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O15060

- ZBT39_HUMAN

UniProt

O15060 - ZBT39_HUMAN

Protein

Zinc finger and BTB domain-containing protein 39

Gene

ZBTB39

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri372 – 39423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50223C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri508 – 53023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri538 – 56023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri605 – 62723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri633 – 65523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri661 – 68323C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 39
    Gene namesi
    Name:ZBTB39
    Synonyms:KIAA0352
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29014. ZBTB39.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670543.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 712712Zinc finger and BTB domain-containing protein 39PRO_0000047744Add
    BLAST

    Proteomic databases

    MaxQBiO15060.
    PaxDbiO15060.
    PRIDEiO15060.

    PTM databases

    PhosphoSiteiO15060.

    Expressioni

    Gene expression databases

    BgeeiO15060.
    CleanExiHS_ZBTB39.
    GenevestigatoriO15060.

    Organism-specific databases

    HPAiHPA016866.
    HPA020306.

    Interactioni

    Protein-protein interaction databases

    BioGridi115211. 2 interactions.
    STRINGi9606.ENSP00000300101.

    Structurei

    3D structure databases

    ProteinModelPortaliO15060.
    SMRiO15060. Positions 1-129, 341-692.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 9667BTBPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi200 – 2078Poly-Pro

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri372 – 39423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50223C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri508 – 53023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri538 – 56023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri605 – 62723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri633 – 65523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri661 – 68323C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG272041.
    HOGENOMiHOG000004862.
    HOVERGENiHBG062784.
    InParanoidiO15060.
    KOiK10511.
    OMAiFRGRSTI.
    OrthoDBiEOG75QR3S.
    PhylomeDBiO15060.
    TreeFamiTF350825.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15060-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMRIKLQST NHPNNLLKEL NKCRLSETMC DVTIVVGSRS FPAHKAVLAC    50
    AAGYFQNLFL NTGLDAARTY VVDFITPANF EKVLSFVYTS ELFTDLINVG 100
    VIYEVAERLG MEDLLQACHS TFPDLESTAR AKPLTSTSES HSGTLSCPSA 150
    EPAHPLGELR GGGDYLGADR NYVLPSDAGG SYKEEEKNVA SDANHSLHLP 200
    QPPPPPPKTE DHDTPAPFTS IPSMMTQPLL GTVSTGIQTS TSSCQPYKVQ 250
    SNGDFSKNSF LTPDNAVDIT TGTNSCLSNS EHSKDPGFGQ MDELQLEDLG 300
    DDDLQFEDPA EDIGTTEEVI ELSDDSEDEL AFGENDNREN KAMPCQVCKK 350
    VLEPNIQLIR QHARDHVDLL TGNCKVCETH FQDRNSRVTH VLSHIGIFLF 400
    SCDMCETKFF TQWQLTLHRR DGIFENNIIV HPNDPLPGKL GLFSGAASPE 450
    LKCAACGKVL AKDFHVVRGH ILDHLNLKGQ ACSVCDQRHL NLCSLMWHTL 500
    SHLGISVFSC SVCANSFVDW HLLEKHMAVH QSLEDALFHC RLCSQSFKSE 550
    AAYRYHVSQH KCNSGLDARP GFGLQHPALQ KRKLPAEEFL GEELALQGQP 600
    GNSKYSCKVC GKRFAHTSEF NYHRRIHTGE KPYQCKVCHK FFRGRSTIKC 650
    HLKTHSGALM YRCTVCGHYS STLNLMSKHV GVHKGSLPPD FTIEQTFMYI 700
    IHSKEADKNP DS 712
    Length:712
    Mass (Da):79,001
    Last modified:January 1, 1998 - v1
    Checksum:iE09D2E2AEE35EF1A
    GO

    Sequence cautioni

    The sequence BAA20809.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti689 – 6891P → A.
    Corresponds to variant rs3741576 [ dbSNP | Ensembl ].
    VAR_019985

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002350 mRNA. Translation: BAA20809.2. Different initiation.
    AK292468 mRNA. Translation: BAF85157.1.
    CH471054 Genomic DNA. Translation: EAW96971.1.
    BC140890 mRNA. Translation: AAI40891.1.
    BC146867 mRNA. Translation: AAI46868.1.
    BC152461 mRNA. Translation: AAI52462.1.
    CCDSiCCDS31839.1.
    RefSeqiNP_055645.1. NM_014830.2.
    UniGeneiHs.591025.

    Genome annotation databases

    EnsembliENST00000300101; ENSP00000300101; ENSG00000166860.
    GeneIDi9880.
    KEGGihsa:9880.
    UCSCiuc001sml.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002350 mRNA. Translation: BAA20809.2 . Different initiation.
    AK292468 mRNA. Translation: BAF85157.1 .
    CH471054 Genomic DNA. Translation: EAW96971.1 .
    BC140890 mRNA. Translation: AAI40891.1 .
    BC146867 mRNA. Translation: AAI46868.1 .
    BC152461 mRNA. Translation: AAI52462.1 .
    CCDSi CCDS31839.1.
    RefSeqi NP_055645.1. NM_014830.2.
    UniGenei Hs.591025.

    3D structure databases

    ProteinModelPortali O15060.
    SMRi O15060. Positions 1-129, 341-692.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115211. 2 interactions.
    STRINGi 9606.ENSP00000300101.

    PTM databases

    PhosphoSitei O15060.

    Proteomic databases

    MaxQBi O15060.
    PaxDbi O15060.
    PRIDEi O15060.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300101 ; ENSP00000300101 ; ENSG00000166860 .
    GeneIDi 9880.
    KEGGi hsa:9880.
    UCSCi uc001sml.2. human.

    Organism-specific databases

    CTDi 9880.
    GeneCardsi GC12M057392.
    HGNCi HGNC:29014. ZBTB39.
    HPAi HPA016866.
    HPA020306.
    neXtProti NX_O15060.
    PharmGKBi PA142670543.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272041.
    HOGENOMi HOG000004862.
    HOVERGENi HBG062784.
    InParanoidi O15060.
    KOi K10511.
    OMAi FRGRSTI.
    OrthoDBi EOG75QR3S.
    PhylomeDBi O15060.
    TreeFami TF350825.

    Miscellaneous databases

    GenomeRNAii 9880.
    NextBioi 37237.
    PROi O15060.

    Gene expression databases

    Bgeei O15060.
    CleanExi HS_ZBTB39.
    Genevestigatori O15060.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    5. "3,400 new expressed sequence tags identify diversity of transcripts in human brain."
      Adams M.D., Kerlavage A.R., Fields C., Venter J.C.
      Nat. Genet. 4:256-267(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-82.
      Tissue: Brain.

    Entry informationi

    Entry nameiZBT39_HUMAN
    AccessioniPrimary (citable) accession number: O15060
    Secondary accession number(s): A7MD38, Q9UD98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3