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O15042

- SR140_HUMAN

UniProt

O15042 - SR140_HUMAN

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Protein
U2 snRNP-associated SURP motif-containing protein
Gene
U2SURP, KIAA0332, SR140
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
U2 snRNP-associated SURP motif-containing protein
Alternative name(s):
140 kDa Ser/Arg-rich domain protein
U2-associated protein SR140
Gene namesi
Name:U2SURP
Synonyms:KIAA0332, SR140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30855. U2SURP.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 10291028U2 snRNP-associated SURP motif-containing protein
PRO_0000280070Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei202 – 2021Phosphoserine1 Publication
Modified residuei485 – 4851Phosphoserine2 Publications
Modified residuei760 – 7601N6-acetyllysine1 Publication
Modified residuei788 – 7881Phosphoserine3 Publications
Modified residuei800 – 8001Phosphoserine2 Publications
Modified residuei811 – 8111Phosphoserine3 Publications
Modified residuei931 – 9311Phosphothreonine1 Publication
Modified residuei946 – 9461Phosphoserine1 Publication
Modified residuei948 – 9481Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO15042.
PaxDbiO15042.
PRIDEiO15042.

PTM databases

PhosphoSiteiO15042.

Miscellaneous databases

PMAP-CutDBO15042.

Expressioni

Gene expression databases

ArrayExpressiO15042.
BgeeiO15042.
GenevestigatoriO15042.

Organism-specific databases

HPAiHPA037545.

Interactioni

Subunit structurei

Interacts with ERBB4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RBM10P981752EBI-310697,EBI-721525
RBM5P527562EBI-310697,EBI-714003

Protein-protein interaction databases

BioGridi116932. 32 interactions.
IntActiO15042. 18 interactions.
MINTiMINT-2795506.

Structurei

3D structure databases

ProteinModelPortaliO15042.
SMRiO15042. Positions 276-353, 538-675.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini274 – 35582RRM
Add
BLAST
Repeati430 – 47344SURP motif
Add
BLAST
Domaini534 – 679146CID
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili92 – 12130 Reviewed prediction
Add
BLAST
Coiled coili192 – 23241 Reviewed prediction
Add
BLAST
Coiled coili837 – 91579 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi357 – 40246Pro-rich
Add
BLAST
Compositional biasi689 – 74658Asp-rich
Add
BLAST
Compositional biasi762 – 917156Glu-rich
Add
BLAST
Compositional biasi922 – 100180Arg/Ser-rich
Add
BLAST

Sequence similaritiesi

Contains 1 CID domain.
Contains 1 SURP motif repeat.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG307351.
HOGENOMiHOG000286037.
HOVERGENiHBG093996.
InParanoidiO15042.
KOiK12842.
OMAiANSPTKW.
OrthoDBiEOG74FF05.
PhylomeDBiO15042.
TreeFamiTF318729.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR013170. mRNA_splic_Cwf21.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF08312. cwf21. 1 hit.
PF00076. RRM_1. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]
SMARTiSM00582. RPR. 1 hit.
SM00360. RRM. 1 hit.
SM00648. SWAP. 1 hit.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
PS50102. RRM. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15042-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP     50
RKHNYRNESA RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE 100
QEELKKKEDE KAAAEIYEEF LAAFEGSDGN KVKTFVRGGV VNAAKEEHET 150
DEKRGKIYKP SSRFADQKNP PNQSSNERPP SLLVIETKKP PLKKGEKEKK 200
KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG QRRSMDAPSR 250
RNRSSGVLDD YAPGSHDVGD PSTTNLYLGN INPQMNEEML CQEFGRFGPL 300
ASVKIMWPRT DEERARERNC GFVAFMNRRD AERALKNLNG KMIMSFEMKL 350
GWGKAVPIPP HPIYIPPSMM EHTLPPPPSG LPFNAQPRER LKNPNAPMLP 400
PPKNKEDFEK TLSQAIVKVV IPTERNLLAL IHRMIEFVVR EGPMFEAMIM 450
NREINNPMFR FLFENQTPAH VYYRWKLYSI LQGDSPTKWR TEDFRMFKNG 500
SFWRPPPLNP YLHGMSEEQE TEAFVEEPSK KGALKEEQRD KLEEILRGLT 550
PRKNDIGDAM VFCLNNAEAA EEIVDCITES LSILKTPLPK KIARLYLVSD 600
VLYNSSAKVA NASYYRKFFE TKLCQIFSDL NATYRTIQGH LQSENFKQRV 650
MTCFRAWEDW AIYPEPFLIK LQNIFLGLVN IIEEKETEDV PDDLDGAPIE 700
EELDGAPLED VDGIPIDATP IDDLDGVPIK SLDDDLDGVP LDATEDSKKN 750
EPIFKVAPSK WEAVDESELE AQAVTTSKWE LFDQHEESEE EENQNQEEES 800
EDEEDTQSSK SEEHHLYSNP IKEEMTESKF SKYSEMSEEK RAKLREIELK 850
VMKFQDELES GKRPKKPGQS FQEQVEHYRD KLLQREKEKE LERERERDKK 900
DKEKLESRSK DKKEKDECTP TRKERKRRHS TSPSPSRSSS GRRVKSPSPK 950
SERSERSERS HKESSRSRSS HKDSPRDVSK KAKRSPSGSR TPKRSRRSRS 1000
RSPKKSGKKS RSQSRSPHRS HKKSKKNKH 1029
Length:1,029
Mass (Da):118,292
Last modified:March 6, 2007 - v2
Checksum:i7AB9235C63299714
GO
Isoform 2 (identifier: O15042-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-256: Missing.

Show »
Length:1,028
Mass (Da):118,235
Checksum:i626B4D73CC24A992
GO
Isoform 3 (identifier: O15042-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.
     410-424: KTLSQAIVKVVIPTE → MLLCYRHLKTKRILR

Show »
Length:620
Mass (Da):72,523
Checksum:iBA78B39559885CBC
GO

Sequence cautioni

The sequence AAH16323.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAI05605.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 409409Missing in isoform 3.
VSP_023522Add
BLAST
Alternative sequencei256 – 2561Missing in isoform 2.
VSP_023523
Alternative sequencei410 – 42415KTLSQ…VIPTE → MLLCYRHLKTKRILR in isoform 3.
VSP_023524Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC018450 Genomic DNA. No translation available.
AC026304 Genomic DNA. No translation available.
BC006474 mRNA. Translation: AAH06474.1.
BC016323 mRNA. Translation: AAH16323.1. Sequence problems.
BC105604 mRNA. Translation: AAI05605.1. Sequence problems.
BC111692 mRNA. Translation: AAI11693.1.
AB002330 mRNA. Translation: BAA20790.1.
BK000564 mRNA. Translation: DAA00075.1.
CCDSiCCDS46928.1. [O15042-1]
RefSeqiNP_001073884.1. NM_001080415.1. [O15042-1]
XP_005247303.1. XM_005247246.2. [O15042-2]
XP_005247306.1. XM_005247249.2. [O15042-3]
UniGeneiHs.596572.

Genome annotation databases

EnsembliENST00000397933; ENSP00000381027; ENSG00000163714. [O15042-3]
ENST00000473835; ENSP00000418563; ENSG00000163714. [O15042-1]
GeneIDi23350.
KEGGihsa:23350.
UCSCiuc003evh.1. human. [O15042-1]
uc003evi.1. human. [O15042-3]
uc003evk.1. human. [O15042-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC018450 Genomic DNA. No translation available.
AC026304 Genomic DNA. No translation available.
BC006474 mRNA. Translation: AAH06474.1 .
BC016323 mRNA. Translation: AAH16323.1 . Sequence problems.
BC105604 mRNA. Translation: AAI05605.1 . Sequence problems.
BC111692 mRNA. Translation: AAI11693.1 .
AB002330 mRNA. Translation: BAA20790.1 .
BK000564 mRNA. Translation: DAA00075.1 .
CCDSi CCDS46928.1. [O15042-1 ]
RefSeqi NP_001073884.1. NM_001080415.1. [O15042-1 ]
XP_005247303.1. XM_005247246.2. [O15042-2 ]
XP_005247306.1. XM_005247249.2. [O15042-3 ]
UniGenei Hs.596572.

3D structure databases

ProteinModelPortali O15042.
SMRi O15042. Positions 276-353, 538-675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116932. 32 interactions.
IntActi O15042. 18 interactions.
MINTi MINT-2795506.

PTM databases

PhosphoSitei O15042.

Proteomic databases

MaxQBi O15042.
PaxDbi O15042.
PRIDEi O15042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397933 ; ENSP00000381027 ; ENSG00000163714 . [O15042-3 ]
ENST00000473835 ; ENSP00000418563 ; ENSG00000163714 . [O15042-1 ]
GeneIDi 23350.
KEGGi hsa:23350.
UCSCi uc003evh.1. human. [O15042-1 ]
uc003evi.1. human. [O15042-3 ]
uc003evk.1. human. [O15042-2 ]

Organism-specific databases

CTDi 23350.
GeneCardsi GC03P142720.
H-InvDB HIX0003746.
HGNCi HGNC:30855. U2SURP.
HPAi HPA037545.
neXtProti NX_O15042.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307351.
HOGENOMi HOG000286037.
HOVERGENi HBG093996.
InParanoidi O15042.
KOi K12842.
OMAi ANSPTKW.
OrthoDBi EOG74FF05.
PhylomeDBi O15042.
TreeFami TF318729.

Miscellaneous databases

ChiTaRSi u2surp. human.
GenomeRNAii 23350.
NextBioi 45335.
PMAP-CutDB O15042.
PROi O15042.

Gene expression databases

ArrayExpressi O15042.
Bgeei O15042.
Genevestigatori O15042.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR013170. mRNA_splic_Cwf21.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000061. Surp.
[Graphical view ]
Pfami PF08312. cwf21. 1 hit.
PF00076. RRM_1. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view ]
SMARTi SM00582. RPR. 1 hit.
SM00360. RRM. 1 hit.
SM00648. SWAP. 1 hit.
[Graphical view ]
SUPFAMi SSF109905. SSF109905. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEi PS51391. CID. 1 hit.
PS50102. RRM. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1029 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-189 (ISOFORMS 1/2).
    Tissue: Lung and Urinary bladder.
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1029 (ISOFORM 1).
    Tissue: Brain.
  4. "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein."
    Will C.L., Urlaub H., Achsel T., Gentzel M., Wilm M., Luehrmann R.
    EMBO J. 21:4978-4988(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-788 AND SER-800, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-788 AND SER-800, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-760, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."
    Gilmore-Hebert M., Ramabhadran R., Stern D.F.
    Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH ERBB4, SUBCELLULAR LOCATION.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-485; SER-811; THR-931; SER-946 AND SER-948, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202; SER-485; SER-788 AND SER-811, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSR140_HUMAN
AccessioniPrimary (citable) accession number: O15042
Secondary accession number(s): A0PJ60
, Q0D2M1, Q2NKQ7, Q9BR70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi