O15050 (TRNK1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TPR and ankyrin repeat-containing protein 1

Alternative name(s):
Lupus brain antigen 1 homolog

Gene names

Name:	TRANK1
Synonyms:	KIAA0342, LBA1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2925 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 6 ANK repeats. Contains 4 TPR repeats.
Sequence caution	The sequence BAC04838.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Coiled coil Repeat TPR repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATP-dependent DNA helicase activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2925	2925	TPR and ankyrin repeat-containing protein 1		PRO_0000348238
Regions
	Repeat	15 – 48	34	TPR 1
	Repeat	50 – 82	33	TPR 2
	Repeat	168 – 198	31	ANK 1
	Repeat	203 – 232	30	ANK 2
	Repeat	240 – 276	37	ANK 3
	Repeat	463 – 492	30	ANK 4
	Repeat	497 – 518	22	ANK 5
	Repeat	546 – 575	30	ANK 6
	Repeat	1699 – 1732	34	TPR 3
	Repeat	1793 – 1826	34	TPR 4
	Coiled coil	2301 – 2330	30	Potential
	Compositional bias	1076 – 1115	40	Glu-rich
Natural variations
	Natural variant	153	1	P → L. Corresponds to variant rs17201603 [ dbSNP | Ensembl ].		VAR_061021
	Natural variant	703	1	P → L. Corresponds to variant rs17201603 [ dbSNP | Ensembl ].		VAR_046117
	Natural variant	1090	1	E → G. Ref.2 Ref.4 Corresponds to variant rs11712950 [ dbSNP | Ensembl ].		VAR_046118
Experimental info
	Sequence conflict	1286	1	I → V in BAC04838. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O15050 [UniParc]. Last modified September 2, 2008. Version 4. Checksum: DE9E997035B98D1D	FASTA	2,925	336,221
	10 20 30 40 50 60 MWDPRAARVP PRDLAVLLCN KSNAFFSLGK WNEAFVAAKE CLQWDPTYVK GYYRAGYSLL 70 80 90 100 110 120 RLHQPYEAAR MFFEGLRLVQ RSQDQAPVAD FLVGVFTTMS SDSIVLQSFL PCFDHIFTTG 130 140 150 160 170 180 FPTEVWQSVI EKLAKKGLWH SFLLLSAKKD RLPRNIHVPE LSLKSLFEKY VFIGLYEKME 190 200 210 220 230 240 QVPKLVQWLI SIGASVETIG PYPLHALMRL CIQARENHLF RWLMDHKPEW KGRINQKDGD 250 260 270 280 290 300 GCTVLHVVAA HSPGYLVKRQ TEDVQMLLRF GADPTLLDRQ SRSVVDVLKR NKNFKAIEKI 310 320 330 340 350 360 NSHLEKLATC SKDLSGFSNG DGPTSENDIF RKVLEQLVKY MNSGNRLLHK NFLKQEVVQR 370 380 390 400 410 420 FLRLLSTLQE IPPDLVCDIN QDCATTVFKF LLEKQRWPEV LLLLTRKVSG EPPLGDCLIK 430 440 450 460 470 480 DCNFSDLDIC TIIPHLSTWD QRKKQLLGCL IDSGALPDGL QESQERPVVT CLKHEDFELA 490 500 510 520 530 540 FLLLTKGADP RAISLTEGDT PLHAALHIFL EIKADIGFSF LSHLLDLFWS NPTEFDYLNP 550 560 570 580 590 600 NVQDSNGNTL MHILFQKGML KRVKKLLDLL VKFDINFNLK NKEGKDARHR IKKNDSLLLA 610 620 630 640 650 660 WNKALMENRR RSRQDSAAHL GKLSKSTAPG HTSQLKSQGS FKSVPCGATA RTLPEGSAVP 670 680 690 700 710 720 DSWETLPGTQ VTRKEPGALR PCSLRDCLMQ DITVLIQQVE VDPSFPEDCL QSSEPLEAGA 730 740 750 760 770 780 GKEGKKDDKP TLGAGAPDCS EVGEGHAQVG LGALQLVPDD NRGKEGNDDQ DDWSTQEIEA 790 800 810 820 830 840 CLQDFDNMTW EIECTSEMLK KLSSKVMTKV IKKKIILAIQ QLGNGEWTQG LQKRLKHLKG 850 860 870 880 890 900 SIQLFEAKLD KGARMLWELA IDFSPRCSEN PEKIIATEQN TCAMEKSGRI YTEIIRIWDI 910 920 930 940 950 960 VLDHCKLADS IKAICNAYNR GLSCVLRKKL KGINKGQVSA NMKIQKRIPR CYVEDTEAEK 970 980 990 1000 1010 1020 GREHVNPEYF PPASAVETEY NIMKFHSFST NMAFNILNDT TATVEYPFRV GELEYAVIDL 1030 1040 1050 1060 1070 1080 NPRPLEPIIL IGRSGTGKTT CCLYRLWKKF HVYWEKAEQA GSPLLAKQVW LKRRLEVEPG 1090 1100 1110 1120 1130 1140 KESPGGEEEE EEEDEEEEDS IEVETVESID EQEYEACAGG AGVEPAGDGQ AAEVCAPEHP 1150 1160 1170 1180 1190 1200 HQLEHLHQIF VTKNHVLCQE VQRNFIELSK STKATSHYKP LDPNIHKLQD LRDENFPLFV 1210 1220 1230 1240 1250 1260 TSKQLLLLLD ASLPKPFFLR NEDGSLKRTI IGWSAQEEST IPSWQEDEEE AEVDGDYSEE 1270 1280 1290 1300 1310 1320 DKAVEMRTGD SDPRVYVTFE VFKNEIWPKM TKGRTAYNPA LIWKEIKSFL KGSFEALSCP 1330 1340 1350 1360 1370 1380 HGRLTEEVYK KLGRKRCPNF KEDRSEIYSL FSLYQQIRSQ KGYFDEEDVL YNISRRLSKL 1390 1400 1410 1420 1430 1440 RVLPWSIHEL YGDEIQDFTQ AELALLMKCI NDPNSMFLTG DTAQSIMKGV AFRFSDLRSL 1450 1460 1470 1480 1490 1500 FHYASRNTID KQCAVRKPKK IHQLYQNYRS HSGILNLASG VVDLLQFYFP ESFDRLPRDS 1510 1520 1530 1540 1550 1560 GLFDGPKPTV LESCSVSDLA ILLRGNKRKT QPIEFGAHQV ILVANETAKE KIPEELGLAL 1570 1580 1590 1600 1610 1620 VLTIYEAKGL EFDDVLLYNF FTDSEAYKEW KIISSFTPTS TDSREENRPL VEVPLDKPGS 1630 1640 1650 1660 1670 1680 SQGRSLMVNP EMYKLLNGEL KQLYTAITRA RVNLWIFDEN REKRAPAFKY FIRRDFVQVV 1690 1700 1710 1720 1730 1740 KTDENKDFDD SMFVKTSTPA EWIAQGDYYA KHQCWKVAAK CYQKGGAFEK EKLALAHDTA 1750 1760 1770 1780 1790 1800 LSMKSKKVSP KEKQLEYLEL AKTYLECKEP TLSLKCLSYA KEFQLSAQLC ERLGKIRDAA 1810 1820 1830 1840 1850 1860 YFYKRSQCYK DAFRCFEQIQ EFDLALKMYC QEELFEEAAI AVEKYEEMLK TKTLPISKLS 1870 1880 1890 1900 1910 1920 YSASQFYLEA AAKYLSANKM KEMMAVLSKL DIEDQLVFLK SRKRLAEAAD LLNREGRREE 1930 1940 1950 1960 1970 1980 AALLMKQHGC LLEAARLTAD KDFQASCLLG AARLNVARDS DIEHTKDILR EALDICYQTG 1990 2000 2010 2020 2030 2040 QLSGIAEAHF LQGVILRDFQ KLRDAFFKFD TLNHSAGVVE ALYEAASQCE AEPEKILGLA 2050 2060 2070 2080 2090 2100 PGGLEILLSL VRALKRVTNN AEKEMVKSCF EFFGISQVDA KYCQIAQNDP GPILRIIFDL 2110 2120 2130 2140 2150 2160 DLNLREKKTK DHFLIMTDQV KLALNKHLLG RLCQITRSLL GKTYRGVCMR FIVGLKCEDE 2170 2180 2190 2200 2210 2220 NCEHFHRPLR RCEAKCLVQS KMNLVAINGL LLEAKKVFPK ILAEELKEID YILSTDMYGL 2230 2240 2250 2260 2270 2280 CKSILDVLFP KHFHQRVLSE NPMACKEILK PNYKSFRFYR FALKEYIHFL FENESARNRR 2290 2300 2310 2320 2330 2340 ESTDLWLSAM QAFLLSSNYP EEFEKLLHQE EDNYNRELKA LESEKDERGR GRGSRIKGIE 2350 2360 2370 2380 2390 2400 GKFGMLAPNR DDENMDKTHL CFIRLLENCI DQFYVYRNPE DYKRLFFRFM NVLIKRCKEP 2410 2420 2430 2440 2450 2460 LIPSIGNTVA LLEFQFIHCG VVLARLWKNV ILCLPKSYIA LLHYWEFLFS KKDKELGDVF 2470 2480 2490 2500 2510 2520 SIIQEYKPKD VTRAIQDFRF HLSYLAKVLC GYENVNFNVL LDAFSEIDYV VSGEAERTLV 2530 2540 2550 2560 2570 2580 LCLVMLVNAE EILQPYCKPL LYRHFREIES RLQLMSMDCP GQVPERLLKV VKRVLVAVNV 2590 2600 2610 2620 2630 2640 KSVAEALQDL LFERDEEYLM DCDWRWDPVH TKGSIVRGLY YEEVRLNRLL CLDPVDYFAE 2650 2660 2670 2680 2690 2700 PECEFGQDEM DELALEDRDH VLATILSQKQ RKASIQRKLR RACLVVSLCI SWRRRVGTQM 2710 2720 2730 2740 2750 2760 ERVREEAREP RAGNFKKADV DRTQCDLCGV KFTRGPENYF SPSKAFEGAA SEVAVLSRAE 2770 2780 2790 2800 2810 2820 LEREECQERN SESYEQHIHL EHHQRQQVAY QKYSEFFHEK VDPAIDEGKL VVQDIEQSVW 2830 2840 2850 2860 2870 2880 IHSHVGSKEH SHMLQKVQEH IKRVSDMVED LYRRKAWAGA EEAMTRLVNI LILSVRDARD 2890 2900 2910 2920 WLMKTETRLK KEGIVQEDDY ENEVEDFGEL RPRRRSRKCG KQRKY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 459-2925, VARIANT GLY-1090. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 713-1525, VARIANT GLY-1090.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC097360 Genomic DNA. No translation available. AC105749 Genomic DNA. No translation available. AC011816 Genomic DNA. No translation available. AB002340 mRNA. Translation: BAA20800.3. AK096678 mRNA. Translation: BAC04838.1. Different initiation.
IPI	IPI00847543.
RefSeq	NP_055646.2. NM_014831.2.
UniGene	Hs.170999.
3D structure databases
ProteinModelPortal	O15050.
SMR	O15050. Positions 212-296, 443-595, 1004-1042, 1902-1931.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15050. 2 interactions.
PTM databases
PhosphoSite	O15050.
Proteomic databases
PRIDE	O15050.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000428977; ENSP00000416826; ENSG00000168016.
GeneID	9881.
KEGG	hsa:9881.
UCSC	uc003cgj.2. human.
Organism-specific databases
CTD	9881.
GeneCards	GC03M036845.
HGNC	HGNC:29011. TRANK1.
HPA	HPA035508.
neXtProt	NX_O15050.
PharmGKB	PA165698606.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07563.
GeneTree	ENSGT00390000012649.
HOGENOM	HBG506583.
HOVERGEN	HBG108082.
OMA	EIWPKMI.
OrthoDB	EOG46Q6RM.
Gene expression databases
ArrayExpress	O15050.
Bgee	O15050.
Genevestigator	O15050.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000212. DNA_helicase_UvrD/REP. IPR013026. TPR-contain. IPR011990. TPR-like_helical. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 2 hits. G3DSA:1.25.40.10. TPR-like_helical. 3 hits.
Pfam	PF00580. UvrD-helicase. 1 hit. [Graphical view]
SMART	SM00248. ANK. 4 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. False negative. PS50005. TPR. False negative. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	37241.

Entry information

Entry name

TRNK1_HUMAN

Accession

Primary (citable) accession number: O15050
Secondary accession number(s): Q8N8K0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	December 14, 2011
This is version 77 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.