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O15049 (N4BP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NEDD4-binding protein 3

Short name=N4BP3
Gene names
Name:N4BP3
Synonyms:KIAA0341
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length544 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Binds NEDD4. Interacts with 14-3-3 proteins. Ref.5 Ref.6

Subcellular location

Cytoplasmic vesicle membrane; Peripheral membrane protein Ref.5.

Sequence caution

The sequence BAA20799.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAC86891.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC86891.1 differs from that shown. Reason: Intron retention.

The sequence BAG58525.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCytoplasmic vesicle
Membrane
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasmic vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 544544NEDD4-binding protein 3
PRO_0000096682

Regions

Coiled coil294 – 530237 Potential
Compositional bias242 – 2476Poly-Pro

Amino acid modifications

Modified residue1761Phosphoserine Ref.7

Experimental info

Sequence conflict291L → P in BAA20799. Ref.1
Sequence conflict1631R → Q in AAH53323. Ref.3
Sequence conflict3171R → H in BAC86891. Ref.4

Sequences

Sequence LengthMass (Da)Tools
O15049 [UniParc].

Last modified April 17, 2007. Version 3.
Checksum: 40F2652D0848C27C

FASTA54460,470
        10         20         30         40         50         60 
MATAPGPAGI AMGSVGSLLE RQDFSPEELR AALAGSRGSR QPDGLLRKGL GQREFLSYLH 

        70         80         90        100        110        120 
LPKKDSKSTK NTKRAPRNEP ADYATLYYRE HSRAGDFSKT SLPERGRFDK CRIRPSVFKP 

       130        140        150        160        170        180 
TAGNGKGFLS MQSLASHKGQ KLWRSNGSLH TLACHPPLSP GPRASQARAQ LLHALSLDEG 

       190        200        210        220        230        240 
GPEPEPSLSD SSSGGSFGRS PGTGPSPFSS SLGHLNHLGG SLDRASQGPK EAGPPAVLSC 

       250        260        270        280        290        300 
LPEPPPPYEF SCSSAEEMGA VLPETCEELK RGLGDEDGSN PFTQVLEERQ RLWLAELKRL 

       310        320        330        340        350        360 
YVERLHEVTQ KAERSERNLQ LQLFMAQQEQ RRLRKELRAQ QGLAPEPRAP GTLPEADPSA 

       370        380        390        400        410        420 
RPEEEARWEV CQKTAEISLL KQQLREAQAE LAQKLAEIFS LKTQLRGSRA QAQAQDAELV 

       430        440        450        460        470        480 
RLREAVRSLQ EQAPREEAPG SCETDDCKSR GLLGEAGGSE ARDSAEQLRA ELLQERLRGQ 

       490        500        510        520        530        540 
EQALRFEQER RTWQEEKERV LRYQREIQGG YMDMYRRNQA LEQELRALRE PPTPWSPRLE 


SSKI 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 285-544.
Tissue: Hippocampus.
[5]"Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase."
Murillas R., Simms K.S., Hatakeyama S., Weissman A.M., Kuehn M.R.
J. Biol. Chem. 277:2897-2907(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NEDD4.
[6]"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization."
Jin J., Smith F.D., Stark C., Wells C.D., Fawcett J.P., Kulkarni S., Metalnikov P., O'Donnell P., Taylor P., Taylor L., Zougman A., Woodgett J.R., Langeberg L.K., Scott J.D., Pawson T.
Curr. Biol. 14:1436-1450(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH 14-3-3 PROTEINS.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB002339 mRNA. Translation: BAA20799.1. Different initiation.
CH471165 Genomic DNA. Translation: EAW53851.1.
CH471165 Genomic DNA. Translation: EAW53852.1.
CH471165 Genomic DNA. Translation: EAW53853.1.
CH471165 Genomic DNA. Translation: EAW53854.1.
BC053323 mRNA. Translation: AAH53323.2.
AK127224 mRNA. Translation: BAC86891.1. Sequence problems.
AK295663 mRNA. Translation: BAG58525.1. Different initiation.
CCDSCCDS34307.1.
RefSeqNP_055926.1. NM_015111.1.
XP_006714897.1. XM_006714834.1.
UniGeneHs.101761.

3D structure databases

ProteinModelPortalO15049.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116755. 4 interactions.
IntActO15049. 2 interactions.
MINTMINT-222654.

PTM databases

PhosphoSiteO15049.

Proteomic databases

MaxQBO15049.
PaxDbO15049.
PRIDEO15049.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274605; ENSP00000274605; ENSG00000145911.
GeneID23138.
KEGGhsa:23138.
UCSCuc003mik.1. human.

Organism-specific databases

CTD23138.
GeneCardsGC05P177540.
H-InvDBHIX0005472.
HGNCHGNC:29852. N4BP3.
HPAHPA030973.
neXtProtNX_O15049.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG75546.
HOGENOMHOG000230889.
HOVERGENHBG052566.
InParanoidO15049.
OMAPFTQVLE.
OrthoDBEOG786H39.
PhylomeDBO15049.
TreeFamTF331420.

Gene expression databases

BgeeO15049.
GenevestigatorO15049.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi23138.
NextBio44407.
PROO15049.

Entry information

Entry nameN4BP3_HUMAN
AccessionPrimary (citable) accession number: O15049
Secondary accession number(s): B4DIL3 expand/collapse secondary AC list , D3DWP3, Q6ZSQ6, Q7Z6I3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 17, 2007
Last modified: July 9, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

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Human chromosome 5: entries, gene names and cross-references to MIM