288 – 340Pro/Ser-richAdd BLAST53
Compositional biasi698 – 701Poly-Arg4

Sequence similaritiesi

Contains 2 doublecortin domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
KOG3757. Eukaryota.
ENOG410YA63. LUCA.
GeneTreeiENSGT00840000129744.
HOGENOMiHOG000233016.
HOVERGENiHBG003790.
InParanoidiO15075.
KOiK08805.
OMAiMVTCLQD.
OrthoDBiEOG091G02RF.
PhylomeDBiO15075.
TreeFamiTF318770.

Family and domain databases

CDDicd01617. DCX. 2 hits.
Gene3Di3.10.20.230. 2 hits.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533. Doublecortin_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF03607. DCX. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50309. DC. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. Type A (AS and AL) and type B (BS and BL) isoforms differ respectively by the presence or absence of the doublecortin domain. An alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms.
Isoform 2 (identifier: O15075-1) [UniParc]FASTAAdd to basket
Also known as: AL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL
60 70 80 90 100
SSEKKAKKVR FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN
110 120 130 140 150
LPQGVRTIYT IDGLKKISSL DQLVEGESYV CGSIEPFKKL EYTKNVNPNW
160 170 180 190 200
SVNVKTTSAS RAVSSLATAK GSPSEVRENK DFIRPKLVTI IRSGVKPRKA
210 220 230 240 250
VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK QVMCLQDFFG
260 270 280 290 300
DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG
310 320 330 340 350
PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG
360 370 380 390 400
GSSTSLASTK VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN
410 420 430 440 450
FAVVKECVER STAREYALKI IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL
460 470 480 490 500
LIEEMDVPTE LYLVMELVKG GDLFDAITST NKYTERDASG MLYNLASAIK
510 520 530 540 550
YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV DGPLYTVCGT
560 570 580 590 600
PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ
610 620 630 640 650
ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD
660 670 680 690 700
GLPENEHQLS VAGKIKKHFN TGPKPNSTAA GVSVIATTAL DKERQVFRRR
710 720 730 740
RNQDVRSRYK AQPAPPELNS ESEDYSPSSS ETVRSPNSPF
Length:740
Mass (Da):82,224
Last modified:May 30, 2000 - v2
Checksum:iD7B6D855099A315C
GO
Isoform 1 (identifier: O15075-2) [UniParc]FASTAAdd to basket
Also known as: AS

The sequence of this isoform differs from the canonical sequence as follows:
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

Show »
Length:729
Mass (Da):81,100
Checksum:i32C685F6B308A6BD
GO
Isoform 3 (identifier: O15075-3) [UniParc]FASTAAdd to basket
Also known as: BS

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

Show »
Length:422
Mass (Da):46,557
Checksum:i945DC91D48ECDB3A
GO
Isoform 4 (identifier: O15075-4) [UniParc]FASTAAdd to basket
Also known as: BL

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE

Show »
Length:433
Mass (Da):47,681
Checksum:i7EA1B5E565ADFC9A
GO

Sequence cautioni

The sequence BAA20824 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04567329G → C in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04567446T → M in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04567593R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_045676291S → F in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_045677292R → H.1 PublicationCorresponds to variant rs56185003dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0049051 – 307Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST307
Alternative sequenceiVSP_004906308 – 313PASTSS → MLELIE in isoform 3 and isoform 4. 2 Publications6
Alternative sequenceiVSP_004907687 – 740TTALD…PNSPF → LDHGFTIKRSGSLDYYQQPG MYWIRPPLLIRRGRFSDEDA TRM in isoform 1 and isoform 3. 5 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002367 mRNA. Translation: BAA20824.2. Different initiation.
AL157760
, AL157694, AL160392, AL390029 Genomic DNA. Translation: CAH70167.1.
AL157760 Genomic DNA. Translation: CAH70170.1.
AK295777 mRNA. Translation: BAH12185.1.
AL157760
, AL157694, AL160392, AL390029 Genomic DNA. Translation: CAH70168.1.
AL160392
, AL157694, AL157760, AL390029 Genomic DNA. Translation: CAH70261.1.
AL160392
, AL157694, AL157760, AL390029 Genomic DNA. Translation: CAH70262.1.
AL157694
, AL157760, AL160392, AL390029 Genomic DNA. Translation: CAH70656.1.
AL157694
, AL157760, AL160392, AL390029 Genomic DNA. Translation: CAH70657.1.
AL390029
, AL157694, AL157760, AL160392 Genomic DNA. Translation: CAI15720.1.
AL390029
, AL157694, AL157760, AL160392 Genomic DNA. Translation: CAI15721.1.
CH471075 Genomic DNA. Translation: EAX08550.1.
CH471075 Genomic DNA. Translation: EAX08551.1.
BC152456 mRNA. Translation: AAI52457.1.
CCDSiCCDS55895.1. [O15075-4]
CCDS73561.1. [O15075-3]
CCDS81762.1. [O15075-1]
CCDS9354.1. [O15075-2]
RefSeqiNP_001182344.1. NM_001195415.1. [O15075-3]
NP_001182345.1. NM_001195416.1. [O15075-4]
NP_001317000.1. NM_001330071.1.
NP_001317001.1. NM_001330072.1.
NP_004725.1. NM_004734.4. [O15075-2]
UniGeneiHs.507755.
Hs.728619.

Genome annotation databases

EnsembliENST00000255448; ENSP00000255448; ENSG00000133083. [O15075-2]
ENST00000360631; ENSP00000353846; ENSG00000133083. [O15075-1]
ENST00000379893; ENSP00000369223; ENSG00000133083. [O15075-4]
ENST00000615680; ENSP00000484452; ENSG00000133083. [O15075-3]
GeneIDi9201.
KEGGihsa:9201.
UCSCiuc001uve.4. human. [O15075-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002367 mRNA. Translation: BAA20824.2. Different initiation.
AL157760
, AL157694, AL160392, AL390029 Genomic DNA. Translation: CAH70167.1.
AL157760 Genomic DNA. Translation: CAH70170.1.
AK295777 mRNA. Translation: BAH12185.1.
AL157760
, AL157694, AL160392, AL390029 Genomic DNA. Translation: CAH70168.1.
AL160392
, AL157694, AL157760, AL390029 Genomic DNA. Translation: CAH70261.1.
AL160392
, AL157694, AL157760, AL390029 Genomic DNA. Translation: CAH70262.1.
AL157694
, AL157760, AL160392, AL390029 Genomic DNA. Translation: CAH70656.1.
AL157694
, AL157760, AL160392, AL390029 Genomic DNA. Translation: CAH70657.1.
AL390029
, AL157694, AL157760, AL160392 Genomic DNA. Translation: CAI15720.1.
AL390029
, AL157694, AL157760, AL160392 Genomic DNA. Translation: CAI15721.1.
CH471075 Genomic DNA. Translation: EAX08550.1.
CH471075 Genomic DNA. Translation: EAX08551.1.
BC152456 mRNA. Translation: AAI52457.1.
CCDSiCCDS55895.1. [O15075-4]
CCDS73561.1. [O15075-3]
CCDS81762.1. [O15075-1]
CCDS9354.1. [O15075-2]
RefSeqiNP_001182344.1. NM_001195415.1. [O15075-3]
NP_001182345.1. NM_001195416.1. [O15075-4]
NP_001317000.1. NM_001330071.1.
NP_001317001.1. NM_001330072.1.
NP_004725.1. NM_004734.4. [O15075-2]
UniGeneiHs.507755.
Hs.728619.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MFWX-ray1.60A49-154[»]
1MG4X-ray1.50A49-154[»]
1UF0NMR-A54-156[»]
5JZJX-ray1.71A/B372-649[»]
5JZNX-ray2.85A/B372-649[»]
ProteinModelPortaliO15075.
SMRiO15075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114635. 14 interactors.
IntActiO15075. 8 interactors.
STRINGi9606.ENSP00000255448.

Chemistry databases

BindingDBiO15075.
ChEMBLiCHEMBL5683.
GuidetoPHARMACOLOGYi2005.

PTM databases

iPTMnetiO15075.
PhosphoSitePlusiO15075.
SwissPalmiO15075.

Polymorphism and mutation databases

BioMutaiDCLK1.

Proteomic databases

MaxQBiO15075.
PaxDbiO15075.
PeptideAtlasiO15075.
PRIDEiO15075.

Protocols and materials databases

DNASUi9201.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255448; ENSP00000255448; ENSG00000133083. [O15075-2]
ENST00000360631; ENSP00000353846; ENSG00000133083. [O15075-1]
ENST00000379893; ENSP00000369223; ENSG00000133083. [O15075-4]
ENST00000615680; ENSP00000484452; ENSG00000133083. [O15075-3]
GeneIDi9201.
KEGGihsa:9201.
UCSCiuc001uve.4. human. [O15075-1]

Organism-specific databases

CTDi9201.
DisGeNETi9201.
GeneCardsiDCLK1.
HGNCiHGNC:2700. DCLK1.
HPAiCAB012405.
HPA015655.
MIMi604742. gene.
neXtProtiNX_O15075.
OpenTargetsiENSG00000133083.
PharmGKBiPA162383325.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
KOG3757. Eukaryota.
ENOG410YA63. LUCA.
GeneTreeiENSGT00840000129744.
HOGENOMiHOG000233016.
HOVERGENiHBG003790.
InParanoidiO15075.
KOiK08805.
OMAiMVTCLQD.
OrthoDBiEOG091G02RF.
PhylomeDBiO15075.
TreeFamiTF318770.

Enzyme and pathway databases

BioCyciZFISH:HS05730-MONOMER.
BRENDAi2.7.11.1. 2681.
SignaLinkiO15075.

Miscellaneous databases

ChiTaRSiDCLK1. human.
EvolutionaryTraceiO15075.
GeneWikiiDCLK1.
GenomeRNAii9201.
PROiO15075.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133083.
CleanExiHS_DCLK1.
ExpressionAtlasiO15075. baseline and differential.
GenevisibleiO15075. HS.

Family and domain databases

CDDicd01617. DCX. 2 hits.
Gene3Di3.10.20.230. 2 hits.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533. Doublecortin_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF03607. DCX. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50309. DC. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCLK1_HUMAN
AccessioniPrimary (citable) accession number: O15075
Secondary accession number(s): B7Z3E9
, Q5VZY8, Q5VZZ0, Q5VZZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.