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Protein

Synaptojanin-2

Gene

SYNJ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS01279-MONOMER.
ZFISH:HS01279-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptojanin-2 (EC:3.1.3.36By similarity)
Alternative name(s):
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2
Gene namesi
Name:SYNJ2
Synonyms:KIAA0348
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11504. SYNJ2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8871.
OpenTargetsiENSG00000078269.
PharmGKBiPA36286.

Polymorphism and mutation databases

BioMutaiSYNJ2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097331 – 1496Synaptojanin-2Add BLAST1496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1124PhosphoserineCombined sources1
Modified residuei1191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15056.
PaxDbiO15056.
PeptideAtlasiO15056.
PRIDEiO15056.

PTM databases

DEPODiO15056.
iPTMnetiO15056.
PhosphoSitePlusiO15056.

Expressioni

Gene expression databases

BgeeiENSG00000078269.
CleanExiHS_SYNJ2.
ExpressionAtlasiO15056. baseline and differential.
GenevisibleiO15056. HS.

Organism-specific databases

HPAiHPA031575.
HPA031953.

Interactioni

Subunit structurei

Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629932EBI-310513,EBI-401755
NCK1P163333EBI-310513,EBI-389883
SH3KBP1Q96B973EBI-310513,EBI-346595

Protein-protein interaction databases

BioGridi114391. 8 interactors.
IntActiO15056. 10 interactors.
MINTiMINT-3976061.
STRINGi9606.ENSP00000347792.

Structurei

Secondary structure

11496
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi891 – 898Combined sources8
Helixi901 – 905Combined sources5
Helixi909 – 922Combined sources14
Beta strandi926 – 931Combined sources6
Beta strandi934 – 938Combined sources5
Helixi943 – 950Combined sources8
Helixi951 – 953Combined sources3
Beta strandi954 – 956Combined sources3
Beta strandi959 – 963Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UFWNMR-A882-963[»]
ProteinModelPortaliO15056.
SMRiO15056.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15056.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 444SACPROSITE-ProRule annotationAdd BLAST325
Domaini889 – 968RRMPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni450 – ?CatalyticBy similarity

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1099 – 1114Pro-richAdd BLAST16
Compositional biasi1209 – 1334Pro-richAdd BLAST126

