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Protein

Zinc finger and BTB domain-containing protein 39

Gene

ZBTB39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166860-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 39
Gene namesi
Name:ZBTB39
Synonyms:KIAA0352
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29014. ZBTB39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166860.
PharmGKBiPA142670543.

Polymorphism and mutation databases

BioMutaiZBTB39.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477441 – 712Zinc finger and BTB domain-containing protein 39Add BLAST712

Proteomic databases

EPDiO15060.
MaxQBiO15060.
PaxDbiO15060.
PeptideAtlasiO15060.
PRIDEiO15060.

PTM databases

iPTMnetiO15060.
PhosphoSitePlusiO15060.

Expressioni

Gene expression databases

BgeeiENSG00000166860.
CleanExiHS_ZBTB39.
GenevisibleiO15060. HS.

Organism-specific databases

HPAiHPA016866.
HPA020306.

Interactioni

Protein-protein interaction databases

BioGridi115211. 4 interactors.
IntActiO15060. 10 interactors.
STRINGi9606.ENSP00000300101.

Structurei

3D structure databases

ProteinModelPortaliO15060.
SMRiO15060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 96BTBPROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi200 – 207Poly-Pro8

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063338.
HOGENOMiHOG000004862.
HOVERGENiHBG062784.
InParanoidiO15060.
KOiK10511.
OMAiSTIKCHL.
OrthoDBiEOG091G02DA.
PhylomeDBiO15060.
TreeFamiTF350825.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRIKLQST NHPNNLLKEL NKCRLSETMC DVTIVVGSRS FPAHKAVLAC
60 70 80 90 100
AAGYFQNLFL NTGLDAARTY VVDFITPANF EKVLSFVYTS ELFTDLINVG
110 120 130 140 150
VIYEVAERLG MEDLLQACHS TFPDLESTAR AKPLTSTSES HSGTLSCPSA
160 170 180 190 200
EPAHPLGELR GGGDYLGADR NYVLPSDAGG SYKEEEKNVA SDANHSLHLP
210 220 230 240 250
QPPPPPPKTE DHDTPAPFTS IPSMMTQPLL GTVSTGIQTS TSSCQPYKVQ
260 270 280 290 300
SNGDFSKNSF LTPDNAVDIT TGTNSCLSNS EHSKDPGFGQ MDELQLEDLG
310 320 330 340 350
DDDLQFEDPA EDIGTTEEVI ELSDDSEDEL AFGENDNREN KAMPCQVCKK
360 370 380 390 400
VLEPNIQLIR QHARDHVDLL TGNCKVCETH FQDRNSRVTH VLSHIGIFLF
410 420 430 440 450
SCDMCETKFF TQWQLTLHRR DGIFENNIIV HPNDPLPGKL GLFSGAASPE
460 470 480 490 500
LKCAACGKVL AKDFHVVRGH ILDHLNLKGQ ACSVCDQRHL NLCSLMWHTL
510 520 530 540 550
SHLGISVFSC SVCANSFVDW HLLEKHMAVH QSLEDALFHC RLCSQSFKSE
560 570 580 590 600
AAYRYHVSQH KCNSGLDARP GFGLQHPALQ KRKLPAEEFL GEELALQGQP
610 620 630 640 650
GNSKYSCKVC GKRFAHTSEF NYHRRIHTGE KPYQCKVCHK FFRGRSTIKC
660 670 680 690 700
HLKTHSGALM YRCTVCGHYS STLNLMSKHV GVHKGSLPPD FTIEQTFMYI
710
IHSKEADKNP DS
Length:712
Mass (Da):79,001
Last modified:January 1, 1998 - v1
Checksum:iE09D2E2AEE35EF1A
GO

Sequence cautioni

The sequence BAA20809 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019985689P → A.Corresponds to variant rs3741576dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002350 mRNA. Translation: BAA20809.2. Different initiation.
AK292468 mRNA. Translation: BAF85157.1.
CH471054 Genomic DNA. Translation: EAW96971.1.
BC140890 mRNA. Translation: AAI40891.1.
BC146867 mRNA. Translation: AAI46868.1.
BC152461 mRNA. Translation: AAI52462.1.
CCDSiCCDS31839.1.
RefSeqiNP_055645.1. NM_014830.2.
UniGeneiHs.591025.

Genome annotation databases

EnsembliENST00000300101; ENSP00000300101; ENSG00000166860.
GeneIDi9880.
KEGGihsa:9880.
UCSCiuc001sml.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002350 mRNA. Translation: BAA20809.2. Different initiation.
AK292468 mRNA. Translation: BAF85157.1.
CH471054 Genomic DNA. Translation: EAW96971.1.
BC140890 mRNA. Translation: AAI40891.1.
BC146867 mRNA. Translation: AAI46868.1.
BC152461 mRNA. Translation: AAI52462.1.
CCDSiCCDS31839.1.
RefSeqiNP_055645.1. NM_014830.2.
UniGeneiHs.591025.

3D structure databases

ProteinModelPortaliO15060.
SMRiO15060.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115211. 4 interactors.
IntActiO15060. 10 interactors.
STRINGi9606.ENSP00000300101.

PTM databases

iPTMnetiO15060.
PhosphoSitePlusiO15060.

Polymorphism and mutation databases

BioMutaiZBTB39.

Proteomic databases

EPDiO15060.
MaxQBiO15060.
PaxDbiO15060.
PeptideAtlasiO15060.
PRIDEiO15060.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300101; ENSP00000300101; ENSG00000166860.
GeneIDi9880.
KEGGihsa:9880.
UCSCiuc001sml.3. human.

Organism-specific databases

CTDi9880.
GeneCardsiZBTB39.
HGNCiHGNC:29014. ZBTB39.
HPAiHPA016866.
HPA020306.
neXtProtiNX_O15060.
OpenTargetsiENSG00000166860.
PharmGKBiPA142670543.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063338.
HOGENOMiHOG000004862.
HOVERGENiHBG062784.
InParanoidiO15060.
KOiK10511.
OMAiSTIKCHL.
OrthoDBiEOG091G02DA.
PhylomeDBiO15060.
TreeFamiTF350825.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166860-MONOMER.

Miscellaneous databases

GenomeRNAii9880.
PROiO15060.

Gene expression databases

BgeeiENSG00000166860.
CleanExiHS_ZBTB39.
GenevisibleiO15060. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT39_HUMAN
AccessioniPrimary (citable) accession number: O15060
Secondary accession number(s): A7MD38, Q9UD98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.