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O15061 (SYNEM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synemin
Alternative name(s):
Desmuslin
Gene names
Name:SYNM
Synonyms:DMN, KIAA0353, SYN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1565 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. Ref.2 Ref.8 Ref.10

Subunit structure

Interacts with GFAP and VIM By similarity. Isoform 1 interacts with TLN1 and VCL. Isoform 2 interacts with DES and DTNA. Isoform 1 and isoform 2 interact with DMD and UTRN. Ref.1 Ref.2 Ref.8 Ref.10 Ref.11

Subcellular location

Cytoplasmcytoskeleton. Cell junctionadherens junction. Note: There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere. Ref.2 Ref.11

Tissue specificity

Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms. Ref.1 Ref.2

Developmental stage

In lens, first detected at 16 weeks when expression is weakly and uniformly distributed. Subsequently, expression becomes much stronger in the epithelium of the anterior part at 25 weeks and later. In retina, weakly expressed at 15 weeks in the nerve fiber and ganglion cell layers (NFL and GCL). From 25 weeks onwards, much stronger expression is observed in the endfeet of Mueller cells, the NFL, and GCL, and much lower expression is observed in a minor subpopulation of cells in the inner cell layer (INL). At 30 and 36 weeks, expression remains in the neural retina, and subsequently becomes stronger in the NFL, GCL, and INL and is decreased in Mueller cells. At 36 weeks, also expressed at the external border of the outer nuclear layer (ONL) (at protein level). Ref.7

Sequence similarities

Belongs to the intermediate filament family.

Sequence caution

The sequence AAI10067.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA20810.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15061-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15061-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1152-1463: Missing.
Isoform 3 (identifier: O15061-3)

The sequence of this isoform differs from the canonical sequence as follows:
     336-339: EFRN → DGCE
     340-1565: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15651565Synemin
PRO_0000063778

Regions

Region1 – 1010Head
Region11 – 320310Interaction with DMD and UTRN
Region11 – 300290Rod
Region11 – 4939Coil 1A
Region50 – 589Linker 1
Region59 – 163105Coil 1B
Region164 – 18623Linker 12
Region187 – 300114Coil 2
Region301 – 15651265Tail
Region1152 – 1463312Interaction with TLN1 and VCL
Region1244 – 1563320Interaction with DMD and UTRN

Amino acid modifications

Modified residue4291Phosphoserine Ref.13
Modified residue5981Phosphothreonine Ref.13
Modified residue10441Phosphoserine Ref.12 Ref.14
Modified residue10491Phosphoserine Ref.12 Ref.14
Modified residue11811Phosphoserine Ref.13 Ref.14
Modified residue11841Phosphoserine Ref.9
Modified residue14351Phosphoserine Ref.12

Natural variations

Alternative sequence336 – 3394EFRN → DGCE in isoform 3.
VSP_036478
Alternative sequence340 – 15651226Missing in isoform 3.
VSP_036479
Alternative sequence1152 – 1463312Missing in isoform 2.
VSP_002465
Natural variant2721A → V. Ref.1 Ref.15
VAR_012295
Natural variant3301V → I. Ref.15
VAR_012296
Natural variant3381R → W. Ref.15
VAR_012297
Natural variant3551R → W. Ref.1 Ref.4 Ref.5
Corresponds to variant rs3743242 [ dbSNP | Ensembl ].
VAR_059378
Natural variant4621G → S. Ref.4 Ref.5
Corresponds to variant rs3134595 [ dbSNP | Ensembl ].
VAR_059379
Natural variant5671P → L. Ref.1 Ref.15
VAR_012298
Natural variant6121E → A. Ref.15
VAR_012299
Natural variant7611P → L. Ref.15
VAR_012300
Natural variant9461R → W. Ref.15
VAR_012301
Natural variant9761Q → R. Ref.15
VAR_012302
Natural variant10591P → L. Ref.15
VAR_012303
Natural variant10671R → P. Ref.15
VAR_012304
Natural variant10771S → L. Ref.15
VAR_012305
Natural variant11301G → S.
Corresponds to variant rs9920074 [ dbSNP | Ensembl ].
VAR_059380
Natural variant13451G → A.
Corresponds to variant rs7167599 [ dbSNP | Ensembl ].
VAR_059381
Natural variant13861G → E. Ref.1
Corresponds to variant rs2292288 [ dbSNP | Ensembl ].
VAR_012306
Natural variant14621F → C.
Corresponds to variant rs2292287 [ dbSNP | Ensembl ].
VAR_012307

Experimental info

Sequence conflict41W → L in CAC83858. Ref.1
Sequence conflict41W → L in CAC83859. Ref.1
Sequence conflict41W → L in CAG27071. Ref.3
Sequence conflict241Missing in CAC83858. Ref.1
Sequence conflict241Missing in CAC83859. Ref.1
Sequence conflict521Missing in CAC83858. Ref.1
Sequence conflict521Missing in CAC83859. Ref.1
Sequence conflict1971E → G in CAG27071. Ref.3
Sequence conflict2411A → T in CAG27071. Ref.3
Sequence conflict2741D → G in CAG27071. Ref.3
Sequence conflict3181E → G in CAG27071. Ref.3
Sequence conflict3221E → Q in CAC83858. Ref.1
Sequence conflict3221E → Q in CAC83859. Ref.1
Sequence conflict3221E → Q in CAG27071. Ref.3
Sequence conflict3731A → V in CAC83858. Ref.1
Sequence conflict3731A → V in CAC83859. Ref.1
Sequence conflict5551Q → H in CAC83858. Ref.1
Sequence conflict5551Q → H in CAC83859. Ref.1
Sequence conflict5641K → N in CAC83858. Ref.1
Sequence conflict5641K → N in CAC83859. Ref.1
Sequence conflict6551E → Q in CAC83858. Ref.1
Sequence conflict6551E → Q in CAC83859. Ref.1
Sequence conflict6661T → A in CAC83858. Ref.1
Sequence conflict6661T → A in CAC83859. Ref.1
Sequence conflict6871V → L in CAC83858. Ref.1
Sequence conflict6871V → L in CAC83859. Ref.1
Sequence conflict7201K → N in CAC83858. Ref.1
Sequence conflict7201K → N in CAC83859. Ref.1
Sequence conflict8451D → N in CAC83858. Ref.1
Sequence conflict8451D → N in CAC83859. Ref.1
Sequence conflict8561E → Q in CAC83858. Ref.1
Sequence conflict8561E → Q in CAC83859. Ref.1
Sequence conflict8741R → P in CAC83858. Ref.1
Sequence conflict8741R → P in CAC83859. Ref.1
Sequence conflict9651R → K in CAC83858. Ref.1
Sequence conflict9651R → K in CAC83859. Ref.1
Sequence conflict10041N → D in CAC83858. Ref.1
Sequence conflict10041N → D in CAC83859. Ref.1
Sequence conflict10191L → V in CAC83858. Ref.1
Sequence conflict10191L → V in CAC83859. Ref.1
Sequence conflict10391L → M in CAC83858. Ref.1
Sequence conflict10391L → M in CAC83859. Ref.1
Sequence conflict10761P → L in CAC83858. Ref.1
Sequence conflict10761P → L in CAC83859. Ref.1
Sequence conflict11511E → G in CAC83859. Ref.1
Sequence conflict12921I → T in CAC83859. Ref.1
Sequence conflict14931A → R in AAI10067. Ref.5
Sequence conflict15091A → V in CAC83858. Ref.1
Sequence conflict15091A → V in CAC83859. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Alpha) [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 18D19000D3CEA537

FASTA1,565172,768
        10         20         30         40         50         60 
MLSWRLQTGP EKAELQELNA RLYDYVCRVR ELERENLLLE EELRGRRGRE GLWAEGQARC 

        70         80         90        100        110        120 
AEEARSLRQQ LDELSWATAL AEGERDALRR ELRELQRLDA EERAARGRLD AELGAQQREL 

       130        140        150        160        170        180 
QEALGARAAL EALLGRLQAE RRGLDAAHER DVRELRARAA SLTMHFRARA TGPAAPPPRL 

       190        200        210        220        230        240 
REVHDSYALL VAESWRETVQ LYEDEVRELE EALRRGQESR LQAEEETRLC AQEAEALRRE 

       250        260        270        280        290        300 
ALGLEQLRAR LEDALLRMRE EYGIQAEERQ RAIDCLEDEK ATLTLAMADW LRDYQDLLQV 

       310        320        330        340        350        360 
KTGLSLEVAT YRALLEGESN PEIVIWAEHV ENMPSEFRNK SYHYTDSLLQ RENERNLFSR 

       370        380        390        400        410        420 
QKAPLASFNH SSALYSNLSG HRGSQTGTSI GGDARRGFLG SGYSSSATTQ QENSYGKAVS 

