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Protein

Synaptojanin-2

Gene

SYNJ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: UniProtKB-EC
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol biosynthetic process Source: Reactome
  2. phosphatidylinositol dephosphorylation Source: InterPro
  3. phospholipid metabolic process Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS01279-MONOMER.
ReactomeiREACT_121025. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptojanin-2 (EC:3.1.3.36)
Alternative name(s):
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2
Gene namesi
Name:SYNJ2
Synonyms:KIAA0348
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:11504. SYNJ2.

Subcellular locationi

Membrane By similarity
Note: Predominantly associated with the particulate fractions.By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14961496Synaptojanin-2PRO_0000209733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1191 – 11911Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15056.
PaxDbiO15056.
PRIDEiO15056.

PTM databases

DEPODiO15056.
PhosphoSiteiO15056.

Expressioni

Gene expression databases

BgeeiO15056.
CleanExiHS_SYNJ2.
ExpressionAtlasiO15056. baseline and differential.
GenevestigatoriO15056.

Organism-specific databases

HPAiHPA031575.
HPA031953.

Interactioni

Subunit structurei

Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629932EBI-310513,EBI-401755
NCK1P163333EBI-310513,EBI-389883
SH3KBP1Q96B973EBI-310513,EBI-346595

Protein-protein interaction databases

BioGridi114391. 10 interactions.
IntActiO15056. 10 interactions.
MINTiMINT-3976061.
STRINGi9606.ENSP00000347792.

Structurei

Secondary structure

1
1496
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi891 – 8988Combined sources
Helixi901 – 9055Combined sources
Helixi909 – 92214Combined sources
Beta strandi926 – 9316Combined sources
Beta strandi934 – 9385Combined sources
Helixi943 – 9508Combined sources
Helixi951 – 9533Combined sources
Beta strandi954 – 9563Combined sources
Beta strandi959 – 9635Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UFWNMR-A882-963[»]
ProteinModelPortaliO15056.
SMRiO15056. Positions 517-881, 884-963.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15056.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 444325SACPROSITE-ProRule annotationAdd
BLAST
Domaini889 – 96880RRMPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni450 – ?CatalyticBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1099 – 111416Pro-richAdd
BLAST
Compositional biasi1209 – 1334126Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the synaptojanin family.Curated
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
Contains 1 SAC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5411.
GeneTreeiENSGT00760000119075.
HOVERGENiHBG079225.
InParanoidiO15056.
KOiK01099.
OMAiVIKGQYG.
OrthoDBiEOG7N63KS.
PhylomeDBiO15056.
TreeFamiTF354311.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
3.60.10.10. 1 hit.
InterProiIPR015047. DUF1866.
IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR002013. SAC_dom.
[Graphical view]
PfamiPF08952. DUF1866. 1 hit.
PF03372. Exo_endo_phos. 1 hit.
PF02383. Syja_N. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 2 hits.
PROSITEiPS50102. RRM. 1 hit.
PS50275. SAC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 2B2 (identifier: O15056-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSKGLRLL GRLGAEGDCS VLLEARGRDD CLLFEAGTVA TLAPEEKEVI
60 70 80 90 100
KGQYGKLTDA YGCLGELRLK SGGTSLSFLV LVTGCTSVGR IPDAEIYKIT
110 120 130 140 150
ATDFYPLQEE AKEEERLIAL KKILSSGVFY FSWPNDGSRF DLTVRTQKQG
160 170 180 190 200
DDSSEWGNSF FWNQLLHVPL RQHQVSCCDW LLKIICGVVT IRTVYASHKQ
210 220 230 240 250
AKACLVSRVS CERTGTRFHT RGVNDDGHVS NFVETEQMIY MDDGVSSFVQ
260 270 280 290 300
IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFDRHMVL LKEQYGQQVV
310 320 330 340 350
VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGGKLEKLE
360 370 380 390 400
TLLRPQLKLH WEDFDVFTKG ENVSPRFQKG TLRMNCLDCL DRTNTVQSFI
410 420 430 440 450
ALEVLHLQLK TLGLSSKPIV DRFVESFKAM WSLNGHSLSK VFTGSRALEG
460 470 480 490 500
KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA IKLLLVGDVY GEEVADKGGM
510 520 530 540 550
LLDSTALLVT PRILKAMTER QSEFTNFKRI RIAMGTWNVN GGKQFRSNVL
560 570 580 590 600
RTAELTDWLL DSPQLSGATD SQDDSSPADI FAVGFEEMVE LSAGNIVNAS
610 620 630 640 650
TTNKKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA
660 670 680 690 700
IDTVKTGMGG KAGNKGAVGI RFQFHSTSFC FICSHLTAGQ SQVKERNEDY
710 720 730 740 750
KEITQKLCFP MGRNVFSHDY VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL
760 770 780 790 800
LEFDQLQLQK SSGKIFKDFH EGAINFGPTY KYDVGSAAYD TSDKCRTPAW
810 820 830 840 850
TDRVLWWRKK HPFDKTAGEL NLLDSDLDVD TKVRHTWSPG ALQYYGRAEL
860 870 880 890 900
QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSFQGPLDA TVVVNLQSPT
910 920 930 940 950
LEEKNEFPED LRTELMQTLG SYGTIVLVRI NQGQMLVTFA DSHSALSVLD
960 970 980 990 1000
VDGMKVKGRA VKIRPKTKDW LKGLREEIIR KRDSMAPVSP TANSCLLEEN
1010 1020 1030 1040 1050
FDFTSLDYES EGDILEDDED YLVDEFNQPG VSDSELGGDD LSDVPGPTAL
1060 1070 1080 1090 1100
APPSKSPALT KKKQHPTYKD DADLVELKRE LEAVGEFRHR SPSRSLSVPN
1110 1120 1130 1140 1150
RPRPPQPPQR PPPPTGLMVK KSASDASISS GTHGQYSILQ TARLLPGAPQ
1160 1170 1180 1190 1200
QPPKARTGIS KPYNVKQIKT TNAQEAEAAI RCLLEARGGA SEEALSAVAP
1210 1220 1230 1240 1250
RDLEASSEPE PTPGAAKPET PQAPPLLPRR PPPRVPAIKK PTLRRTGKPL
1260 1270 1280 1290 1300
SPEEQFEQQT VHFTIGPPET SVEAPPVVTA PRVPPVPKPR TFQPGKAAER
1310 1320 1330 1340 1350
PSHRKPASDE APPGAGASVP PPLEAPPLVP KVPPRRKKSA PAAFHLQVLQ
1360 1370 1380 1390 1400
SNSQLLQGLT YNSSDSPSGH PPAAGTVFPQ GDFLSTSSAT SPDSDGTKAM
1410 1420 1430 1440 1450
KPEAAPLLGD YQDPFWNLLH HPKLLNNTWL SKSSDPLDSG TRSPKRDPID
1460 1470 1480 1490
PVSAGASAAK AELPPDHEHK TLGHWVTISD QEKRTALQVF DPLAKT
Length:1,496
Mass (Da):165,538
Last modified:March 1, 2005 - v3
Checksum:i7CC9E368585ACF21
GO
Isoform 2B1 (identifier: O15056-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1070-1114: Missing.