Sequence similaritiesi

Belongs to the synaptojanin family.Curated
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
Contains 1 SAC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0566. Eukaryota.
COG5329. LUCA.
COG5411. LUCA.
GeneTreeiENSGT00760000119075.
HOVERGENiHBG079225.
InParanoidiO15056.
KOiK20279.
OMAiLWWRKKH.
OrthoDBiEOG091G011G.
PhylomeDBiO15056.
TreeFamiTF354311.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
3.60.10.10. 1 hit.
InterProiIPR015047. DUF1866.
IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR002013. SAC_dom.
[Graphical view]
PfamiPF08952. DUF1866. 1 hit.
PF03372. Exo_endo_phos. 1 hit.
PF02383. Syja_N. 1 hit.
[Graphical view]
SMARTiSM01165. DUF1866. 1 hit.
SM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF56219. SSF56219. 2 hits.
PROSITEiPS50102. RRM. 1 hit.
PS50275. SAC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 2B2 (identifier: O15056-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSKGLRLL GRLGAEGDCS VLLEARGRDD CLLFEAGTVA TLAPEEKEVI
60 70 80 90 100
KGQYGKLTDA YGCLGELRLK SGGTSLSFLV LVTGCTSVGR IPDAEIYKIT
110 120 130 140 150
ATDFYPLQEE AKEEERLIAL KKILSSGVFY FSWPNDGSRF DLTVRTQKQG
160 170 180 190 200
DDSSEWGNSF FWNQLLHVPL RQHQVSCCDW LLKIICGVVT IRTVYASHKQ
210 220 230 240 250
AKACLVSRVS CERTGTRFHT RGVNDDGHVS NFVETEQMIY MDDGVSSFVQ
260 270 280 290 300
IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFDRHMVL LKEQYGQQVV
310 320 330 340 350
VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGGKLEKLE
360 370 380 390 400
TLLRPQLKLH WEDFDVFTKG ENVSPRFQKG TLRMNCLDCL DRTNTVQSFI
410 420 430 440 450
ALEVLHLQLK TLGLSSKPIV DRFVESFKAM WSLNGHSLSK VFTGSRALEG
460 470 480 490 500
KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA IKLLLVGDVY GEEVADKGGM
510 520 530 540 550
LLDSTALLVT PRILKAMTER QSEFTNFKRI RIAMGTWNVN GGKQFRSNVL
560 570 580 590 600
RTAELTDWLL DSPQLSGATD SQDDSSPADI FAVGFEEMVE LSAGNIVNAS
610 620 630 640 650
TTNKKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA
660 670 680 690 700
IDTVKTGMGG KAGNKGAVGI RFQFHSTSFC FICSHLTAGQ SQVKERNEDY
710 720 730 740 750
KEITQKLCFP MGRNVFSHDY VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL
760 770 780 790 800
LEFDQLQLQK SSGKIFKDFH EGAINFGPTY KYDVGSAAYD TSDKCRTPAW
810 820 830 840 850
TDRVLWWRKK HPFDKTAGEL NLLDSDLDVD TKVRHTWSPG ALQYYGRAEL
860 870 880 890 900
QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSFQGPLDA TVVVNLQSPT
910 920 930 940 950
LEEKNEFPED LRTELMQTLG SYGTIVLVRI NQGQMLVTFA DSHSALSVLD
960 970 980 990 1000
VDGMKVKGRA VKIRPKTKDW LKGLREEIIR KRDSMAPVSP TANSCLLEEN
1010 1020 1030 1040 1050
FDFTSLDYES EGDILEDDED YLVDEFNQPG VSDSELGGDD LSDVPGPTAL
1060 1070 1080 1090 1100
APPSKSPALT KKKQHPTYKD DADLVELKRE LEAVGEFRHR SPSRSLSVPN
1110 1120 1130 1140 1150
RPRPPQPPQR PPPPTGLMVK KSASDASISS GTHGQYSILQ TARLLPGAPQ
1160 1170 1180 1190 1200
QPPKARTGIS KPYNVKQIKT TNAQEAEAAI RCLLEARGGA SEEALSAVAP
1210 1220 1230 1240 1250
RDLEASSEPE PTPGAAKPET PQAPPLLPRR PPPRVPAIKK PTLRRTGKPL
1260 1270 1280 1290 1300
SPEEQFEQQT VHFTIGPPET SVEAPPVVTA PRVPPVPKPR TFQPGKAAER
1310 1320 1330 1340 1350
PSHRKPASDE APPGAGASVP PPLEAPPLVP KVPPRRKKSA PAAFHLQVLQ
1360 1370 1380 1390 1400
SNSQLLQGLT YNSSDSPSGH PPAAGTVFPQ GDFLSTSSAT SPDSDGTKAM
1410 1420 1430 1440 1450
KPEAAPLLGD YQDPFWNLLH HPKLLNNTWL SKSSDPLDSG TRSPKRDPID
1460 1470 1480 1490
PVSAGASAAK AELPPDHEHK TLGHWVTISD QEKRTALQVF DPLAKT
Length:1,496
Mass (Da):165,538
Last modified:March 1, 2005 - v3
Checksum:i7CC9E368585ACF21
GO
Isoform 2B1 (identifier: O15056-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1070-1114: Missing.

Note: No experimental confirmation available.
Show »
Length:1,451
Mass (Da):160,434
Checksum:i42E19A35A791EA6A
GO
Isoform 2A (identifier: O15056-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1249-1288: PLSPEEQFEQ...TAPRVPPVPK → IVFCSRSQAS...ASVDTSGSSV
     1289-1496: Missing.

