O15069 (NACAD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAC-alpha domain-containing protein 1

Gene names

Name:	NACAD
Synonyms:	KIAA0363

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1562 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the NAC-alpha family. Contains 1 NAC-A/B (NAC-alpha/beta) domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1562	1562	NAC-alpha domain-containing protein 1		PRO_0000280748
Regions
	Domain	1411 – 1476	66	NAC-A/B
	Compositional bias	332 – 337	6	Poly-Glu
	Compositional bias	1509 – 1517	9	Poly-Glu
Amino acid modifications
	Modified residue	1046	1	Phosphoserine By similarity
Natural variations
	Natural variant	438	1	D → E. Corresponds to variant rs3735495 [ dbSNP | Ensembl ].		VAR_031195
	Natural variant	498	1	V → A. Corresponds to variant rs3735494 [ dbSNP | Ensembl ].		VAR_031196
	Natural variant	591	1	K → E. Corresponds to variant rs7777835 [ dbSNP | Ensembl ].		VAR_031197
	Natural variant	1105	1	D → E. Corresponds to variant rs10243185 [ dbSNP | Ensembl ].		VAR_031198
	Natural variant	1152	1	C → F. Corresponds to variant rs3735493 [ dbSNP | Ensembl ].		VAR_031199
Experimental info
	Sequence conflict	1086	1	P → L in BAA20818. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O15069 [UniParc]. Last modified November 24, 2009. Version 3. Checksum: 790B73CAF05D7D93	FASTA	1,562	161,101
	10 20 30 40 50 60 MPGEAARAEL LLPEADRPGP RTDLSCDAAA ATTILGGDRR EPCALTPGPS HLALTFLPSK 70 80 90 100 110 120 PGARPQPEGA SWDAGPGGAP SAWADPGEGG PSPMLLPEGL SSQALSTEAP LPATLEPRIV 130 140 150 160 170 180 MGEETCQALL SPRAARTALR DQEGGHASPD PPPELCSQGD LSVPSPPPDP DSFFTPPSTP 190 200 210 220 230 240 TKTTYALLPA CGPHGDARDS EAELRDELLD SPPASPSGSY ITADGDSWAS SPSCSLSLLA 250 260 270 280 290 300 PAEGLDFPSG WGLSPQGSMV DERELHPAGT PEPPSSESSL SADSSSSWGQ EGHFFDLDFL 310 320 330 340 350 360 ANDPMIPAAL LPFQGSLIFQ VEAVEVTPLS PEEEEEEAVA DPDPGGDLAG EGEEDSTSAS 370 380 390 400 410 420 FLQSLSDLSI TEGMDEAFAF RDDTSAASSD SDSASYAEAD DERLYSGEPH AQATLLQDSV 430 440 450 460 470 480 QKTEEESGGG AKGLQAQDGT VSWAVEAAPQ TSDRGAYLSQ RQELISEVTE EGLALGQEST 490 500 510 520 530 540 ATVTPHTLQV APGLQVEVAT RVTPQAGEEE TDSTAGQESA AMAMPQPSQE GISEILGQES 550 560 570 580 590 600 VTAEKLPTPQ EETSLTLCPD SPQNLKEEGG LDLPSGRKPV AAATIVPRQA KEDLTLPQDS 610 620 630 640 650 660 AMTPPLPLQD TDLSSAPKPV AAATIVSQQA EEGLTLPQDS VMTPPLPLQD TELSSAPKPV 670 680 690 700 710 720 AAATLVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATLVSQQA EEGLTLPQDS 730 740 750 760 770 780 AMTPPLPLQD TDLSSAPKPV AAATLVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV 790 800 810 820 830 840 AAATIVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATIVSQQA EEGLTLPQDS 850 860 870 880 890 900 AMTPPLPLQD TDLSSAPKPV AAATPVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV 910 920 930 940 950 960 AAATPVSQQA EEGLTLPQDS AMTAPLPLQD TGPTSGPEPL AVATPQTLQA EAGCAPGTEP 970 980 990 1000 1010 1020 VATMAQQEVG EALGPRPAPE EKNAALPTVP EPAALDQVQQ DDPQPAAEAG TPWAAQEDAD 1030 1040 1050 1060 1070 1080 STLGMEALSL PEPASGAGEE IAEALSRPGR EACLEARAHT GDGAKPDSPQ KETLEVENQQ 1090 1100 1110 1120 1130 1140 EGGLKPLAQE HGPRSALGGA REVPDAPPAA CPEVSQARLL SPAREERGLS GKSTPEPTLP 1150 1160 1170 1180 1190 1200 SAVATEASLD SCPESSVGAV SSLDRGCPDA PAPTSAPTSQ QPEPVLGLGS VEQPHEVPSV 1210 1220 1230 1240 1250 1260 LGTPLLQPPE NLAKGQPSTP VDRPLGPDPS APGTLAGAAL PPLEPPAPCL CQDPQEDSVE 1270 1280 1290 1300 1310 1320 DEEPPGSLGL PPPQAGVQPA AAAVSGTTQP LGTGPRVSLS PHSPLLSPKV ASMDAKDLAL 1330 1340 1350 1360 1370 1380 QILPPCQVPP PSGPQSPAGP QGLSAPEQQE DEDSLEEDSP RALGSGQHSD SHGESSAELD 1390 1400 1410 1420 1430 1440 EQDILAPQTV QCPAQAPAGG SEETIAKAKQ SRSEKKARKA MSKLGLRQIQ GVTRITIQKS 1450 1460 1470 1480 1490 1500 KNILFVIAKP DVFKSPASDT YVVFGEAKIE DLSQQVHKAA AEKFKVPSEP SALVPESAPR 1510 1520 1530 1540 1550 1560 PRVRLECKEE EEEEEEEVDE AGLELRDIEL VMAQANVSRA KAVRALRDNH SDIVNAIMEL TM

References

[1]

"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-1562. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC013416 Genomic DNA. No translation available. AB002361 mRNA. Translation: BAA20818.1.
IPI	IPI00929627.
RefSeq	NP_001139806.1. NM_001146334.1.
UniGene	Hs.96633.
3D structure databases
ProteinModelPortal	O15069.
SMR	O15069. Positions 1420-1560.
ModBase	Search...
PTM databases
PhosphoSite	O15069.
Proteomic databases
PRIDE	O15069.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258775; ENSP00000258775; ENSG00000136274.
GeneID	23148.
KEGG	hsa:23148.
UCSC	uc003tmt.1. human.
Organism-specific databases
CTD	23148.
GeneCards	GC07M045120.
H-InvDB	HIX0006663.
HGNC	HGNC:22196. NACAD.
neXtProt	NX_O15069.
PharmGKB	PA162396706.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16779.
GeneTree	ENSGT00440000033468.
HOGENOM	HBG507016.
HOVERGEN	HBG096144.
InParanoid	O15069.
OMA	EAPECPE.
Gene expression databases
ArrayExpress	O15069.
Bgee	O15069.
CleanEx	HS_NACAD.
Genevestigator	O15069.
Family and domain databases
InterPro	IPR002715. Nas_poly-pep-assoc_cplx. [Graphical view]
Pfam	PF01849. NAC. 1 hit. [Graphical view]
PROSITE	PS51151. NAC_AB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NACAD_HUMAN

Accession

Primary (citable) accession number: O15069

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	November 24, 2009
Last modified:	January 25, 2012
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.