Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NEDD4-binding protein 3

Gene

N4BP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD4-binding protein 3
Short name:
N4BP3
Gene namesi
Name:N4BP3
Synonyms:KIAA0341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145911.5.
HGNCiHGNC:29852. N4BP3.

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145911.

Polymorphism and mutation databases

BioMutaiN4BP3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966821 – 544NEDD4-binding protein 3Add BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei176PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15049.
MaxQBiO15049.
PaxDbiO15049.
PeptideAtlasiO15049.
PRIDEiO15049.

PTM databases

iPTMnetiO15049.
PhosphoSitePlusiO15049.

Expressioni

Gene expression databases

BgeeiENSG00000145911.
GenevisibleiO15049. HS.

Organism-specific databases

HPAiHPA030972.
HPA030973.
HPA061387.

Interactioni

Subunit structurei

Binds NEDD4 (PubMed:11717310). Interacts with 14-3-3 proteins (PubMed:15324660).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116755. 17 interactors.
IntActiO15049. 28 interactors.
MINTiMINT-222654.
STRINGi9606.ENSP00000274605.

Structurei

3D structure databases

ProteinModelPortaliO15049.
SMRiO15049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili294 – 530Sequence analysisAdd BLAST237

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi242 – 247Poly-Pro6

Sequence similaritiesi

Belongs to the N4BP3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE8K. Eukaryota.
ENOG410XQRF. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052566.
InParanoidiO15049.
OMAiTTLYYRE.
OrthoDBiEOG091G03L2.
PhylomeDBiO15049.
TreeFamiTF331420.

Family and domain databases

InterProiView protein in InterPro
IPR033571. N4BP3.
PANTHERiPTHR32274. PTHR32274. 1 hit.

Sequencei

Sequence statusi: Complete.

O15049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAPGPAGI AMGSVGSLLE RQDFSPEELR AALAGSRGSR QPDGLLRKGL
60 70 80 90 100
GQREFLSYLH LPKKDSKSTK NTKRAPRNEP ADYATLYYRE HSRAGDFSKT
110 120 130 140 150
SLPERGRFDK CRIRPSVFKP TAGNGKGFLS MQSLASHKGQ KLWRSNGSLH
160 170 180 190 200
TLACHPPLSP GPRASQARAQ LLHALSLDEG GPEPEPSLSD SSSGGSFGRS
210 220 230 240 250
PGTGPSPFSS SLGHLNHLGG SLDRASQGPK EAGPPAVLSC LPEPPPPYEF
260 270 280 290 300
SCSSAEEMGA VLPETCEELK RGLGDEDGSN PFTQVLEERQ RLWLAELKRL
310 320 330 340 350
YVERLHEVTQ KAERSERNLQ LQLFMAQQEQ RRLRKELRAQ QGLAPEPRAP
360 370 380 390 400
GTLPEADPSA RPEEEARWEV CQKTAEISLL KQQLREAQAE LAQKLAEIFS
410 420 430 440 450
LKTQLRGSRA QAQAQDAELV RLREAVRSLQ EQAPREEAPG SCETDDCKSR
460 470 480 490 500
GLLGEAGGSE ARDSAEQLRA ELLQERLRGQ EQALRFEQER RTWQEEKERV
510 520 530 540
LRYQREIQGG YMDMYRRNQA LEQELRALRE PPTPWSPRLE SSKI
Length:544
Mass (Da):60,470
Last modified:April 17, 2007 - v3
Checksum:i40F2652D0848C27C
GO

Sequence cautioni

The sequence BAA20799 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC86891 differs from that shown. Intron retention.Curated
The sequence BAC86891 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG58525 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29L → P in BAA20799 (PubMed:9205841).Curated1
Sequence conflicti163R → Q in AAH53323 (PubMed:15489334).Curated1
Sequence conflicti317R → H in BAC86891 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002339 mRNA. Translation: BAA20799.1. Different initiation.
CH471165 Genomic DNA. Translation: EAW53851.1.
CH471165 Genomic DNA. Translation: EAW53852.1.
CH471165 Genomic DNA. Translation: EAW53853.1.
CH471165 Genomic DNA. Translation: EAW53854.1.
BC053323 mRNA. Translation: AAH53323.2.
AK127224 mRNA. Translation: BAC86891.1. Sequence problems.
AK295663 mRNA. Translation: BAG58525.1. Different initiation.
CCDSiCCDS34307.1.
RefSeqiNP_055926.1. NM_015111.1.
XP_006714897.1. XM_006714834.3.
XP_011532775.1. XM_011534473.1.
XP_011532776.1. XM_011534474.1.
UniGeneiHs.101761.

Genome annotation databases

EnsembliENST00000274605; ENSP00000274605; ENSG00000145911.
GeneIDi23138.
KEGGihsa:23138.
UCSCiuc003mik.2. human.

Similar proteinsi

Entry informationi

Entry nameiN4BP3_HUMAN
AccessioniPrimary (citable) accession number: O15049
Secondary accession number(s): B4DIL3
, D3DWP3, Q6ZSQ6, Q7Z6I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 17, 2007
Last modified: November 22, 2017
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families