       430        440        450        460        470        480 
SQTNVRTFSP TYGLLRNTEA QVKTFPDRPK AGDTREVPVY IGEDSTIARE SYRDRRDKVA 

       490        500        510        520        530        540 
AGASESTRSN ERTVILGKKT EVKATREQER NRPETIRTKP EEKMFDSKEK ASEERNLRWE 

       550        560        570        580        590        600 
ELTKLDKEAR QRESQQMKEK AKEKDSPKEK SVREREVPIS LEVSQDRRAE VSPKGLQTPV 

       610        620        630        640        650        660 
KDAGGGTGRE AEARELRFRL GTSDATGSLQ GDSMTETVAE NIVTSILKQF TQSPETEASA 

       670        680        690        700        710        720 
DSFPDTKVTY VDRKELPGER KTKTEIVVES KLTEDVDVSD EAGLDYLLSK DIKEVGLKGK 

       730        740        750        760        770        780 
SAEQMIGDII NLGLKGREGR AKVVNVEIVE EPVSYVSGEK PEEFSVPFKV EEVEDVSPGP 

       790        800        810        820        830        840 
WGLVKEEEGY GESDVTFSVN QHRRTKQPQE NTTHVEEVTE AGDSEGEQSY FVSTPDEHPG 

       850        860        870        880        890        900 
GHDRDDGSVY GQIHIEEEST IRYSWQDEIV QGTRRRTQKD GAVGEKVVKP LDVPAPSLEG 

       910        920        930        940        950        960 
DLGSTHWKEQ ARSGEFHAEP TVIEKEIKIP HEFHTSMKGI SSKEPRQQLV EVIGQLEETL 

       970        980        990       1000       1010       1020 
PERMREELSA LTREGQGGPG SVSVDVKKVQ GAGGSSVTLV AEVNVSQTVD ADRLDLEELS 

      1030       1040       1050       1060       1070       1080 
KDEASEMEKA VESVVRESLS RQRSPAPGSP DEEGGAEAPA AGIRFRRWAT RELYIPSGES 

      1090       1100       1110       1120       1130       1140 
EVAGGASHSS GQRTPQGPVS ATVEVSSPTG FAQSQVLEDV SQAARHIKLG PSEVWRTERM 

      1150       1160       1170       1180       1190       1200 
SYEGPTAEVV EVSAGGDLSQ AASPTGASRS VRHVTLGPGQ SPLSREVIFL GPAPACPEAW 

      1210       1220       1230       1240       1250       1260 
GSPEPGPAES SADMDGSGRH STFGCRQFHA EKEIIFQGPI SAAGKVGDYF ATEESVGTQT 

      1270       1280       1290       1300       1310       1320 
SVRQLQLGPK EGFSGQIQFT APLSDKVELG VIGDSVHMEG LPGSSTSIRH ISIGPQRHQT 

      1330       1340       1350       1360       1370       1380 
TQQIVYHGLV PQLGESGDSE STVHGEGSAD VHQATHSHTS GRQTVMTEKS TFQSVVSESP 

      1390       1400       1410       1420       1430       1440 
QEDSAGDTSG AEMTSGVSRS FRHIRLGPTE TETSEHIAIR GPVSRTFVLA GSADSPELGK 

      1450       1460       1470       1480       1490       1500 
LADSSRTLRH IAPGPKETSF TFQMDVSNVE AIRSRTQEAG ALGVSDRGSW RDADSRNDQA 

      1510       1520       1530       1540       1550       1560 
VGVSFKASAG EGDQAHREQG KEQAMFDKKV QLQRMVDQRS VISDEKKVAL LYLDNEEEEN 


DGHWF 

« Hide

Isoform 2 (Beta) [UniParc].

Checksum: 88162E538D848F2A
Show »

FASTA1,253140,135
Isoform 3 [UniParc].

