O15056 (SYNJ2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptojanin-2
EC=3.1.3.36

Alternative name(s):
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2

Gene names

Name:	SYNJ2
Synonyms:	KIAA0348

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1496 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
Catalytic activity	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Subunit structure	Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.
Subcellular location	Membrane By similarity. Note: Predominantly associated with the particulate fractions By similarity. Ref.2
Sequence similarities	Belongs to the synaptojanin family. In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. Contains 1 RRM (RNA recognition motif) domain. Contains 1 SAC domain.
Sequence caution	The sequence AAH43277.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	RNA-binding
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylinositol biosynthetic process Traceable author statement. Source: Reactome phosphatidylinositol phosphorylation Inferred from electronic annotation. Source: InterPro small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GRB2	P62993	2	EBI-310513,EBI-401755
NCK1	P16333	3	EBI-310513,EBI-389883

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 2B2 (identifier: O15056-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2B1 (identifier: O15056-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1070-1114: Missing.

Note: No experimental confirmation available.

Isoform 2A (identifier: O15056-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1249-1288: PLSPEEQFEQ...TAPRVPPVPK → IVFCSRSQAS...ASVDTSGSSV
     1289-1496: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1496

1496

Synaptojanin-2

PRO_0000209733

Regions

Domain

120 – 444

325

SAC

Domain

889 – 968

80

RRM

Region

450 – ?

Catalytic By similarity

Compositional bias

1099 – 1114

16

Pro-rich

Compositional bias

1209 – 1334

126

Pro-rich

Natural variations

Alternative sequence

1070 – 1114

45

Missing in isoform 2B1.

VSP_012911

Alternative sequence

1249 – 1288

40

PLSPE…PPVPK → IVFCSRSQASQPCLLLQRHE FVRTVAAQRLASVDTSGSSV in isoform 2A.

VSP_012912

Alternative sequence

1289 – 1496

208

Missing in isoform 2A.

VSP_012913

Natural variant

1468

1

E → G. Ref.6
Corresponds to variant rs2502601 [ dbSNP | Ensembl ].

VAR_024507

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1496

Helix Strand Turn

Details...

Beta strand

891 – 898

8

Helix

901 – 905

5

Helix

909 – 922

14

Beta strand

926 – 931

6

Beta strand

934 – 938

5

Helix

943 – 950

8

Helix

951 – 953

3

Beta strand

954 – 956

3

Beta strand

959 – 963

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2B2 [UniParc]. Last modified March 1, 2005. Version 3. Checksum: 7CC9E368585ACF21	FASTA	1,496	165,538
	10 20 30 40 50 60 MALSKGLRLL GRLGAEGDCS VLLEARGRDD CLLFEAGTVA TLAPEEKEVI KGQYGKLTDA 70 80 90 100 110 120 YGCLGELRLK SGGTSLSFLV LVTGCTSVGR IPDAEIYKIT ATDFYPLQEE AKEEERLIAL 130 140 150 160 170 180 KKILSSGVFY FSWPNDGSRF DLTVRTQKQG DDSSEWGNSF FWNQLLHVPL RQHQVSCCDW 190 200 210 220 230 240 LLKIICGVVT IRTVYASHKQ AKACLVSRVS CERTGTRFHT RGVNDDGHVS NFVETEQMIY 250 260 270 280 290 300 MDDGVSSFVQ IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFDRHMVL LKEQYGQQVV 310 320 330 340 350 360 VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGGKLEKLE TLLRPQLKLH 370 380 390 400 410 420 WEDFDVFTKG ENVSPRFQKG TLRMNCLDCL DRTNTVQSFI ALEVLHLQLK TLGLSSKPIV 430 440 450 460 470 480 DRFVESFKAM WSLNGHSLSK VFTGSRALEG KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA 490 500 510 520 530 540 IKLLLVGDVY GEEVADKGGM LLDSTALLVT PRILKAMTER QSEFTNFKRI RIAMGTWNVN 550 560 570 580 590 600 GGKQFRSNVL RTAELTDWLL DSPQLSGATD SQDDSSPADI FAVGFEEMVE LSAGNIVNAS 610 620 630 640 650 660 TTNKKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA IDTVKTGMGG 670 680 690 700 710 720 KAGNKGAVGI RFQFHSTSFC FICSHLTAGQ SQVKERNEDY KEITQKLCFP MGRNVFSHDY 730 740 750 760 770 780 VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL LEFDQLQLQK SSGKIFKDFH EGAINFGPTY 790 800 810 820 830 840 KYDVGSAAYD TSDKCRTPAW TDRVLWWRKK HPFDKTAGEL NLLDSDLDVD TKVRHTWSPG 850 860 870 880 890 900 ALQYYGRAEL QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSFQGPLDA TVVVNLQSPT 910 920 930 940 950 960 LEEKNEFPED LRTELMQTLG SYGTIVLVRI NQGQMLVTFA DSHSALSVLD VDGMKVKGRA 970 980 990 1000 1010 1020 VKIRPKTKDW LKGLREEIIR KRDSMAPVSP TANSCLLEEN FDFTSLDYES EGDILEDDED 1030 1040 1050 1060 1070 1080 YLVDEFNQPG VSDSELGGDD LSDVPGPTAL APPSKSPALT KKKQHPTYKD DADLVELKRE 1090 1100 1110 1120 1130 1140 LEAVGEFRHR SPSRSLSVPN RPRPPQPPQR PPPPTGLMVK KSASDASISS GTHGQYSILQ 1150 1160 1170 1180 1190 1200 TARLLPGAPQ QPPKARTGIS KPYNVKQIKT TNAQEAEAAI RCLLEARGGA SEEALSAVAP 1210 1220 1230 1240 1250 1260 RDLEASSEPE PTPGAAKPET PQAPPLLPRR PPPRVPAIKK PTLRRTGKPL SPEEQFEQQT 1270 1280 1290 1300 1310 1320 VHFTIGPPET SVEAPPVVTA PRVPPVPKPR TFQPGKAAER PSHRKPASDE APPGAGASVP 1330 1340 1350 1360 1370 1380 PPLEAPPLVP KVPPRRKKSA PAAFHLQVLQ SNSQLLQGLT YNSSDSPSGH PPAAGTVFPQ 1390 1400 1410 1420 1430 1440 GDFLSTSSAT SPDSDGTKAM KPEAAPLLGD YQDPFWNLLH HPKLLNNTWL SKSSDPLDSG 1450 1460 1470 1480 1490 TRSPKRDPID PVSAGASAAK AELPPDHEHK TLGHWVTISD QEKRTALQVF DPLAKT
	Isoform 2B1 [UniParc]. Checksum: 42E19A35A791EA6A	FASTA	1,451	160,434
	10 20 30 40 50 60 MALSKGLRLL GRLGAEGDCS VLLEARGRDD CLLFEAGTVA TLAPEEKEVI KGQYGKLTDA 70 80 90 100 110 120 YGCLGELRLK SGGTSLSFLV LVTGCTSVGR IPDAEIYKIT ATDFYPLQEE AKEEERLIAL 130 140 150 160 170 180 KKILSSGVFY FSWPNDGSRF DLTVRTQKQG DDSSEWGNSF FWNQLLHVPL RQHQVSCCDW 190 200 210 220 230 240 LLKIICGVVT IRTVYASHKQ AKACLVSRVS CERTGTRFHT RGVNDDGHVS NFVETEQMIY 250 260 270 280 290 300 MDDGVSSFVQ IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFDRHMVL LKEQYGQQVV 310 320 330 340 350 360 VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGGKLEKLE TLLRPQLKLH 370 380 390 400 410 420 WEDFDVFTKG ENVSPRFQKG TLRMNCLDCL DRTNTVQSFI ALEVLHLQLK TLGLSSKPIV 430 440 450 460 470 480 DRFVESFKAM WSLNGHSLSK VFTGSRALEG KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA 490 500 510 520 530 540 IKLLLVGDVY GEEVADKGGM LLDSTALLVT PRILKAMTER QSEFTNFKRI RIAMGTWNVN 550 560 570 580 590 600 GGKQFRSNVL RTAELTDWLL DSPQLSGATD SQDDSSPADI FAVGFEEMVE LSAGNIVNAS 610 620 630 640 650 660 TTNKKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA IDTVKTGMGG 670 680 690 700 710 720 KAGNKGAVGI RFQFHSTSFC FICSHLTAGQ SQVKERNEDY KEITQKLCFP MGRNVFSHDY 730 740 750 760 770 780 VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL LEFDQLQLQK SSGKIFKDFH EGAINFGPTY 790 800 810 820 830 840 KYDVGSAAYD TSDKCRTPAW TDRVLWWRKK HPFDKTAGEL NLLDSDLDVD TKVRHTWSPG 850 860 870 880 890 900 ALQYYGRAEL QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSFQGPLDA TVVVNLQSPT 910 920 930 940 950 960 LEEKNEFPED LRTELMQTLG SYGTIVLVRI NQGQMLVTFA DSHSALSVLD VDGMKVKGRA 970 980 990 1000 1010 1020 VKIRPKTKDW LKGLREEIIR KRDSMAPVSP