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O15049

- N4BP3_HUMAN

UniProt

O15049 - N4BP3_HUMAN

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Protein

NEDD4-binding protein 3

Gene

N4BP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD4-binding protein 3
Short name:
N4BP3
Gene namesi
Name:N4BP3
Synonyms:KIAA0341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:29852. N4BP3.

Subcellular locationi

Cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544NEDD4-binding protein 3PRO_0000096682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei176 – 1761Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15049.
PaxDbiO15049.
PRIDEiO15049.

PTM databases

PhosphoSiteiO15049.

Expressioni

Gene expression databases

BgeeiO15049.
GenevestigatoriO15049.

Organism-specific databases

HPAiHPA030973.

Interactioni

Subunit structurei

Binds NEDD4. Interacts with 14-3-3 proteins.2 Publications

Protein-protein interaction databases

BioGridi116755. 4 interactions.
IntActiO15049. 2 interactions.
MINTiMINT-222654.

Structurei

3D structure databases

ProteinModelPortaliO15049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili294 – 530237Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi242 – 2476Poly-Pro

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG75546.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052566.
InParanoidiO15049.
OMAiPFTQVLE.
OrthoDBiEOG786H39.
PhylomeDBiO15049.
TreeFamiTF331420.

Sequencei

Sequence statusi: Complete.

O15049 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATAPGPAGI AMGSVGSLLE RQDFSPEELR AALAGSRGSR QPDGLLRKGL
60 70 80 90 100
GQREFLSYLH LPKKDSKSTK NTKRAPRNEP ADYATLYYRE HSRAGDFSKT
110 120 130 140 150
SLPERGRFDK CRIRPSVFKP TAGNGKGFLS MQSLASHKGQ KLWRSNGSLH
160 170 180 190 200
TLACHPPLSP GPRASQARAQ LLHALSLDEG GPEPEPSLSD SSSGGSFGRS
210 220 230 240 250
PGTGPSPFSS SLGHLNHLGG SLDRASQGPK EAGPPAVLSC LPEPPPPYEF
260 270 280 290 300
SCSSAEEMGA VLPETCEELK RGLGDEDGSN PFTQVLEERQ RLWLAELKRL
310 320 330 340 350
YVERLHEVTQ KAERSERNLQ LQLFMAQQEQ RRLRKELRAQ QGLAPEPRAP
360 370 380 390 400
GTLPEADPSA RPEEEARWEV CQKTAEISLL KQQLREAQAE LAQKLAEIFS
410 420 430 440 450
LKTQLRGSRA QAQAQDAELV RLREAVRSLQ EQAPREEAPG SCETDDCKSR
460 470 480 490 500
GLLGEAGGSE ARDSAEQLRA ELLQERLRGQ EQALRFEQER RTWQEEKERV
510 520 530 540
LRYQREIQGG YMDMYRRNQA LEQELRALRE PPTPWSPRLE SSKI
Length:544
Mass (Da):60,470
Last modified:April 17, 2007 - v3
Checksum:i40F2652D0848C27C
GO

Sequence cautioni

The sequence BAC86891.1 differs from that shown. Reason: Intron retention.
The sequence BAA20799.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAC86891.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG58525.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291L → P in BAA20799. (PubMed:9205841)Curated
Sequence conflicti163 – 1631R → Q in AAH53323. (PubMed:15489334)Curated
Sequence conflicti317 – 3171R → H in BAC86891. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002339 mRNA. Translation: BAA20799.1. Different initiation.
CH471165 Genomic DNA. Translation: EAW53851.1.
CH471165 Genomic DNA. Translation: EAW53852.1.
CH471165 Genomic DNA. Translation: EAW53853.1.
CH471165 Genomic DNA. Translation: EAW53854.1.
BC053323 mRNA. Translation: AAH53323.2.
AK127224 mRNA. Translation: BAC86891.1. Sequence problems.
AK295663 mRNA. Translation: BAG58525.1. Different initiation.
CCDSiCCDS34307.1.
RefSeqiNP_055926.1. NM_015111.1.
XP_006714897.1. XM_006714834.1.
UniGeneiHs.101761.

Genome annotation databases

EnsembliENST00000274605; ENSP00000274605; ENSG00000145911.
GeneIDi23138.
KEGGihsa:23138.
UCSCiuc003mik.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002339 mRNA. Translation: BAA20799.1 . Different initiation.
CH471165 Genomic DNA. Translation: EAW53851.1 .
CH471165 Genomic DNA. Translation: EAW53852.1 .
CH471165 Genomic DNA. Translation: EAW53853.1 .
CH471165 Genomic DNA. Translation: EAW53854.1 .
BC053323 mRNA. Translation: AAH53323.2 .
AK127224 mRNA. Translation: BAC86891.1 . Sequence problems.
AK295663 mRNA. Translation: BAG58525.1 . Different initiation.
CCDSi CCDS34307.1.
RefSeqi NP_055926.1. NM_015111.1.
XP_006714897.1. XM_006714834.1.
UniGenei Hs.101761.

3D structure databases

ProteinModelPortali O15049.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116755. 4 interactions.
IntActi O15049. 2 interactions.
MINTi MINT-222654.

PTM databases

PhosphoSitei O15049.

Proteomic databases

MaxQBi O15049.
PaxDbi O15049.
PRIDEi O15049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274605 ; ENSP00000274605 ; ENSG00000145911 .
GeneIDi 23138.
KEGGi hsa:23138.
UCSCi uc003mik.1. human.

Organism-specific databases

CTDi 23138.
GeneCardsi GC05P177540.
H-InvDB HIX0005472.
HGNCi HGNC:29852. N4BP3.
HPAi HPA030973.
neXtProti NX_O15049.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG75546.
GeneTreei ENSGT00510000046769.
HOGENOMi HOG000230889.
HOVERGENi HBG052566.
InParanoidi O15049.
OMAi PFTQVLE.
OrthoDBi EOG786H39.
PhylomeDBi O15049.
TreeFami TF331420.

Miscellaneous databases

GenomeRNAii 23138.
NextBioi 44407.
PROi O15049.

Gene expression databases

Bgeei O15049.
Genevestigatori O15049.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 285-544.
    Tissue: Hippocampus.
  5. "Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase."
    Murillas R., Simms K.S., Hatakeyama S., Weissman A.M., Kuehn M.R.
    J. Biol. Chem. 277:2897-2907(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NEDD4.
  6. "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization."
    Jin J., Smith F.D., Stark C., Wells C.D., Fawcett J.P., Kulkarni S., Metalnikov P., O'Donnell P., Taylor P., Taylor L., Zougman A., Woodgett J.R., Langeberg L.K., Scott J.D., Pawson T.
    Curr. Biol. 14:1436-1450(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH 14-3-3 PROTEINS.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiN4BP3_HUMAN
AccessioniPrimary (citable) accession number: O15049
Secondary accession number(s): B4DIL3
, D3DWP3, Q6ZSQ6, Q7Z6I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM

External Data

Dasty 3