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Protein

Zinc finger and BTB domain-containing protein 5

Gene

ZBTB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri613 – 63523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri641 – 66424C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 5
Gene namesi
Name:ZBTB5
Synonyms:KIAA0354
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23836. ZBTB5.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134969268.

Polymorphism and mutation databases

BioMutaiZBTB5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Zinc finger and BTB domain-containing protein 5PRO_0000047713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei371 – 3711PhosphoserineCombined sources
Cross-linki404 – 404Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO15062.
PeptideAtlasiO15062.
PRIDEiO15062.

PTM databases

iPTMnetiO15062.
PhosphoSiteiO15062.

Expressioni

Gene expression databases

BgeeiO15062.
CleanExiHS_ZBTB5.
ExpressionAtlasiO15062. baseline and differential.
GenevisibleiO15062. HS.

Organism-specific databases

HPAiHPA021521.
HPA054895.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DCXO436023EBI-722671,EBI-8646694
SWAP70Q9UH653EBI-722671,EBI-310749
ZBTB7BO151563EBI-722671,EBI-740434

Protein-protein interaction databases

BioGridi115253. 22 interactions.
IntActiO15062. 12 interactions.
MINTiMINT-1397364.
STRINGi9606.ENSP00000307604.

Structurei

3D structure databases

ProteinModelPortaliO15062.
SMRiO15062. Positions 3-119, 584-662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9370BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri613 – 63523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri641 – 66424C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234181.
HOVERGENiHBG058500.
InParanoidiO15062.
KOiK10492.
OMAiSFGAQED.
OrthoDBiEOG77WWBW.
PhylomeDBiO15062.
TreeFamiTF330979.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR
60 70 80 90 100
ALFSVAEGDQ TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL
110 120 130 140 150
LAASHLHLNS VVKACKHYLT TRTLPMSPPS ERVQEQSARM QRSFMLQQLG
160 170 180 190 200
LSIVSSALNS SQNGEEQPAP MSSSMRSNLD QRTPFPMRRL HKRKQSAEER
210 220 230 240 250
ARQRLRPSID ESAISDVTPE NGPSGVHSRE EFFSPDSLKI VDNPKADGMT
260 270 280 290 300
DNQEDSAIMF DQSFGTQEDA QVPSQSDNSA GNMAQLSMAS RATQVETSFD
310 320 330 340 350
QEAAPEKSSF QCENPEVGLG EKEHMRVVVK SEPLSSPEPQ DEVSDVTSQA
360 370 380 390 400
EGSESVEVEG VVVSAEKIDL SPESSDRSFS DPQSSTDRVG DIHILEVTNN
410 420 430 440 450
LEHKSTFSIS NFLNKSRGNN FTANQNNDDN IPNTTSDCRL ESEAPYLLSP
460 470 480 490 500
EAGPAGGPSS APGSHVENPF SEPADSHFVR PMQEVMGLPC VQTSGYQGGE
510 520 530 540 550
QFGMDFSRSG LGLHSSFSRV MIGSPRGGAS NFPYYRRIAP KMPVVTSVRS
560 570 580 590 600
SQIPENSTSS QLMMNGATSS FENGHPSQPG PPQLTRASAD VLSKCKKALS
610 620 630 640 650
EHNVLVVEGA RKYACKICCK TFLTLTDCKK HIRVHTGEKP YACLKCGKRF
660 670
SQSSHLYKHS KTTCLRWQSS NLPSTLL
Length:677
Mass (Da):74,278
Last modified:January 1, 1998 - v1
Checksum:i0F17A0AEE3FD827B
GO

Sequence cautioni

The sequence BAA20811.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti300 – 3001D → G.
Corresponds to variant rs17502738 [ dbSNP | Ensembl ].
VAR_052915

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002352 mRNA. Translation: BAA20811.2. Different initiation.
BC010007 mRNA. Translation: AAH10007.1.
CCDSiCCDS6610.1.
RefSeqiNP_055687.1. NM_014872.2.
XP_005251691.1. XM_005251634.1.
UniGeneiHs.161276.

Genome annotation databases

EnsembliENST00000307750; ENSP00000307604; ENSG00000168795.
GeneIDi9925.
KEGGihsa:9925.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002352 mRNA. Translation: BAA20811.2. Different initiation.
BC010007 mRNA. Translation: AAH10007.1.
CCDSiCCDS6610.1.
RefSeqiNP_055687.1. NM_014872.2.
XP_005251691.1. XM_005251634.1.
UniGeneiHs.161276.

3D structure databases

ProteinModelPortaliO15062.
SMRiO15062. Positions 3-119, 584-662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115253. 22 interactions.
IntActiO15062. 12 interactions.
MINTiMINT-1397364.
STRINGi9606.ENSP00000307604.

PTM databases

iPTMnetiO15062.
PhosphoSiteiO15062.

Polymorphism and mutation databases

BioMutaiZBTB5.

Proteomic databases

PaxDbiO15062.
PeptideAtlasiO15062.
PRIDEiO15062.

Protocols and materials databases

DNASUi9925.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307750; ENSP00000307604; ENSG00000168795.
GeneIDi9925.
KEGGihsa:9925.

Organism-specific databases

CTDi9925.
GeneCardsiZBTB5.
HGNCiHGNC:23836. ZBTB5.
HPAiHPA021521.
HPA054895.
MIMi616590. gene.
neXtProtiNX_O15062.
PharmGKBiPA134969268.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234181.
HOVERGENiHBG058500.
InParanoidiO15062.
KOiK10492.
OMAiSFGAQED.
OrthoDBiEOG77WWBW.
PhylomeDBiO15062.
TreeFamiTF330979.

Miscellaneous databases

ChiTaRSiZBTB5. human.
GenomeRNAii9925.
PROiO15062.
SOURCEiSearch...

Gene expression databases

BgeeiO15062.
CleanExiHS_ZBTB5.
ExpressionAtlasiO15062. baseline and differential.
GenevisibleiO15062. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-371, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  4. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-404, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZBTB5_HUMAN
AccessioniPrimary (citable) accession number: O15062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.