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O15056

- SYNJ2_HUMAN

UniProt

O15056 - SYNJ2_HUMAN

Protein

Synaptojanin-2

Gene

SYNJ2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 3 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: UniProtKB-EC
    3. protein binding Source: IntAct
    4. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. phosphatidylinositol biosynthetic process Source: Reactome
    2. phosphatidylinositol dephosphorylation Source: InterPro
    3. phospholipid metabolic process Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS01279-MONOMER.
    ReactomeiREACT_121025. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptojanin-2 (EC:3.1.3.36)
    Alternative name(s):
    Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2
    Gene namesi
    Name:SYNJ2
    Synonyms:KIAA0348
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:11504. SYNJ2.

    Subcellular locationi

    Membrane By similarity
    Note: Predominantly associated with the particulate fractions.By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36286.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14961496Synaptojanin-2PRO_0000209733Add
    BLAST

    Proteomic databases

    MaxQBiO15056.
    PaxDbiO15056.
    PRIDEiO15056.

    PTM databases

    PhosphoSiteiO15056.

    Expressioni

    Gene expression databases

    ArrayExpressiO15056.
    BgeeiO15056.
    CleanExiHS_SYNJ2.
    GenevestigatoriO15056.

    Organism-specific databases

    HPAiHPA031575.
    HPA031953.

    Interactioni

    Subunit structurei

    Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GRB2P629932EBI-310513,EBI-401755
    NCK1P163333EBI-310513,EBI-389883
    SH3KBP1Q96B973EBI-310513,EBI-346595

    Protein-protein interaction databases

    BioGridi114391. 10 interactions.
    IntActiO15056. 10 interactions.
    MINTiMINT-3976061.
    STRINGi9606.ENSP00000347792.

    Structurei

    Secondary structure

    1
    1496
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi891 – 8988
    Helixi901 – 9055
    Helixi909 – 92214
    Beta strandi926 – 9316
    Beta strandi934 – 9385
    Helixi943 – 9508
    Helixi951 – 9533
    Beta strandi954 – 9563
    Beta strandi959 – 9635

