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O15042 (SR140_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U2 snRNP-associated SURP motif-containing protein
Alternative name(s):
140 kDa Ser/Arg-rich domain protein
U2-associated protein SR140
Gene names
Name:U2SURP
Synonyms:KIAA0332, SR140
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1029 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with ERBB4. Ref.9

Subcellular location

Nucleus Ref.9.

Sequence similarities

Belongs to the splicing factor SR family.

Contains 1 CID domain.

Contains 1 RRM (RNA recognition motif) domain.

Contains 1 SURP motif repeat.

Sequence caution

The sequence AAH16323.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAI05605.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   LigandRNA-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA processing

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleus

Inferred from direct assay Ref.9. Source: UniProtKB

   Molecular_functionnucleotide binding

Inferred from electronic annotation. Source: InterPro

poly(A) RNA binding

Inferred from direct assay PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RBM10P981752EBI-310697,EBI-721525
RBM5P527562EBI-310697,EBI-714003

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15042-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15042-2)

The sequence of this isoform differs from the canonical sequence as follows:
     256-256: Missing.
Isoform 3 (identifier: O15042-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.
     410-424: KTLSQAIVKVVIPTE → MLLCYRHLKTKRILR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.13
Chain2 – 10291028U2 snRNP-associated SURP motif-containing protein
PRO_0000280070

Regions

Domain274 – 35582RRM
Repeat430 – 47344SURP motif
Domain534 – 679146CID
Coiled coil92 – 12130 Potential
Coiled coil192 – 23241 Potential
Coiled coil837 – 91579 Potential
Compositional bias357 – 40246Pro-rich
Compositional bias689 – 74658Asp-rich
Compositional bias762 – 917156Glu-rich
Compositional bias922 – 100180Arg/Ser-rich

Amino acid modifications

Modified residue21N-acetylalanine Ref.13
Modified residue2021Phosphoserine Ref.12
Modified residue4851Phosphoserine Ref.10 Ref.12
Modified residue7601N6-acetyllysine Ref.8
Modified residue7881Phosphoserine Ref.6 Ref.7 Ref.12
Modified residue8001Phosphoserine Ref.6 Ref.7
Modified residue8111Phosphoserine Ref.5 Ref.10 Ref.12
Modified residue9311Phosphothreonine Ref.10
Modified residue9461Phosphoserine Ref.10
Modified residue9481Phosphoserine Ref.10

Natural variations

Alternative sequence1 – 409409Missing in isoform 3.
VSP_023522
Alternative sequence2561Missing in isoform 2.
VSP_023523
Alternative sequence410 – 42415KTLSQ…VIPTE → MLLCYRHLKTKRILR in isoform 3.
VSP_023524

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 6, 2007. Version 2.
Checksum: 7AB9235C63299714

FASTA1,029118,292
        10         20         30         40         50         60 
MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP RKHNYRNESA 

        70         80         90        100        110        120 
RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE QEELKKKEDE KAAAEIYEEF 

       130        140        150        160        170        180 
LAAFEGSDGN KVKTFVRGGV VNAAKEEHET DEKRGKIYKP SSRFADQKNP PNQSSNERPP 

       190        200        210        220        230        240 
SLLVIETKKP PLKKGEKEKK KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG 

       250        260        270        280        290        300 
QRRSMDAPSR RNRSSGVLDD YAPGSHDVGD PSTTNLYLGN INPQMNEEML CQEFGRFGPL 

       310        320        330        340        350        360 
ASVKIMWPRT DEERARERNC GFVAFMNRRD AERALKNLNG KMIMSFEMKL GWGKAVPIPP 

       370        380        390        400        410        420 
HPIYIPPSMM EHTLPPPPSG LPFNAQPRER LKNPNAPMLP PPKNKEDFEK TLSQAIVKVV 

       430        440        450        460        470        480 
IPTERNLLAL IHRMIEFVVR EGPMFEAMIM NREINNPMFR FLFENQTPAH VYYRWKLYSI 

       490        500        510        520        530        540 
LQGDSPTKWR TEDFRMFKNG SFWRPPPLNP YLHGMSEEQE TEAFVEEPSK KGALKEEQRD 

       550        560        570        580        590        600 
KLEEILRGLT PRKNDIGDAM VFCLNNAEAA EEIVDCITES LSILKTPLPK KIARLYLVSD 

       610        620        630        640        650        660 
VLYNSSAKVA NASYYRKFFE TKLCQIFSDL NATYRTIQGH LQSENFKQRV MTCFRAWEDW 

       670        680        690        700        710        720 
AIYPEPFLIK LQNIFLGLVN IIEEKETEDV PDDLDGAPIE EELDGAPLED VDGIPIDATP 

