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Protein

U2 snRNP-associated SURP motif-containing protein

Gene

U2SURP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U2 snRNP-associated SURP motif-containing protein
Alternative name(s):
140 kDa Ser/Arg-rich domain protein
U2-associated protein SR140
Gene namesi
Name:U2SURP
Synonyms:KIAA0332, SR140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30855. U2SURP.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23350.
OpenTargetsiENSG00000163714.

Polymorphism and mutation databases

BioMutaiU2SURP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002800702 – 1029U2 snRNP-associated SURP motif-containing proteinAdd BLAST1028

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki168Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei202PhosphoserineCombined sources1
Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei236PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1
Modified residuei719PhosphothreonineCombined sources1
Cross-linki748Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki749Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei760N6-acetyllysine; alternateCombined sources1
Cross-linki760Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei788PhosphoserineCombined sources1
Modified residuei800PhosphoserineCombined sources1
Modified residuei811PhosphoserineCombined sources1
Cross-linki822Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki829Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki832Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei931PhosphothreonineCombined sources1
Modified residuei946PhosphoserineCombined sources1
Modified residuei948PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO15042.
MaxQBiO15042.
PaxDbiO15042.
PeptideAtlasiO15042.
PRIDEiO15042.

PTM databases

iPTMnetiO15042.
PhosphoSitePlusiO15042.
SwissPalmiO15042.

Miscellaneous databases

PMAP-CutDBiO15042.

Expressioni

Gene expression databases

BgeeiENSG00000163714.
ExpressionAtlasiO15042. baseline and differential.
GenevisibleiO15042. HS.

Organism-specific databases

HPAiHPA037545.
HPA037546.
HPA061407.

Interactioni

Subunit structurei

Interacts with ERBB4.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116932. 59 interactors.
IntActiO15042. 24 interactors.
MINTiMINT-2795506.
STRINGi9606.ENSP00000322376.

Structurei

3D structure databases

ProteinModelPortaliO15042.
SMRiO15042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 355RRMPROSITE-ProRule annotationAdd BLAST82
Repeati430 – 473SURP motifAdd BLAST44
Domaini534 – 679CIDPROSITE-ProRule annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili92 – 121Sequence analysisAdd BLAST30
Coiled coili192 – 232Sequence analysisAdd BLAST41
Coiled coili837 – 915Sequence analysisAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi357 – 402Pro-richAdd BLAST46
Compositional biasi689 – 746Asp-richAdd BLAST58
Compositional biasi762 – 917Glu-richAdd BLAST156
Compositional biasi922 – 1001Arg/Ser-richAdd BLAST80

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0151. Eukaryota.
ENOG410XSUI. LUCA.
GeneTreeiENSGT00390000010687.
HOGENOMiHOG000286037.
HOVERGENiHBG093996.
InParanoidiO15042.
KOiK12842.
OMAiHNCTVKV.
OrthoDBiEOG091G035C.
PhylomeDBiO15042.
TreeFamiTF318729.

Family and domain databases

CDDicd12223. RRM_SR140. 1 hit.
Gene3Di1.25.40.90. 1 hit.
InterProiView protein in InterPro
IPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR013170. mRNA_splic_Cwf21_dom.
IPR000504. RRM_dom.
IPR035009. SR140_RRM.
IPR000061. Surp.
PfamiView protein in Pfam
PF08312. cwf21. 1 hit.
PF00076. RRM_1. 1 hit.
PF01805. Surp. 1 hit.
SMARTiView protein in SMART
SM01115. cwf21. 1 hit.
SM00582. RPR. 1 hit.
SM00360. RRM. 1 hit.
SM00648. SWAP. 1 hit.
SUPFAMiSSF109905. SSF109905. 1 hit.
SSF48464. SSF48464. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS51391. CID. 1 hit.
PS50102. RRM. 1 hit.
PS50128. SURP. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15042-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP
60 70 80 90 100
RKHNYRNESA RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE
110 120 130 140 150
QEELKKKEDE KAAAEIYEEF LAAFEGSDGN KVKTFVRGGV VNAAKEEHET
160 170 180 190 200
DEKRGKIYKP SSRFADQKNP PNQSSNERPP SLLVIETKKP PLKKGEKEKK
210 220 230 240 250
KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG QRRSMDAPSR
260 270 280 290 300
RNRSSGVLDD YAPGSHDVGD PSTTNLYLGN INPQMNEEML CQEFGRFGPL
310 320 330 340 350
ASVKIMWPRT DEERARERNC GFVAFMNRRD AERALKNLNG KMIMSFEMKL
360 370 380 390 400
GWGKAVPIPP HPIYIPPSMM EHTLPPPPSG LPFNAQPRER LKNPNAPMLP
410 420 430 440 450
PPKNKEDFEK TLSQAIVKVV IPTERNLLAL IHRMIEFVVR EGPMFEAMIM
460 470 480 490 500
NREINNPMFR FLFENQTPAH VYYRWKLYSI LQGDSPTKWR TEDFRMFKNG
510 520 530 540 550
SFWRPPPLNP YLHGMSEEQE TEAFVEEPSK KGALKEEQRD KLEEILRGLT
560 570 580 590 600
PRKNDIGDAM VFCLNNAEAA EEIVDCITES LSILKTPLPK KIARLYLVSD
610 620 630 640 650
VLYNSSAKVA NASYYRKFFE TKLCQIFSDL NATYRTIQGH LQSENFKQRV
660 670 680 690 700
MTCFRAWEDW AIYPEPFLIK LQNIFLGLVN IIEEKETEDV PDDLDGAPIE
710 720 730 740 750
EELDGAPLED VDGIPIDATP IDDLDGVPIK SLDDDLDGVP LDATEDSKKN
760 770 780 790 800
EPIFKVAPSK WEAVDESELE AQAVTTSKWE LFDQHEESEE EENQNQEEES
810 820 830 840 850
EDEEDTQSSK SEEHHLYSNP IKEEMTESKF SKYSEMSEEK RAKLREIELK
860 870 880 890 900
VMKFQDELES GKRPKKPGQS FQEQVEHYRD KLLQREKEKE LERERERDKK
910 920 930 940 950
DKEKLESRSK DKKEKDECTP TRKERKRRHS TSPSPSRSSS GRRVKSPSPK
960 970 980 990 1000
SERSERSERS HKESSRSRSS HKDSPRDVSK KAKRSPSGSR TPKRSRRSRS
1010 1020
RSPKKSGKKS RSQSRSPHRS HKKSKKNKH
Length:1,029
Mass (Da):118,292
Last modified:March 6, 2007 - v2
Checksum:i7AB9235C63299714
GO
Isoform 2 (identifier: O15042-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-256: Missing.

Show »
Length:1,028
Mass (Da):118,235
Checksum:i626B4D73CC24A992
GO
Isoform 3 (identifier: O15042-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.
     410-424: KTLSQAIVKVVIPTE → MLLCYRHLKTKRILR

Show »
Length:620
Mass (Da):72,523
Checksum:iBA78B39559885CBC
GO

Sequence cautioni

The sequence AAH16323 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI05605 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0235221 – 409Missing in isoform 3. 1 PublicationAdd BLAST409
Alternative sequenceiVSP_023523256Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_023524410 – 424KTLSQ…VIPTE → MLLCYRHLKTKRILR in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018450 Genomic DNA. No translation available.
AC026304 Genomic DNA. No translation available.
BC006474 mRNA. Translation: AAH06474.1.
BC016323 mRNA. Translation: AAH16323.1. Sequence problems.
BC105604 mRNA. Translation: AAI05605.1. Sequence problems.
BC111692 mRNA. Translation: AAI11693.1.
AB002330 mRNA. Translation: BAA20790.1.
BK000564 mRNA. Translation: DAA00075.1.
CCDSiCCDS46928.1. [O15042-1]
RefSeqiNP_001073884.1. NM_001080415.1. [O15042-1]
NP_001307148.1. NM_001320219.1. [O15042-2]
NP_001307149.1. NM_001320220.1. [O15042-3]
NP_001307151.1. NM_001320222.1.
XP_016861527.1. XM_017006038.1. [O15042-3]
XP_016861528.1. XM_017006039.1. [O15042-3]
UniGeneiHs.596572.

Genome annotation databases

EnsembliENST00000473835; ENSP00000418563; ENSG00000163714. [O15042-1]
GeneIDi23350.
KEGGihsa:23350.
UCSCiuc003evh.2. human. [O15042-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSR140_HUMAN
AccessioniPrimary (citable) accession number: O15042
Secondary accession number(s): A0PJ60
, Q0D2M1, Q2NKQ7, Q9BR70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: August 30, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families