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Protein

RIMS-binding protein 2

Gene

RIMBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.By similarity

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000060709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RIMS-binding protein 2
Short name:
RIM-BP2
Gene namesi
Name:RIMBP2
Synonyms:KIAA0318, RBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30339. RIMBP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi23504.
OpenTargetsiENSG00000060709.
PharmGKBiPA143485594.

Polymorphism and mutation databases

BioMutaiRIMBP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002213831 – 1052RIMS-binding protein 2Add BLAST1052

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei704PhosphoserineBy similarity1
Modified residuei712PhosphoserineBy similarity1
Modified residuei832PhosphoserineBy similarity1
Modified residuei839PhosphoserineBy similarity1
Modified residuei841PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15034.
PaxDbiO15034.
PeptideAtlasiO15034.
PRIDEiO15034.

PTM databases

iPTMnetiO15034.
PhosphoSitePlusiO15034.

Expressioni

Gene expression databases

BgeeiENSG00000060709.
CleanExiHS_RBP2.
HS_RIMBP2.
ExpressionAtlasiO15034. baseline and differential.
GenevisibleiO15034. HS.

Organism-specific databases

HPAiHPA041494.
HPA044114.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, CACNA1D and CACNA1B, and potentially with other Ca2+ channel alpha-1 isoforms.By similarity

Protein-protein interaction databases

BioGridi117051. 3 interactors.
IntActiO15034. 3 interactors.
STRINGi9606.ENSP00000261655.

Structurei

Secondary structure

11052
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni164 – 166Combined sources3
Beta strandi169 – 176Combined sources8
Helixi180 – 182Combined sources3
Turni188 – 190Combined sources3
Beta strandi199 – 205Combined sources7
Beta strandi208 – 210Combined sources3
Beta strandi213 – 216Combined sources4
Beta strandi228 – 230Combined sources3
Beta strandi491 – 495Combined sources5
Beta strandi503 – 509Combined sources7
Beta strandi519 – 522Combined sources4
Beta strandi524 – 539Combined sources16
Beta strandi545 – 551Combined sources7
Helixi552 – 557Combined sources6
Beta strandi562 – 570Combined sources9
Helixi583 – 586Combined sources4
Beta strandi851 – 854Combined sources4
Turni861 – 863Combined sources3
Beta strandi864 – 866Combined sources3
Helixi868 – 871Combined sources4
Beta strandi882 – 889Combined sources8
Beta strandi894 – 899Combined sources6
Beta strandi902 – 907Combined sources6
Turni908 – 910Combined sources3
Beta strandi911 – 913Combined sources3
Beta strandi955 – 958Combined sources4
Turni965 – 967Combined sources3
Beta strandi971 – 973Combined sources3
Turni974 – 976Combined sources3
Beta strandi985 – 991Combined sources7
Beta strandi994 – 1002Combined sources9
Beta strandi1005 – 1010Combined sources6
Helixi1011 – 1013Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIENMR-A160-242[»]
2CSINMR-A955-1017[»]
2CSPNMR-A477-593[»]
2CSQNMR-A841-924[»]
ProteinModelPortaliO15034.
SMRiO15034.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15034.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 234SH3 1PROSITE-ProRule annotationAdd BLAST68
Domaini297 – 390Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini393 – 475Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST83
Domaini489 – 590Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST102
Domaini848 – 916SH3 2PROSITE-ProRule annotationAdd BLAST69
Domaini952 – 1019SH3 3PROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi582 – 663Pro-richAdd BLAST82

Domaini

The SH3 domains mediate binding to a proline-rich motif in RIMS1, RIMS2, CACNA1D and CACNA1B.By similarity

Sequence similaritiesi

Belongs to the RIMBP family.Curated
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 3 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3632. Eukaryota.
ENOG410XZ8W. LUCA.
GeneTreeiENSGT00390000017228.
HOGENOMiHOG000139176.
HOVERGENiHBG079131.
InParanoidiO15034.
KOiK17591.
OMAiGKGQESA.
OrthoDBiEOG091G02RN.
PhylomeDBiO15034.
TreeFamiTF316230.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00060. FN3. 3 hits.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF50044. SSF50044. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50002. SH3. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15034-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MREAAERRQQ LQLEHDQALA VLSAKQQEID LLQKSKVREL EEKCRTQSEQ
60 70 80 90 100
FNLLSRDLEK FRQHAGKIDL LGGSAVAPLD ISTAPSKPFP QFMNGLATSL
110 120 130 140 150
GKGQESAIGG SSAIGEYIRP LPQPGDRPEP LSAKPTFLSR SGSARCRSES
160 170 180 190 200
DMENERNSNT SKQRYSGKVH LCVARYSYNP FDGPNENPEA ELPLTAGKYL
210 220 230 240 250
YVYGDMDEDG FYEGELLDGQ RGLVPSNFVD FVQDNESRLA STLGNEQDQN
260 270 280 290 300
FINHSGIGLE GEHILDLHSP THIDAGITDN SAGTLDVNID DIGEDIVPYP
310 320 330 340 350
RKITLIKQLA KSVIVGWEPP AVPPGWGTVS SYNVLVDKET RMNLTLGSRT
360 370 380 390 400
KALIEKLNMA ACTYRISVQC VTSRGSSDEL QCTLLVGKDV VVAPSHLRVD
410 420 430 440 450
NITQISAQLS WLPTNSNYSH VIFLNEEEFD IVKAARYKYQ FFNLRPNMAY
460 470 480 490 500
KVKVLAKPHQ MPWQLPLEQR EKKEAFVEFS TLPAGPPAPP QDVTVQAGVT
510 520 530 540 550
PATIRVSWRP PVLTPTGLSN GANVTGYGVY AKGQRVAEVI FPTADSTAVE
560 570 580 590 600
LVRLRSLEAK GVTVRTLSAQ GESVDSAVAA VPPELLVPPT PHPRPAPQSK
610 620 630 640 650
PLASSGVPET KDEHLGPHAR MDEAWEQSRA PGPVHGHMLE PPVGPGRRSP
660 670 680 690 700
SPSRILPQPQ GTPVSTTVAK AMAREAAQRV AESSRLEKRS VFLERSSAGQ
710 720 730 740 750
YAASDEEDAY DSPDFKRRGA SVDDFLKGSE LGKQPHCCHG DEYHTESSRG
760 770 780 790 800
SDLSDIMEED EEELYSEMQL EDGGRRRPSG TSHNALKILG NPASAGRVDH
810 820 830 840 850
MGRRFPRGSA GPQRSRPVTV PSIDDYGRDR LSPDFYEESE TDPGAEELPA
860 870 880 890 900
RIFVALFDYD PLTMSPNPDA AEEELPFKEG QIIKVYGDKD ADGFYRGETC
910 920 930 940 950
ARLGLIPCNM VSEIQADDEE MMDQLLRQGF LPLNTPVEKI ERSRRSGRRH
960 970 980 990 1000
SVSTRRMVAL YDYDPRESSP NVDVEAELTF CTGDIITVFG EIDEDGFYYG
1010 1020 1030 1040 1050
ELNGQKGLVP SNFLEEVPDD VEVYLSDAPS HYSQDTPMRS KAKRKKSVHF

TP
Length:1,052
Mass (Da):116,026
Last modified:June 16, 2009 - v3
Checksum:i065FADD690A7A8BC
GO
Isoform 2 (identifier: O15034-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     735-737: PHC → MVS
     738-1052: Missing.

