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Protein

NAC-alpha domain-containing protein 1

Gene

NACAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136274-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAC-alpha domain-containing protein 1
Gene namesi
Name:NACAD
Synonyms:KIAA0363
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22196. NACAD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136274.
PharmGKBiPA162396706.

Polymorphism and mutation databases

BioMutaiNACAD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807481 – 1562NAC-alpha domain-containing protein 1Add BLAST1562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1068PhosphoserineCombined sources1
Modified residuei1354PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15069.
PaxDbiO15069.
PeptideAtlasiO15069.
PRIDEiO15069.

PTM databases

iPTMnetiO15069.
PhosphoSitePlusiO15069.

Expressioni

Gene expression databases

BgeeiENSG00000136274.
CleanExiHS_NACAD.
GenevisibleiO15069. HS.

Organism-specific databases

HPAiHPA020981.

Interactioni

Protein-protein interaction databases

BioGridi116763. 13 interactors.
IntActiO15069. 9 interactors.
MINTiMINT-8247385.
STRINGi9606.ENSP00000420477.

Structurei

3D structure databases

ProteinModelPortaliO15069.
SMRiO15069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1411 – 1476NAC-A/BPROSITE-ProRule annotationAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi332 – 337Poly-Glu6
Compositional biasi1509 – 1517Poly-Glu9

Sequence similaritiesi

Belongs to the NAC-alpha family.Curated
Contains 1 NAC-A/B (NAC-alpha/beta) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2239. Eukaryota.
COG1308. LUCA.
GeneTreeiENSGT00440000033468.
HOGENOMiHOG000113723.
HOVERGENiHBG096144.
InParanoidiO15069.
OMAiVPRQAEE.
OrthoDBiEOG091G0292.
PhylomeDBiO15069.
TreeFamiTF313348.

Family and domain databases

InterProiIPR016641. EGD2/NACA.
IPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view]
PANTHERiPTHR21713. PTHR21713. 1 hit.
PfamiPF01849. NAC. 1 hit.
[Graphical view]
SMARTiSM01407. NAC. 1 hit.
[Graphical view]
PROSITEiPS51151. NAC_AB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGEAARAEL LLPEADRPGP RTDLSCDAAA ATTILGGDRR EPCALTPGPS
60 70 80 90 100
HLALTFLPSK PGARPQPEGA SWDAGPGGAP SAWADPGEGG PSPMLLPEGL
110 120 130 140 150
SSQALSTEAP LPATLEPRIV MGEETCQALL SPRAARTALR DQEGGHASPD
160 170 180 190 200
PPPELCSQGD LSVPSPPPDP DSFFTPPSTP TKTTYALLPA CGPHGDARDS
210 220 230 240 250
EAELRDELLD SPPASPSGSY ITADGDSWAS SPSCSLSLLA PAEGLDFPSG
260 270 280 290 300
WGLSPQGSMV DERELHPAGT PEPPSSESSL SADSSSSWGQ EGHFFDLDFL
310 320 330 340 350
ANDPMIPAAL LPFQGSLIFQ VEAVEVTPLS PEEEEEEAVA DPDPGGDLAG
360 370 380 390 400
EGEEDSTSAS FLQSLSDLSI TEGMDEAFAF RDDTSAASSD SDSASYAEAD
410 420 430 440 450
DERLYSGEPH AQATLLQDSV QKTEEESGGG AKGLQAQDGT VSWAVEAAPQ
460 470 480 490 500
TSDRGAYLSQ RQELISEVTE EGLALGQEST ATVTPHTLQV APGLQVEVAT
510 520 530 540 550
RVTPQAGEEE TDSTAGQESA AMAMPQPSQE GISEILGQES VTAEKLPTPQ
560 570 580 590 600
EETSLTLCPD SPQNLKEEGG LDLPSGRKPV AAATIVPRQA KEDLTLPQDS
610 620 630 640 650
AMTPPLPLQD TDLSSAPKPV AAATIVSQQA EEGLTLPQDS VMTPPLPLQD
660 670 680 690 700
TELSSAPKPV AAATLVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV
710 720 730 740 750
AAATLVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATLVSQQA
760 770 780 790 800
EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATIVSQQA EEGLTLPQDS
810 820 830 840 850
AMTPPLPLQD TDLSSAPKPV AAATIVSQQA EEGLTLPQDS AMTPPLPLQD
860 870 880 890 900
TDLSSAPKPV AAATPVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV
910 920 930 940 950
AAATPVSQQA EEGLTLPQDS AMTAPLPLQD TGPTSGPEPL AVATPQTLQA
960 970 980 990 1000
EAGCAPGTEP VATMAQQEVG EALGPRPAPE EKNAALPTVP EPAALDQVQQ
1010 1020 1030 1040 1050
DDPQPAAEAG TPWAAQEDAD STLGMEALSL PEPASGAGEE IAEALSRPGR
1060 1070 1080 1090 1100
EACLEARAHT GDGAKPDSPQ KETLEVENQQ EGGLKPLAQE HGPRSALGGA
1110 1120 1130 1140 1150
REVPDAPPAA CPEVSQARLL SPAREERGLS GKSTPEPTLP SAVATEASLD
1160 1170 1180 1190 1200
SCPESSVGAV SSLDRGCPDA PAPTSAPTSQ QPEPVLGLGS VEQPHEVPSV
1210 1220 1230 1240 1250
LGTPLLQPPE NLAKGQPSTP VDRPLGPDPS APGTLAGAAL PPLEPPAPCL
1260 1270 1280 1290 1300
CQDPQEDSVE DEEPPGSLGL PPPQAGVQPA AAAVSGTTQP LGTGPRVSLS
1310 1320 1330 1340 1350
PHSPLLSPKV ASMDAKDLAL QILPPCQVPP PSGPQSPAGP QGLSAPEQQE
1360 1370 1380 1390 1400
DEDSLEEDSP RALGSGQHSD SHGESSAELD EQDILAPQTV QCPAQAPAGG
1410 1420 1430 1440 1450
SEETIAKAKQ SRSEKKARKA MSKLGLRQIQ GVTRITIQKS KNILFVIAKP
1460 1470 1480 1490 1500
DVFKSPASDT YVVFGEAKIE DLSQQVHKAA AEKFKVPSEP SALVPESAPR
1510 1520 1530 1540 1550
PRVRLECKEE EEEEEEEVDE AGLELRDIEL VMAQANVSRA KAVRALRDNH
1560
SDIVNAIMEL TM
Length:1,562
Mass (Da):161,101
Last modified:November 24, 2009 - v3
Checksum:i790B73CAF05D7D93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1086P → L in BAA20818 (PubMed:9205841).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031195438D → E.Corresponds to variant rs3735495dbSNPEnsembl.1
Natural variantiVAR_031196498V → A.Corresponds to variant rs3735494dbSNPEnsembl.1
Natural variantiVAR_031197591K → E.Corresponds to variant rs7777835dbSNPEnsembl.1
Natural variantiVAR_0311981105D → E.Corresponds to variant rs10243185dbSNPEnsembl.1
Natural variantiVAR_0311991152C → F.Corresponds to variant rs3735493dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013416 Genomic DNA. No translation available.
AB002361 mRNA. Translation: BAA20818.1.
CCDSiCCDS47582.1.
RefSeqiNP_001139806.1. NM_001146334.1.
UniGeneiHs.96633.