Note: No experimental confirmation available.

Show »
Length:1,451
Mass (Da):160,434
Checksum:i42E19A35A791EA6A
GO
Isoform 2A (identifier: O15056-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1249-1288: PLSPEEQFEQ...TAPRVPPVPK → IVFCSRSQAS...ASVDTSGSSV
     1289-1496: Missing.

Show »
Length:1,288
Mass (Da):143,445
Checksum:i9A4EAA3AA9AE2451
GO

Sequence cautioni

The sequence AAH43277.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1468 – 14681E → G.1 Publication
Corresponds to variant rs2502601 [ dbSNP | Ensembl ].
VAR_024507

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1070 – 111445Missing in isoform 2B1. CuratedVSP_012911Add
BLAST
Alternative sequencei1249 – 128840PLSPE…PPVPK → IVFCSRSQASQPCLLLQRHE FVRTVAAQRLASVDTSGSSV in isoform 2A. 1 PublicationVSP_012912Add
BLAST
Alternative sequencei1289 – 1496208Missing in isoform 2A. 1 PublicationVSP_012913Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152396 mRNA. Translation: AAN73051.1.
AF318616 mRNA. Translation: AAG46036.1.
AL139330 Genomic DNA. Translation: CAI12978.1.
AL139330 Genomic DNA. Translation: CAI12983.1.
AL139330 Genomic DNA. Translation: CAI12984.1.
AF039945 mRNA. Translation: AAD02178.1.
AB002346 mRNA. Translation: BAA20805.2.
BC043277 mRNA. Translation: AAH43277.1. Different initiation.
CCDSiCCDS5254.1. [O15056-1]
RefSeqiNP_003889.1. NM_003898.3. [O15056-1]
XP_006715655.1. XM_006715592.1. [O15056-3]
UniGeneiHs.434494.

Genome annotation databases

EnsembliENST00000355585; ENSP00000347792; ENSG00000078269. [O15056-1]
GeneIDi8871.
KEGGihsa:8871.
UCSCiuc003qqw.2. human. [O15056-3]
uc003qqx.2. human. [O15056-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152396 mRNA. Translation: AAN73051.1.
AF318616 mRNA. Translation: AAG46036.1.
AL139330 Genomic DNA. Translation: CAI12978.1.
AL139330 Genomic DNA. Translation: CAI12983.1.
AL139330 Genomic DNA. Translation: CAI12984.1.
AF039945 mRNA. Translation: AAD02178.1.
AB002346 mRNA. Translation: BAA20805.2.
BC043277 mRNA. Translation: AAH43277.1. Different initiation.
CCDSiCCDS5254.1. [O15056-1]
RefSeqiNP_003889.1. NM_003898.3. [O15056-1]
XP_006715655.1. XM_006715592.1. [O15056-3]
UniGeneiHs.434494.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UFWNMR-A882-963[»]
ProteinModelPortaliO15056.
SMRiO15056. Positions 517-881, 884-963.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114391. 10 interactions.
IntActiO15056. 10 interactions.
MINTiMINT-3976061.
STRINGi9606.ENSP00000347792.

PTM databases

DEPODiO15056.
PhosphoSiteiO15056.

Proteomic databases

MaxQBiO15056.
PaxDbiO15056.
PRIDEiO15056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355585; ENSP00000347792; ENSG00000078269. [O15056-1]
GeneIDi8871.
KEGGihsa:8871.
UCSCiuc003qqw.2. human. [O15056-3]
uc003qqx.2. human. [O15056-1]

Organism-specific databases

CTDi8871.
GeneCardsiGC06P158402.
HGNCiHGNC:11504. SYNJ2.
HPAiHPA031575.
HPA031953.
MIMi609410. gene.
neXtProtiNX_O15056.
PharmGKBiPA36286.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5411.
GeneTreeiENSGT00760000119075.
HOVERGENiHBG079225.
InParanoidiO15056.
KOiK01099.
OMAiVIKGQYG.
OrthoDBiEOG7N63KS.
PhylomeDBiO15056.
TreeFamiTF354311.

Enzyme and pathway databases

BioCyciMetaCyc:HS01279-MONOMER.
ReactomeiREACT_121025. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

EvolutionaryTraceiO15056.
GenomeRNAii8871.
NextBioi33305.
PROiO15056.
SOURCEiSearch...

Gene expression databases

BgeeiO15056.
CleanExiHS_SYNJ2.
ExpressionAtlasiO15056. baseline and differential.
GenevestigatoriO15056.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
3.60.10.10. 1 hit.
InterProiIPR015047. DUF1866.
IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR002013. SAC_dom.
[Graphical view]
PfamiPF08952. DUF1866. 1 hit.
PF03372. Exo_endo_phos. 1 hit.
PF02383. Syja_N. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 2 hits.
PROSITEiPS50102. RRM. 1 hit.
PS50275. SAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of human SH3 domain-containing proteins, synaptojanin 2A."
    Jeong S.-Y., Youle R.J.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2A).
  2. "Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis."
    Malecz N., McCabe P.C., Spaargaren C., Qiu R.-G., Chuang Y.-Y., Symons M.
    Curr. Biol. 10:1383-1386(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2B2), SUBCELLULAR LOCATION.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals."
    Nemoto Y., Wenk M.R., Watanabe M., Daniell L., Murakami T., Ringstad N., Yamada H., Takei K., De Camilli P.
    J. Biol. Chem. 276:41133-41142(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-1496 (ISOFORM 2B2).
    Tissue: Brain.
  5. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-1496 (ISOFORM 2B2).
    Tissue: Brain.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 647-1496 (ISOFORM 2B2), VARIANT GLY-1468.
    Tissue: Testis.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "Solution structure of RNP domain in synaptojanin 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (DEC-2003) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 819-969.

Entry informationi

Entry nameiSYNJ2_HUMAN
AccessioniPrimary (citable) accession number: O15056
Secondary accession number(s): Q5TA13
, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 1, 2005
Last modified: March 4, 2015
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.