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O15034 (RIMB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RIMS-binding protein 2

Short name=RIM-BP2
Gene names
Name:RIMBP2
Synonyms:KIAA0318, RBP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1052 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B By similarity.

Subunit structure

Interacts with RIMS1, RIMS2, CACNA1D and CACNA1B, and potentially with other Ca2+ channel alpha-1 isoforms By similarity.

Subcellular location

Cell membrane By similarity. Cell junctionsynapse By similarity. Note: Synaptic plasma membrane By similarity.

Domain

The SH3 domains mediate binding to a proline-rich motif in RIMS1, RIMS2, CACNA1D and CACNA1B By similarity.

Sequence similarities

Belongs to the RIMBP family.

Contains 3 fibronectin type-III domains.

Contains 3 SH3 domains.

Sequence caution

The sequence BAA20776.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15034-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15034-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     735-737: PHC → MVS
     738-1052: Missing.
Isoform 3 (identifier: O15034-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-863: Missing.
     1045-1052: KKSVHFTP → VSKPI
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10521052RIMS-binding protein 2
PRO_0000221383

Regions

Domain167 – 23468SH3 1
Domain297 – 39094Fibronectin type-III 1
Domain393 – 47583Fibronectin type-III 2
Domain489 – 590102Fibronectin type-III 3
Domain848 – 91669SH3 2
Domain952 – 101968SH3 3
Compositional bias582 – 66382Pro-rich

Amino acid modifications

Cross-link727Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5
Cross-link733Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5

Natural variations

Alternative sequence1 – 863863Missing in isoform 3.
VSP_009213
Alternative sequence1 – 9292Missing in isoform 2.
VSP_009212
Alternative sequence735 – 7373PHC → MVS in isoform 2.
VSP_009214
Alternative sequence738 – 1052315Missing in isoform 2.
VSP_009215
Alternative sequence1045 – 10528KKSVHFTP → VSKPI in isoform 3.
VSP_009216
Natural variant5931P → R.
Corresponds to variant rs2292664 [ dbSNP | Ensembl ].
VAR_057714
Natural variant8881D → N.
Corresponds to variant rs11060869 [ dbSNP | Ensembl ].
VAR_057715

Experimental info

Sequence conflict10511T → I in BAA20776. Ref.1

Secondary structure

............................................................. 1052
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 16, 2009. Version 3.
Checksum: 065FADD690A7A8BC

FASTA1,052116,026
        10         20         30         40         50         60 
MREAAERRQQ LQLEHDQALA VLSAKQQEID LLQKSKVREL EEKCRTQSEQ FNLLSRDLEK 

        70         80         90        100        110        120 
FRQHAGKIDL LGGSAVAPLD ISTAPSKPFP QFMNGLATSL GKGQESAIGG SSAIGEYIRP 

       130        140        150        160        170        180 
LPQPGDRPEP LSAKPTFLSR SGSARCRSES DMENERNSNT SKQRYSGKVH LCVARYSYNP 

       190        200        210        220        230        240 
FDGPNENPEA ELPLTAGKYL YVYGDMDEDG FYEGELLDGQ RGLVPSNFVD FVQDNESRLA 

       250        260        270        280        290        300 
STLGNEQDQN FINHSGIGLE GEHILDLHSP THIDAGITDN SAGTLDVNID DIGEDIVPYP 

       310        320        330        340        350        360 
RKITLIKQLA KSVIVGWEPP AVPPGWGTVS SYNVLVDKET RMNLTLGSRT KALIEKLNMA 

       370        380        390        400        410        420 
ACTYRISVQC VTSRGSSDEL QCTLLVGKDV VVAPSHLRVD NITQISAQLS WLPTNSNYSH 

       430        440        450        460        470        480 
VIFLNEEEFD IVKAARYKYQ FFNLRPNMAY KVKVLAKPHQ MPWQLPLEQR EKKEAFVEFS 

       490        500        510        520        530        540 
TLPAGPPAPP QDVTVQAGVT PATIRVSWRP PVLTPTGLSN GANVTGYGVY AKGQRVAEVI 

       550        560        570        580        590        600 
FPTADSTAVE LVRLRSLEAK GVTVRTLSAQ GESVDSAVAA VPPELLVPPT PHPRPAPQSK 

       610        620        630        640        650        660 
PLASSGVPET KDEHLGPHAR MDEAWEQSRA PGPVHGHMLE PPVGPGRRSP SPSRILPQPQ 

       670        680        690        700        710        720 
GTPVSTTVAK AMAREAAQRV AESSRLEKRS VFLERSSAGQ YAASDEEDAY DSPDFKRRGA 

       730        740        750        760        770        780 
SVDDFLKGSE LGKQPHCCHG DEYHTESSRG SDLSDIMEED EEELYSEMQL EDGGRRRPSG 

       790        800        810        820        830        840 
TSHNALKILG NPASAGRVDH MGRRFPRGSA GPQRSRPVTV PSIDDYGRDR LSPDFYEESE 

       850        860        870        880        890        900 
TDPGAEELPA RIFVALFDYD PLTMSPNPDA AEEELPFKEG QIIKVYGDKD ADGFYRGETC 

       910        920        930        940        950        960 
ARLGLIPCNM VSEIQADDEE MMDQLLRQGF LPLNTPVEKI ERSRRSGRRH SVSTRRMVAL 

       970        980        990       1000       1010       1020 
YDYDPRESSP NVDVEAELTF CTGDIITVFG EIDEDGFYYG ELNGQKGLVP SNFLEEVPDD 

      1030       1040       1050 
VEVYLSDAPS HYSQDTPMRS KAKRKKSVHF TP 

« Hide

Isoform 2 [UniParc].

Checksum: 7E978DF41DAB449A
Show »

FASTA64570,108
Isoform 3 [UniParc].

Checksum: 4DAF7B9B3328436B
Show »

FASTA18620,992

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Fetal kidney.
[3]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[5]"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-727 AND LYS-733.
Tissue: Mammary cancer.
[6]"Solution structure of the SH3 domains and FNIII domain of KIAA0318 protein."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 158-244; 477-593 AND 839-1017.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB002316 mRNA. Translation: BAA20776.1. Different initiation.
BX641152 mRNA. Translation: CAE46066.1.
AC063926 Genomic DNA. No translation available.
BC007632 mRNA. Translation: AAH07632.1.
RefSeqNP_056162.4. NM_015347.4.
UniGeneHs.657441.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WIENMR-A160-242[»]
2CSINMR-A955-1017[»]
2CSPNMR-A477-593[»]
2CSQNMR-A841-924[»]
ProteinModelPortalO15034.
SMRO15034. Positions 162-244, 391-593, 839-1019.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117051. 4 interactions.
IntActO15034. 3 interactions.
STRING9606.ENSP00000261655.

PTM databases

PhosphoSiteO15034.

Proteomic databases

PaxDbO15034.
PRIDEO15034.

Protocols and materials databases

DNASU23504.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261655; ENSP00000261655; ENSG00000060709. [O15034-1]
ENST00000535703; ENSP00000440347; ENSG00000060709. [O15034-2]
ENST00000536002; ENSP00000439159; ENSG00000060709. [O15034-2]
GeneID23504.
KEGGhsa:23504.
UCSCuc001uil.2. human. [O15034-1]
uc001uim.3. human. [O15034-2]

Organism-specific databases

CTD23504.
GeneCardsGC12M130880.
H-InvDBHIX0011135.
HIX0026522.
HGNCHGNC:30339. RIMBP2.
HPAHPA041494.
HPA044114.
MIM611602. gene.
neXtProtNX_O15034.
PharmGKBPA143485594.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327664.
HOGENOMHOG000139176.
HOVERGENHBG079131.
InParanoidO15034.
KOK17591.
OMAFNLRPNM.
OrthoDBEOG76738Z.
PhylomeDBO15034.
TreeFamTF316230.

Gene expression databases

ArrayExpressO15034.
BgeeO15034.
CleanExHS_RBP2.
HS_RIMBP2.
GenevestigatorO15034.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00060. FN3. 3 hits.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
SSF50044. SSF50044. 3 hits.
PROSITEPS50853. FN3. 3 hits.
PS50002. SH3. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRIMBP2. human.
EvolutionaryTraceO15034.
GenomeRNAi23504.
NextBio45885.
PROO15034.
SOURCESearch...

Entry information

Entry nameRIMB2_HUMAN
AccessionPrimary (citable) accession number: O15034
Secondary accession number(s): Q96ID2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 16, 2009
Last modified: March 19, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM