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O15066

- KIF3B_HUMAN

UniProt

O15066 - KIF3B_HUMAN

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Protein
Kinesin-like protein KIF3B
Gene
KIF3B, KIAA0359
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi96 – 1038ATP

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. Rho GTPase binding Source: BHF-UCL
  3. microtubule motor activity Source: ProtInc
  4. plus-end-directed microtubule motor activity Source: ProtInc
  5. protein binding Source: IntAct

GO - Biological processi

  1. anterograde axon cargo transport Source: ProtInc
  2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  3. blood coagulation Source: Reactome
  4. determination of left/right symmetry Source: ProtInc
  5. membrane organization Source: Reactome
  6. metabolic process Source: GOC
  7. microtubule-based movement Source: Reactome
  8. mitotic centrosome separation Source: BHF-UCL
  9. mitotic spindle organization Source: BHF-UCL
  10. plus-end-directed vesicle transport along microtubule Source: BHF-UCL
  11. spindle assembly involved in mitosis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_25201. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3B
Alternative name(s):
HH0048
Microtubule plus end-directed kinesin motor 3B
Cleaved into the following chain:
Gene namesi
Name:KIF3B
Synonyms:KIAA0359
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:6320. KIF3B.

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. centrosome Source: BHF-UCL
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: UniProt
  4. kinesin II complex Source: BHF-UCL
  5. microtubule Source: UniProtKB-KW
  6. microtubule cytoskeleton Source: BHF-UCL
  7. midbody Source: Ensembl
  8. plus-end kinesin complex Source: ProtInc
  9. spindle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30103.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Kinesin-like protein KIF3B
PRO_0000125395Add
BLAST
Initiator methioninei1 – 11Removed; alternate1 Publication
Chaini2 – 747746Kinesin-like protein KIF3B, N-terminally processed
PRO_0000424495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei2 – 21N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processed1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO15066.
PaxDbiO15066.
PeptideAtlasiO15066.
PRIDEiO15066.

PTM databases

PhosphoSiteiO15066.

Expressioni

Gene expression databases

ArrayExpressiO15066.
BgeeiO15066.
CleanExiHS_KIF3B.
GenevestigatoriO15066.

Organism-specific databases

HPAiHPA007119.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20 By similarity. Interacts with the SMC3 subunit of the cohesin complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGEF10O150133EBI-3931791,EBI-2515636

Protein-protein interaction databases

BioGridi114772. 11 interactions.
IntActiO15066. 3 interactions.
MINTiMINT-1185610.
STRINGi9606.ENSP00000364864.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 166
Helixi21 – 255
Beta strandi32 – 354
Turni36 – 394
Beta strandi40 – 434
Turni49 – 513
Beta strandi55 – 584
Beta strandi60 – 634
Helixi69 – 757
Helixi77 – 859
Beta strandi90 – 978
Helixi102 – 1065
Helixi113 – 1153
Helixi118 – 13114
Beta strandi137 – 14812
Beta strandi151 – 1544
Beta strandi166 – 1694
Turni170 – 1723
Beta strandi173 – 1764
Helixi187 – 20115
Turni202 – 2043
Helixi208 – 2136
Beta strandi215 – 22713
Beta strandi235 – 24511
Beta strandi261 – 2644
Helixi265 – 2673
Helixi270 – 28314
Helixi292 – 2943
Helixi296 – 3005
Turni301 – 3066
Beta strandi307 – 31711
Helixi321 – 3233
Helixi324 – 33714

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B6UX-ray1.80A/B6-359[»]
ProteinModelPortaliO15066.
SMRiO15066. Positions 7-358.

Miscellaneous databases

EvolutionaryTraceiO15066.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 340332Kinesin motor
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni580 – 747168Globular
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili346 – 579234 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi386 – 3938Poly-Gly
Compositional biasi394 – 40613Poly-Glu
Add
BLAST
Compositional biasi723 – 7308Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiO15066.
KOiK10394.
OMAiDNQQMMK.
OrthoDBiEOG7WX086.
PhylomeDBiO15066.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15066-1 [UniParc]FASTAAdd to Basket

« Hide

MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTA    50
HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT 100
GKTYTMEGIR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE 150
EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN 200
RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE 250
RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL 300
LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP 350
KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG 400
EEGEEEGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM 450
EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA 500
EQKRREREIQ QQMESRDEET LELKETYSSL QQEVDIKTKK LKKLFSKLQA 550
VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKSKIM 600
NRAFFDEEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR 650
PEARYRAENI VLLELDMPSR TTRDYEGPAI APKVQAALDA ALQDEDEIQV 700
DASSFESTAN KKSKARPKSG RKSGSSSSSS GTPASQLYPQ SRGLVPK 747
Length:747
Mass (Da):85,125
Last modified:January 1, 1998 - v1
Checksum:i97FA4573AFA87023
GO

Sequence cautioni

The sequence BAA20815.2 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002357 mRNA. Translation: BAA20815.2. Different initiation.
AL121897 Genomic DNA. Translation: CAC16425.1.
CH471077 Genomic DNA. Translation: EAW76381.1.
CH471077 Genomic DNA. Translation: EAW76382.1.
BC136310 mRNA. Translation: AAI36311.1.
BC136311 mRNA. Translation: AAI36312.1.
CCDSiCCDS13200.1.
RefSeqiNP_004789.1. NM_004798.3.
UniGeneiHs.369670.

Genome annotation databases

EnsembliENST00000375712; ENSP00000364864; ENSG00000101350.
GeneIDi9371.
KEGGihsa:9371.
UCSCiuc002wxq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002357 mRNA. Translation: BAA20815.2 . Different initiation.
AL121897 Genomic DNA. Translation: CAC16425.1 .
CH471077 Genomic DNA. Translation: EAW76381.1 .
CH471077 Genomic DNA. Translation: EAW76382.1 .
BC136310 mRNA. Translation: AAI36311.1 .
BC136311 mRNA. Translation: AAI36312.1 .
CCDSi CCDS13200.1.
RefSeqi NP_004789.1. NM_004798.3.
UniGenei Hs.369670.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3B6U X-ray 1.80 A/B 6-359 [» ]
ProteinModelPortali O15066.
SMRi O15066. Positions 7-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114772. 11 interactions.
IntActi O15066. 3 interactions.
MINTi MINT-1185610.
STRINGi 9606.ENSP00000364864.

Chemistry

BindingDBi O15066.
ChEMBLi CHEMBL6109.

PTM databases

PhosphoSitei O15066.

Proteomic databases

MaxQBi O15066.
PaxDbi O15066.
PeptideAtlasi O15066.
PRIDEi O15066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375712 ; ENSP00000364864 ; ENSG00000101350 .
GeneIDi 9371.
KEGGi hsa:9371.
UCSCi uc002wxq.3. human.

Organism-specific databases

CTDi 9371.
GeneCardsi GC20P030865.
HGNCi HGNC:6320. KIF3B.
HPAi HPA007119.
MIMi 603754. gene.
neXtProti NX_O15066.
PharmGKBi PA30103.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
HOGENOMi HOG000116164.
HOVERGENi HBG052255.
InParanoidi O15066.
KOi K10394.
OMAi DNQQMMK.
OrthoDBi EOG7WX086.
PhylomeDBi O15066.
TreeFami TF105223.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_25201. Kinesins.

Miscellaneous databases

ChiTaRSi KIF3B. human.
EvolutionaryTracei O15066.
GeneWikii KIF3B.
GenomeRNAii 9371.
NextBioi 35098.
PROi O15066.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15066.
Bgeei O15066.
CleanExi HS_KIF3B.
Genevestigatori O15066.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  5. "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide."
    Shimizu K., Shirataki H., Honda T., Minami S., Takai Y.
    J. Biol. Chem. 273:6591-6594(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH SMC3 AND KIFAP3B.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. "Motor domain of human kinesin family member 3B in complex with ADP."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 6-359IN COMPLEX WITH ADP.

Entry informationi

Entry nameiKIF3B_HUMAN
AccessioniPrimary (citable) accession number: O15066
Secondary accession number(s): B2RMP4, E1P5M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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