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Protein

Zinc finger and BTB domain-containing protein 39

Gene

ZBTB39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68323C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 39
Gene namesi
Name:ZBTB39
Synonyms:KIAA0352
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29014. ZBTB39.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712Zinc finger and BTB domain-containing protein 39PRO_0000047744Add
BLAST

Proteomic databases

MaxQBiO15060.
PaxDbiO15060.
PRIDEiO15060.

PTM databases

PhosphoSiteiO15060.

Expressioni

Gene expression databases

BgeeiO15060.
CleanExiHS_ZBTB39.
GenevestigatoriO15060.

Organism-specific databases

HPAiHPA016866.
HPA020306.

Interactioni

Protein-protein interaction databases

BioGridi115211. 2 interactions.
STRINGi9606.ENSP00000300101.

Structurei

3D structure databases

ProteinModelPortaliO15060.
SMRiO15060. Positions 1-129, 361-425, 478-684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9667BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi200 – 2078Poly-Pro

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68323C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG272041.
GeneTreeiENSGT00530000063338.
HOGENOMiHOG000004862.
HOVERGENiHBG062784.
InParanoidiO15060.
KOiK10511.
OMAiFRGRSTI.
OrthoDBiEOG75QR3S.
PhylomeDBiO15060.
TreeFamiTF350825.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRIKLQST NHPNNLLKEL NKCRLSETMC DVTIVVGSRS FPAHKAVLAC
60 70 80 90 100
AAGYFQNLFL NTGLDAARTY VVDFITPANF EKVLSFVYTS ELFTDLINVG
110 120 130 140 150
VIYEVAERLG MEDLLQACHS TFPDLESTAR AKPLTSTSES HSGTLSCPSA
160 170 180 190 200
EPAHPLGELR GGGDYLGADR NYVLPSDAGG SYKEEEKNVA SDANHSLHLP
210 220 230 240 250
QPPPPPPKTE DHDTPAPFTS IPSMMTQPLL GTVSTGIQTS TSSCQPYKVQ
260 270 280 290 300
SNGDFSKNSF LTPDNAVDIT TGTNSCLSNS EHSKDPGFGQ MDELQLEDLG
310 320 330 340 350
DDDLQFEDPA EDIGTTEEVI ELSDDSEDEL AFGENDNREN KAMPCQVCKK
360 370 380 390 400
VLEPNIQLIR QHARDHVDLL TGNCKVCETH FQDRNSRVTH VLSHIGIFLF
410 420 430 440 450
SCDMCETKFF TQWQLTLHRR DGIFENNIIV HPNDPLPGKL GLFSGAASPE
460 470 480 490 500
LKCAACGKVL AKDFHVVRGH ILDHLNLKGQ ACSVCDQRHL NLCSLMWHTL
510 520 530 540 550
SHLGISVFSC SVCANSFVDW HLLEKHMAVH QSLEDALFHC RLCSQSFKSE
560 570 580 590 600
AAYRYHVSQH KCNSGLDARP GFGLQHPALQ KRKLPAEEFL GEELALQGQP
610 620 630 640 650
GNSKYSCKVC GKRFAHTSEF NYHRRIHTGE KPYQCKVCHK FFRGRSTIKC
660 670 680 690 700
HLKTHSGALM YRCTVCGHYS STLNLMSKHV GVHKGSLPPD FTIEQTFMYI
710
IHSKEADKNP DS
Length:712
Mass (Da):79,001
Last modified:December 31, 1997 - v1
Checksum:iE09D2E2AEE35EF1A
GO

Sequence cautioni

The sequence BAA20809.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti689 – 6891P → A.
Corresponds to variant rs3741576 [ dbSNP | Ensembl ].
VAR_019985

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002350 mRNA. Translation: BAA20809.2. Different initiation.
AK292468 mRNA. Translation: BAF85157.1.
CH471054 Genomic DNA. Translation: EAW96971.1.
BC140890 mRNA. Translation: AAI40891.1.
BC146867 mRNA. Translation: AAI46868.1.
BC152461 mRNA. Translation: AAI52462.1.
CCDSiCCDS31839.1.
RefSeqiNP_055645.1. NM_014830.2.
UniGeneiHs.591025.

Genome annotation databases

EnsembliENST00000300101; ENSP00000300101; ENSG00000166860.
GeneIDi9880.
KEGGihsa:9880.
UCSCiuc001sml.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002350 mRNA. Translation: BAA20809.2. Different initiation.
AK292468 mRNA. Translation: BAF85157.1.
CH471054 Genomic DNA. Translation: EAW96971.1.
BC140890 mRNA. Translation: AAI40891.1.
BC146867 mRNA. Translation: AAI46868.1.
BC152461 mRNA. Translation: AAI52462.1.
CCDSiCCDS31839.1.
RefSeqiNP_055645.1. NM_014830.2.
UniGeneiHs.591025.

3D structure databases

ProteinModelPortaliO15060.
SMRiO15060. Positions 1-129, 361-425, 478-684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115211. 2 interactions.
STRINGi9606.ENSP00000300101.

PTM databases

PhosphoSiteiO15060.

Proteomic databases

MaxQBiO15060.
PaxDbiO15060.
PRIDEiO15060.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300101; ENSP00000300101; ENSG00000166860.
GeneIDi9880.
KEGGihsa:9880.
UCSCiuc001sml.2. human.

Organism-specific databases

CTDi9880.
GeneCardsiGC12M057392.
HGNCiHGNC:29014. ZBTB39.
HPAiHPA016866.
HPA020306.
neXtProtiNX_O15060.
PharmGKBiPA142670543.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272041.
GeneTreeiENSGT00530000063338.
HOGENOMiHOG000004862.
HOVERGENiHBG062784.
InParanoidiO15060.
KOiK10511.
OMAiFRGRSTI.
OrthoDBiEOG75QR3S.
PhylomeDBiO15060.
TreeFamiTF350825.

Miscellaneous databases

GenomeRNAii9880.
NextBioi37237.
PROiO15060.

Gene expression databases

BgeeiO15060.
CleanExiHS_ZBTB39.
GenevestigatoriO15060.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. "3,400 new expressed sequence tags identify diversity of transcripts in human brain."
    Adams M.D., Kerlavage A.R., Fields C., Venter J.C.
    Nat. Genet. 4:256-267(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-82.
    Tissue: Brain.

Entry informationi

Entry nameiZBT39_HUMAN
AccessioniPrimary (citable) accession number: O15060
Secondary accession number(s): A7MD38, Q9UD98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2001
Last sequence update: December 31, 1997
Last modified: January 6, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.