Show »
Length:1,288
Mass (Da):143,445
Checksum:i9A4EAA3AA9AE2451
GO

Sequence cautioni

The sequence AAH43277 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0245071468E → G.1 PublicationCorresponds to variant rs2502601dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0129111070 – 1114Missing in isoform 2B1. CuratedAdd BLAST45
Alternative sequenceiVSP_0129121249 – 1288PLSPE…PPVPK → IVFCSRSQASQPCLLLQRHE FVRTVAAQRLASVDTSGSSV in isoform 2A. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0129131289 – 1496Missing in isoform 2A. 1 PublicationAdd BLAST208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152396 mRNA. Translation: AAN73051.1.
AF318616 mRNA. Translation: AAG46036.1.
AL139330 Genomic DNA. Translation: CAI12978.1.
AL139330 Genomic DNA. Translation: CAI12983.1.
AL139330 Genomic DNA. Translation: CAI12984.1.
AF039945 mRNA. Translation: AAD02178.1.
AB002346 mRNA. Translation: BAA20805.2.
BC043277 mRNA. Translation: AAH43277.1. Different initiation.
CCDSiCCDS5254.1. [O15056-1]
RefSeqiNP_001171559.1. NM_001178088.1.
NP_003889.1. NM_003898.3. [O15056-1]
XP_006715655.1. XM_006715592.3. [O15056-3]
XP_011534527.1. XM_011536225.1.
UniGeneiHs.434494.

Genome annotation databases

EnsembliENST00000355585; ENSP00000347792; ENSG00000078269. [O15056-1]
GeneIDi8871.
KEGGihsa:8871.
UCSCiuc003qqx.3. human. [O15056-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152396 mRNA. Translation: AAN73051.1.
AF318616 mRNA. Translation: AAG46036.1.
AL139330 Genomic DNA. Translation: CAI12978.1.
AL139330 Genomic DNA. Translation: CAI12983.1.
AL139330 Genomic DNA. Translation: CAI12984.1.
AF039945 mRNA. Translation: AAD02178.1.
AB002346 mRNA. Translation: BAA20805.2.
BC043277 mRNA. Translation: AAH43277.1. Different initiation.
CCDSiCCDS5254.1. [O15056-1]
RefSeqiNP_001171559.1. NM_001178088.1.
NP_003889.1. NM_003898.3. [O15056-1]
XP_006715655.1. XM_006715592.3. [O15056-3]
XP_011534527.1. XM_011536225.1.
UniGeneiHs.434494.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UFWNMR-A882-963[»]
ProteinModelPortaliO15056.
SMRiO15056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114391. 8 interactors.
IntActiO15056. 10 interactors.
MINTiMINT-3976061.
STRINGi9606.ENSP00000347792.

PTM databases

DEPODiO15056.
iPTMnetiO15056.
PhosphoSitePlusiO15056.

Polymorphism and mutation databases

BioMutaiSYNJ2.

Proteomic databases

MaxQBiO15056.
PaxDbiO15056.
PeptideAtlasiO15056.
PRIDEiO15056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355585; ENSP00000347792; ENSG00000078269. [O15056-1]
GeneIDi8871.
KEGGihsa:8871.
UCSCiuc003qqx.3. human. [O15056-1]

Organism-specific databases

CTDi8871.
DisGeNETi8871.
GeneCardsiSYNJ2.
HGNCiHGNC:11504. SYNJ2.
HPAiHPA031575.
HPA031953.
MIMi609410. gene.
neXtProtiNX_O15056.
OpenTargetsiENSG00000078269.
PharmGKBiPA36286.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0566. Eukaryota.
COG5329. LUCA.
COG5411. LUCA.
GeneTreeiENSGT00760000119075.
HOVERGENiHBG079225.
InParanoidiO15056.
KOiK20279.
OMAiLWWRKKH.
OrthoDBiEOG091G011G.
PhylomeDBiO15056.
TreeFamiTF354311.

Enzyme and pathway databases

BioCyciMetaCyc:HS01279-MONOMER.
ZFISH:HS01279-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

EvolutionaryTraceiO15056.
GenomeRNAii8871.
PROiO15056.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000078269.
CleanExiHS_SYNJ2.
ExpressionAtlasiO15056. baseline and differential.
GenevisibleiO15056. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
3.60.10.10. 1 hit.
InterProiIPR015047. DUF1866.
IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR002013. SAC_dom.
[Graphical view]
PfamiPF08952. DUF1866. 1 hit.
PF03372. Exo_endo_phos. 1 hit.
PF02383. Syja_N. 1 hit.
[Graphical view]
SMARTiSM01165. DUF1866. 1 hit.
SM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF56219. SSF56219. 2 hits.
PROSITEiPS50102. RRM. 1 hit.
PS50275. SAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYNJ2_HUMAN
AccessioniPrimary (citable) accession number: O15056
Secondary accession number(s): Q5TA13
, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 1, 2005
Last modified: November 30, 2016
This is version 170 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.