O15075 (DCLK1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase DCLK1
EC=2.7.11.1

Alternative name(s):
Doublecortin domain-containing protein 3A
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1

Gene names

Name:	DCLK1
Synonyms:	DCAMKL1, DCDC3A, KIAA0369

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	740 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Tissue specificity	In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. Ref.8
Induction	Up-regulated in response to enterovirus 71 (EV71) infection (at protein level). Ref.9
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 2 doublecortin domains. Contains 1 protein kinase domain.
Sequence caution	The sequence BAA20824.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon extension Inferred from electronic annotation. Source: Compara central nervous system development Traceable author statement Ref.8. Source: ProtInc central nervous system projection neuron axonogenesis Inferred from electronic annotation. Source: Compara dendrite morphogenesis Inferred from electronic annotation. Source: Compara endosomal transport Non-traceable author statement PubMed 14613930. Source: UniProtKB forebrain development Inferred from electronic annotation. Source: Compara intracellular signal transduction Inferred from electronic annotation. Source: InterPro neuron migration Inferred from electronic annotation. Source: Compara response to virus Inferred from expression pattern Ref.9. Source: UniProtKB
Cellular_component	integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase activity Traceable author statement Ref.1. Source: ProtInc protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW receptor signaling protein activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist. Type A (AS and AL) and type B (BS and BL) isoforms differ respectively by the presence or absence of the doublecortin domain. An alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms.

Isoform 2 (identifier: O15075-1)

Also known as: AL;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: O15075-2)

Also known as: AS;

The sequence of this isoform differs from the canonical sequence as follows:
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

Isoform 3 (identifier: O15075-3)

Also known as: BS;

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

Isoform 4 (identifier: O15075-4)

Also known as: BL;

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 740

740

Serine/threonine-protein kinase DCLK1

PRO_0000085919

Regions

Domain

57 – 143

87

Doublecortin 1

Domain

186 – 269

84

Doublecortin 2

Domain

390 – 647

258

Protein kinase

Nucleotide binding

396 – 404

9

ATP By similarity

Compositional bias

288 – 340

53

Pro/Ser-rich

Compositional bias

698 – 701

4

Poly-Arg

Sites

Active site

511

1

Proton acceptor By similarity

Binding site

419

1

ATP By similarity

Amino acid modifications

Modified residue

32

1

Phosphoserine By similarity

Modified residue

36

1

Phosphoserine By similarity

Modified residue

305

1

Phosphoserine By similarity

Modified residue

307

1

Phosphoserine By similarity

Modified residue

330

1

Phosphoserine By similarity

Modified residue

332

1

Phosphoserine By similarity

Modified residue

336

1

Phosphothreonine By similarity

Modified residue

337

1

Phosphoserine By similarity

Modified residue

352

1

Phosphoserine Ref.10

Modified residue

364

1

Phosphoserine By similarity

Modified residue

376

1

Phosphoserine By similarity

Modified residue

493

1

Phosphotyrosine By similarity

Modified residue

520

1

Phosphotyrosine By similarity

Modified residue

722

1

Phosphoserine By similarity

Modified residue

726

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 307

307

Missing in isoform 3 and isoform 4.

VSP_004905

Alternative sequence

308 – 313

6

PASTSS → MLELIE in isoform 3 and isoform 4.

VSP_004906

Alternative sequence

687 – 740

54

TTALD…PNSPF → LDHGFTIKRSGSLDYYQQPG MYWIRPPLLIRRGRFSDEDA TRM in isoform 1 and isoform 3.

VSP_004907

Natural variant

29

1

G → C in a gastric adenocarcinoma sample; somatic mutation. Ref.12

VAR_045673

Natural variant

46

1

T → M in a gastric adenocarcinoma sample; somatic mutation. Ref.12

VAR_045674

Natural variant

93

1

R → Q in a gastric adenocarcinoma sample; somatic mutation. Ref.12

VAR_045675

Natural variant

291

1

S → F in a gastric adenocarcinoma sample; somatic mutation. Ref.12

VAR_045676

Natural variant

292

1

R → H. Ref.12
Corresponds to variant rs56185003 [ dbSNP | Ensembl ].

VAR_045677

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

740

Helix Strand Turn

Details...

