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O15060 (ZBT39_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and BTB domain-containing protein 39
Gene names
Name:ZBTB39
Synonyms:KIAA0352
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length712 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 1 BTB (POZ) domain.

Contains 8 C2H2-type zinc fingers.

Sequence caution

The sequence BAA20809.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 712712Zinc finger and BTB domain-containing protein 39
PRO_0000047744

Regions

Domain30 – 9667BTB
Zinc finger372 – 39423C2H2-type 1
Zinc finger400 – 42223C2H2-type 2; atypical
Zinc finger480 – 50223C2H2-type 3; atypical
Zinc finger508 – 53023C2H2-type 4
Zinc finger538 – 56023C2H2-type 5
Zinc finger605 – 62723C2H2-type 6
Zinc finger633 – 65523C2H2-type 7
Zinc finger661 – 68323C2H2-type 8; atypical
Compositional bias200 – 2078Poly-Pro

Natural variations

Natural variant6891P → A.
Corresponds to variant rs3741576 [ dbSNP | Ensembl ].
VAR_019985

Sequences

Sequence LengthMass (Da)Tools
O15060 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: E09D2E2AEE35EF1A

FASTA71279,001
        10         20         30         40         50         60 
MGMRIKLQST NHPNNLLKEL NKCRLSETMC DVTIVVGSRS FPAHKAVLAC AAGYFQNLFL 

        70         80         90        100        110        120 
NTGLDAARTY VVDFITPANF EKVLSFVYTS ELFTDLINVG VIYEVAERLG MEDLLQACHS 

       130        140        150        160        170        180 
TFPDLESTAR AKPLTSTSES HSGTLSCPSA EPAHPLGELR GGGDYLGADR NYVLPSDAGG 

       190        200        210        220        230        240 
SYKEEEKNVA SDANHSLHLP QPPPPPPKTE DHDTPAPFTS IPSMMTQPLL GTVSTGIQTS 

       250        260        270        280        290        300 
TSSCQPYKVQ SNGDFSKNSF LTPDNAVDIT TGTNSCLSNS EHSKDPGFGQ MDELQLEDLG 

       310        320        330        340        350        360 
DDDLQFEDPA EDIGTTEEVI ELSDDSEDEL AFGENDNREN KAMPCQVCKK VLEPNIQLIR 

       370        380        390        400        410        420 
QHARDHVDLL TGNCKVCETH FQDRNSRVTH VLSHIGIFLF SCDMCETKFF TQWQLTLHRR 

       430        440        450        460        470        480 
DGIFENNIIV HPNDPLPGKL GLFSGAASPE LKCAACGKVL AKDFHVVRGH ILDHLNLKGQ 

       490        500        510        520        530        540 
ACSVCDQRHL NLCSLMWHTL SHLGISVFSC SVCANSFVDW HLLEKHMAVH QSLEDALFHC 

       550        560        570        580        590        600 
RLCSQSFKSE AAYRYHVSQH KCNSGLDARP GFGLQHPALQ KRKLPAEEFL GEELALQGQP 

       610        620        630        640        650        660 
GNSKYSCKVC GKRFAHTSEF NYHRRIHTGE KPYQCKVCHK FFRGRSTIKC HLKTHSGALM 

       670        680        690        700        710 
YRCTVCGHYS STLNLMSKHV GVHKGSLPPD FTIEQTFMYI IHSKEADKNP DS 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[5]"3,400 new expressed sequence tags identify diversity of transcripts in human brain."
Adams M.D., Kerlavage A.R., Fields C., Venter J.C.
Nat. Genet. 4:256-267(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-82.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB002350 mRNA. Translation: BAA20809.2. Different initiation.
AK292468 mRNA. Translation: BAF85157.1.
CH471054 Genomic DNA. Translation: EAW96971.1.
BC140890 mRNA. Translation: AAI40891.1.
BC146867 mRNA. Translation: AAI46868.1.
BC152461 mRNA. Translation: AAI52462.1.
RefSeqNP_055645.1. NM_014830.2.
UniGeneHs.591025.

3D structure databases

ProteinModelPortalO15060.
SMRO15060. Positions 1-120, 338-688.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115211. 2 interactions.
STRING9606.ENSP00000300101.

PTM databases

PhosphoSiteO15060.

Proteomic databases

PaxDbO15060.
PRIDEO15060.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300101; ENSP00000300101; ENSG00000166860.
GeneID9880.
KEGGhsa:9880.
UCSCuc001sml.2. human.

Organism-specific databases

CTD9880.
GeneCardsGC12M057392.
HGNCHGNC:29014. ZBTB39.
HPAHPA016866.
HPA020306.
neXtProtNX_O15060.
PharmGKBPA142670543.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272041.
HOGENOMHOG000004862.
HOVERGENHBG062784.
InParanoidO15060.
KOK10511.
OMAFRGRSTI.
OrthoDBEOG75QR3S.
PhylomeDBO15060.
TreeFamTF350825.

Gene expression databases

BgeeO15060.
CleanExHS_ZBTB39.
GenevestigatorO15060.

Family and domain databases

Gene3D3.30.160.60. 2 hits.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9880.
NextBio37237.
PROO15060.

Entry information

Entry nameZBT39_HUMAN
AccessionPrimary (citable) accession number: O15060
Secondary accession number(s): A7MD38, Q9UD98
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: March 19, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM