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Protein

Zinc finger and BTB domain-containing protein 5

Gene

ZBTB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri613 – 635C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 664C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 5
Gene namesi
Name:ZBTB5
Synonyms:KIAA0354
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000168795.4.
HGNCiHGNC:23836. ZBTB5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9925.
OpenTargetsiENSG00000168795.
PharmGKBiPA134969268.

Polymorphism and mutation databases

BioMutaiZBTB5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477131 – 677Zinc finger and BTB domain-containing protein 5Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234PhosphoserineCombined sources1
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki322Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei371PhosphoserineCombined sources1
Cross-linki404Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki415Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki541Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki594Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki597Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki645Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO15062.
PaxDbiO15062.
PeptideAtlasiO15062.
PRIDEiO15062.

PTM databases

iPTMnetiO15062.
PhosphoSitePlusiO15062.

Expressioni

Gene expression databases

BgeeiENSG00000168795.
CleanExiHS_ZBTB5.
ExpressionAtlasiO15062. baseline and differential.
GenevisibleiO15062. HS.

Organism-specific databases

HPAiHPA021521.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115253. 23 interactors.
DIPiDIP-41566N.
IntActiO15062. 15 interactors.
MINTiMINT-1397364.
STRINGi9606.ENSP00000307604.

Structurei

3D structure databases

ProteinModelPortaliO15062.
SMRiO15062.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 93BTBPROSITE-ProRule annotationAdd BLAST70

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri613 – 635C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 664C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000234181.
HOVERGENiHBG058500.
InParanoidiO15062.
KOiK10492.
OMAiMMGSPRG.
OrthoDBiEOG091G0570.
PhylomeDBiO15062.
TreeFamiTF330979.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF00651. BTB. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF57667. SSF57667. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.

Sequencei

Sequence statusi: Complete.

O15062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR
60 70 80 90 100
ALFSVAEGDQ TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL
110 120 130 140 150
LAASHLHLNS VVKACKHYLT TRTLPMSPPS ERVQEQSARM QRSFMLQQLG
160 170 180 190 200
LSIVSSALNS SQNGEEQPAP MSSSMRSNLD QRTPFPMRRL HKRKQSAEER
210 220 230 240 250
ARQRLRPSID ESAISDVTPE NGPSGVHSRE EFFSPDSLKI VDNPKADGMT
260 270 280 290 300
DNQEDSAIMF DQSFGTQEDA QVPSQSDNSA GNMAQLSMAS RATQVETSFD
310 320 330 340 350
QEAAPEKSSF QCENPEVGLG EKEHMRVVVK SEPLSSPEPQ DEVSDVTSQA
360 370 380 390 400
EGSESVEVEG VVVSAEKIDL SPESSDRSFS DPQSSTDRVG DIHILEVTNN
410 420 430 440 450
LEHKSTFSIS NFLNKSRGNN FTANQNNDDN IPNTTSDCRL ESEAPYLLSP
460 470 480 490 500
EAGPAGGPSS APGSHVENPF SEPADSHFVR PMQEVMGLPC VQTSGYQGGE
510 520 530 540 550
QFGMDFSRSG LGLHSSFSRV MIGSPRGGAS NFPYYRRIAP KMPVVTSVRS
560 570 580 590 600
SQIPENSTSS QLMMNGATSS FENGHPSQPG PPQLTRASAD VLSKCKKALS
610 620 630 640 650
EHNVLVVEGA RKYACKICCK TFLTLTDCKK HIRVHTGEKP YACLKCGKRF
660 670
SQSSHLYKHS KTTCLRWQSS NLPSTLL
Length:677
Mass (Da):74,278
Last modified:January 1, 1998 - v1
Checksum:i0F17A0AEE3FD827B
GO

Sequence cautioni

The sequence BAA20811 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052915300D → G. Corresponds to variant dbSNP:rs17502738Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002352 mRNA. Translation: BAA20811.2. Different initiation.
BC010007 mRNA. Translation: AAH10007.1.
CCDSiCCDS6610.1.
RefSeqiNP_055687.1. NM_014872.2.
XP_005251691.1. XM_005251634.1.
UniGeneiHs.161276.

Genome annotation databases

EnsembliENST00000307750; ENSP00000307604; ENSG00000168795.
GeneIDi9925.
KEGGihsa:9925.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZBTB5_HUMAN
AccessioniPrimary (citable) accession number: O15062
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot