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Protein

Protein transport protein Sec16A

Gene

SEC16A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization.2 Publications

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • endoplasmic reticulum organization Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • substantia nigra development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148396-MONOMER.
ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
SIGNORiO15027.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec16A
Alternative name(s):
SEC16 homolog A
Gene namesi
Name:SEC16A
Synonyms:KIAA0310, SEC16, SEC16L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:29006. SEC16A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: HPA
  • Golgi membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9919.
OpenTargetsiENSG00000148396.
PharmGKBiPA162402611.

Polymorphism and mutation databases

BioMutaiSEC16A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507461 – 2179Protein transport protein Sec16AAdd BLAST2179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei415PhosphothreonineCombined sources1
Modified residuei417PhosphoserineCombined sources1
Modified residuei891PhosphoserineCombined sources1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1051PhosphoserineCombined sources1
Modified residuei1127PhosphoserineCombined sources1
Modified residuei1147PhosphothreonineCombined sources1
Modified residuei1149PhosphoserineCombined sources1
Modified residuei1169PhosphoserineCombined sources1
Modified residuei1172PhosphoserineCombined sources1
Modified residuei1178PhosphoserineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1184PhosphoserineCombined sources1
Modified residuei1191PhosphoserineCombined sources1
Modified residuei1395PhosphoserineCombined sources1
Modified residuei1423PhosphoserineCombined sources1
Modified residuei1729PhosphothreonineCombined sources1
Modified residuei1761PhosphoserineCombined sources1
Modified residuei1786PhosphoserineCombined sources1
Modified residuei1844PhosphoserineCombined sources1
Modified residuei1864PhosphoserineCombined sources1
Modified residuei1876PhosphothreonineCombined sources1
Modified residuei1878PhosphoserineCombined sources1
Modified residuei1895PhosphoserineCombined sources1
Modified residuei1905PhosphoserineCombined sources1
Modified residuei2093PhosphoserineCombined sources1
Modified residuei2113PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15027.
MaxQBiO15027.
PaxDbiO15027.
PeptideAtlasiO15027.
PRIDEiO15027.

PTM databases

iPTMnetiO15027.
PhosphoSitePlusiO15027.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at higher levels in the pancreas.1 Publication

Gene expression databases

BgeeiENSG00000148396.
CleanExiHS_SEC16A.
ExpressionAtlasiO15027. baseline and differential.
GenevisibleiO15027. HS.

Organism-specific databases

HPAiHPA005684.

Interactioni

Subunit structurei

SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. Interacts with SEC23A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0076EBI-357515,EBI-5323863

Protein-protein interaction databases

BioGridi115247. 149 interactors.
DIPiDIP-27588N.
IntActiO15027. 119 interactors.
MINTiMINT-1155646.
STRINGi9606.ENSP00000325827.

Structurei

3D structure databases

ProteinModelPortaliO15027.
SMRiO15027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni924 – 1227Required for endoplasmic reticulum localizationAdd BLAST304
Regioni1928 – 2179Required for interaction with SEC23A1 PublicationAdd BLAST252

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi935 – 1003Pro-richAdd BLAST69
Compositional biasi981 – 984Poly-Tyr4
Compositional biasi1413 – 1416Poly-Glu4
Compositional biasi1753 – 2107Pro-richAdd BLAST355

Sequence similaritiesi

Belongs to the SEC16 family.Curated

Phylogenomic databases

eggNOGiKOG1913. Eukaryota.
ENOG4111J6D. LUCA.
GeneTreeiENSGT00530000063746.
HOVERGENiHBG079941.
InParanoidiO15027.
KOiK20353.
PhylomeDBiO15027.

