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O15075

- DCLK1_HUMAN

UniProt

O15075 - DCLK1_HUMAN

Protein

Serine/threonine-protein kinase DCLK1

Gene

DCLK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei419 – 4191ATPPROSITE-ProRule annotation
    Active sitei511 – 5111Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi396 – 4049ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein kinase activity Source: ProtInc
    3. protein serine/threonine kinase activity Source: UniProtKB-KW
    4. receptor signaling protein activity Source: ProtInc

    GO - Biological processi

    1. axon extension Source: Ensembl
    2. central nervous system development Source: ProtInc
    3. central nervous system projection neuron axonogenesis Source: Ensembl
    4. dendrite morphogenesis Source: Ensembl
    5. endosomal transport Source: UniProtKB
    6. forebrain development Source: Ensembl
    7. nervous system development Source: ProtInc
    8. neuron migration Source: Ensembl
    9. protein phosphorylation Source: ProtInc
    10. response to virus Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 2681.
    SignaLinkiO15075.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase DCLK1 (EC:2.7.11.1)
    Alternative name(s):
    Doublecortin domain-containing protein 3A
    Doublecortin-like and CAM kinase-like 1
    Doublecortin-like kinase 1
    Gene namesi
    Name:DCLK1
    Synonyms:DCAMKL1, DCDC3A, KIAA0369
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:2700. DCLK1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162383325.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 740740Serine/threonine-protein kinase DCLK1PRO_0000085919Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei307 – 3071PhosphoserineBy similarity
    Modified residuei330 – 3301PhosphoserineBy similarity
    Modified residuei332 – 3321PhosphoserineBy similarity
    Modified residuei337 – 3371PhosphoserineBy similarity
    Modified residuei352 – 3521Phosphoserine1 Publication
    Modified residuei376 – 3761PhosphoserineBy similarity
    Modified residuei520 – 5201PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO15075.
    PaxDbiO15075.
    PRIDEiO15075.

    PTM databases

    PhosphoSiteiO15075.

    Expressioni

    Tissue specificityi

    In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.1 Publication

    Inductioni

    Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiO15075.
    BgeeiO15075.
    CleanExiHS_DCLK1.
    GenevestigatoriO15075.

    Organism-specific databases

    HPAiCAB012405.
    HPA015655.

    Interactioni

    Protein-protein interaction databases

    BioGridi114635. 2 interactions.
    IntActiO15075. 1 interaction.
    STRINGi9606.ENSP00000255448.

    Structurei

    Secondary structure

    1
    740
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi53 – 553
    Beta strandi56 – 638
    Beta strandi72 – 765
    Turni78 – 803
    Helixi84 – 9512
    Beta strandi98 – 1014
    Beta strandi107 – 1104
    Helixi120 – 1223
    Beta strandi128 – 1358
    Turni142 – 1454
    Helixi148 – 1514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MFWX-ray1.60A49-154[»]
    1MG4X-ray1.50A49-154[»]
    1UF0NMR-A54-156[»]
    ProteinModelPortaliO15075.
    SMRiO15075. Positions 54-154, 340-711.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO15075.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 14387Doublecortin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 26984Doublecortin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini390 – 647258Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi288 – 34053Pro/Ser-richAdd
    BLAST
    Compositional biasi698 – 7014Poly-Arg

    Sequence similaritiesi

    Contains 2 doublecortin domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233016.
    HOVERGENiHBG003790.
    InParanoidiO15075.
    KOiK08805.
    OMAiFLLDESX.
    OrthoDBiEOG7M98FQ.
    PhylomeDBiO15075.
    TreeFamiTF318770.

    Family and domain databases

    Gene3Di3.10.20.230. 2 hits.
    InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR003533. Doublecortin_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR24347. PTHR24347. 1 hit.
    PfamiPF03607. DCX. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00537. DCX. 2 hits.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50309. DC. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist. Type A (AS and AL) and type B (BS and BL) isoforms differ respectively by the presence or absence of the doublecortin domain. An alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms.

    Isoform 2 (identifier: O15075-1) [UniParc]FASTAAdd to Basket

    Also known as: AL

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL    50
    SSEKKAKKVR FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN 100
    LPQGVRTIYT IDGLKKISSL DQLVEGESYV CGSIEPFKKL EYTKNVNPNW 150
    SVNVKTTSAS RAVSSLATAK GSPSEVRENK DFIRPKLVTI IRSGVKPRKA 200
    VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK QVMCLQDFFG 250
    DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG 300
    PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG 350
    GSSTSLASTK VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN 400
    FAVVKECVER STAREYALKI IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL 450
    LIEEMDVPTE LYLVMELVKG GDLFDAITST NKYTERDASG MLYNLASAIK 500
    YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV DGPLYTVCGT 550
    PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ 600
    ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD 650
    GLPENEHQLS VAGKIKKHFN TGPKPNSTAA GVSVIATTAL DKERQVFRRR 700
    RNQDVRSRYK AQPAPPELNS ESEDYSPSSS ETVRSPNSPF 740
    Length:740
    Mass (Da):82,224
    Last modified:May 30, 2000 - v2
    Checksum:iD7B6D855099A315C
    GO
    Isoform 1 (identifier: O15075-2) [UniParc]FASTAAdd to Basket

    Also known as: AS

    The sequence of this isoform differs from the canonical sequence as follows:
         687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

    Show »
    Length:729
    Mass (Da):81,100
    Checksum:i32C685F6B308A6BD
    GO
    Isoform 3 (identifier: O15075-3) [UniParc]FASTAAdd to Basket

    Also known as: BS

    The sequence of this isoform differs from the canonical sequence as follows:
         1-307: Missing.
         308-313: PASTSS → MLELIE
         687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

    Show »
    Length:422
    Mass (Da):46,557
    Checksum:i945DC91D48ECDB3A
    GO
    Isoform 4 (identifier: O15075-4) [UniParc]FASTAAdd to Basket

    Also known as: BL

    The sequence of this isoform differs from the canonical sequence as follows:
         1-307: Missing.
         308-313: PASTSS → MLELIE

    Show »
    Length:433
    Mass (Da):47,681
    Checksum:i7EA1B5E565ADFC9A
    GO

    Sequence cautioni

    The sequence BAA20824.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291G → C in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_045673
    Natural varianti46 – 461T → M in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_045674
    Natural varianti93 – 931R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_045675
    Natural varianti291 – 2911S → F in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_045676
    Natural varianti292 – 2921R → H.1 Publication
    Corresponds to variant rs56185003 [ dbSNP | Ensembl ].
    VAR_045677

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 307307Missing in isoform 3 and isoform 4. 2 PublicationsVSP_004905Add
    BLAST
    Alternative sequencei308 – 3136PASTSS → MLELIE in isoform 3 and isoform 4. 2 PublicationsVSP_004906
    Alternative sequencei687 – 74054TTALD…PNSPF → LDHGFTIKRSGSLDYYQQPG MYWIRPPLLIRRGRFSDEDA TRM in isoform 1 and isoform 3. 5 PublicationsVSP_004907Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002367 mRNA. Translation: BAA20824.2. Different initiation.
    AL157760
    , AL157694, AL160392, AL390029 Genomic DNA. Translation: CAH70167.1.
    AL157760 Genomic DNA. Translation: CAH70170.1.
    AK295777 mRNA. Translation: BAH12185.1.
    AL157760
    , AL157694, AL160392, AL390029 Genomic DNA. Translation: CAH70168.1.
    AL160392
    , AL157694, AL157760, AL390029 Genomic DNA. Translation: CAH70261.1.
    AL160392
    , AL157694, AL157760, AL390029 Genomic DNA. Translation: CAH70262.1.
    AL157694
    , AL157760, AL160392, AL390029 Genomic DNA. Translation: CAH70656.1.
    AL157694
    , AL157760, AL160392, AL390029 Genomic DNA. Translation: CAH70657.1.
    AL390029
    , AL157694, AL157760, AL160392 Genomic DNA. Translation: CAI15720.1.
    AL390029
    , AL157694, AL157760, AL160392 Genomic DNA. Translation: CAI15721.1.
    CH471075 Genomic DNA. Translation: EAX08550.1.
    CH471075 Genomic DNA. Translation: EAX08551.1.
    BC152456 mRNA. Translation: AAI52457.1.
    CCDSiCCDS55895.1. [O15075-4]
    CCDS9354.1. [O15075-2]
    RefSeqiNP_001182344.1. NM_001195415.1. [O15075-3]
    NP_001182345.1. NM_001195416.1. [O15075-4]
    NP_004725.1. NM_004734.4. [O15075-2]
    XP_005266649.1. XM_005266592.1. [O15075-1]
    XP_006719956.1. XM_006719893.1. [O15075-1]
    UniGeneiHs.507755.
    Hs.728619.

    Genome annotation databases

    EnsembliENST00000255448; ENSP00000255448; ENSG00000133083. [O15075-2]
    ENST00000360631; ENSP00000353846; ENSG00000133083. [O15075-1]
    ENST00000379893; ENSP00000369223; ENSG00000133083. [O15075-4]
    GeneIDi9201.
    KEGGihsa:9201.
    UCSCiuc001uve.4. human. [O15075-3]
    uc001uvf.3. human. [O15075-2]
    uc010teh.2. human. [O15075-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002367 mRNA. Translation: BAA20824.2 . Different initiation.
    AL157760
    , AL157694 , AL160392 , AL390029 Genomic DNA. Translation: CAH70167.1 .
    AL157760 Genomic DNA. Translation: CAH70170.1 .
    AK295777 mRNA. Translation: BAH12185.1 .
    AL157760
    , AL157694 , AL160392 , AL390029 Genomic DNA. Translation: CAH70168.1 .
    AL160392
    , AL157694 , AL157760 , AL390029 Genomic DNA. Translation: CAH70261.1 .
    AL160392
    , AL157694 , AL157760 , AL390029 Genomic DNA. Translation: CAH70262.1 .
    AL157694
    , AL157760 , AL160392 , AL390029 Genomic DNA. Translation: CAH70656.1 .
    AL157694
    , AL157760 , AL160392 , AL390029 Genomic DNA. Translation: CAH70657.1 .
    AL390029
    , AL157694 , AL157760 , AL160392 Genomic DNA. Translation: CAI15720.1 .
    AL390029
    , AL157694 , AL157760 , AL160392 Genomic DNA. Translation: CAI15721.1 .
    CH471075 Genomic DNA. Translation: EAX08550.1 .
    CH471075 Genomic DNA. Translation: EAX08551.1 .
    BC152456 mRNA. Translation: AAI52457.1 .
    CCDSi CCDS55895.1. [O15075-4 ]
    CCDS9354.1. [O15075-2 ]
    RefSeqi NP_001182344.1. NM_001195415.1. [O15075-3 ]
    NP_001182345.1. NM_001195416.1. [O15075-4 ]
    NP_004725.1. NM_004734.4. [O15075-2 ]
    XP_005266649.1. XM_005266592.1. [O15075-1 ]
    XP_006719956.1. XM_006719893.1. [O15075-1 ]
    UniGenei Hs.507755.
    Hs.728619.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MFW X-ray 1.60 A 49-154 [» ]
    1MG4 X-ray 1.50 A 49-154 [» ]
    1UF0 NMR - A 54-156 [» ]
    ProteinModelPortali O15075.
    SMRi O15075. Positions 54-154, 340-711.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114635. 2 interactions.
    IntActi O15075. 1 interaction.
    STRINGi 9606.ENSP00000255448.

    Chemistry

    BindingDBi O15075.
    ChEMBLi CHEMBL5683.
    GuidetoPHARMACOLOGYi 2005.

    PTM databases

    PhosphoSitei O15075.

    Proteomic databases

    MaxQBi O15075.
    PaxDbi O15075.
    PRIDEi O15075.

    Protocols and materials databases

    DNASUi 9201.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255448 ; ENSP00000255448 ; ENSG00000133083 . [O15075-2 ]
    ENST00000360631 ; ENSP00000353846 ; ENSG00000133083 . [O15075-1 ]
    ENST00000379893 ; ENSP00000369223 ; ENSG00000133083 . [O15075-4 ]
    GeneIDi 9201.
    KEGGi hsa:9201.
    UCSCi uc001uve.4. human. [O15075-3 ]
    uc001uvf.3. human. [O15075-2 ]
    uc010teh.2. human. [O15075-4 ]

    Organism-specific databases

    CTDi 9201.
    GeneCardsi GC13M036343.
    HGNCi HGNC:2700. DCLK1.
    HPAi CAB012405.
    HPA015655.
    MIMi 604742. gene.
    neXtProti NX_O15075.
    PharmGKBi PA162383325.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233016.
    HOVERGENi HBG003790.
    InParanoidi O15075.
    KOi K08805.
    OMAi FLLDESX.
    OrthoDBi EOG7M98FQ.
    PhylomeDBi O15075.
    TreeFami TF318770.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 2681.
    SignaLinki O15075.

    Miscellaneous databases

    ChiTaRSi DCLK1. human.
    EvolutionaryTracei O15075.
    GeneWikii DCLK1.
    GenomeRNAii 9201.
    NextBioi 34489.
    PROi O15075.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15075.
    Bgeei O15075.
    CleanExi HS_DCLK1.
    Genevestigatori O15075.

    Family and domain databases

    Gene3Di 3.10.20.230. 2 hits.
    InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR003533. Doublecortin_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR24347. PTHR24347. 1 hit.
    Pfami PF03607. DCX. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00537. DCX. 2 hits.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50309. DC. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin."
      Omori Y., Suzuki M., Ozaki K., Harada Y., Nakamura Y., Takahashi E., Fujiwara T.
      J. Hum. Genet. 43:169-177(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
    2. "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)."
      Sossey-Alaoui K., Srivastava A.K.
      Genomics 56:121-126(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Fetal brain.
    3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Hippocampus.
    5. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS)."
      Matsumoto N., Pilz D.T., Ledbetter D.H.
      Genomics 56:179-183(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
      Leong W.F., Chow V.T.
      Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Solution structure of the N-terminal DCX domain of human doublecortin-like kinase."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2003) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 51-156.
    12. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-29; MET-46; GLN-93; PHE-291 AND HIS-292.

    Entry informationi

    Entry nameiDCLK1_HUMAN
    AccessioniPrimary (citable) accession number: O15075
    Secondary accession number(s): B7Z3E9
    , Q5VZY8, Q5VZZ0, Q5VZZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3