Show »
Length:645
Mass (Da):70,108
Checksum:i7E978DF41DAB449A
GO
Isoform 3 (identifier: O15034-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-863: Missing.
     1045-1052: KKSVHFTP → VSKPI

Note: No experimental confirmation available.
Show »
Length:186
Mass (Da):20,992
Checksum:i4DAF7B9B3328436B
GO

Sequence cautioni

The sequence BAA20776 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1051T → I in BAA20776 (PubMed:9205841).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057714593P → R.Corresponds to variant rs2292664dbSNPEnsembl.1
Natural variantiVAR_057715888D → N.Corresponds to variant rs11060869dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0092131 – 863Missing in isoform 3. 1 PublicationAdd BLAST863
Alternative sequenceiVSP_0092121 – 92Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_009214735 – 737PHC → MVS in isoform 2. 1 Publication3
Alternative sequenceiVSP_009215738 – 1052Missing in isoform 2. 1 PublicationAdd BLAST315
Alternative sequenceiVSP_0092161045 – 1052KKSVHFTP → VSKPI in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002316 mRNA. Translation: BAA20776.1. Different initiation.
BX641152 mRNA. Translation: CAE46066.1.
AC063926 Genomic DNA. No translation available.
BC007632 mRNA. Translation: AAH07632.1.
CCDSiCCDS31925.1. [O15034-1]
RefSeqiNP_056162.4. NM_015347.4. [O15034-1]
UniGeneiHs.657441.

Genome annotation databases

EnsembliENST00000261655; ENSP00000261655; ENSG00000060709. [O15034-1]
ENST00000535703; ENSP00000440347; ENSG00000060709. [O15034-2]
GeneIDi23504.
KEGGihsa:23504.
UCSCiuc001uil.3. human. [O15034-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002316 mRNA. Translation: BAA20776.1. Different initiation.
BX641152 mRNA. Translation: CAE46066.1.
AC063926 Genomic DNA. No translation available.
BC007632 mRNA. Translation: AAH07632.1.
CCDSiCCDS31925.1. [O15034-1]
RefSeqiNP_056162.4. NM_015347.4. [O15034-1]
UniGeneiHs.657441.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIENMR-A160-242[»]
2CSINMR-A955-1017[»]
2CSPNMR-A477-593[»]
2CSQNMR-A841-924[»]
ProteinModelPortaliO15034.
SMRiO15034.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117051. 3 interactors.
IntActiO15034. 3 interactors.
STRINGi9606.ENSP00000261655.

PTM databases

iPTMnetiO15034.
PhosphoSitePlusiO15034.

Polymorphism and mutation databases

BioMutaiRIMBP2.

Proteomic databases

EPDiO15034.
PaxDbiO15034.
PeptideAtlasiO15034.
PRIDEiO15034.

Protocols and materials databases

DNASUi23504.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261655; ENSP00000261655; ENSG00000060709. [O15034-1]
ENST00000535703; ENSP00000440347; ENSG00000060709. [O15034-2]
GeneIDi23504.
KEGGihsa:23504.
UCSCiuc001uil.3. human. [O15034-1]

Organism-specific databases

CTDi23504.
DisGeNETi23504.
GeneCardsiRIMBP2.
H-InvDBHIX0011135.
HIX0026522.
HGNCiHGNC:30339. RIMBP2.
HPAiHPA041494.
HPA044114.
MIMi611602. gene.
neXtProtiNX_O15034.
OpenTargetsiENSG00000060709.
PharmGKBiPA143485594.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3632. Eukaryota.
ENOG410XZ8W. LUCA.
GeneTreeiENSGT00390000017228.
HOGENOMiHOG000139176.
HOVERGENiHBG079131.
InParanoidiO15034.
KOiK17591.
OMAiGKGQESA.
OrthoDBiEOG091G02RN.
PhylomeDBiO15034.
TreeFamiTF316230.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000060709-MONOMER.

Miscellaneous databases

ChiTaRSiRIMBP2. human.
EvolutionaryTraceiO15034.
GenomeRNAii23504.
PROiO15034.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000060709.
CleanExiHS_RBP2.
HS_RIMBP2.
ExpressionAtlasiO15034. baseline and differential.
GenevisibleiO15034. HS.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00060. FN3. 3 hits.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF50044. SSF50044. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50002. SH3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIMB2_HUMAN
AccessioniPrimary (citable) accession number: O15034
Secondary accession number(s): Q96ID2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 16, 2009
Last modified: November 30, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.