Checksum: 090EEA199A0041C4
Show »

FASTA33939,042

References

« Hide 'large scale' references
[1]"Human synemin gene generates splice variants encoding two distinct intermediate filament proteins."
Titeux M., Brocheriou V., Xue Z., Gao J., Pellissier J.-F., Guicheney P., Paulin D., Li Z.
Eur. J. Biochem. 268:6435-6449(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBUNIT, TISSUE SPECIFICITY, VARIANTS VAL-272; TRP-355; LEU-567 AND GLU-1386.
Tissue: Placenta and Skeletal muscle.
[2]"Desmuslin, an intermediate filament protein that interacts with alpha-dystrobrevin and desmin."
Mizuno Y., Thompson T.G., Guyon J.R., Lidov H.G.W., Brosius M., Imamura M., Ozawa E., Watkins S.C., Kunkel L.M.
Proc. Natl. Acad. Sci. U.S.A. 98:6156-6161(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH DES AND DTNA, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Skeletal muscle.
[3]"Synemin gene generates different spliced isoforms expressed selectively in either astrocytes or neurons."
Xue Z., Izmiryan A., Paulin D., Li Z.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[4]Nagase T., Kikuno R., Yamakawa H., Ohara O.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS TRP-355 AND SER-462.
Tissue: Brain.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS TRP-355 AND SER-462.
[6]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-1565 (ISOFORM 1).
Tissue: Brain.
[7]"Synemin expression in developing normal and pathological human retina and lens."
Tawk M., Titeux M., Fallet C., Li Z., Daumas-Duport C., Cavalcante L.A., Paulin D., Moura-Neto V.
Exp. Neurol. 183:499-507(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[8]"Interactions of intermediate filament protein synemin with dystrophin and utrophin."
Bhosle R.C., Michele D.E., Campbell K.P., Li Z., Robson R.M.
Biochem. Biophys. Res. Commun. 346:768-777(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH DMD AND UTRN.
[9]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Human alpha-synemin interacts directly with vinculin and metavinculin."
Sun N., Critchley D.R., Paulin D., Li Z., Robson R.M.
Biochem. J. 409:657-667(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH VCL.
[11]"Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin."
Sun N., Critchley D.R., Paulin D., Li Z., Robson R.M.
Exp. Cell Res. 314:1839-1849(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TLN1, SUBCELLULAR LOCATION.
[12]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1044; SER-1049 AND SER-1435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429; THR-598 AND SER-1181, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1044; SER-1049 AND SER-1181, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[15]"Genomic organization and single-nucleotide polymorphism map of desmuslin, a novel intermediate filament protein on chromosome 15q26.3."
Mizuno Y., Puca A.A., O'Brien K.F., Beggs A.H., Kunkel L.M.
BMC Genet. 2:8-8(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS VAL-272; ILE-330; TRP-338; LEU-567; ALA-612; LEU-761; TRP-946; ARG-976; LEU-1059; PRO-1067 AND LEU-1077.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ310521 mRNA. Translation: CAC83858.1.
AJ310522 mRNA. Translation: CAC83859.1.
AF359284 mRNA. Translation: AAK57487.1.
AJ697971 mRNA. Translation: CAG27071.1.
AB002351 mRNA. Translation: BAA20810.2. Different initiation.
BC110066 mRNA. Translation: AAI10067.1. Different initiation.
BC151243 mRNA. Translation: AAI51244.1.
RefSeqNP_056101.5. NM_015286.5.
NP_663780.2. NM_145728.2.
UniGeneHs.207106.

3D structure databases

ProteinModelPortalO15061.
SMRO15061. Positions 251-318.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116923. 12 interactions.
IntActO15061. 1 interaction.
MINTMINT-198289.
STRING9606.ENSP00000336775.

PTM databases

PhosphoSiteO15061.

Proteomic databases

MaxQBO15061.
PaxDbO15061.
PRIDEO15061.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336292; ENSP00000336775; ENSG00000182253.
GeneID23336.
KEGGhsa:23336.
UCSCuc002buo.3. human. [O15061-2]
uc002bup.3. human. [O15061-1]

Organism-specific databases

CTD23336.
GeneCardsGC15P099645.
H-InvDBHIX0172820.
HGNCHGNC:24466. SYNM.
HPACAB017192.
MIM606087. gene.
neXtProtNX_O15061.
PharmGKBPA164726408.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG139727.
HOGENOMHOG000154476.
HOVERGENHBG008974.
InParanoidO15061.
KOK10376.
PhylomeDBO15061.

Gene expression databases

ArrayExpressO15061.
BgeeO15061.
CleanExHS_SYNM.
GenevestigatorO15061.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSYNM. human.
GenomeRNAi23336.
NextBio45283.
PROO15061.
SOURCESearch...

Entry information

Entry nameSYNEM_HUMAN
AccessionPrimary (citable) accession number: O15061
Secondary accession number(s): A7E2Y2 expand/collapse secondary AC list , Q2TBJ4, Q5NJJ9, Q8TE61, Q8TE62
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: June 11, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM