Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O15049

- N4BP3_HUMAN

UniProt

O15049 - N4BP3_HUMAN

Protein

NEDD4-binding protein 3

Gene

N4BP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (17 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NEDD4-binding protein 3
    Short name:
    N4BP3
    Gene namesi
    Name:N4BP3
    Synonyms:KIAA0341
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:29852. N4BP3.

    Subcellular locationi

    Cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 544544NEDD4-binding protein 3PRO_0000096682Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei176 – 1761Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO15049.
    PaxDbiO15049.
    PRIDEiO15049.

    PTM databases

    PhosphoSiteiO15049.

    Expressioni

    Gene expression databases

    BgeeiO15049.
    GenevestigatoriO15049.

    Organism-specific databases

    HPAiHPA030973.

    Interactioni

    Subunit structurei

    Binds NEDD4. Interacts with 14-3-3 proteins.2 Publications

    Protein-protein interaction databases

    BioGridi116755. 4 interactions.
    IntActiO15049. 2 interactions.
    MINTiMINT-222654.

    Structurei

    3D structure databases

    ProteinModelPortaliO15049.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili294 – 530237Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi242 – 2476Poly-Pro

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG75546.
    HOGENOMiHOG000230889.
    HOVERGENiHBG052566.
    InParanoidiO15049.
    OMAiPFTQVLE.
    OrthoDBiEOG786H39.
    PhylomeDBiO15049.
    TreeFamiTF331420.

    Sequencei

    Sequence statusi: Complete.

    O15049-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATAPGPAGI AMGSVGSLLE RQDFSPEELR AALAGSRGSR QPDGLLRKGL    50
    GQREFLSYLH LPKKDSKSTK NTKRAPRNEP ADYATLYYRE HSRAGDFSKT 100
    SLPERGRFDK CRIRPSVFKP TAGNGKGFLS MQSLASHKGQ KLWRSNGSLH 150
    TLACHPPLSP GPRASQARAQ LLHALSLDEG GPEPEPSLSD SSSGGSFGRS 200
    PGTGPSPFSS SLGHLNHLGG SLDRASQGPK EAGPPAVLSC LPEPPPPYEF 250
    SCSSAEEMGA VLPETCEELK RGLGDEDGSN PFTQVLEERQ RLWLAELKRL 300
    YVERLHEVTQ KAERSERNLQ LQLFMAQQEQ RRLRKELRAQ QGLAPEPRAP 350
    GTLPEADPSA RPEEEARWEV CQKTAEISLL KQQLREAQAE LAQKLAEIFS 400
    LKTQLRGSRA QAQAQDAELV RLREAVRSLQ EQAPREEAPG SCETDDCKSR 450
    GLLGEAGGSE ARDSAEQLRA ELLQERLRGQ EQALRFEQER RTWQEEKERV 500
    LRYQREIQGG YMDMYRRNQA LEQELRALRE PPTPWSPRLE SSKI 544
    Length:544
    Mass (Da):60,470
    Last modified:April 17, 2007 - v3
    Checksum:i40F2652D0848C27C
    GO

    Sequence cautioni

    The sequence BAC86891.1 differs from that shown. Reason: Intron retention.
    The sequence BAA20799.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAC86891.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG58525.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291L → P in BAA20799. (PubMed:9205841)Curated
    Sequence conflicti163 – 1631R → Q in AAH53323. (PubMed:15489334)Curated
    Sequence conflicti317 – 3171R → H in BAC86891. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002339 mRNA. Translation: BAA20799.1. Different initiation.
    CH471165 Genomic DNA. Translation: EAW53851.1.
    CH471165 Genomic DNA. Translation: EAW53852.1.
    CH471165 Genomic DNA. Translation: EAW53853.1.
    CH471165 Genomic DNA. Translation: EAW53854.1.
    BC053323 mRNA. Translation: AAH53323.2.
    AK127224 mRNA. Translation: BAC86891.1. Sequence problems.
    AK295663 mRNA. Translation: BAG58525.1. Different initiation.
    CCDSiCCDS34307.1.
    RefSeqiNP_055926.1. NM_015111.1.
    XP_006714897.1. XM_006714834.1.
    UniGeneiHs.101761.

    Genome annotation databases

    EnsembliENST00000274605; ENSP00000274605; ENSG00000145911.
    GeneIDi23138.
    KEGGihsa:23138.
    UCSCiuc003mik.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002339 mRNA. Translation: BAA20799.1 . Different initiation.
    CH471165 Genomic DNA. Translation: EAW53851.1 .
    CH471165 Genomic DNA. Translation: EAW53852.1 .
    CH471165 Genomic DNA. Translation: EAW53853.1 .
    CH471165 Genomic DNA. Translation: EAW53854.1 .
    BC053323 mRNA. Translation: AAH53323.2 .
    AK127224 mRNA. Translation: BAC86891.1 . Sequence problems.
    AK295663 mRNA. Translation: BAG58525.1 . Different initiation.
    CCDSi CCDS34307.1.
    RefSeqi NP_055926.1. NM_015111.1.
    XP_006714897.1. XM_006714834.1.
    UniGenei Hs.101761.

    3D structure databases

    ProteinModelPortali O15049.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116755. 4 interactions.
    IntActi O15049. 2 interactions.
    MINTi MINT-222654.

    PTM databases

    PhosphoSitei O15049.

    Proteomic databases

    MaxQBi O15049.
    PaxDbi O15049.
    PRIDEi O15049.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274605 ; ENSP00000274605 ; ENSG00000145911 .
    GeneIDi 23138.
    KEGGi hsa:23138.
    UCSCi uc003mik.1. human.

    Organism-specific databases

    CTDi 23138.
    GeneCardsi GC05P177540.
    H-InvDB HIX0005472.
    HGNCi HGNC:29852. N4BP3.
    HPAi HPA030973.
    neXtProti NX_O15049.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG75546.
    HOGENOMi HOG000230889.
    HOVERGENi HBG052566.
    InParanoidi O15049.
    OMAi PFTQVLE.
    OrthoDBi EOG786H39.
    PhylomeDBi O15049.
    TreeFami TF331420.

    Miscellaneous databases

    GenomeRNAii 23138.
    NextBioi 44407.
    PROi O15049.

    Gene expression databases

    Bgeei O15049.
    Genevestigatori O15049.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 285-544.
      Tissue: Hippocampus.
    5. "Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase."
      Murillas R., Simms K.S., Hatakeyama S., Weissman A.M., Kuehn M.R.
      J. Biol. Chem. 277:2897-2907(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NEDD4.
    6. "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization."
      Jin J., Smith F.D., Stark C., Wells C.D., Fawcett J.P., Kulkarni S., Metalnikov P., O'Donnell P., Taylor P., Taylor L., Zougman A., Woodgett J.R., Langeberg L.K., Scott J.D., Pawson T.
      Curr. Biol. 14:1436-1450(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH 14-3-3 PROTEINS.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiN4BP3_HUMAN
    AccessioniPrimary (citable) accession number: O15049
    Secondary accession number(s): B4DIL3
    , D3DWP3, Q6ZSQ6, Q7Z6I3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM

    External Data

    Dasty 3