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O15041

- SEM3E_HUMAN

UniProt

O15041 - SEM3E_HUMAN

Protein

Semaphorin-3E

Gene

SEMA3E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor activity Source: InterPro

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. negative regulation of angiogenesis Source: UniProtKB
    3. negative regulation of cell-matrix adhesion Source: UniProtKB
    4. patterning of blood vessels Source: UniProtKB
    5. regulation of actin cytoskeleton reorganization Source: UniProtKB
    6. regulation of cell shape Source: UniProtKB
    7. semaphorin-plexin signaling pathway Source: UniProtKB
    8. sprouting angiogenesis Source: UniProtKB
    9. synapse organization Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Angiogenesis, Differentiation, Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_19200. Other semaphorin interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-3E
    Gene namesi
    Name:SEMA3E
    Synonyms:KIAA0331, SEMAH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:10727. SEMA3E.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: ProtInc
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti138. CHARGE syndrome.
    PharmGKBiPA35649.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 775750Semaphorin-3EPRO_0000032317Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi105 ↔ 115By similarity
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 142By similarity
    Disulfide bondi270 ↔ 382By similarity
    Disulfide bondi294 ↔ 342By similarity
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi519 ↔ 537By similarity
    Glycosylationi595 – 5951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi654 ↔ 729By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO15041.
    PRIDEiO15041.

    PTM databases

    PhosphoSiteiO15041.

    Expressioni

    Gene expression databases

    ArrayExpressiO15041.
    BgeeiO15041.
    CleanExiHS_SEMA3E.
    GenevestigatoriO15041.

    Organism-specific databases

    HPAiHPA029419.

    Interactioni

    Subunit structurei

    Interacts with PLXND1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PLXND1Q9Y4D72EBI-7283693,EBI-310731

    Protein-protein interaction databases

    IntActiO15041. 1 interaction.
    MINTiMINT-4507944.
    STRINGi9606.ENSP00000303212.

    Structurei

    3D structure databases

    ProteinModelPortaliO15041.
    SMRiO15041. Positions 31-567, 590-660.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 516485SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini581 – 66989Ig-like C2-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi737 – 77034Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG324739.
    HOGENOMiHOG000039964.
    HOVERGENiHBG055071.
    InParanoidiO15041.
    KOiK06840.
    OMAiEIHWPST.
    OrthoDBiEOG7M0NQV.
    PhylomeDBiO15041.
    TreeFamiTF352628.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    IPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015513. Semaphorin_3E.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PTHR11036:SF22. PTHR11036:SF22. 1 hit.
    PfamiPF00047. ig. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15041-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASAGHIITL LLWGYLLELW TGGHTADTTH PRLRLSHKEL LNLNRTSIFH    50
    SPFGFLDLHT MLLDEYQERL FVGGRDLVYS LSLERISDGY KEIHWPSTAL 100
    KMEECIMKGK DAGECANYVR VLHHYNRTHL LTCGTGAFDP VCAFIRVGYH 150
    LEDPLFHLES PRSERGRGRC PFDPSSSFIS TLIGSELFAG LYSDYWSRDA 200
    AIFRSMGRLA HIRTEHDDER LLKEPKFVGS YMIPDNEDRD DNKVYFFFTE 250
    KALEAENNAH AIYTRVGRLC VNDVGGQRIL VNKWSTFLKA RLVCSVPGMN 300
    GIDTYFDELE DVFLLPTRDH KNPVIFGLFN TTSNIFRGHA ICVYHMSSIR 350
    AAFNGPYAHK EGPEYHWSVY EGKVPYPRPG SCASKVNGGR YGTTKDYPDD 400
    AIRFARSHPL MYQAIKPAHK KPILVKTDGK YNLKQIAVDR VEAEDGQYDV 450
    LFIGTDNGIV LKVITIYNQE MESMEEVILE ELQIFKDPVP IISMEISSKR 500
    QQLYIGSASA VAQVRFHHCD MYGSACADCC LARDPYCAWD GISCSRYYPT 550
    GTHAKRRFRR QDVRHGNAAQ QCFGQQFVGD ALDKTEEHLA YGIENNSTLL 600
    ECTPRSLQAK VIWFVQKGRE TRKEEVKTDD RVVKMDLGLL FLRLHKSDAG 650
    TYFCQTVEHS FVHTVRKITL EVVEEEKVED MFNKDDEEDR HHRMPCPAQS 700
    SISQGAKPWY KEFLQLIGYS NFQRVEEYCE KVWCTDRKRK KLKMSPSKWK 750
    YANPQEKKLR SKPEHYRLPR HTLDS 775
    Length:775
    Mass (Da):89,228
    Last modified:January 1, 1998 - v1
    Checksum:iCD6079C1AE48F779
    GO
    Isoform 2 (identifier: O15041-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:715
    Mass (Da):82,424
    Checksum:iF50FFAD229C17EAA
    GO