Genome annotation databases

EnsembliENST00000490531; ENSP00000420477; ENSG00000136274.
GeneIDi23148.
KEGGihsa:23148.
UCSCiuc003tmt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013416 Genomic DNA. No translation available.
AB002361 mRNA. Translation: BAA20818.1.
CCDSiCCDS47582.1.
RefSeqiNP_001139806.1. NM_001146334.1.
UniGeneiHs.96633.

3D structure databases

ProteinModelPortaliO15069.
SMRiO15069.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116763. 13 interactors.
IntActiO15069. 9 interactors.
MINTiMINT-8247385.
STRINGi9606.ENSP00000420477.

PTM databases

iPTMnetiO15069.
PhosphoSitePlusiO15069.

Polymorphism and mutation databases

BioMutaiNACAD.

Proteomic databases

MaxQBiO15069.
PaxDbiO15069.
PeptideAtlasiO15069.
PRIDEiO15069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000490531; ENSP00000420477; ENSG00000136274.
GeneIDi23148.
KEGGihsa:23148.
UCSCiuc003tmt.4. human.

Organism-specific databases

CTDi23148.
GeneCardsiNACAD.
H-InvDBHIX0006663.
HGNCiHGNC:22196. NACAD.
HPAiHPA020981.
neXtProtiNX_O15069.
OpenTargetsiENSG00000136274.
PharmGKBiPA162396706.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2239. Eukaryota.
COG1308. LUCA.
GeneTreeiENSGT00440000033468.
HOGENOMiHOG000113723.
HOVERGENiHBG096144.
InParanoidiO15069.
OMAiVPRQAEE.
OrthoDBiEOG091G0292.
PhylomeDBiO15069.
TreeFamiTF313348.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136274-MONOMER.

Miscellaneous databases

ChiTaRSiNACAD. human.
GenomeRNAii23148.
PROiO15069.

Gene expression databases

BgeeiENSG00000136274.
CleanExiHS_NACAD.
GenevisibleiO15069. HS.

Family and domain databases

InterProiIPR016641. EGD2/NACA.
IPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view]
PANTHERiPTHR21713. PTHR21713. 1 hit.
PfamiPF01849. NAC. 1 hit.
[Graphical view]
SMARTiSM01407. NAC. 1 hit.
[Graphical view]
PROSITEiPS51151. NAC_AB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNACAD_HUMAN
AccessioniPrimary (citable) accession number: O15069
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 24, 2009
Last modified: November 2, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.