O15062 (ZBTB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 5

Gene names

Name:	ZBTB5
Synonyms:	KIAA0354

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	677 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 2 C2H2-type zinc fingers.
Sequence caution	The sequence BAA20811.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 677	677	Zinc finger and BTB domain-containing protein 5		PRO_0000047713
Regions
	Domain	24 – 93	70	BTB
	Zinc finger	613 – 635	23	C2H2-type 1
	Zinc finger	641 – 664	24	C2H2-type 2; atypical
Amino acid modifications
	Modified residue	371	1	Phosphoserine Ref.3
Natural variations
	Natural variant	300	1	D → G. Corresponds to variant rs17502738 [ dbSNP | Ensembl ].		VAR_052915

Sequences

	Sequence		Length	Mass (Da)
	O15062 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 0F17A0AEE3FD827B	FASTA	677	74,278
	10 20 30 40 50 60 MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR ALFSVAEGDQ 70 80 90 100 110 120 TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL LAASHLHLNS VVKACKHYLT 130 140 150 160 170 180 TRTLPMSPPS ERVQEQSARM QRSFMLQQLG LSIVSSALNS SQNGEEQPAP MSSSMRSNLD 190 200 210 220 230 240 QRTPFPMRRL HKRKQSAEER ARQRLRPSID ESAISDVTPE NGPSGVHSRE EFFSPDSLKI 250 260 270 280 290 300 VDNPKADGMT DNQEDSAIMF DQSFGTQEDA QVPSQSDNSA GNMAQLSMAS RATQVETSFD 310 320 330 340 350 360 QEAAPEKSSF QCENPEVGLG EKEHMRVVVK SEPLSSPEPQ DEVSDVTSQA EGSESVEVEG 370 380 390 400 410 420 VVVSAEKIDL SPESSDRSFS DPQSSTDRVG DIHILEVTNN LEHKSTFSIS NFLNKSRGNN 430 440 450 460 470 480 FTANQNNDDN IPNTTSDCRL ESEAPYLLSP EAGPAGGPSS APGSHVENPF SEPADSHFVR 490 500 510 520 530 540 PMQEVMGLPC VQTSGYQGGE QFGMDFSRSG LGLHSSFSRV MIGSPRGGAS NFPYYRRIAP 550 560 570 580 590 600 KMPVVTSVRS SQIPENSTSS QLMMNGATSS FENGHPSQPG PPQLTRASAD VLSKCKKALS 610 620 630 640 650 660 EHNVLVVEGA RKYACKICCK TFLTLTDCKK HIRVHTGEKP YACLKCGKRF SQSSHLYKHS 670 KTTCLRWQSS NLPSTLL

References

[1]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[3]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-371, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB002352 mRNA. Translation: BAA20811.2. Different initiation. BC010007 mRNA. Translation: AAH10007.1.
IPI	IPI00006671.
RefSeq	NP_055687.1. NM_014872.2.
UniGene	Hs.161276.
3D structure databases
ProteinModelPortal	O15062.
SMR	O15062. Positions 1-120, 515-665.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15062. 4 interactions.
MINT	MINT-1397364.
STRING	O15062.
PTM databases
PhosphoSite	O15062.
Proteomic databases
PeptideAtlas	O15062.
PRIDE	O15062.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307750; ENSP00000307604; ENSG00000168795.
GeneID	9925.
KEGG	hsa:9925.
UCSC	uc003zzx.1. human.
Organism-specific databases
CTD	9925.
GeneCards	GC09M037431.
H-InvDB	HIX0008037.
HGNC	HGNC:23836. ZBTB5.
neXtProt	NX_O15062.
PharmGKB	PA134969268.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09878.
HOGENOM	HBG444994.
HOVERGEN	HBG058500.
InParanoid	O15062.
OMA	ARKYACK.
OrthoDB	EOG4NCMCK.
PhylomeDB	O15062.
Gene expression databases
ArrayExpress	O15062.
Bgee	O15062.
CleanEx	HS_ZBTB5.
Genevestigator	O15062.
GermOnline	ENSG00000168795. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 2 hits.
KO	K10492.
Pfam	PF00651. BTB. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 2 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 1 hit. PS50157. ZINC_FINGER_C2H2_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	37446.

Entry information

Entry name

ZBTB5_HUMAN

Accession

Primary (citable) accession number: O15062

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	January 1, 1998
Last modified:	December 14, 2011
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.