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UFWNMR-A882-963[»]
    ProteinModelPortaliO15056.
    SMRiO15056. Positions 517-881, 884-963.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO15056.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini120 – 444325SACPROSITE-ProRule annotationAdd
    BLAST
    Domaini889 – 96880RRMPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni450 – ?CatalyticBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1099 – 111416Pro-richAdd
    BLAST
    Compositional biasi1209 – 1334126Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptojanin family.Curated
    In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Curated
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
    Contains 1 SAC domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5411.
    HOVERGENiHBG079225.
    InParanoidiO15056.
    KOiK01099.
    OMAiVIKGQYG.
    OrthoDBiEOG7N63KS.
    PhylomeDBiO15056.
    TreeFamiTF354311.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    3.60.10.10. 1 hit.
    InterProiIPR015047. DUF1866.
    IPR005135. Endo/exonuclease/phosphatase.
    IPR000300. IPPc.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR002013. Syja_N.
    [Graphical view]
    PfamiPF08952. DUF1866. 1 hit.
    PF03372. Exo_endo_phos. 1 hit.
    PF02383. Syja_N. 1 hit.
    [Graphical view]
    SMARTiSM00128. IPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56219. SSF56219. 2 hits.
    PROSITEiPS50102. RRM. 1 hit.
    PS50275. SAC. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 2B2 (identifier: O15056-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALSKGLRLL GRLGAEGDCS VLLEARGRDD CLLFEAGTVA TLAPEEKEVI     50
    KGQYGKLTDA YGCLGELRLK SGGTSLSFLV LVTGCTSVGR IPDAEIYKIT 100
    ATDFYPLQEE AKEEERLIAL KKILSSGVFY FSWPNDGSRF DLTVRTQKQG 150
    DDSSEWGNSF FWNQLLHVPL RQHQVSCCDW LLKIICGVVT IRTVYASHKQ 200
    AKACLVSRVS CERTGTRFHT RGVNDDGHVS NFVETEQMIY MDDGVSSFVQ 250
    IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFDRHMVL LKEQYGQQVV 300
    VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGGKLEKLE 350
    TLLRPQLKLH WEDFDVFTKG ENVSPRFQKG TLRMNCLDCL DRTNTVQSFI 400
    ALEVLHLQLK TLGLSSKPIV DRFVESFKAM WSLNGHSLSK VFTGSRALEG 450
    KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA IKLLLVGDVY GEEVADKGGM 500
    LLDSTALLVT PRILKAMTER QSEFTNFKRI RIAMGTWNVN GGKQFRSNVL 550
    RTAELTDWLL DSPQLSGATD SQDDSSPADI FAVGFEEMVE LSAGNIVNAS 600
    TTNKKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA 650
    IDTVKTGMGG KAGNKGAVGI RFQFHSTSFC FICSHLTAGQ SQVKERNEDY 700
    KEITQKLCFP MGRNVFSHDY VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL 750
    LEFDQLQLQK SSGKIFKDFH EGAINFGPTY KYDVGSAAYD TSDKCRTPAW 800
    TDRVLWWRKK HPFDKTAGEL NLLDSDLDVD TKVRHTWSPG ALQYYGRAEL 850
    QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSFQGPLDA TVVVNLQSPT 900
    LEEKNEFPED LRTELMQTLG SYGTIVLVRI NQGQMLVTFA DSHSALSVLD 950
    VDGMKVKGRA VKIRPKTKDW LKGLREEIIR KRDSMAPVSP TANSCLLEEN 1000
    FDFTSLDYES EGDILEDDED YLVDEFNQPG VSDSELGGDD LSDVPGPTAL 1050
    APPSKSPALT KKKQHPTYKD DADLVELKRE LEAVGEFRHR SPSRSLSVPN 1100
    RPRPPQPPQR PPPPTGLMVK KSASDASISS GTHGQYSILQ TARLLPGAPQ 1150
    QPPKARTGIS KPYNVKQIKT TNAQEAEAAI RCLLEARGGA SEEALSAVAP 1200
    RDLEASSEPE PTPGAAKPET PQAPPLLPRR PPPRVPAIKK PTLRRTGKPL 1250
    SPEEQFEQQT VHFTIGPPET SVEAPPVVTA PRVPPVPKPR TFQPGKAAER 1300
    PSHRKPASDE APPGAGASVP PPLEAPPLVP KVPPRRKKSA PAAFHLQVLQ 1350
    SNSQLLQGLT YNSSDSPSGH PPAAGTVFPQ GDFLSTSSAT SPDSDGTKAM 1400
    KPEAAPLLGD YQDPFWNLLH HPKLLNNTWL SKSSDPLDSG TRSPKRDPID 1450
    PVSAGASAAK AELPPDHEHK TLGHWVTISD QEKRTALQVF DPLAKT 1496
    Length:1,496
    Mass (Da):165,538
    Last modified:March 1, 2005 - v3
    Checksum:i7CC9E368585ACF21
    GO
    Isoform 2B1 (identifier: O15056-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1070-1114: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,451
    Mass (Da):160,434
    Checksum:i42E19A35A791EA6A
    GO
    Isoform 2A (identifier: O15056-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1249-1288: PLSPEEQFEQ...TAPRVPPVPK → IVFCSRSQAS...ASVDTSGSSV
         1289-1496: Missing.

    Show »
    Length:1,288
    Mass (Da):143,445
    Checksum:i9A4EAA3AA9AE2451
    GO

    Sequence cautioni

    The sequence AAH43277.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1468 – 14681E → G.1 Publication
    Corresponds to variant rs2502601 [ dbSNP | Ensembl ].
    VAR_024507

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1070 – 111445Missing in isoform 2B1. CuratedVSP_012911Add
    BLAST
    Alternative sequencei1249 – 128840PLSPE…PPVPK → IVFCSRSQASQPCLLLQRHE FVRTVAAQRLASVDTSGSSV in isoform 2A. 1 PublicationVSP_012912Add
    BLAST
    Alternative sequencei1289 – 1496208Missing in isoform 2A. 1 PublicationVSP_012913Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY152396 mRNA. Translation: AAN73051.1.
    AF318616 mRNA. Translation: AAG46036.1.
    AL139330 Genomic DNA. Translation: CAI12978.1.
    AL139330 Genomic DNA. Translation: CAI12983.1.
    AL139330 Genomic DNA. Translation: CAI12984.1.
    AF039945 mRNA. Translation: AAD02178.1.
    AB002346 mRNA. Translation: BAA20805.2.
    BC043277 mRNA. Translation: AAH43277.1. Different initiation.
    CCDSiCCDS5254.1. [O15056-1]
    RefSeqiNP_003889.1. NM_003898.3. [O15056-1]
    XP_006715655.1. XM_006715592.1. [O15056-3]
    UniGeneiHs.434494.

    Genome annotation databases

    EnsembliENST00000355585; ENSP00000347792; ENSG00000078269. [O15056-1]
    GeneIDi8871.
    KEGGihsa:8871.
    UCSCiuc003qqw.2. human. [O15056-3]
    uc003qqx.2. human. [O15056-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY152396 mRNA. Translation: AAN73051.1 .
    AF318616 mRNA. Translation: AAG46036.1 .
    AL139330 Genomic DNA. Translation: CAI12978.1 .
    AL139330 Genomic DNA. Translation: CAI12983.1 .
    AL139330 Genomic DNA. Translation: CAI12984.1 .
    AF039945 mRNA. Translation: AAD02178.1 .
    AB002346 mRNA. Translation: BAA20805.2 .
    BC043277 mRNA. Translation: AAH43277.1 . Different initiation.
    CCDSi CCDS5254.1. [O15056-1 ]
    RefSeqi NP_003889.1. NM_003898.3. [O15056-1 ]
    XP_006715655.1. XM_006715592.1. [O15056-3 ]
    UniGenei Hs.434494.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UFW NMR - A 882-963 [» ]
    ProteinModelPortali O15056.
    SMRi O15056. Positions 517-881, 884-963.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114391. 10 interactions.
    IntActi O15056. 10 interactions.
    MINTi MINT-3976061.
    STRINGi 9606.ENSP00000347792.

    PTM databases

    PhosphoSitei O15056.

    Proteomic databases

    MaxQBi O15056.
    PaxDbi O15056.
    PRIDEi O15056.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355585 ; ENSP00000347792 ; ENSG00000078269 . [O15056-1 ]
    GeneIDi 8871.
    KEGGi hsa:8871.
    UCSCi uc003qqw.2. human. [O15056-3 ]
    uc003qqx.2. human. [O15056-1 ]

    Organism-specific databases

    CTDi 8871.
    GeneCardsi GC06P158402.
    HGNCi HGNC:11504. SYNJ2.
    HPAi HPA031575.
    HPA031953.
    MIMi 609410. gene.
    neXtProti NX_O15056.
    PharmGKBi PA36286.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5411.
    HOVERGENi HBG079225.
    InParanoidi O15056.
    KOi K01099.
    OMAi VIKGQYG.
    OrthoDBi EOG7N63KS.
    PhylomeDBi O15056.
    TreeFami TF354311.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS01279-MONOMER.
    Reactomei REACT_121025. Synthesis of PIPs at the plasma membrane.

    Miscellaneous databases

    EvolutionaryTracei O15056.
    GenomeRNAii 8871.
    NextBioi 33305.
    PROi O15056.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15056.
    Bgeei O15056.
    CleanExi HS_SYNJ2.
    Genevestigatori O15056.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    3.60.10.10. 1 hit.
    InterProi IPR015047. DUF1866.
    IPR005135. Endo/exonuclease/phosphatase.
    IPR000300. IPPc.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR002013. Syja_N.
    [Graphical view ]
    Pfami PF08952. DUF1866. 1 hit.
    PF03372. Exo_endo_phos. 1 hit.
    PF02383. Syja_N. 1 hit.
    [Graphical view ]
    SMARTi SM00128. IPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56219. SSF56219. 2 hits.
    PROSITEi PS50102. RRM. 1 hit.
    PS50275. SAC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of human SH3 domain-containing proteins, synaptojanin 2A."
      Jeong S.-Y., Youle R.J.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2A).
    2. "Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis."
      Malecz N., McCabe P.C., Spaargaren C., Qiu R.-G., Chuang Y.-Y., Symons M.
      Curr. Biol. 10:1383-1386(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2B2), SUBCELLULAR LOCATION.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals."
      Nemoto Y., Wenk M.R., Watanabe M., Daniell L., Murakami T., Ringstad N., Yamada H., Takei K., De Camilli P.
      J. Biol. Chem. 276:41133-41142(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-1496 (ISOFORM 2B2).
      Tissue: Brain.
    5. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-1496 (ISOFORM 2B2).
      Tissue: Brain.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 647-1496 (ISOFORM 2B2), VARIANT GLY-1468.
      Tissue: Testis.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Solution structure of RNP domain in synaptojanin 2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (DEC-2003) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 819-969.

    Entry informationi

    Entry nameiSYNJ2_HUMAN
    AccessioniPrimary (citable) accession number: O15056
    Secondary accession number(s): Q5TA13
    , Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 148 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3