TANSCLLEEN FDFTSLDYES EGDILEDDED 1030 1040 1050 1060 1070 1080 YLVDEFNQPG VSDSELGGDD LSDVPGPTAL APPSKSPALT KKKQHPTYKT GLMVKKSASD 1090 1100 1110 1120 1130 1140 ASISSGTHGQ YSILQTARLL PGAPQQPPKA RTGISKPYNV KQIKTTNAQE AEAAIRCLLE 1150 1160 1170 1180 1190 1200 ARGGASEEAL SAVAPRDLEA SSEPEPTPGA AKPETPQAPP LLPRRPPPRV PAIKKPTLRR 1210 1220 1230 1240 1250 1260 TGKPLSPEEQ FEQQTVHFTI GPPETSVEAP PVVTAPRVPP VPKPRTFQPG KAAERPSHRK 1270 1280 1290 1300 1310 1320 PASDEAPPGA GASVPPPLEA PPLVPKVPPR RKKSAPAAFH LQVLQSNSQL LQGLTYNSSD 1330 1340 1350 1360 1370 1380 SPSGHPPAAG TVFPQGDFLS TSSATSPDSD GTKAMKPEAA PLLGDYQDPF WNLLHHPKLL 1390 1400 1410 1420 1430 1440 NNTWLSKSSD PLDSGTRSPK RDPIDPVSAG ASAAKAELPP DHEHKTLGHW VTISDQEKRT 1450 ALQVFDPLAK T
	Isoform 2A [UniParc]. Checksum: 9A4EAA3AA9AE2451	FASTA	1,288	143,445
	10 20 30 40 50 60 MALSKGLRLL GRLGAEGDCS VLLEARGRDD CLLFEAGTVA TLAPEEKEVI KGQYGKLTDA 70 80 90 100 110 120 YGCLGELRLK SGGTSLSFLV LVTGCTSVGR IPDAEIYKIT ATDFYPLQEE AKEEERLIAL 130 140 150 160 170 180 KKILSSGVFY FSWPNDGSRF DLTVRTQKQG DDSSEWGNSF FWNQLLHVPL RQHQVSCCDW 190 200 210 220 230 240 LLKIICGVVT IRTVYASHKQ AKACLVSRVS CERTGTRFHT RGVNDDGHVS NFVETEQMIY 250 260 270 280 290 300 MDDGVSSFVQ IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFDRHMVL LKEQYGQQVV 310 320 330 340 350 360 VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGGKLEKLE TLLRPQLKLH 370 380 390 400 410 420 WEDFDVFTKG ENVSPRFQKG TLRMNCLDCL DRTNTVQSFI ALEVLHLQLK TLGLSSKPIV 430 440 450 460 470 480 DRFVESFKAM WSLNGHSLSK VFTGSRALEG KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA 490 500 510 520 530 540 IKLLLVGDVY GEEVADKGGM LLDSTALLVT PRILKAMTER QSEFTNFKRI RIAMGTWNVN 550 560 570 580 590 600 GGKQFRSNVL RTAELTDWLL DSPQLSGATD SQDDSSPADI FAVGFEEMVE LSAGNIVNAS 610 620 630 640 650 660 TTNKKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA IDTVKTGMGG 670 680 690 700 710 720 KAGNKGAVGI RFQFHSTSFC FICSHLTAGQ SQVKERNEDY KEITQKLCFP MGRNVFSHDY 730 740 750 760 770 780 VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL LEFDQLQLQK SSGKIFKDFH EGAINFGPTY 790 800 810 820 830 840 KYDVGSAAYD TSDKCRTPAW TDRVLWWRKK HPFDKTAGEL NLLDSDLDVD TKVRHTWSPG 850 860 870 880 890 900 ALQYYGRAEL QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSFQGPLDA TVVVNLQSPT 910 920 930 940 950 960 LEEKNEFPED LRTELMQTLG SYGTIVLVRI NQGQMLVTFA DSHSALSVLD VDGMKVKGRA 970 980 990 1000 1010 1020 VKIRPKTKDW LKGLREEIIR KRDSMAPVSP TANSCLLEEN FDFTSLDYES EGDILEDDED 1030 1040 1050 1060 1070 1080 YLVDEFNQPG VSDSELGGDD LSDVPGPTAL APPSKSPALT KKKQHPTYKD DADLVELKRE 1090 1100 1110 1120 1130 1140 LEAVGEFRHR SPSRSLSVPN RPRPPQPPQR PPPPTGLMVK KSASDASISS GTHGQYSILQ 1150 1160 1170 1180 1190 1200 TARLLPGAPQ QPPKARTGIS KPYNVKQIKT TNAQEAEAAI RCLLEARGGA SEEALSAVAP 1210 1220 1230 1240 1250 1260 RDLEASSEPE PTPGAAKPET PQAPPLLPRR PPPRVPAIKK PTLRRTGKIV FCSRSQASQP 1270 1280 CLLLQRHEFV RTVAAQRLAS VDTSGSSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of human SH3 domain-containing proteins, synaptojanin 2A." Jeong S.-Y., Youle R.J. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2A).
[2]	"Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis." Malecz N., McCabe P.C., Spaargaren C., Qiu R.-G., Chuang Y.-Y., Symons M. Curr. Biol. 10:1383-1386(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2B2), SUBCELLULAR LOCATION.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals." Nemoto Y., Wenk M.R., Watanabe M., Daniell L., Murakami T., Ringstad N., Yamada H., Takei K., De Camilli P. J. Biol. Chem. 276:41133-41142(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-1496 (ISOFORM 2B2). Tissue: Brain.
[5]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-1496 (ISOFORM 2B2). Tissue: Brain.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 647-1496 (ISOFORM 2B2), VARIANT GLY-1468. Tissue: Testis.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Solution structure of RNP domain in synaptojanin 2." RIKEN structural genomics initiative (RSGI) Submitted (DEC-2003) to the PDB data bank Cited for: STRUCTURE BY NMR OF 819-969.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY152396 mRNA. Translation: AAN73051.1.
AF318616 mRNA. Translation: AAG46036.1.
AL139330 Genomic DNA. Translation: CAI12978.1.
AL139330 Genomic DNA. Translation: CAI12983.1.
AL139330 Genomic DNA. Translation: CAI12984.1.
AF039945 mRNA. Translation: AAD02178.1.
AB002346 mRNA. Translation: BAA20805.2.
BC043277 mRNA. Translation: AAH43277.1. Different initiation.

IPI

IPI00300621.
IPI00477078.
IPI00515001.

RefSeq

NP_003889.1. NM_003898.3.

UniGene

Hs.434494.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UFW	NMR	-	A	882-963	[»]

ProteinModelPortal

O15056.

ModBase

Search...

Protein-protein interaction databases

IntAct

O15056. 7 interactions.

MINT

MINT-3976061.

STRING

9606.ENSP00000347792.

PTM databases

PhosphoSite

O15056.

Proteomic databases

PaxDb

O15056.

PRIDE

O15056.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000355585; ENSP00000347792; ENSG00000078269.
ENST00000367112; ENSP00000356079; ENSG00000078269.
ENST00000367121; ENSP00000356088; ENSG00000078269.

GeneID

8871.

KEGG

hsa:8871.

UCSC

uc003qqw.2. human.
uc003qqx.2. human.

Organism-specific databases

CTD

8871.

GeneCards

GC06P158402.

HGNC

HGNC:11504. SYNJ2.

HPA

HPA031575.
HPA031953.

MIM

609410. gene.

neXtProt

NX_O15056.

PharmGKB

PA36286.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5411.

HOVERGEN

HBG079225.

InParanoid

O15056.

KO

K01099.

OMA

VIKGQYG.

OrthoDB

EOG4JDH60.

PhylomeDB

O15056.

Enzyme and pathway databases

BioCyc

MetaCyc:HS01279-MONOMER.

Reactome

REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

O15056.

Bgee

O15056.

CleanEx

HS_SYNJ2.

Genevestigator

O15056.

GermOnline

ENSG00000078269. Homo sapiens.

Family and domain databases

Gene3D

3.30.70.330. 1 hit.

InterPro

IPR015047. DUF1866.
IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR002013. Syja_N.
[Graphical view]

Pfam

PF08952. DUF1866. 1 hit.
PF03372. Exo_endo_phos. 1 hit.
PF02383. Syja_N. 1 hit.
[Graphical view]

SMART

SM00128. IPPc. 1 hit.
[Graphical view]

SUPFAM

SSF56219. Exo_endo_phos. 1 hit.

PROSITE

PS50102. RRM. 1 hit.
PS50275. SAC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O15056.

GenomeRNAi

8871.

NextBio

33305.

SOURCE

Search...

Entry information

Entry name

SYNJ2_HUMAN

Accession

Primary (citable) accession number: O15056
Secondary accession number(s): Q5TA13 , Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	March 1, 2005
Last modified:	May 1, 2013
This is version 134 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.