Family and domain databases

InterProiIPR024298. ACE1_Sec16_Sec31.
IPR024880. Sec16.
IPR024340. Sec16_CCD.
[Graphical view]
PANTHERiPTHR13402. PTHR13402. 2 hits.
PfamiPF12932. Sec16. 1 hit.
PF12931. Sec16_C. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15027-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGLDRPLSR QNPHDGVVTP AASPSLPQPG LQMPGQWGPV QGGPQPSGQH
60 70 80 90 100
RSPCPEGPVP SGVPCATSVP HFPTPSILHQ GPGHEQHSPL VAPPAALPSD
110 120 130 140 150
GRDEVSHLQS GSHLANNSDP ESTFRQNPRI VNHWASPELR QNPGVKNEHR
160 170 180 190 200
PASALVNPLA RGDSPENRTH HPLGAGAGSG CAPLEADSGA SGALAMFFQG
210 220 230 240 250
GETENEENLS SEKAGLSGQA DFDDFCSSPG LGRPPAPTHV GAGSLCQALL
260 270 280 290 300
PGPSNEAAGD VWGDTASTGV PDASGSQYEN VENLEFVQNQ EVLPSEPLNL
310 320 330 340 350
DPSSPSDQFR YGPLPGPAVP RHGAVCHTGA PDATLHTVHP DSVSSSYSSR
360 370 380 390 400
SHGRLSGSAR PQELVGTFIQ QEVGKPEDEA SGSFFKQIDS SPVGGETDET
410 420 430 440 450
TVSQNYRGSV SQPSTPSPPK PTGIFQTSAN SSFEPVKSHL VGVKPFEADR
460 470 480 490 500
ANVVGEVRET CVRQKQCRPA AALPDASPGN LEQPPDNMET LCAPQVCPLP
510 520 530 540 550
LNSTTEAVHM LPHAGAPPLD TVYPAPEKRP SARTQGPVKC ESPATTLWAQ
560 570 580 590 600
SELPDFGGNV LLAPAAPALY VCAKPQPPVV QPPEEAMSGQ QSRNPSSAAP
610 620 630 640 650
VQSRGGIGAS ENLENPPKMG EEEALQSQAS SGYASLLSSP PTESLQNPPV
660 670 680 690 700
LIAQPDHSYN LAQPINFSVS LSNSHEKNQS WREALVGDRP AVSSWALGGD
710 720 730 740 750
SGENTSLSGI PTSSVLSLSL PSSVAQSNFP QGSGASEMVS NQPANLLVQP
760 770 780 790 800
PSQPVPENLV PESQKDRKAG SALPGFANSP AGSTSVVLVP PAHGTLVPDG
810 820 830 840 850
NKANHSSHQE DTYGALDFTL SRTLENPVNV YNPSHSDSLA SQQSVASHPR
860 870 880 890 900
QSGPGAPNLD RFYQQVTKDA QGQPGLERAQ QELVPPQQQA SPPQLPKAMF
910 920 930 940 950
SELSNPESLP AQGQAQNSAQ SPASLVLVDA GQQLPPRPPQ SSSVSLVSSG
960 970 980 990 1000
SGQAAVPSEQ PWPQPVPALA PGPPPQDLAA YYYYRPLYDA YQPQYSLPYP
1010 1020 1030 1040 1050
PEPGAASLYY QDVYSLYEPR YRPYDGAASA YAQNYRYPEP ERPSSRASHS
1060 1070 1080 1090 1100
SERPPPRQGY PEGYYSSKSG WSSQSDYYAS YYSSQYDYGD PGHWDRYHYS
1110 1120 1130 1140 1150
ARVRDPRTYD RRYWCDAEYD AYRREHSAFG DRPEKRDNNW RYDPRFTGSF
1160 1170 1180 1190 1200
DDDPDPHRDP YGEEVDRRSV HSEHSARSLH SAHSLASRRS SLSSHSHQSQ
1210 1220 1230 1240 1250
IYRSHNVAAG SYEAPLPPGS FHGDFAYGTY RSNFSSGPGF PEYGYPADTV
1260 1270 1280 1290 1300
WPAMEQVSSR PTSPEKFSVP HVCARFGPGG QLIKVIPNLP SEGQPALVEV
1310 1320 1330 1340 1350
HSMEALLQHT SEQEEMRAFP GPLAKDDTHK VDVINFAQNK AMKCLQNENL
1360 1370 1380 1390 1400
IDKESASLLW NFIVLLCRQN GTVVGTDIAE LLLRDHRTVW LPGKSPNEAN
1410 1420 1430 1440 1450
LIDFTNEAVE QVEEEESGEA QLSFLTGGPA AAASSLERET ERFRELLLYG
1460 1470 1480 1490 1500
RKKDALESAM KNGLWGHALL LASKMDSRTH ARVMTRFANS LPINDPLQTV
1510 1520 1530 1540 1550
YQLMSGRMPA ASTCCGDEKW GDWRPHLAMV LSNLNNNMDV ESRTMATMGD
1560 1570 1580 1590 1600
TLASRGLLDA AHFCYLMAQA GFGVYTKKTT KLVLIGSNHS LPFLKFATNE
1610 1620 1630 1640 1650
AIQRTEAYEY AQSLGAETCP LPSFQVFKFI YSCRLAEMGL ATQAFHYCEA
1660 1670 1680 1690 1700
IAKSILTQPH LYSPVLISQL VQMASQLRLF DPQLKEKPEE ESLAAPTWLV
1710 1720 1730 1740 1750
HLQQVERQIK EGAGVWHQDG ALPQQCPGTP SSEMEQLDRP GLSQPGALGI
1760 1770 1780 1790 1800
ANPLLAVPAP SPEHSSPSVR LLPSAPQTLP DGPLASPARV PMFPVPLPPG
1810 1820 1830 1840 1850
PLEPGPGCVT PGPALGFLEP SGPGLPPGVP PLQERRHLLQ EARSPDPGIV
1860 1870 1880 1890 1900
PQEAPVGNSL SELSEENFDG KFANLTPSRT VPDSEAPPGW DRADSGPTQP
1910 1920 1930 1940 1950
PLSLSPAPET KRPGQAAKKE TKEPKKGESW FFRWLPGKKK TEAYLPDDKN
1960 1970 1980 1990 2000
KSIVWDEKKN QWVNLNEPEE EKKAPPPPPT SMPKTVQAAP PALPGPPGAP
2010 2020 2030 2040 2050
VNMYSRRAAG TRARYVDVLN PSGTQRSEPA LAPADFVAPL APLPIPSNLF
2060 2070 2080 2090 2100
VPTPDAEEPQ LPDGTGREGP AAARGLANPE PAPEPKVLSS AASLPGSELP
2110 2120 2130 2140 2150
SSRPEGSQGG ELSRCSSMSS LSREVSQHFN QAPGDLPAAG GPPSGAMPFY
2160 2170
NPAQLAQACA TSGSSRLGRI GQRKHLVLN
Length:2,179
Mass (Da):233,517
Last modified:August 30, 2005 - v3
Checksum:i7E2CB328F87B8211
GO
Isoform 2 (identifier: O15027-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2087-2131: Missing.

Note: No experimental confirmation available.
Show »
Length:2,134
Mass (Da):228,870
Checksum:iFA89ECBF1F97F4F7
GO
Isoform 3 (identifier: O15027-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2112-2131: Missing.

Note: No experimental confirmation available.
Show »
Length:2,159
Mass (Da):231,252
Checksum:iEE0FBD9AE12E80DF
GO
Isoform 4 (identifier: O15027-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2087-2111: Missing.

Show »
Length:2,154
Mass (Da):231,136
Checksum:i51E525859C1AD868
GO
Isoform 5 (identifier: O15027-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2053-2053: T → TPVSSVRPQGRSGRNDGLLALSS

Note: No experimental confirmation available.
Show »
Length:2,201
Mass (Da):235,753
Checksum:iECE7CD89574B3FF5
GO

Sequence cautioni

The sequence BAA20769 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI13949 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI13951 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1099Y → A in AAH28183 (PubMed:15489334).Curated1
Sequence conflicti2101S → P in AAH28183 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023332861R → C.Corresponds to variant rs3812594dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0360292053T → TPVSSVRPQGRSGRNDGLLA LSS in isoform 5. 1 Publication1
Alternative sequenceiVSP_0152522087 – 2131Missing in isoform 2. CuratedAdd BLAST45
Alternative sequenceiVSP_0343702087 – 2111Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0152532112 – 2131Missing in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ903855 mRNA. Translation: ABI78944.1.
AB002308 mRNA. Translation: BAA20769.4. Different initiation.
AL592301 Genomic DNA. Translation: CAI13949.1. Sequence problems.
AL592301 Genomic DNA. Translation: CAI13951.1. Sequence problems.
AL592301 Genomic DNA. Translation: CAI13952.1.
BC008332 mRNA. Translation: AAH08332.1.
BC028183 mRNA. Translation: AAH28183.1.
BC098454 mRNA. Translation: AAH98454.1.
RefSeqiNP_001263347.1. NM_001276418.1.
NP_055681.1. NM_014866.1.
XP_011517554.1. XM_011519252.2.
UniGeneiHs.522500.

Genome annotation databases

EnsembliENST00000371706; ENSP00000360771; ENSG00000148396. [O15027-2]
ENST00000431893; ENSP00000387583; ENSG00000148396. [O15027-4]
GeneIDi9919.
KEGGihsa:9919.
UCSCiuc064xch.1. human. [O15027-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ903855 mRNA. Translation: ABI78944.1.
AB002308 mRNA. Translation: BAA20769.4. Different initiation.
AL592301 Genomic DNA. Translation: CAI13949.1. Sequence problems.
AL592301 Genomic DNA. Translation: CAI13951.1. Sequence problems.
AL592301 Genomic DNA. Translation: CAI13952.1.
BC008332 mRNA. Translation: AAH08332.1.
BC028183 mRNA. Translation: AAH28183.1.
BC098454 mRNA. Translation: AAH98454.1.
RefSeqiNP_001263347.1. NM_001276418.1.
NP_055681.1. NM_014866.1.
XP_011517554.1. XM_011519252.2.
UniGeneiHs.522500.

3D structure databases

ProteinModelPortaliO15027.
SMRiO15027.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115247. 149 interactors.
DIPiDIP-27588N.
IntActiO15027. 119 interactors.
MINTiMINT-1155646.
STRINGi9606.ENSP00000325827.

PTM databases

iPTMnetiO15027.
PhosphoSitePlusiO15027.

Polymorphism and mutation databases

BioMutaiSEC16A.

Proteomic databases

EPDiO15027.
MaxQBiO15027.
PaxDbiO15027.
PeptideAtlasiO15027.
PRIDEiO15027.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371706; ENSP00000360771; ENSG00000148396. [O15027-2]
ENST00000431893; ENSP00000387583; ENSG00000148396. [O15027-4]
GeneIDi9919.
KEGGihsa:9919.
UCSCiuc064xch.1. human. [O15027-1]

Organism-specific databases

CTDi9919.
DisGeNETi9919.
GeneCardsiSEC16A.
H-InvDBHIX0169092.
HGNCiHGNC:29006. SEC16A.
HPAiHPA005684.
MIMi612854. gene.
neXtProtiNX_O15027.
OpenTargetsiENSG00000148396.
PharmGKBiPA162402611.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1913. Eukaryota.
ENOG4111J6D. LUCA.
GeneTreeiENSGT00530000063746.
HOVERGENiHBG079941.
InParanoidiO15027.
KOiK20353.
PhylomeDBiO15027.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148396-MONOMER.
ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
SIGNORiO15027.

Miscellaneous databases

GeneWikiiSEC16A.
GenomeRNAii9919.
PROiO15027.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148396.
CleanExiHS_SEC16A.
ExpressionAtlasiO15027. baseline and differential.
GenevisibleiO15027. HS.

Family and domain databases

InterProiIPR024298. ACE1_Sec16_Sec31.
IPR024880. Sec16.
IPR024340. Sec16_CCD.
[Graphical view]
PANTHERiPTHR13402. PTHR13402. 2 hits.
PfamiPF12932. Sec16. 1 hit.
PF12931. Sec16_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC16A_HUMAN
AccessioniPrimary (citable) accession number: O15027
Secondary accession number(s): A1YCA4
, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 30, 2005
Last modified: November 30, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.