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Protein

Zinc finger and BTB domain-containing protein 5

Gene

ZBTB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri613 – 635C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 664C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168795-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 5
Gene namesi
Name:ZBTB5
Synonyms:KIAA0354
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23836. ZBTB5.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9925.
OpenTargetsiENSG00000168795.
PharmGKBiPA134969268.

Polymorphism and mutation databases

BioMutaiZBTB5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477131 – 677Zinc finger and BTB domain-containing protein 5Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1
Cross-linki404Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO15062.
PeptideAtlasiO15062.
PRIDEiO15062.

PTM databases

iPTMnetiO15062.
PhosphoSitePlusiO15062.

Expressioni

Gene expression databases

BgeeiENSG00000168795.
CleanExiHS_ZBTB5.
ExpressionAtlasiO15062. baseline and differential.
GenevisibleiO15062. HS.

Organism-specific databases

HPAiHPA021521.
HPA054895.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DCXO436023EBI-722671,EBI-8646694
SWAP70Q9UH653EBI-722671,EBI-310749
ZBTB7BO151563EBI-722671,EBI-740434

Protein-protein interaction databases

BioGridi115253. 22 interactors.
DIPiDIP-41566N.
IntActiO15062. 15 interactors.
MINTiMINT-1397364.
STRINGi9606.ENSP00000307604.

Structurei

3D structure databases

ProteinModelPortaliO15062.
SMRiO15062.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 93BTBPROSITE-ProRule annotationAdd BLAST70

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri613 – 635C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 664C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000234181.
HOVERGENiHBG058500.
InParanoidiO15062.
KOiK10492.
OMAiSFGAQED.
OrthoDBiEOG091G0570.
PhylomeDBiO15062.
TreeFamiTF330979.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR
60 70 80 90 100
ALFSVAEGDQ TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL
110 120 130 140 150
LAASHLHLNS VVKACKHYLT TRTLPMSPPS ERVQEQSARM QRSFMLQQLG
160 170 180 190 200
LSIVSSALNS SQNGEEQPAP MSSSMRSNLD QRTPFPMRRL HKRKQSAEER
210 220 230 240 250
ARQRLRPSID ESAISDVTPE NGPSGVHSRE EFFSPDSLKI VDNPKADGMT
260 270 280 290 300
DNQEDSAIMF DQSFGTQEDA QVPSQSDNSA GNMAQLSMAS RATQVETSFD
310 320 330 340 350
QEAAPEKSSF QCENPEVGLG EKEHMRVVVK SEPLSSPEPQ DEVSDVTSQA
360 370 380 390 400
EGSESVEVEG VVVSAEKIDL SPESSDRSFS DPQSSTDRVG DIHILEVTNN
410 420 430 440 450
LEHKSTFSIS NFLNKSRGNN FTANQNNDDN IPNTTSDCRL ESEAPYLLSP
460 470 480 490 500
EAGPAGGPSS APGSHVENPF SEPADSHFVR PMQEVMGLPC VQTSGYQGGE
510 520 530 540 550
QFGMDFSRSG LGLHSSFSRV MIGSPRGGAS NFPYYRRIAP KMPVVTSVRS
560 570 580 590 600
SQIPENSTSS QLMMNGATSS FENGHPSQPG PPQLTRASAD VLSKCKKALS
610 620 630 640 650
EHNVLVVEGA RKYACKICCK TFLTLTDCKK HIRVHTGEKP YACLKCGKRF
660 670
SQSSHLYKHS KTTCLRWQSS NLPSTLL
Length:677
Mass (Da):74,278
Last modified:January 1, 1998 - v1
Checksum:i0F17A0AEE3FD827B
GO

Sequence cautioni

The sequence BAA20811 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052915300D → G.Corresponds to variant rs17502738dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002352 mRNA. Translation: BAA20811.2. Different initiation.
BC010007 mRNA. Translation: AAH10007.1.
CCDSiCCDS6610.1.
RefSeqiNP_055687.1. NM_014872.2.
XP_005251691.1. XM_005251634.1.
UniGeneiHs.161276.

Genome annotation databases

EnsembliENST00000307750; ENSP00000307604; ENSG00000168795.
GeneIDi9925.
KEGGihsa:9925.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002352 mRNA. Translation: BAA20811.2. Different initiation.
BC010007 mRNA. Translation: AAH10007.1.
CCDSiCCDS6610.1.
RefSeqiNP_055687.1. NM_014872.2.
XP_005251691.1. XM_005251634.1.
UniGeneiHs.161276.

3D structure databases

ProteinModelPortaliO15062.
SMRiO15062.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115253. 22 interactors.
DIPiDIP-41566N.
IntActiO15062. 15 interactors.
MINTiMINT-1397364.
STRINGi9606.ENSP00000307604.

PTM databases

iPTMnetiO15062.
PhosphoSitePlusiO15062.

Polymorphism and mutation databases

BioMutaiZBTB5.

Proteomic databases

PaxDbiO15062.
PeptideAtlasiO15062.
PRIDEiO15062.

Protocols and materials databases

DNASUi9925.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307750; ENSP00000307604; ENSG00000168795.
GeneIDi9925.
KEGGihsa:9925.

Organism-specific databases

CTDi9925.
DisGeNETi9925.
GeneCardsiZBTB5.
HGNCiHGNC:23836. ZBTB5.
HPAiHPA021521.
HPA054895.
MIMi616590. gene.
neXtProtiNX_O15062.
OpenTargetsiENSG00000168795.
PharmGKBiPA134969268.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000234181.
HOVERGENiHBG058500.
InParanoidiO15062.
KOiK10492.
OMAiSFGAQED.
OrthoDBiEOG091G0570.
PhylomeDBiO15062.
TreeFamiTF330979.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168795-MONOMER.

Miscellaneous databases

ChiTaRSiZBTB5. human.
GenomeRNAii9925.
PROiO15062.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168795.
CleanExiHS_ZBTB5.
ExpressionAtlasiO15062. baseline and differential.
GenevisibleiO15062. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBTB5_HUMAN
AccessioniPrimary (citable) accession number: O15062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.