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Protein

Kinesin-like protein KIF3B

Gene

KIF3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 103ATP8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: ProtInc
  • microtubule binding Source: Ensembl
  • microtubule motor activity Source: ProtInc
  • Rho GTPase binding Source: BHF-UCL

GO - Biological processi

  • anterograde axonal transport Source: ProtInc
  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  • determination of left/right symmetry Source: ProtInc
  • intraciliary transport involved in cilium assembly Source: Reactome
  • microtubule-based movement Source: Reactome
  • mitotic centrosome separation Source: BHF-UCL
  • mitotic spindle assembly Source: BHF-UCL
  • mitotic spindle organization Source: BHF-UCL
  • plus-end-directed vesicle transport along microtubule Source: BHF-UCL
  • positive regulation of cytokinesis Source: Ensembl
  • retrograde vesicle-mediated transport, Golgi to ER Source: Reactome

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-2132295 MHC class II antigen presentation
R-HSA-5620924 Intraflagellar transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3B
Alternative name(s):
HH0048
Microtubule plus end-directed kinesin motor 3B
Cleaved into the following chain:
Gene namesi
Name:KIF3B
Synonyms:KIAA0359
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101350.7
HGNCiHGNC:6320 KIF3B
MIMi603754 gene
neXtProtiNX_O15066

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi9371
OpenTargetsiENSG00000101350
PharmGKBiPA30103

Chemistry databases

ChEMBLiCHEMBL6109

Polymorphism and mutation databases

BioMutaiKIF3B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253951 – 747Kinesin-like protein KIF3BAdd BLAST747
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004244952 – 747Kinesin-like protein KIF3B, N-terminally processedAdd BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processedCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO15066
MaxQBiO15066
PaxDbiO15066
PeptideAtlasiO15066
PRIDEiO15066

PTM databases

iPTMnetiO15066
PhosphoSitePlusiO15066
SwissPalmiO15066

Expressioni

Gene expression databases

BgeeiENSG00000101350
CleanExiHS_KIF3B
GenevisibleiO15066 HS

Organism-specific databases

HPAiHPA007119

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20 (By similarity). Interacts with the SMC3 subunit of the cohesin complex.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • microtubule binding Source: Ensembl
  • Rho GTPase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114772, 30 interactors
CORUMiO15066
IntActiO15066, 13 interactors
MINTiO15066
STRINGi9606.ENSP00000364864

Chemistry databases

BindingDBiO15066

Structurei

Secondary structure

1747
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 16Combined sources6
Helixi21 – 25Combined sources5
Beta strandi32 – 35Combined sources4
Turni36 – 39Combined sources4
Beta strandi40 – 43Combined sources4
Turni49 – 51Combined sources3
Beta strandi55 – 58Combined sources4
Beta strandi60 – 63Combined sources4
Helixi69 – 75Combined sources7
Helixi77 – 85Combined sources9
Beta strandi90 – 97Combined sources8
Helixi102 – 106Combined sources5
Helixi113 – 115Combined sources3
Helixi118 – 131Combined sources14
Beta strandi137 – 148Combined sources12
Beta strandi151 – 154Combined sources4
Beta strandi166 – 169Combined sources4
Turni170 – 172Combined sources3
Beta strandi173 – 176Combined sources4
Helixi187 – 201Combined sources15
Turni202 – 204Combined sources3
Helixi208 – 213Combined sources6
Beta strandi215 – 228Combined sources14
Beta strandi235 – 245Combined sources11
Beta strandi261 – 264Combined sources4
Helixi265 – 267Combined sources3
Helixi270 – 283Combined sources14
Helixi292 – 294Combined sources3
Helixi296 – 300Combined sources5
Turni301 – 306Combined sources6
Beta strandi307 – 317Combined sources11
Helixi321 – 323Combined sources3
Helixi324 – 337Combined sources14
Helixi354 – 357Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B6UX-ray1.80A/B6-359[»]
ProteinModelPortaliO15066
SMRiO15066
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15066

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 340Kinesin motorPROSITE-ProRule annotationAdd BLAST332

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni580 – 747GlobularAdd BLAST168

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili346 – 579Sequence analysisAdd BLAST234

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi386 – 393Poly-Gly8
Compositional biasi394 – 406Poly-GluAdd BLAST13
Compositional biasi723 – 730Poly-Ser8

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0240 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000143992
HOGENOMiHOG000116164
HOVERGENiHBG052255
InParanoidiO15066
KOiK20196
OMAiDMPARTT
OrthoDBiEOG091G03RO
PhylomeDBiO15066
TreeFamiTF105223

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15066-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTA
60 70 80 90 100
HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT
110 120 130 140 150
GKTYTMEGIR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE
160 170 180 190 200
EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN
210 220 230 240 250
RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE
260 270 280 290 300
RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL
310 320 330 340 350
LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP
360 370 380 390 400
KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG
410 420 430 440 450
EEGEEEGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM
460 470 480 490 500
EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA
510 520 530 540 550
EQKRREREIQ QQMESRDEET LELKETYSSL QQEVDIKTKK LKKLFSKLQA
560 570 580 590 600
VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKSKIM
610 620 630 640 650
NRAFFDEEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR
660 670 680 690 700
PEARYRAENI VLLELDMPSR TTRDYEGPAI APKVQAALDA ALQDEDEIQV
710 720 730 740
DASSFESTAN KKSKARPKSG RKSGSSSSSS GTPASQLYPQ SRGLVPK
Length:747
Mass (Da):85,125
Last modified:January 1, 1998 - v1
Checksum:i97FA4573AFA87023
GO
Isoform 2 (identifier: O15066-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.
     375-436: Missing.

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):43,269
Checksum:i1B9F29FF59BA9DD2
GO

Sequence cautioni

The sequence BAA20815 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564891 – 312Missing in isoform 2. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_056490375 – 436Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002357 mRNA Translation: BAA20815.2 Different initiation.
AK299877 mRNA Translation: BAG61727.1
AL121897 Genomic DNA No translation available.
AL354800 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76381.1
CH471077 Genomic DNA Translation: EAW76382.1
BC136310 mRNA Translation: AAI36311.1
BC136311 mRNA Translation: AAI36312.1
CCDSiCCDS13200.1 [O15066-1]
RefSeqiNP_004789.1, NM_004798.3 [O15066-1]
UniGeneiHs.369670

Genome annotation databases

EnsembliENST00000375712; ENSP00000364864; ENSG00000101350 [O15066-1]
GeneIDi9371
KEGGihsa:9371
UCSCiuc002wxq.4 human [O15066-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKIF3B_HUMAN
AccessioniPrimary (citable) accession number: O15066
Secondary accession number(s): B2RMP4, B4DSR5, E1P5M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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