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Protein

Zinc finger and BTB domain-containing protein 39

Gene

ZBTB39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 39
Gene namesi
Name:ZBTB39
Synonyms:KIAA0352
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000166860.2
HGNCiHGNC:29014 ZBTB39
neXtProtiNX_O15060

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166860
PharmGKBiPA142670543

Polymorphism and mutation databases

BioMutaiZBTB39

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477441 – 712Zinc finger and BTB domain-containing protein 39Add BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki183Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki439Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO15060
MaxQBiO15060
PaxDbiO15060
PeptideAtlasiO15060
PRIDEiO15060

PTM databases

iPTMnetiO15060
PhosphoSitePlusiO15060

Expressioni

Gene expression databases

BgeeiENSG00000166860
CleanExiHS_ZBTB39
GenevisibleiO15060 HS

Organism-specific databases

HPAiHPA016866
HPA020306

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115211, 6 interactors
IntActiO15060, 12 interactors
STRINGi9606.ENSP00000300101

Structurei

3D structure databases

ProteinModelPortaliO15060
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 96BTBPROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi200 – 207Poly-Pro8

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063338
HOGENOMiHOG000004862
HOVERGENiHBG062784
InParanoidiO15060
KOiK10511
OMAiSTIKCHL
OrthoDBiEOG091G02DA
PhylomeDBiO15060
TreeFamiTF350825

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

O15060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRIKLQST NHPNNLLKEL NKCRLSETMC DVTIVVGSRS FPAHKAVLAC
60 70 80 90 100
AAGYFQNLFL NTGLDAARTY VVDFITPANF EKVLSFVYTS ELFTDLINVG
110 120 130 140 150
VIYEVAERLG MEDLLQACHS TFPDLESTAR AKPLTSTSES HSGTLSCPSA
160 170 180 190 200
EPAHPLGELR GGGDYLGADR NYVLPSDAGG SYKEEEKNVA SDANHSLHLP
210 220 230 240 250
QPPPPPPKTE DHDTPAPFTS IPSMMTQPLL GTVSTGIQTS TSSCQPYKVQ
260 270 280 290 300
SNGDFSKNSF LTPDNAVDIT TGTNSCLSNS EHSKDPGFGQ MDELQLEDLG
310 320 330 340 350
DDDLQFEDPA EDIGTTEEVI ELSDDSEDEL AFGENDNREN KAMPCQVCKK
360 370 380 390 400
VLEPNIQLIR QHARDHVDLL TGNCKVCETH FQDRNSRVTH VLSHIGIFLF
410 420 430 440 450
SCDMCETKFF TQWQLTLHRR DGIFENNIIV HPNDPLPGKL GLFSGAASPE
460 470 480 490 500
LKCAACGKVL AKDFHVVRGH ILDHLNLKGQ ACSVCDQRHL NLCSLMWHTL
510 520 530 540 550
SHLGISVFSC SVCANSFVDW HLLEKHMAVH QSLEDALFHC RLCSQSFKSE
560 570 580 590 600
AAYRYHVSQH KCNSGLDARP GFGLQHPALQ KRKLPAEEFL GEELALQGQP
610 620 630 640 650
GNSKYSCKVC GKRFAHTSEF NYHRRIHTGE KPYQCKVCHK FFRGRSTIKC
660 670 680 690 700
HLKTHSGALM YRCTVCGHYS STLNLMSKHV GVHKGSLPPD FTIEQTFMYI
710
IHSKEADKNP DS
Length:712
Mass (Da):79,001
Last modified:January 1, 1998 - v1
Checksum:iE09D2E2AEE35EF1A
GO

Sequence cautioni

The sequence BAA20809 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019985689P → A. Corresponds to variant dbSNP:rs3741576Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002350 mRNA Translation: BAA20809.2 Different initiation.
AK292468 mRNA Translation: BAF85157.1
CH471054 Genomic DNA Translation: EAW96971.1
BC140890 mRNA Translation: AAI40891.1
BC146867 mRNA Translation: AAI46868.1
BC152461 mRNA Translation: AAI52462.1
CCDSiCCDS31839.1
RefSeqiNP_055645.1, NM_014830.2
UniGeneiHs.591025

Genome annotation databases

EnsembliENST00000300101; ENSP00000300101; ENSG00000166860
GeneIDi9880
KEGGihsa:9880
UCSCiuc001sml.3 human

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiZBT39_HUMAN
AccessioniPrimary (citable) accession number: O15060
Secondary accession number(s): A7MD38, Q9UD98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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