Helix

53 – 55

3

Beta strand

56 – 63

8

Beta strand

72 – 76

5

Turn

78 – 80

3

Helix

84 – 95

12

Beta strand

98 – 101

4

Beta strand

107 – 110

4

Helix

120 – 122

3

Beta strand

128 – 135

8

Turn

142 – 145

4

Helix

148 – 151

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 (AL) [UniParc]. Last modified May 30, 2000. Version 2. Checksum: D7B6D855099A315C	FASTA	740	82,224
	10 20 30 40 50 60 MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL SSEKKAKKVR 70 80 90 100 110 120 FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN LPQGVRTIYT IDGLKKISSL 130 140 150 160 170 180 DQLVEGESYV CGSIEPFKKL EYTKNVNPNW SVNVKTTSAS RAVSSLATAK GSPSEVRENK 190 200 210 220 230 240 DFIRPKLVTI IRSGVKPRKA VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK 250 260 270 280 290 300 QVMCLQDFFG DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG 310 320 330 340 350 360 PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG GSSTSLASTK 370 380 390 400 410 420 VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN FAVVKECVER STAREYALKI 430 440 450 460 470 480 IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL LIEEMDVPTE LYLVMELVKG GDLFDAITST 490 500 510 520 530 540 NKYTERDASG MLYNLASAIK YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV 550 560 570 580 590 600 DGPLYTVCGT PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ 610 620 630 640 650 660 ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD GLPENEHQLS 670 680 690 700 710 720 VAGKIKKHFN TGPKPNSTAA GVSVIATTAL DKERQVFRRR RNQDVRSRYK AQPAPPELNS 730 740 ESEDYSPSSS ETVRSPNSPF
	Isoform 1 (AS) [UniParc]. Checksum: 32C685F6B308A6BD	FASTA	729	81,100
	10 20 30 40 50 60 MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL SSEKKAKKVR 70 80 90 100 110 120 FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN LPQGVRTIYT IDGLKKISSL 130 140 150 160 170 180 DQLVEGESYV CGSIEPFKKL EYTKNVNPNW SVNVKTTSAS RAVSSLATAK GSPSEVRENK 190 200 210 220 230 240 DFIRPKLVTI IRSGVKPRKA VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK 250 260 270 280 290 300 QVMCLQDFFG DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG 310 320 330 340 350 360 PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG GSSTSLASTK 370 380 390 400 410 420 VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN FAVVKECVER STAREYALKI 430 440 450 460 470 480 IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL LIEEMDVPTE LYLVMELVKG GDLFDAITST 490 500 510 520 530 540 NKYTERDASG MLYNLASAIK YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV 550 560 570 580 590 600 DGPLYTVCGT PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ 610 620 630 640 650 660 ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD GLPENEHQLS 670 680 690 700 710 720 VAGKIKKHFN TGPKPNSTAA GVSVIALDHG FTIKRSGSLD YYQQPGMYWI RPPLLIRRGR FSDEDATRM
	Isoform 3 (BS) [UniParc]. Checksum: 945DC91D48ECDB3A	FASTA	422	46,557
	10 20 30 40 50 60 MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRSS QHGGSSTSLA STKVCSSMDE 70 80 90 100 110 120 NDGPGEEVSE EGFQIPATIT ERYKVGRTIG DGNFAVVKEC VERSTAREYA LKIIKKSKCR 130 140 150 160 170 180 GKEHMIQNEV SILRRVKHPN IVLLIEEMDV PTELYLVMEL VKGGDLFDAI TSTNKYTERD 190 200 210 220 230 240 ASGMLYNLAS AIKYLHSLNI VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV 250 260 270 280 290 300 CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD 310 320 330 340 350 360 FPSPYWDNVS DSAKELITMM LLVDVDQRFS AVQVLEHPWV NDDGLPENEH QLSVAGKIKK 370 380 390 400 410 420 HFNTGPKPNS TAAGVSVIAL DHGFTIKRSG SLDYYQQPGM YWIRPPLLIR RGRFSDEDAT RM
	Isoform 4 (BL) [UniParc]. Checksum: 7EA1B5E565ADFC9A	FASTA	433	47,681
	10 20 30 40 50 60 MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRSS QHGGSSTSLA STKVCSSMDE 70 80 90 100 110 120 NDGPGEEVSE EGFQIPATIT ERYKVGRTIG DGNFAVVKEC VERSTAREYA LKIIKKSKCR 130 140 150 160 170 180 GKEHMIQNEV SILRRVKHPN IVLLIEEMDV PTELYLVMEL VKGGDLFDAI TSTNKYTERD 190 200 210 220 230 240 ASGMLYNLAS AIKYLHSLNI VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV 250 260 270 280 290 300 CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD 310 320 330 340 350 360 FPSPYWDNVS DSAKELITMM LLVDVDQRFS AVQVLEHPWV NDDGLPENEH QLSVAGKIKK 370 380 390 400 410 420 HFNTGPKPNS TAAGVSVIAT TALDKERQVF RRRRNQDVRS RYKAQPAPPE LNSESEDYSP 430 SSSETVRSPN SPF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin." Omori Y., Suzuki M., Ozaki K., Harada Y., Nakamura Y., Takahashi E., Fujiwara T. J. Hum. Genet. 43:169-177(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
[2]	"DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)." Sossey-Alaoui K., Srivastava A.K. Genomics 56:121-126(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Fetal brain.
[3]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Hippocampus.
[5]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]	"Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS)." Matsumoto N., Pilz D.T., Ledbetter D.H. Genomics 56:179-183(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection." Leong W.F., Chow V.T. Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION, MASS SPECTROMETRY.
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352, MASS SPECTROMETRY.
[11]	"Solution structure of the N-terminal DCX domain of human doublecortin-like kinase." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2003) to the PDB data bank Cited for: STRUCTURE BY NMR OF 51-156.
[12]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-29; MET-46; GLN-93; PHE-291 AND HIS-292.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB002367 mRNA. Translation: BAA20824.2. Different initiation.
AL157760 , AL157694, AL160392, AL390029 Genomic DNA. Translation: CAH70167.1.
AL157760 Genomic DNA. Translation: CAH70170.1.
AK295777 mRNA. Translation: BAH12185.1.
AL157760 , AL157694, AL160392, AL390029 Genomic DNA. Translation: CAH70168.1.
AL160392 , AL157694, AL157760, AL390029 Genomic DNA. Translation: CAH70261.1.
AL160392 , AL157694, AL157760, AL390029 Genomic DNA. Translation: CAH70262.1.
AL157694 , AL157760, AL160392, AL390029 Genomic DNA. Translation: CAH70656.1.
AL157694 , AL157760, AL160392, AL390029 Genomic DNA. Translation: CAH70657.1.
AL390029 , AL157694, AL157760, AL160392 Genomic DNA. Translation: CAI15720.1.
AL390029 , AL157694, AL157760, AL160392 Genomic DNA. Translation: CAI15721.1.
CH471075 Genomic DNA. Translation: EAX08550.1.
CH471075 Genomic DNA. Translation: EAX08551.1.
BC152456 mRNA. Translation: AAI52457.1.

IPI

IPI00004560.
IPI00217247.
IPI00217249.
IPI00472852.

RefSeq

NP_001182344.1. NM_001195415.1.
NP_001182345.1. NM_001195416.1.
NP_004725.1. NM_004734.4.

UniGene

Hs.507755.
Hs.728619.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MFW	X-ray	1.60	A	49-154	[»]
1MG4	X-ray	1.50	A	49-154	[»]
1UF0	NMR	-	A	54-156	[»]

ProteinModelPortal

O15075.

ModBase

Search...

Protein-protein interaction databases

IntAct

O15075. 1 interaction.

STRING

9606.ENSP00000255448.

PTM databases

PhosphoSite

O15075.

Proteomic databases

PaxDb

O15075.

PRIDE

O15075.

Protocols and materials databases

DNASU

9201.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000255448; ENSP00000255448; ENSG00000133083.
ENST00000360631; ENSP00000353846; ENSG00000133083.
ENST00000379893; ENSP00000369223; ENSG00000133083.

GeneID

9201.

KEGG

hsa:9201.

UCSC

uc001uve.4. human.
uc001uvf.3. human.
uc010teh.2. human.

Organism-specific databases

CTD

9201.

GeneCards

GC13M036343.

HGNC

HGNC:2700. DCLK1.

HPA

CAB012405.
HPA015655.

MIM

604742. gene.

neXtProt

NX_O15075.

PharmGKB

PA162383325.

HUGE

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GenAtlas

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Phylogenomic databases

eggNOG

COG0515.

HOGENOM

HOG000233016.

HOVERGEN

HBG003790.

InParanoid

O15075.

KO

K08805.

OMA

FLLDESX.

OrthoDB

EOG4H9XK1.

PhylomeDB

O15075.

Enzyme and pathway databases

BRENDA

2.7.11.1. 2681.

Gene expression databases

ArrayExpress

O15075.

Bgee

O15075.

CleanEx

HS_DCLK1.

Genevestigator

O15075.

GermOnline

ENSG00000133083. Homo sapiens.

Family and domain databases

Gene3D

3.10.20.230. 2 hits.

InterPro

IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533. Doublecortin_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]

PANTHER

PTHR24347. PTHR24347. 1 hit.

Pfam

PF03607. DCX. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]

SMART

SM00537. DCX. 2 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]

SUPFAM

SSF89837. Doublecortin_dom. 2 hits.
SSF56112. Kinase_like. 1 hit.

PROSITE

PS50309. DC. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

O15075.

ChEMBL

CHEMBL5683.

ChiTaRS

DCLK1. human.

EvolutionaryTrace

O15075.

GenomeRNAi

9201.

NextBio

34489.

SOURCE

Search...

Entry information

Entry name

DCLK1_HUMAN

Accession

Primary (citable) accession number: O15075
Secondary accession number(s): B7Z3E9 , Q5VZY8, Q5VZZ0, Q5VZZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	May 1, 2013
This is version 132 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.