       730        740        750        760        770        780 
IDDLDGVPIK SLDDDLDGVP LDATEDSKKN EPIFKVAPSK WEAVDESELE AQAVTTSKWE 

       790        800        810        820        830        840 
LFDQHEESEE EENQNQEEES EDEEDTQSSK SEEHHLYSNP IKEEMTESKF SKYSEMSEEK 

       850        860        870        880        890        900 
RAKLREIELK VMKFQDELES GKRPKKPGQS FQEQVEHYRD KLLQREKEKE LERERERDKK 

       910        920        930        940        950        960 
DKEKLESRSK DKKEKDECTP TRKERKRRHS TSPSPSRSSS GRRVKSPSPK SERSERSERS 

       970        980        990       1000       1010       1020 
HKESSRSRSS HKDSPRDVSK KAKRSPSGSR TPKRSRRSRS RSPKKSGKKS RSQSRSPHRS 


HKKSKKNKH 

« Hide

Isoform 2 [UniParc].

Checksum: 626B4D73CC24A992
Show »

FASTA1,028118,235
Isoform 3 [UniParc].

Checksum: BA78B39559885CBC
Show »

FASTA62072,523

References

« Hide 'large scale' references
[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1029 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-189 (ISOFORMS 1/2).
Tissue: Lung and Urinary bladder.
[3]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1029 (ISOFORM 1).
Tissue: Brain.
[4]"Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein."
Will C.L., Urlaub H., Achsel T., Gentzel M., Wilm M., Luehrmann R.
EMBO J. 21:4978-4988(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY.
[5]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-788 AND SER-800, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-788 AND SER-800, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-760, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."
Gilmore-Hebert M., Ramabhadran R., Stern D.F.
Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH ERBB4, SUBCELLULAR LOCATION.
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-485; SER-811; THR-931; SER-946 AND SER-948, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202; SER-485; SER-788 AND SER-811, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC018450 Genomic DNA. No translation available.
AC026304 Genomic DNA. No translation available.
BC006474 mRNA. Translation: AAH06474.1.
BC016323 mRNA. Translation: AAH16323.1. Sequence problems.
BC105604 mRNA. Translation: AAI05605.1. Sequence problems.
BC111692 mRNA. Translation: AAI11693.1.
AB002330 mRNA. Translation: BAA20790.1.
BK000564 mRNA. Translation: DAA00075.1.
RefSeqNP_001073884.1. NM_001080415.1.
XP_005247303.1. XM_005247246.2.
XP_005247306.1. XM_005247249.2.
UniGeneHs.596572.

3D structure databases

ProteinModelPortalO15042.
SMRO15042. Positions 276-353, 426-487, 539-677.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116932. 27 interactions.
IntActO15042. 18 interactions.
MINTMINT-2795506.

PTM databases

PhosphoSiteO15042.

Proteomic databases

PaxDbO15042.
PRIDEO15042.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397933; ENSP00000381027; ENSG00000163714. [O15042-3]
ENST00000473835; ENSP00000418563; ENSG00000163714. [O15042-1]
GeneID23350.
KEGGhsa:23350.
UCSCuc003evh.1. human. [O15042-1]
uc003evi.1. human. [O15042-3]
uc003evk.1. human. [O15042-2]

Organism-specific databases

CTD23350.
GeneCardsGC03P142720.
H-InvDBHIX0003746.
HGNCHGNC:30855. U2SURP.
HPAHPA037545.
neXtProtNX_O15042.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG307351.
HOGENOMHOG000286037.
HOVERGENHBG093996.
InParanoidO15042.
KOK12842.
OMAANSPTKW.
OrthoDBEOG74FF05.
PhylomeDBO15042.
TreeFamTF318729.

Gene expression databases

ArrayExpressO15042.
BgeeO15042.
GenevestigatorO15042.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR013170. mRNA_splic_Cwf21.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000061. Surp.
[Graphical view]
PfamPF08312. cwf21. 1 hit.
PF00076. RRM_1. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]
SMARTSM00582. RPR. 1 hit.
SM00360. RRM. 1 hit.
SM00648. SWAP. 1 hit.
[Graphical view]
SUPFAMSSF109905. SSF109905. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEPS51391. CID. 1 hit.
PS50102. RRM. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSu2surp. human.
GenomeRNAi23350.
NextBio45335.
PMAP-CutDBO15042.
PROO15042.

Entry information

Entry nameSR140_HUMAN
AccessionPrimary (citable) accession number: O15042
Secondary accession number(s): A0PJ60 expand/collapse secondary AC list , Q0D2M1, Q2NKQ7, Q9BR70
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM