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O15054

- KDM6B_HUMAN

UniProt

O15054 - KDM6B_HUMAN

Protein

Lysine-specific demethylase 6B

Gene

KDM6B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 4 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.2 Publications

    Cofactori

    Ascorbate.By similarity
    Fe2+.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1390 – 13901IronCurated
    Metal bindingi1392 – 13921IronCurated

    GO - Molecular functioni

    1. dioxygenase activity Source: UniProtKB-KW
    2. histone demethylase activity (H3-K27 specific) Source: Reactome
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: IntAct
    5. sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. cardiac muscle cell differentiation Source: BHF-UCL
    2. endothelial cell differentiation Source: BHF-UCL
    3. histone H3-K27 demethylation Source: GOC
    4. inflammatory response Source: UniProtKB-KW
    5. mesodermal cell differentiation Source: BHF-UCL
    6. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL

    Keywords - Molecular functioni

    Chromatin regulator, Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Inflammatory response

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_169436. Oxidative Stress Induced Senescence.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine-specific demethylase 6B (EC:1.14.11.-)
    Alternative name(s):
    JmjC domain-containing protein 3
    Jumonji domain-containing protein 3
    Lysine demethylase 6B
    Gene namesi
    Name:KDM6B
    Synonyms:JMJD3, KIAA0346
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:29012. KDM6B.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16431643Lysine-specific demethylase 6BPRO_0000292007Add
    BLAST

    Proteomic databases

    MaxQBiO15054.
    PaxDbiO15054.
    PRIDEiO15054.

    PTM databases

    PhosphoSiteiO15054.

    Expressioni

    Inductioni

    By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells.1 Publication

    Gene expression databases

    ArrayExpressiO15054.
    BgeeiO15054.
    CleanExiHS_JMJD3.
    GenevestigatoriO15054.

    Organism-specific databases

    HPAiHPA037988.

    Interactioni

    Subunit structurei

    Interacts with TLE1 By similarity. Component of the MLL4 complex, at least composed of KMT2B/MLL4, ASH2L, RBBP5, WDR5, and KDM6B.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ESR1P033722EBI-2831260,EBI-78473

    Protein-protein interaction databases

    BioGridi116752. 12 interactions.
    DIPiDIP-59912N.
    IntActiO15054. 5 interactions.
    MINTiMINT-7002224.
    STRINGi9606.ENSP00000254846.

    Structurei

    Secondary structure

    1
    1643
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1178 – 11814
    Beta strandi1187 – 11893
    Helixi1193 – 11953
    Helixi1199 – 12068
    Beta strandi1211 – 12177
    Helixi1218 – 12225
    Helixi1226 – 12294
    Helixi1231 – 12388
    Beta strandi1242 – 12498
    Beta strandi1261 – 12644
    Beta strandi1271 – 12766
    Helixi1277 – 128913
    Beta strandi1325 – 13339
    Helixi1337 – 134711
    Helixi1352 – 13543
    Turni1356 – 13594
    Beta strandi1363 – 13653
    Beta strandi1366 – 13683
    Turni1371 – 13733
    Beta strandi1375 – 13817
    Beta strandi1386 – 13905
    Helixi1393 – 13953
    Beta strandi1397 – 140610
    Beta strandi1408 – 14136
    Helixi1415 – 14173
    Helixi1418 – 142710
    Turni1432 – 14343
    Helixi1441 – 14466
    Beta strandi1452 – 14565
    Beta strandi1461 – 14644
    Beta strandi1469 – 148719
    Helixi1491 – 14955
    Helixi1514 – 152411
    Helixi1530 – 155728
    Beta strandi1561 – 15633
    Turni1576 – 15783
    Beta strandi1584 – 15907
    Beta strandi1598 – 16014
    Helixi1603 – 16086
    Turni1610 – 16156
    Beta strandi1617 – 16226
    Helixi1624 – 163310

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XUEX-ray2.00A/B1141-1643[»]
    2XXZX-ray1.80A/B1176-1505[»]
    4ASKX-ray1.86A/B1141-1643[»]
    ProteinModelPortaliO15054.
    SMRiO15054. Positions 1157-1638.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO15054.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1339 – 1502164JmjCPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi32 – 8554Pro-richAdd
    BLAST
    Compositional biasi195 – 906712Pro-richAdd
    BLAST
    Compositional biasi738 – 76427Thr-richAdd
    BLAST
    Compositional biasi1046 – 108237Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UTX family.Curated
    Contains 1 JmjC domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG246325.
    HOGENOMiHOG000113217.
    InParanoidiO15054.
    KOiK11448.
    OMAiMDPLPRP.
    OrthoDBiEOG7CG6Z5.
    PhylomeDBiO15054.
    TreeFamiTF317405.

    Family and domain databases

    InterProiIPR003347. JmjC_dom.
    IPR029518. KDM6B.
    [Graphical view]
    PANTHERiPTHR14017:SF5. PTHR14017:SF5. 1 hit.
    PfamiPF02373. JmjC. 1 hit.
    [Graphical view]
    SMARTiSM00558. JmjC. 1 hit.
    [Graphical view]
    PROSITEiPS51184. JMJC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: O15054-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHRAVDPPGA RAAREAFALG GLSCAGAWSS CPPHPPPRSA WLPGGRCSAS     50
    IGQPPLPAPL PPSHGSSSGH PSKPYYAPGA PTPRPLHGKL ESLHGCVQAL 100
    LREPAQPGLW EQLGQLYESE HDSEEATRCY HSALRYGGSF AELGPRIGRL 150
    QQAQLWNFHT GSCQHRAKVL PPLEQVWNLL HLEHKRNYGA KRGGPPVKRA 200
    AEPPVVQPVP PAALSGPSGE EGLSPGGKRR RGCNSEQTGL PPGLPLPPPP 250
    LPPPPPPPPP PPPPLPGLAT SPPFQLTKPG LWSTLHGDAW GPERKGSAPP 300
    ERQEQRHSLP HPYPYPAPAY TAHPPGHRLV PAAPPGPGPR PPGAESHGCL 350
    PATRPPGSDL RESRVQRSRM DSSVSPAATT ACVPYAPSRP PGLPGTTTSS 400
    SSSSSSNTGL RGVEPNPGIP GADHYQTPAL EVSHHGRLGP SAHSSRKPFL 450
    GAPAATPHLS LPPGPSSPPP PPCPRLLRPP PPPAWLKGPA CRAAREDGEI 500
    LEELFFGTEG PPRPAPPPLP HREGFLGPPA SRFSVGTQDS HTPPTPPTPT 550
    TSSSNSNSGS HSSSPAGPVS FPPPPYLARS IDPLPRPPSP AQNPQDPPLV 600
    PLTLALPPAP PSSCHQNTSG SFRRPESPRP RVSFPKTPEV GPGPPPGPLS 650
    KAPQPVPPGV GELPARGPRL FDFPPTPLED QFEEPAEFKI LPDGLANIMK 700
    MLDESIRKEE EQQQHEAGVA PQPPLKEPFA SLQSPFPTDT APTTTAPAVA 750
    VTTTTTTTTT TTATQEEEKK PPPALPPPPP LAKFPPPSQP QPPPPPPPSP 800
    ASLLKSLASV LEGQKYCYRG TGAAVSTRPG PLPTTQYSPG PPSGATALPP 850
    TSAAPSAQGS PQPSASSSSQ FSTSGGPWAR ERRAGEEPVP GPMTPTQPPP 900
    PLSLPPARSE SEVLEEISRA CETLVERVGR SATDPADPVD TAEPADSGTE 950
    RLLPPAQAKE EAGGVAAVSG SCKRRQKEHQ KEHRRHRRAC KDSVGRRPRE 1000
    GRAKAKAKVP KEKSRRVLGN LDLQSEEIQG REKSRPDLGG ASKAKPPTAP 1050
    APPSAPAPSA QPTPPSASVP GKKAREEAPG PPGVSRADML KLRSLSEGPP 1100
    KELKIRLIKV ESGDKETFIA SEVEERRLRM ADLTISHCAA DVVRASRNAK 1150
    VKGKFRESYL SPAQSVKPKI NTEEKLPREK LNPPTPSIYL ESKRDAFSPV 1200
    LLQFCTDPRN PITVIRGLAG SLRLNLGLFS TKTLVEASGE HTVEVRTQVQ 1250
    QPSDENWDLT GTRQIWPCES SRSHTTIAKY AQYQASSFQE SLQEEKESED 1300
    EESEEPDSTT GTPPSSAPDP KNHHIIKFGT NIDLSDAKRW KPQLQELLKL 1350
    PAFMRVTSTG NMLSHVGHTI LGMNTVQLYM KVPGSRTPGH QENNNFCSVN 1400
    INIGPGDCEW FAVHEHYWET ISAFCDRHGV DYLTGSWWPI LDDLYASNIP 1450
    VYRFVQRPGD LVWINAGTVH WVQATGWCNN IAWNVGPLTA YQYQLALERY 1500
    EWNEVKNVKS IVPMIHVSWN VARTVKISDP DLFKMIKFCL LQSMKHCQVQ 1550
    RESLVRAGKK IAYQGRVKDE PAYYCNECDV EVFNILFVTS ENGSRNTYLV 1600
    HCEGCARRRS AGLQGVVVLE QYRTEELAQA YDAFTLAPAS TSR 1643

    Note: Gene prediction based on similarity to mouse ortholog.

    Length:1,643
    Mass (Da):176,632
    Last modified:November 30, 2010 - v4
    Checksum:i8CE32AE602683BA3
    GO
    Isoform 1 (identifier: O15054-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1636-1636: L → LVRARRARGQRRRALGQAAGTGFGSPAAPFPEPPPAFSPQ

    Show »
    Length:1,682
    Mass (Da):180,702
    Checksum:iE4264890580649AB
    GO

    Sequence cautioni

    The sequence BAA21572.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti252 – 2543Missing in BAA21572. (PubMed:9205841)Curated
    Sequence conflicti252 – 2543Missing in AAH09994. (PubMed:16625196)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti203 – 2031P → A.
    Corresponds to variant rs60738318 [ dbSNP | Ensembl ].
    VAR_061670
    Natural varianti308 – 3081S → L.
    Corresponds to variant rs2270516 [ dbSNP | Ensembl ].
    VAR_032927

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1636 – 16361L → LVRARRARGQRRRALGQAAG TGFGSPAAPFPEPPPAFSPQ in isoform 1. 1 PublicationVSP_040102

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002344 mRNA. Translation: BAA21572.2. Different initiation.
    AC104581 Genomic DNA. No translation available.
    BC009994 mRNA. Translation: AAH09994.1.
    CCDSiCCDS32552.1. [O15054-1]
    RefSeqiNP_001073893.1. NM_001080424.1. [O15054-1]
    XP_005256606.1. XM_005256549.1. [O15054-1]
    XP_005256607.1. XM_005256550.2. [O15054-1]
    XP_005256608.1. XM_005256551.1. [O15054-1]
    XP_005256609.1. XM_005256552.2. [O15054-1]
    XP_005256611.1. XM_005256554.2. [O15054-2]
    XP_006721546.1. XM_006721483.1. [O15054-1]
    UniGeneiHs.223678.

    Genome annotation databases

    EnsembliENST00000254846; ENSP00000254846; ENSG00000132510. [O15054-1]
    ENST00000448097; ENSP00000412513; ENSG00000132510. [O15054-2]
    GeneIDi23135.
    KEGGihsa:23135.
    UCSCiuc002giw.1. human. [O15054-1]
    uc002gix.3. human. [O15054-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002344 mRNA. Translation: BAA21572.2 . Different initiation.
    AC104581 Genomic DNA. No translation available.
    BC009994 mRNA. Translation: AAH09994.1 .
    CCDSi CCDS32552.1. [O15054-1 ]
    RefSeqi NP_001073893.1. NM_001080424.1. [O15054-1 ]
    XP_005256606.1. XM_005256549.1. [O15054-1 ]
    XP_005256607.1. XM_005256550.2. [O15054-1 ]
    XP_005256608.1. XM_005256551.1. [O15054-1 ]
    XP_005256609.1. XM_005256552.2. [O15054-1 ]
    XP_005256611.1. XM_005256554.2. [O15054-2 ]
    XP_006721546.1. XM_006721483.1. [O15054-1 ]
    UniGenei Hs.223678.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XUE X-ray 2.00 A/B 1141-1643 [» ]
    2XXZ X-ray 1.80 A/B 1176-1505 [» ]
    4ASK X-ray 1.86 A/B 1141-1643 [» ]
    ProteinModelPortali O15054.
    SMRi O15054. Positions 1157-1638.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116752. 12 interactions.
    DIPi DIP-59912N.
    IntActi O15054. 5 interactions.
    MINTi MINT-7002224.
    STRINGi 9606.ENSP00000254846.

    Chemistry

    BindingDBi O15054.
    ChEMBLi CHEMBL1938211.
    GuidetoPHARMACOLOGYi 2685.

    PTM databases

    PhosphoSitei O15054.

    Proteomic databases

    MaxQBi O15054.
    PaxDbi O15054.
    PRIDEi O15054.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254846 ; ENSP00000254846 ; ENSG00000132510 . [O15054-1 ]
    ENST00000448097 ; ENSP00000412513 ; ENSG00000132510 . [O15054-2 ]
    GeneIDi 23135.
    KEGGi hsa:23135.
    UCSCi uc002giw.1. human. [O15054-1 ]
    uc002gix.3. human. [O15054-2 ]

    Organism-specific databases

    CTDi 23135.
    GeneCardsi GC17P007686.
    HGNCi HGNC:29012. KDM6B.
    HPAi HPA037988.
    MIMi 611577. gene.
    neXtProti NX_O15054.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246325.
    HOGENOMi HOG000113217.
    InParanoidi O15054.
    KOi K11448.
    OMAi MDPLPRP.
    OrthoDBi EOG7CG6Z5.
    PhylomeDBi O15054.
    TreeFami TF317405.

    Enzyme and pathway databases

    Reactomei REACT_169436. Oxidative Stress Induced Senescence.

    Miscellaneous databases

    EvolutionaryTracei O15054.
    GenomeRNAii 23135.
    NextBioi 44391.
    PROi O15054.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15054.
    Bgeei O15054.
    CleanExi HS_JMJD3.
    Genevestigatori O15054.

    Family and domain databases

    InterProi IPR003347. JmjC_dom.
    IPR029518. KDM6B.
    [Graphical view ]
    PANTHERi PTHR14017:SF5. PTHR14017:SF5. 1 hit.
    Pfami PF02373. JmjC. 1 hit.
    [Graphical view ]
    SMARTi SM00558. JmjC. 1 hit.
    [Graphical view ]
    PROSITEi PS51184. JMJC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1000-1643 (ISOFORM 2).
      Tissue: Brain.
    5. "An efficient strategy to identify early TPA-responsive genes during differentiation of HL-60 cells."
      Hu L.Y., Tepper C.G., Lo S.H., Lin W.C.
      Gene Expr. 13:179-189(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY TPA.
    6. "The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing."
      De Santa F., Totaro M.G., Prosperini E., Notarbartolo S., Testa G., Natoli G.
      Cell 130:1083-1094(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME ACTIVITY, COFACTOR, SUBCELLULAR LOCATION, IDENTIFICATION IN THE MLL4 COMPLEX.
    7. Cited for: FUNCTION, ENZYME ACTIVITY.
    8. "Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases."
      Hong S., Cho Y.W., Yu L.-R., Yu H., Veenstra T.D., Ge K.
      Proc. Natl. Acad. Sci. U.S.A. 104:18439-18444(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME ACTIVITY.
    9. "Crystal structure of the human JMJD3 Jumonji domain."
      Structural genomics consortium (SGC)
      Submitted (DEC-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1176-1502 IN COMPLEX WITH NICKEL IONS AND 8-HYDROXYQUINOLINE-5-CARBOXYLIC ACID.

    Entry informationi

    Entry nameiKDM6B_HUMAN
    AccessioniPrimary (citable) accession number: O15054
    Secondary accession number(s): C9IZ40, Q96G33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 108 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3