O15040 (TCPR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tectonin beta-propeller repeat-containing protein 2

Alternative name(s):
WD repeat-containing protein KIAA0329/KIAA0297

Gene names

Name:	TECPR2
Synonyms:	KIAA0297, KIAA0329

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1411 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the WD repeat KIAA0329 family. Contains 6 TECPR repeats. Contains 3 WD repeats.
Sequence caution	The sequence BAA20787.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GABARAP	O95166	2	EBI-2946991,EBI-712001
GABARAPL1	Q9H0R8	2	EBI-2946991,EBI-746969
GABARAPL2	P60520	2	EBI-2946991,EBI-720116
MAP1LC3C	Q9BXW4	2	EBI-2946991,EBI-2603996

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15040-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15040-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1264-1267: PAGV → VSRS
     1268-1411: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1411	1411	Tectonin beta-propeller repeat-containing protein 2		PRO_0000050747
Regions
	Repeat	30 – 71	42	WD 1
	Repeat	125 – 163	39	WD 2
	Repeat	170 – 207	38	WD 3
	Repeat	945 – 976	32	TECPR 1
	Repeat	994 – 1027	34	TECPR 2
	Repeat	1179 – 1209	31	TECPR 3
	Repeat	1226 – 1259	34	TECPR 4
	Repeat	1279 – 1310	32	TECPR 5
	Repeat	1322 – 1353	32	TECPR 6
	Compositional bias	462 – 471	10	Poly-Lys
Natural variations
	Alternative sequence	1264 – 1267	4	PAGV → VSRS in isoform 2.		VSP_044793
	Alternative sequence	1268 – 1411	144	Missing in isoform 2.		VSP_044794
	Natural variant	320	1	V → I. Ref.1 Ref.4 Corresponds to variant rs1309353 [ dbSNP | Ensembl ].		VAR_046529
	Natural variant	386	1	A → T. Corresponds to variant rs11845676 [ dbSNP | Ensembl ].		VAR_046530
	Natural variant	439	1	P → S. Corresponds to variant rs2273906 [ dbSNP | Ensembl ].		VAR_046531
	Natural variant	683	1	I → V. Corresponds to variant rs10149146 [ dbSNP | Ensembl ].		VAR_046532
Experimental info
	Sequence conflict	60	1	Y → H in AAI42668. Ref.4
	Sequence conflict	60	1	Y → H in AAI42716. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 4. Checksum: 7B7C699A614AD547	FASTA	1,411	153,848
	10 20 30 40 50 60 MASISEPVTF REFCPLYYLL NAIPTKIQKG FRSIVVYLTA LDTNGDYIAV GSSIGMLYLY 70 80 90 100 110 120 CRHLNQMRKY NFEGKTESIT VVKLLSCFDD LVAAGTASGR VAVFQLVSSL PGRNKQLRRF 130 140 150 160 170 180 DVTGIHKNSI TALAWSPNGM KLFSGDDKGK IVYSSLDLDQ GLCNSQLVLE EPSSIVQLDY 190 200 210 220 230 240 SQKVLLVSTL QRSLLFYTEE KSVRQIGTQP RKSTGKFGAC FIPGLCKQSD LTLYASRPGL 250 260 270 280 290 300 RLWKADVHGT VQATFILKDA FAGGVKPFEL HPRLESPNSG SCSLPERHLG LVSCFFQEGW 310 320 330 340 350 360 VLSWNEYSIY LLDTVNQATV AGLEGSGDIV SVSCTENEIF FLKGDRNIIR ISSRPEGLTS 370 380 390 400 410 420 TVRDGLEMSG CSERVHVQQA EKLPGATVSE TRLRGSSMAS SVASEPRSRS SSLNSTDSGS 430 440 450 460 470 480 GLLPPGLQAT PELGKGSQPL SQRFNAISSE DFDQELVVKP IKVKRKKKKK KTEGGSRSTC 490 500 510 520 530 540 HSSLESTPCS EFPGDSPQSL NTDLLSMTSS VLGSSVDQLS AESPDQESSF NGEVNGVPQE 550 560 570 580 590 600 NTDPETFNVL EVSGSMPDSL AEEDDIRTEM PHCHHAHGRE LLNGAREDVG GSDVTGLGDE 610 620 630 640 650 660 PCPADDGPNS TQLPFQEQDS SPGAHDGEDI QPIGPQSTFC EVPLLNSLTV PSSLSWAPSA 670 680 690 700 710 720 EQWLPGTRAD EGSPVEPSQE QDILTSMEAS GHLSTNLWHA VTDDDTGQKE IPISERVLGS 730 740 750 760 770 780 VGGQLTPVSA LAASTHKPWL EQPPRDQTLT SSDEEDIYAH GLPSSSSETS VTELGPSCSQ 790 800 810 820 830 840 QDLSRLGAED AGLLKPDQFA ESWMGYSGPG YGILSLVVSE KYIWCLDYKG GLFCSALPGA 850 860 870 880 890 900 GLRWQKFEDA VQQVAVSPSG ALLWKIEQKS NRAFACGKVT IKGKRHWYEA LPQAVFVALS 910 920 930 940 950 960 DDTAWIIRTS GDLYLQTGLS VDRPCARAVK VDCPYPLSQI TARNNVVWAL TEQRALLYRE 970 980 990 1000 1010 1020 GVSSFCPEGE QWKCDIVSER QALEPVCITL GDQQTLWALD IHGNLWFRTG IISKKPQGDD 1030 1040 1050 1060 1070 1080 DHWWQVSITD YVVFDQCSLF QTIIHATHSV ATAAQAPVEK VADKLRMAFW SQQLQCQPSL 1090 1100 1110 1120 1130 1140 LGVNNSGVWI SSGKNEFHVA KGSLIGTYWN HVVPRGTASA TKWAFVLASA APTKEGSFLW 1150 1160 1170 1180 1190 1200 LCQSSKDLCS VSAQSAQSRP STVQLPPEAE MRAYAACQDA LWALDSLGQV FIRTLSKSCP 1210 1220 1230 1240 1250 1260 TGMHWTRLDL SQLGAVKLTS LACGNQHIWA CDSRGGVYFR VGTQPLNPSL MLPAWIMIEP 1270 1280 1290 1300 1310 1320 PVQPAGVSLV SVHSSPNDQM LWVLDSRWNV HVRTGITEEM PVGTAWEHVP GLQACQLALS 1330 1340 1350 1360 1370 1380 TRTVWARCPN GDLARRYGVT DKNPAGDYWK KIPGSVSCFT VTASDELWAV GPPGYLLQRL 1390 1400 1410 TKTFSHSHGT QKSSQAAMPH PEDLEDEWEV I
	Isoform 2 [UniParc]. Checksum: 062E4192DD8856DC	FASTA	1,267	137,944
	10 20 30 40 50 60 MASISEPVTF REFCPLYYLL NAIPTKIQKG FRSIVVYLTA LDTNGDYIAV GSSIGMLYLY 70 80 90 100 110 120 CRHLNQMRKY NFEGKTESIT VVKLLSCFDD LVAAGTASGR VAVFQLVSSL PGRNKQLRRF 130 140 150 160 170 180 DVTGIHKNSI TALAWSPNGM KLFSGDDKGK IVYSSLDLDQ GLCNSQLVLE EPSSIVQLDY 190 200 210 220 230 240 SQKVLLVSTL QRSLLFYTEE KSVRQIGTQP RKSTGKFGAC FIPGLCKQSD LTLYASRPGL 250 260 270 280 290 300 RLWKADVHGT VQATFILKDA FAGGVKPFEL HPRLESPNSG SCSLPERHLG LVSCFFQEGW 310 320 330 340 350 360 VLSWNEYSIY LLDTVNQATV AGLEGSGDIV SVSCTENEIF FLKGDRNIIR ISSRPEGLTS 370 380 390 400 410 420 TVRDGLEMSG CSERVHVQQA EKLPGATVSE TRLRGSSMAS SVASEPRSRS SSLNSTDSGS 430 440 450 460 470 480 GLLPPGLQAT PELGKGSQPL SQRFNAISSE DFDQELVVKP IKVKRKKKKK KTEGGSRSTC 490 500 510 520 530 540 HSSLESTPCS EFPGDSPQSL NTDLLSMTSS VLGSSVDQLS AESPDQESSF NGEVNGVPQE 550 560 570 580 590 600 NTDPETFNVL EVSGSMPDSL AEEDDIRTEM PHCHHAHGRE LLNGAREDVG GSDVTGLGDE 610 620 630 640 650 660 PCPADDGPNS TQLPFQEQDS SPGAHDGEDI QPIGPQSTFC EVPLLNSLTV PSSLSWAPSA 670 680 690 700 710 720 EQWLPGTRAD EGSPVEPSQE QDILTSMEAS GHLSTNLWHA VTDDDTGQKE IPISERVLGS 730 740 750 760 770 780 VGGQLTPVSA LAASTHKPWL EQPPRDQTLT SSDEEDIYAH GLPSSSSETS VTELGPSCSQ 790 800 810 820 830 840 QDLSRLGAED AGLLKPDQFA ESWMGYSGPG YGILSLVVSE KYIWCLDYKG GLFCSALPGA 850 860 870 880 890 900 GLRWQKFEDA VQQVAVSPSG ALLWKIEQKS NRAFACGKVT IKGKRHWYEA LPQAVFVALS 910 920 930 940 950 960 DDTAWIIRTS GDLYLQTGLS VDRPCARAVK VDCPYPLSQI TARNNVVWAL TEQRALLYRE 970 980 990 1000 1010 1020 GVSSFCPEGE QWKCDIVSER QALEPVCITL GDQQTLWALD IHGNLWFRTG IISKKPQGDD 1030 1040 1050 1060 1070 1080 DHWWQVSITD YVVFDQCSLF QTIIHATHSV ATAAQAPVEK VADKLRMAFW SQQLQCQPSL 1090 1100 1110 1120 1130 1140 LGVNNSGVWI SSGKNEFHVA KGSLIGTYWN HVVPRGTASA TKWAFVLASA APTKEGSFLW 1150 1160 1170 1180 1190 1200 LCQSSKDLCS VSAQSAQSRP STVQLPPEAE MRAYAACQDA LWALDSLGQV FIRTLSKSCP 1210 1220 1230 1240 1250 1260 TGMHWTRLDL SQLGAVKLTS LACGNQHIWA CDSRGGVYFR VGTQPLNPSL MLPAWIMIEP PVQVSRS

References

[1]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-320. Tissue: Brain.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ILE-320.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB002295 mRNA. Translation: BAA20757.1. AB002327 mRNA. Translation: BAA20787.2. Different initiation. AL137229 Genomic DNA. No translation available. AL136293 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW81789.1. BC136647 mRNA. Translation: AAI36648.1. BC142667 mRNA. Translation: AAI42668.1. BC142715 mRNA. Translation: AAI42716.1. BC151230 mRNA. Translation: AAI51231.1.
IPI	IPI00415054. IPI00444144.
RefSeq	NP_001166102.1. NM_001172631.1. NP_055659.2. NM_014844.3.
UniGene	Hs.195667.
3D structure databases
ProteinModelPortal	O15040.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15040. 5 interactions.
STRING	9606.ENSP00000352510.
PTM databases
PhosphoSite	O15040.
Proteomic databases
PaxDb	O15040.
PRIDE	O15040.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359520; ENSP00000352510; ENSG00000196663. ENST00000558678; ENSP00000453671; ENSG00000196663.
GeneID	9895.
KEGG	hsa:9895.
UCSC	uc001ylw.2. human.
Organism-specific databases
CTD	9895.
GeneCards	GC14P102829.
HGNC	HGNC:19957. TECPR2.
HPA	HPA000658.
MIM	615000. gene.
neXtProt	NX_O15040.
PharmGKB	PA164726437.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG268164.
HOGENOM	HOG000113144.
HOVERGEN	HBG081819.
InParanoid	O15040.
OMA	LDQGVCN.
Gene expression databases
ArrayExpress	O15040.
Bgee	O15040.
CleanEx	HS_KIAA0329.
Genevestigator	O15040.
GermOnline	ENSG00000196663. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR006624. Beta-propeller_rpt_TECPR. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF06462. Hyd_WA. 6 hits. [Graphical view]
SMART	SM00706. TECPR. 10 hits. SM00320. WD40. 3 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9895.
NextBio	37307.
SOURCE	Search...

Entry information

Entry name

TCPR2_HUMAN

Accession

Primary (citable) accession number: O15040
Secondary accession number(s): A5PKY3 , A6NFY9, A7E2X3, H0YMM9, Q9UEG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 102 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.