Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kinesin-like protein KIF3B

Gene

KIF3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 103ATP8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: ProtInc
  • microtubule motor activity Source: ProtInc
  • Rho GTPase binding Source: BHF-UCL

GO - Biological processi

  • anterograde axonal transport Source: ProtInc
  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  • determination of left/right symmetry Source: ProtInc
  • microtubule-based movement Source: Reactome
  • mitotic centrosome separation Source: BHF-UCL
  • mitotic spindle assembly Source: BHF-UCL
  • mitotic spindle organization Source: BHF-UCL
  • plus-end-directed vesicle transport along microtubule Source: BHF-UCL
  • positive regulation of cytokinesis Source: Ensembl
  • retrograde vesicle-mediated transport, Golgi to ER Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101350-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-5620924. Intraflagellar transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3B
Alternative name(s):
HH0048
Microtubule plus end-directed kinesin motor 3B
Cleaved into the following chain:
Gene namesi
Name:KIF3B
Synonyms:KIAA0359
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:6320. KIF3B.

Subcellular locationi

GO - Cellular componenti

  • axon cytoplasm Source: GOC
  • centrosome Source: BHF-UCL
  • ciliary tip Source: Reactome
  • cilium Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • intraciliary transport particle Source: Ensembl
  • kinesin II complex Source: BHF-UCL
  • membrane Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: BHF-UCL
  • midbody Source: Ensembl
  • plus-end kinesin complex Source: ProtInc
  • spindle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi9371.
OpenTargetsiENSG00000101350.
PharmGKBiPA30103.

Chemistry databases

ChEMBLiCHEMBL6109.

Polymorphism and mutation databases

BioMutaiKIF3B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253951 – 747Kinesin-like protein KIF3BAdd BLAST747
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004244952 – 747Kinesin-like protein KIF3B, N-terminally processedAdd BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processedCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO15066.
MaxQBiO15066.
PaxDbiO15066.
PeptideAtlasiO15066.
PRIDEiO15066.

PTM databases

iPTMnetiO15066.
PhosphoSitePlusiO15066.
SwissPalmiO15066.

Expressioni

Gene expression databases

BgeeiENSG00000101350.
CleanExiHS_KIF3B.
GenevisibleiO15066. HS.

Organism-specific databases

HPAiHPA007119.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20 (By similarity). Interacts with the SMC3 subunit of the cohesin complex.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGEF10O150133EBI-3931791,EBI-2515636
KIFAP3Q928456EBI-3931791,EBI-954040

GO - Molecular functioni

  • Rho GTPase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114772. 22 interactors.
IntActiO15066. 12 interactors.
MINTiMINT-1185610.
STRINGi9606.ENSP00000364864.

Chemistry databases

BindingDBiO15066.

Structurei

Secondary structure

1747
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 16Combined sources6
Helixi21 – 25Combined sources5
Beta strandi32 – 35Combined sources4
Turni36 – 39Combined sources4
Beta strandi40 – 43Combined sources4
Turni49 – 51Combined sources3
Beta strandi55 – 58Combined sources4
Beta strandi60 – 63Combined sources4
Helixi69 – 75Combined sources7
Helixi77 – 85Combined sources9
Beta strandi90 – 97Combined sources8
Helixi102 – 106Combined sources5
Helixi113 – 115Combined sources3
Helixi118 – 131Combined sources14
Beta strandi137 – 148Combined sources12
Beta strandi151 – 154Combined sources4
Beta strandi166 – 169Combined sources4
Turni170 – 172Combined sources3
Beta strandi173 – 176Combined sources4
Helixi187 – 201Combined sources15
Turni202 – 204Combined sources3
Helixi208 – 213Combined sources6
Beta strandi215 – 228Combined sources14
Beta strandi235 – 245Combined sources11
Beta strandi261 – 264Combined sources4
Helixi265 – 267Combined sources3
Helixi270 – 283Combined sources14
Helixi292 – 294Combined sources3
Helixi296 – 300Combined sources5
Turni301 – 306Combined sources6
Beta strandi307 – 317Combined sources11
Helixi321 – 323Combined sources3
Helixi324 – 337Combined sources14
Helixi354 – 357Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B6UX-ray1.80A/B6-359[»]
ProteinModelPortaliO15066.
SMRiO15066.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15066.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 340Kinesin motorPROSITE-ProRule annotationAdd BLAST332

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni580 – 747GlobularAdd BLAST168

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili346 – 579Sequence analysisAdd BLAST234

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi386 – 393Poly-Gly8
Compositional biasi394 – 406Poly-GluAdd BLAST13
Compositional biasi723 – 730Poly-Ser8

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0240. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiO15066.
KOiK20196.
OMAiSEFIMSK.
OrthoDBiEOG091G03RO.
PhylomeDBiO15066.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15066-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTA
60 70 80 90 100
HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT
110 120 130 140 150
GKTYTMEGIR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE
160 170 180 190 200
EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN
210 220 230 240 250
RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE
260 270 280 290 300
RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL
310 320 330 340 350
LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP
360 370 380 390 400
KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG
410 420 430 440 450
EEGEEEGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM
460 470 480 490 500
EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA
510 520 530 540 550
EQKRREREIQ QQMESRDEET LELKETYSSL QQEVDIKTKK LKKLFSKLQA
560 570 580 590 600
VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKSKIM
610 620 630 640 650
NRAFFDEEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR
660 670 680 690 700
PEARYRAENI VLLELDMPSR TTRDYEGPAI APKVQAALDA ALQDEDEIQV
710 720 730 740
DASSFESTAN KKSKARPKSG RKSGSSSSSS GTPASQLYPQ SRGLVPK
Length:747
Mass (Da):85,125
Last modified:January 1, 1998 - v1
Checksum:i97FA4573AFA87023
GO
Isoform 2 (identifier: O15066-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.
     375-436: Missing.

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):43,269
Checksum:i1B9F29FF59BA9DD2
GO

Sequence cautioni

The sequence BAA20815 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564891 – 312Missing in isoform 2. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_056490375 – 436Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002357 mRNA. Translation: BAA20815.2. Different initiation.
AK299877 mRNA. Translation: BAG61727.1.
AL121897 Genomic DNA. Translation: CAC16425.1.
AL354800 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW76381.1.
CH471077 Genomic DNA. Translation: EAW76382.1.
BC136310 mRNA. Translation: AAI36311.1.
BC136311 mRNA. Translation: AAI36312.1.
CCDSiCCDS13200.1. [O15066-1]
RefSeqiNP_004789.1. NM_004798.3. [O15066-1]
UniGeneiHs.369670.

Genome annotation databases

EnsembliENST00000375712; ENSP00000364864; ENSG00000101350. [O15066-1]
GeneIDi9371.
KEGGihsa:9371.
UCSCiuc002wxq.4. human. [O15066-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002357 mRNA. Translation: BAA20815.2. Different initiation.
AK299877 mRNA. Translation: BAG61727.1.
AL121897 Genomic DNA. Translation: CAC16425.1.
AL354800 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW76381.1.
CH471077 Genomic DNA. Translation: EAW76382.1.
BC136310 mRNA. Translation: AAI36311.1.
BC136311 mRNA. Translation: AAI36312.1.
CCDSiCCDS13200.1. [O15066-1]
RefSeqiNP_004789.1. NM_004798.3. [O15066-1]
UniGeneiHs.369670.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B6UX-ray1.80A/B6-359[»]
ProteinModelPortaliO15066.
SMRiO15066.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114772. 22 interactors.
IntActiO15066. 12 interactors.
MINTiMINT-1185610.
STRINGi9606.ENSP00000364864.

Chemistry databases

BindingDBiO15066.
ChEMBLiCHEMBL6109.

PTM databases

iPTMnetiO15066.
PhosphoSitePlusiO15066.
SwissPalmiO15066.

Polymorphism and mutation databases

BioMutaiKIF3B.

Proteomic databases

EPDiO15066.
MaxQBiO15066.
PaxDbiO15066.
PeptideAtlasiO15066.
PRIDEiO15066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375712; ENSP00000364864; ENSG00000101350. [O15066-1]
GeneIDi9371.
KEGGihsa:9371.
UCSCiuc002wxq.4. human. [O15066-1]

Organism-specific databases

CTDi9371.
DisGeNETi9371.
GeneCardsiKIF3B.
HGNCiHGNC:6320. KIF3B.
HPAiHPA007119.
MIMi603754. gene.
neXtProtiNX_O15066.
OpenTargetsiENSG00000101350.
PharmGKBiPA30103.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0240. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiO15066.
KOiK20196.
OMAiSEFIMSK.
OrthoDBiEOG091G03RO.
PhylomeDBiO15066.
TreeFamiTF105223.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101350-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-5620924. Intraflagellar transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKIF3B. human.
EvolutionaryTraceiO15066.
GeneWikiiKIF3B.
GenomeRNAii9371.
PROiO15066.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101350.
CleanExiHS_KIF3B.
GenevisibleiO15066. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF3B_HUMAN
AccessioniPrimary (citable) accession number: O15066
Secondary accession number(s): B2RMP4, B4DSR5, E1P5M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.