    Sequence cautioni

    The sequence BAA20789.2 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6060Missing in isoform 2. 1 PublicationVSP_046237Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002329 mRNA. Translation: BAA20789.2. Different initiation.
    AK303925 mRNA. Translation: BAG64853.1.
    AC004954 Genomic DNA. Translation: AAC69513.1.
    AC006204 Genomic DNA. No translation available.
    AC079799 Genomic DNA. Translation: AAS07488.1.
    AC079987 Genomic DNA. Translation: AAS07487.1.
    CCDSiCCDS34674.1. [O15041-1]
    CCDS55121.1. [O15041-2]
    RefSeqiNP_001171600.1. NM_001178129.1. [O15041-2]
    NP_036563.1. NM_012431.2. [O15041-1]
    UniGeneiHs.528721.

    Genome annotation databases

    EnsembliENST00000307792; ENSP00000303212; ENSG00000170381. [O15041-1]
    ENST00000427262; ENSP00000405052; ENSG00000170381. [O15041-2]
    GeneIDi9723.
    KEGGihsa:9723.
    UCSCiuc003uhy.2. human. [O15041-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002329 mRNA. Translation: BAA20789.2 . Different initiation.
    AK303925 mRNA. Translation: BAG64853.1 .
    AC004954 Genomic DNA. Translation: AAC69513.1 .
    AC006204 Genomic DNA. No translation available.
    AC079799 Genomic DNA. Translation: AAS07488.1 .
    AC079987 Genomic DNA. Translation: AAS07487.1 .
    CCDSi CCDS34674.1. [O15041-1 ]
    CCDS55121.1. [O15041-2 ]
    RefSeqi NP_001171600.1. NM_001178129.1. [O15041-2 ]
    NP_036563.1. NM_012431.2. [O15041-1 ]
    UniGenei Hs.528721.

    3D structure databases

    ProteinModelPortali O15041.
    SMRi O15041. Positions 31-567, 590-660.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O15041. 1 interaction.
    MINTi MINT-4507944.
    STRINGi 9606.ENSP00000303212.

    PTM databases

    PhosphoSitei O15041.

    Proteomic databases

    PaxDbi O15041.
    PRIDEi O15041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307792 ; ENSP00000303212 ; ENSG00000170381 . [O15041-1 ]
    ENST00000427262 ; ENSP00000405052 ; ENSG00000170381 . [O15041-2 ]
    GeneIDi 9723.
    KEGGi hsa:9723.
    UCSCi uc003uhy.2. human. [O15041-1 ]

    Organism-specific databases

    CTDi 9723.
    GeneCardsi GC07M082993.
    HGNCi HGNC:10727. SEMA3E.
    HPAi HPA029419.
    MIMi 608166. gene.
    neXtProti NX_O15041.
    Orphaneti 138. CHARGE syndrome.
    PharmGKBi PA35649.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG324739.
    HOGENOMi HOG000039964.
    HOVERGENi HBG055071.
    InParanoidi O15041.
    KOi K06840.
    OMAi EIHWPST.
    OrthoDBi EOG7M0NQV.
    PhylomeDBi O15041.
    TreeFami TF352628.

    Enzyme and pathway databases

    Reactomei REACT_19200. Other semaphorin interactions.

    Miscellaneous databases

    GenomeRNAii 9723.
    NextBioi 36577.
    PROi O15041.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15041.
    Bgeei O15041.
    CleanExi HS_SEMA3E.
    Genevestigatori O15041.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    IPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015513. Semaphorin_3E.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    PTHR11036:SF22. PTHR11036:SF22. 1 hit.
    Pfami PF00047. ig. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Trachea.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSEM3E_HUMAN
    AccessioniPrimary (citable) accession number: O15041
    Secondary accession number(s): B4E1P1, Q75M94, Q75M97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3