O15021 (MAST4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microtubule-associated serine/threonine-protein kinase 4
EC=2.7.11.1

Gene names

Name:	MAST4
Synonyms:	KIAA0303

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2626 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Subcellular location	Cytoplasm Potential.
Tissue specificity	Highly expressed in most normal human tissues, with an exception of in testis, small intestine, colon and peripheral blood leukocyte. Ref.1
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 PDZ (DHR) domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15021-5)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15021-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: MGEKVSEAPE...ELSLPRRGSL → MDMSDPNFWTVLSNFTLPHLRSGNRLRRTQS
     278-280: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: O15021-4)

The sequence of this isoform differs from the canonical sequence as follows:
     226-250: CRTSNRKSLIGNGQSPALPRPHSPL → IDSQKWNCLVKRPVCPNAGRTSPLG
     251-2626: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: O15021-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: MGEKVSEAPE...ELSLPRRGSL → MKAQRERLQI...SPLLAFHFWS

Isoform 3 (identifier: O15021-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: MGEKVSEAPE...ELSLPRRGSL → MDESSILRRR...SQKWNCLVKR
     278-280: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2626

2626

Microtubule-associated serine/threonine-protein kinase 4

PRO_0000252256

Regions

Domain

573 – 846

274

Protein kinase

Domain

847 – 919

73

AGC-kinase C-terminal

Domain

1144 – 1232

89

PDZ

Nucleotide binding

579 – 587

9

ATP By similarity

Compositional bias

1026 – 1140

115

Ser-rich

Compositional bias

1284 – 1346

63

Ser-rich

Compositional bias

2128 – 2211

84

Pro-rich

Sites

Active site

696

1

Proton acceptor By similarity

Binding site

602

1

ATP By similarity

Amino acid modifications

Modified residue

1526

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 225

225

MGEKV…RRGSL → MDMSDPNFWTVLSNFTLPHL RSGNRLRRTQS in isoform 2.

VSP_020888

Alternative sequence

1 – 225

225

MGEKV…RRGSL → MDESSILRRRGLQKELSLPR RGSLIDSQKWNCLVKR in isoform 3.

VSP_023109

Alternative sequence

1 – 225

225

MGEKV…RRGSL → MKAQRERLQIPGLTLDLTPR SLSPTPSSPGSPCSPLLAFH FWS in isoform 5.

VSP_035851

Alternative sequence

226 – 250

25

CRTSN…PHSPL → IDSQKWNCLVKRPVCPNAGR TSPLG in isoform 4.

VSP_035852

Alternative sequence

251 – 2626

2376

Missing in isoform 4.

VSP_035853

Alternative sequence

278 – 280

3

Missing in isoform 2 and isoform 3.

VSP_023110

Natural variant

77

1

A → P.
Corresponds to variant rs6867856 [ dbSNP | Ensembl ].

VAR_059768

Natural variant

923

1

Q → R. Ref.6

VAR_040787

Natural variant

1957

1

R → W. Ref.6

VAR_040788

Natural variant

2201

1

P → L. Ref.6

VAR_040789

Natural variant

2293

1

S → C. Ref.6

VAR_040790

Natural variant

2470

1

E → D in a lung squamous cell carcinoma sample; somatic mutation. Ref.6

VAR_040791

Experimental info

Sequence conflict

665

1

M → T in AK131421. Ref.4

Sequence conflict

677 – 681

5

FAETV → YIVKL in BAB71532. Ref.4

Sequence conflict

1627

1

R → P in AAW52510. Ref.1

Sequence conflict

1627

1

R → P in BAA20762. Ref.5

Sequence conflict

1802

1

K → E in AAW52510. Ref.1

Sequence conflict

1802

1

K → E in BAA20762. Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

2626

Helix Strand Turn

Details...

Beta strand

1145 – 1148

4

Beta strand

1156 – 1164

9

Beta strand

1171 – 1180

10

Helix

1185 – 1189

5

Beta strand

1196 – 1200

5

Helix

1210 – 1218

9

Turn

1219 – 1222

4

Beta strand

1223 – 1229

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: 74198B02E112789B	FASTA	2,626	284,378
	10 20 30 40 50 60 MGEKVSEAPE PVPRGCSGHG SRTPASALVA ASSPGASSAE SSSGSETLSE EGEPGGFSRE 70 80 90 100 110 120 HQPPPPPPLG GTLGARAPAA WAPASVLLER GVLALPPPLP GGAVPPAPRG SSASQEEQDE 130 140 150 160 170 180 ELDHILSPPP MPFRKCSNPD VASGPGKSLK YKRQLSEDGR QLRRGSLGGA LTGRYLLPNP 190 200 210 220 230 240 VAGQAWPASA ETSNLVRMRS QALGQSAPSL TASLKELSLP RRGSLCRTSN RKSLIGNGQS 250 260 270 280 290 300 PALPRPHSPL SAHAGNSPQD SPRNFSPSAS AHFSFARSLN RTDGRRWSLA SLPSSGYGTN 310 320 330 340 350 360 TPSSTVSSSC SSQEKLHQLP YQPTPDELHF LSKHFCTTES IATENRCRNT PMRPRSRSLS 370 380 390 400 410 420 PGRSPACCDH EIIMMNHVYK ERFPKATAQM EERLKEIITS YSPDNVLPLA DGVLSFTHHQ 430 440 450 460 470 480 IIELARDCLD KSHQGLITSR YFLELQHKLD KLLQEAHDRS ESGELAFIKQ LVRKILIVIA 490 500 510 520 530 540 RPARLLECLE FDPEEFYYLL EAAEGHAKEG QGIKTDIPRY IISQLGLNKD PLEEMAHLGN 550 560 570 580 590 600 YDSGTAETPE TDESVSSSNA SLKLRRKPRE SDFETIKLIS NGAYGAVYFV RHKESRQRFA 610 620 630 640 650 660 MKKINKQNLI LRNQIQQAFV ERDILTFAEN PFVVSMYCSF ETRRHLCMVM EYVEGGDCAT 670 680 690 700 710 720 LMKNMGPLPV DMARMYFAET VLALEYLHNY GIVHRDLKPD NLLVTSMGHI KLTDFGLSKV 730 740 750 760 770 780 GLMSMTTNLY EGHIEKDARE FLDKQVCGTP EYIAPEVILR QGYGKPVDWW AMGIILYEFL 790 800 810 820 830 840 VGCVPFFGDT PEELFGQVIS DEINWPEKDE APPPDAQDLI TLLLRQNPLE RLGTGGAYEV 850 860 870 880 890 900 KQHRFFRSLD WNSLLRQKAE FIPQLESEDD TSYFDTRSEK YHHMETEEED DTNDEDFNVE 910 920 930 940 950 960 IRQFSSCSHR FSKVFSSIDR ITQNSAEEKE DSVDKTKSTT LPSTETLSWS SEYSEMQQLS 970 980 990 1000 1010 1020 TSNSSDTESN RHKLSSGLLP KLAISTEGEQ DEAASCPGDP HEEPGKPALP PEECAQEEPE 1030 1040 1050 1060 1070 1080 VTTPASTISS STLSVGSFSE HLDQINGRSE CVDSTDNSSK PSSEPASHMA RQRLESTEKK 1090 1100 1110 1120 1130 1140 KISGKVTKSL SASALSLMIP GDMFAVSPLG SPMSPHSLSS DPSSSRDSSP SRDSSAASAS 1150 1160 1170 1180 1190 1200 PHQPIVIHSS GKNYGFTIRA IRVYVGDSDI YTVHHIVWNV EEGSPACQAG LKAGDLITHI 1210 1220 1230 1240 1250 1260 NGEPVHGLVH TEVIELLLKS GNKVSITTTP FENTSIKTGP ARRNSYKSRM VRRSKKSKKK 1270 1280 1290 1300 1310 1320 ESLERRRSLF KKLAKQPSPL LHTSRSFSCL NRSLSSGESL PGSPTHSLSP RSPTPSYRST 1330 1340 1350 1360 1370 1380 PDFPSGTNSS QSSSPSSSAP NSPAGSGHIR PSTLHGLAPK LGGQRYRSGR RKSAGNIPLS 1390 1400 1410 1420 1430 1440 PLARTPSPTP QPTSPQRSPS PLLGHSLGNS KIAQAFPSKM HSPPTIVRHI VRPKSAEPPR 1450 1460 1470 1480 1490 1500 SPLLKRVQSE EKLSPSYGSD KKHLCSRKHS LEVTQEEVQR EQSQREAPLQ SLDENVCDVP 1510 1520 1530 1540 1550 1560 PLSRARPVEQ GCLKRPVSRK VGRQESVDDL DRDKLKAKVV VKKADGFPEK QESHQKSHGP 1570 1580 1590 1600 1610 1620 GSDLENFALF KLEEREKKVY PKAVERSSTF ENKASMQEAP PLGSLLKDAL HKQASVRASE 1630 1640 1650 1660 1670 1680 GAMSDGRVPA EHRQGGGDFR RAPAPGTLQD GLCHSLDRGI SGKGEGTEKS SQAKELLRCE 1690 1700 1710 1720 1730 1740 KLDSKLANID YLRKKMSLED KEDNLCPVLK PKMTAGSHEC LPGNPVRPTG GQQEPPPASE 1750 1760 1770 1780 1790 1800 SRAFVSSTHA AQMSAVSFVP LKALTGRVDS GTEKPGLVAP ESPVRKSPSE YKLEGRSVSC 1810 1820 1830 1840 1850 1860 LKPIEGTLDI ALLSGPQASK TELPSPESAQ SPSPSGDVRA SVPPVLPSSS GKKNDTTSAR 1870 1880 1890 1900 1910 1920 ELSPSSLKMN KSYLLEPWFL PPSRGLQNSP AVSLPDPEFK RDRKGPHPTA RSPGTVMESN 1930 1940 1950 1960 1970 1980 PQQREGSSPK HQDHTTDPKL LTCLGQNLHS PDLARPRCPL PPEASPSREK PGLRESSERG 1990 2000 2010 2020 2030 2040 PPTARSERSA ARADTCREPS MELCFPETAK TSDNSKNLLS VGRTHPDFYT QTQAMEKAWA 2050 2060 2070 2080 2090 2100 PGGKTNHKDG PGEARPPPRD NSSLHSAGIP CEKELGKVRR GVEPKPEALL ARRSLQPPGI 2110 2120 2130 2140 2150 2160 ESEKSEKLSS FPSLQKDGAK EPERKEQPLQ RHPSSIPPPP LTAKDLSSPA ARQHCSSPSH 2170 2180 2190 2200 2210 2220 ASGREPGAKP STAEPSSSPQ DPPKPVAAHS ESSSHKPRPG PDPGPPKTKH PDRSLSSQKP 2230 2240 2250 2260 2270 2280 SVGATKGKEP ATQSLGGSSR EGKGHSKSGP DVFPATPGSQ NKASDGIGQG EGGPSVPLHT 2290 2300 2310 2320 2330 2340 DRAPLDAKPQ PTSGGRPLEV LEKPVHLPRP GHPGPSEPAD QKLSAVGEKQ TLSPKHPKPS 2350 2360 2370 2380 2390 2400 TVKDCPTLCK QTDNRQTDKS PSQPAANTDR RAEGKKCTEA LYAPAEGDKL EAGLSFVHSE 2410 2420 2430 2440 2450 2460 NRLKGAERPA AGVGKGFPEA RGKGPGPQKP PTEADKPNGM KRSPSATGQS SFRSTALPEK 2470 2480 2490 2500 2510 2520 SLSCSSSFPE TRAGVREASA ASSDTSSAKA AGGMLELPAP SNRDHRKAQP AGEGRTHMTK 2530 2540 2550 2560 2570 2580 SDSLPSFRVS TLPLESHHPD PNTMGGASHR DRALSVTATV GETKGKDPAP AQPPPARKQN 2590 2600 2610 2620 VGRDVTKPSP APNTDRPISL SNEKDFVVRQ RRGKESLRSS PHKKAL
	Isoform 2 [UniParc]. Checksum: 522EC091B431DA62	FASTA	2,429	264,762
	10 20 30 40 50 60 MDMSDPNFWT VLSNFTLPHL RSGNRLRRTQ SCRTSNRKSL IGNGQSPALP RPHSPLSAHA 70 80 90 100 110 120 GNSPQDSPRN FSPSASAHFS FARRTDGRRW SLASLPSSGY GTNTPSSTVS SSCSSQEKLH 130 140 150 160 170 180 QLPYQPTPDE LHFLSKHFCT TESIATENRC RNTPMRPRSR SLSPGRSPAC CDHEIIMMNH 190 200 210 220 230 240 VYKERFPKAT AQMEERLKEI ITSYSPDNVL PLADGVLSFT HHQIIELARD CLDKSHQGLI 250 260 270 280 290 300 TSRYFLELQH KLDKLLQEAH DRSESGELAF IKQLVRKILI VIARPARLLE CLEFDPEEFY 310 320 330 340 350 360 YLLEAAEGHA KEGQGIKTDI PRYIISQLGL NKDPLEEMAH LGNYDSGTAE TPETDESVSS 370 380 390 400 410 420 SNASLKLRRK PRESDFETIK LISNGAYGAV YFVRHKESRQ RFAMKKINKQ NLILRNQIQQ 430 440 450 460 470 480 AFVERDILTF AENPFVVSMY CSFETRRHLC MVMEYVEGGD CATLMKNMGP LPVDMARMYF 490 500 510 520 530 540 AETVLALEYL HNYGIVHRDL KPDNLLVTSM GHIKLTDFGL SKVGLMSMTT NLYEGHIEKD 550 560 570 580 590 600 AREFLDKQVC GTPEYIAPEV ILRQGYGKPV DWWAMGIILY EFLVGCVPFF GDTPEELFGQ 610 620 630 640 650 660 VISDEINWPE KDEAPPPDAQ DLITLLLRQN PLERLGTGGA YEVKQHRFFR SLDWNSLLRQ 670 680 690 700 710 720 KAEFIPQLES EDDTSYFDTR SEKYHHMETE EEDDTNDEDF NVEIRQFSSC SHRFSKVFSS 730 740 750 760 770 780 IDRITQNSAE EKEDSVDKTK STTLPSTETL SWSSEYSEMQ QLSTSNSSDT ESNRHKLSSG 790 800 810 820 830 840 LLPKLAISTE GEQDEAASCP GDPHEEPGKP ALPPEECAQE EPEVTTPAST ISSSTLSVGS 850 860 870 880 890 900 FSEHLDQING RSECVDSTDN SSKPSSEPAS HMARQRLEST EKKKISGKVT KSLSASALSL 910 920 930 940 950 960 MIPGDMFAVS PLGSPMSPHS LSSDPSSSRD SSPSRDSSAA SASPHQPIVI HSSGKNYGFT 970 980 990 1000 1010 1020 IRAIRVYVGD SDIYTVHHIV WNVEEGSPAC QAGLKAGDLI THINGEPVHG LVHTEVIELL 1030 1040 1050 1060 1070 1080 LKSGNKVSIT TTPFENTSIK TGPARRNSYK SRMVRRSKKS KKKESLERRR SLFKKLAKQP 1090 1100 1110 1120 1130 1140 SPLLHTSRSF SCLNRSLSSG ESLPGSPTHS LSPRSPTPSY RSTPDFPSGT NSSQSSSPSS 1150 1160 1170 1180 1190 1200 SAPNSPAGSG HIRPSTLHGL APKLGGQRYR SGRRKSAGNI PLSPLARTPS PTPQPTSPQR 1210 1220 1230 1240 1250 1260 SPSPLLGHSL GNSKIAQAFP SKMHSPPTIV RHIVRPKSAE PPRSPLLKRV QSEEKLSPSY 1270 1280 1290 1300 1310 1320 GSDKKHLCSR KHSLEVTQEE VQREQSQREA PLQSLDENVC DVPPLSRARP VEQGCLKRPV 1330 1340 1350 1360 1370 1380 SRKVGRQESV DDLDRDKLKA KVVVKKADGF PEKQESHQKS HGPGSDLENF ALFKLEEREK 1390 1400 1410 1420 1430 1440 KVYPKAVERS STFENKASMQ EAPPLGSLLK DALHKQASVR ASEGAMSDGR VPAEHRQGGG 1450 1460 1470 1480 1490 1500 DFRRAPAPGT LQDGLCHSLD RGISGKGEGT EKSSQAKELL RCEKLDSKLA NIDYLRKKMS 1510 1520 1530 1540 1550 1560 LEDKEDNLCP VLKPKMTAGS HECLPGNPVR PTGGQQEPPP ASESRAFVSS THAAQMSAVS 1570 1580 1590 1600 1610 1620 FVPLKALTGR VDSGTEKPGL VAPESPVRKS PSEYKLEGRS VSCLKPIEGT LDIALLSGPQ 1630 1640 1650 1660 1670 1680 ASKTELPSPE SAQSPSPSGD VRASVPPVLP SSSGKKNDTT SARELSPSSL KMNKSYLLEP 1690 1700 1710 1720 1730 1740 WFLPPSRGLQ NSPAVSLPDP EFKRDRKGPH PTARSPGTVM ESNPQQREGS SPKHQDHTTD 1750 1760 1770 1780 1790 1800 PKLLTCLGQN LHSPDLARPR CPLPPEASPS REKPGLRESS ERGPPTARSE RSAARADTCR 1810 1820 1830 1840 1850 1860 EPSMELCFPE TAKTSDNSKN LLSVGRTHPD FYTQTQAMEK AWAPGGKTNH KDGPGEARPP 1870 1880 1890 1900 1910 1920 PRDNSSLHSA GIPCEKELGK VRRGVEPKPE ALLARRSLQP PGIESEKSEK LSSFPSLQKD 1930 1940 1950 1960 1970 1980 GAKEPERKEQ PLQRHPSSIP PPPLTAKDLS SPAARQHCSS PSHASGREPG AKPSTAEPSS 1990 2000 2010 2020 2030 2040 SPQDPPKPVA AHSESSSHKP RPGPDPGPPK TKHPDRSLSS QKPSVGATKG KEPATQSLGG 2050 2060 2070 2080 2090 2100 SSREGKGHSK SGPDVFPATP GSQNKASDGI GQGEGGPSVP LHTDRAPLDA KPQPTSGGRP 2110 2120 2130 2140 2150 2160 LEVLEKPVHL PRPGHPGPSE PADQKLSAVG EKQTLSPKHP KPSTVKDCPT LCKQTDNRQT 2170 2180 2190 2200 2210 2220 DKSPSQPAAN TDRRAEGKKC TEALYAPAEG DKLEAGLSFV HSENRLKGAE RPAAGVGKGF 2230 2240 2250 2260 2270 2280 PEARGKGPGP QKPPTEADKP NGMKRSPSAT GQSSFRSTAL PEKSLSCSSS FPETRAGVRE 2290 2300 2310 2320 2330 2340 ASAASSDTSS AKAAGGMLEL PAPSNRDHRK AQPAGEGRTH MTKSDSLPSF RVSTLPLESH 2350 2360 2370 2380 2390 2400 HPDPNTMGGA SHRDRALSVT ATVGETKGKD PAPAQPPPAR KQNVGRDVTK PSPAPNTDRP 2410 2420 ISLSNEKDFV VRQRRGKESL RSSPHKKAL
	Isoform 4 [UniParc]. Checksum: 8CAF56901F60C75F	FASTA	250	25,702
	10 20 30 40 50 60 MGEKVSEAPE PVPRGCSGHG SRTPASALVA ASSPGASSAE SSSGSETLSE EGEPGGFSRE 70 80 90 100 110 120 HQPPPPPPLG GTLGARAPAA WAPASVLLER GVLALPPPLP GGAVPPAPRG SSASQEEQDE 130 140 150 160 170 180 ELDHILSPPP MPFRKCSNPD VASGPGKSLK YKRQLSEDGR QLRRGSLGGA LTGRYLLPNP 190 200 210 220 230 240 VAGQAWPASA ETSNLVRMRS QALGQSAPSL TASLKELSLP RRGSLIDSQK WNCLVKRPVC 250 PNAGRTSPLG
	Isoform 5 [UniParc]. Checksum: 63BEFB8FEAC67DDB	FASTA	2,444	266,119
	10 20 30 40 50 60 MKAQRERLQI PGLTLDLTPR SLSPTPSSPG SPCSPLLAFH FWSCRTSNRK SLIGNGQSPA 70 80 90 100 110 120 LPRPHSPLSA HAGNSPQDSP RNFSPSASAH FSFARSLNRT DGRRWSLASL PSSGYGTNTP 130 140 150 160 170 180 SSTVSSSCSS QEKLHQLPYQ PTPDELHFLS KHFCTTESIA TENRCRNTPM RPRSRSLSPG 190 200 210 220 230 240 RSPACCDHEI IMMNHVYKER FPKATAQMEE RLKEIITSYS PDNVLPLADG VLSFTHHQII 250 260 270 280 290 300 ELARDCLDKS HQGLITSRYF LELQHKLDKL LQEAHDRSES GELAFIKQLV RKILIVIARP 310 320 330 340 350 360 ARLLECLEFD PEEFYYLLEA AEGHAKEGQG IKTDIPRYII SQLGLNKDPL EEMAHLGNYD 370 380 390 400 410 420 SGTAETPETD ESVSSSNASL KLRRKPRESD FETIKLISNG AYGAVYFVRH KESRQRFAMK 430 440 450 460 470 480 KINKQNLILR NQIQQAFVER DILTFAENPF VVSMYCSFET RRHLCMVMEY VEGGDCATLM 490 500 510 520 530 540 KNMGPLPVDM ARMYFAETVL ALEYLHNYGI VHRDLKPDNL LVTSMGHIKL TDFGLSKVGL 550 560 570 580 590 600 MSMTTNLYEG HIEKDAREFL DKQVCGTPEY IAPEVILRQG YGKPVDWWAM GIILYEFLVG 610 620 630 640 650 660 CVPFFGDTPE ELFGQVISDE INWPEKDEAP PPDAQDLITL LLRQNPLERL GTGGAYEVKQ 670 680 690 700 710 720 HRFFRSLDWN SLLRQKAEFI PQLESEDDTS YFDTRSEKYH HMETEEEDDT NDEDFNVEIR 730 740 750 760 770 780 QFSSCSHRFS KVFSSIDRIT QNSAEEKEDS VDKTKSTTLP STETLSWSSE YSEMQQLSTS 790 800 810 820 830 840 NSSDTESNRH KLSSGLLPKL AISTEGEQDE AASCPGDPHE EPGKPALPPE ECAQEEPEVT 850 860 870 880 890 900 TPASTISSST LSVGSFSEHL DQINGRSECV DSTDNSSKPS SEPASHMARQ RLESTEKKKI 910 920 930 940 950 960 SGKVTKSLSA SALSLMIPGD MFAVSPLGSP MSPHSLSSDP SSSRDSSPSR DSSAASASPH 970 980 990 1000 1010 1020 QPIVIHSSGK NYGFTIRAIR VYVGDSDIYT VHHIVWNVEE GSPACQAGLK AGDLITHING 1030 1040 1050 1060 1070 1080 EPVHGLVHTE VIELLLKSGN KVSITTTPFE NTSIKTGPAR RNSYKSRMVR RSKKSKKKES 1090 1100 1110 1120 1130 1140 LERRRSLFKK LAKQPSPLLH TSRSFSCLNR SLSSGESLPG SPTHSLSPRS PTPSYRSTPD 1150 1160 1170 1180 1190 1200 FPSGTNSSQS SSPSSSAPNS PAGSGHIRPS TLHGLAPKLG GQRYRSGRRK SAGNIPLSPL 1210 1220 1230 1240 1250 1260 ARTPSPTPQP TSPQRSPSPL LGHSLGNSKI AQAFPSKMHS PPTIVRHIVR PKSAEPPRSP 1270 1280 1290 1300 1310 1320 LLKRVQSEEK LSPSYGSDKK HLCSRKHSLE VTQEEVQREQ SQREAPLQSL DENVCDVPPL 1330 1340 1350 1360 1370 1380 SRARPVEQGC LKRPVSRKVG RQESVDDLDR DKLKAKVVVK KADGFPEKQE SHQKSHGPGS 1390 1400 1410 1420 1430 1440 DLENFALFKL EEREKKVYPK AVERSSTFEN KASMQEAPPL GSLLKDALHK QASVRASEGA 1450 1460 1470 1480 1490 1500 MSDGRVPAEH RQGGGDFRRA PAPGTLQDGL CHSLDRGISG KGEGTEKSSQ AKELLRCEKL 1510 1520 1530 1540 1550 1560 DSKLANIDYL RKKMSLEDKE DNLCPVLKPK MTAGSHECLP GNPVRPTGGQ QEPPPASESR 1570 1580 1590 1600 1610 1620 AFVSSTHAAQ MSAVSFVPLK ALTGRVDSGT EKPGLVAPES PVRKSPSEYK LEGRSVSCLK 1630 1640 1650 1660 1670 1680 PIEGTLDIAL LSGPQASKTE LPSPESAQSP SPSGDVRASV PPVLPSSSGK KNDTTSAREL 1690 1700 1710 1720 1730 1740 SPSSLKMNKS YLLEPWFLPP SRGLQNSPAV SLPDPEFKRD RKGPHPTARS PGTVMESNPQ 1750 1760 1770 1780 1790 1800 QREGSSPKHQ DHTTDPKLLT CLGQNLHSPD LARPRCPLPP EASPSREKPG LRESSERGPP 1810 1820 1830 1840 1850 1860 TARSERSAAR ADTCREPSME LCFPETAKTS DNSKNLLSVG RTHPDFYTQT QAMEKAWAPG 1870 1880 1890 1900 1910 1920 GKTNHKDGPG EARPPPRDNS SLHSAGIPCE KELGKVRRGV EPKPEALLAR RSLQPPGIES 1930 1940 1950 1960 1970 1980 EKSEKLSSFP SLQKDGAKEP ERKEQPLQRH PSSIPPPPLT AKDLSSPAAR QHCSSPSHAS 1990 2000 2010 2020 2030 2040 GREPGAKPST AEPSSSPQDP PKPVAAHSES SSHKPRPGPD PGPPKTKHPD RSLSSQKPSV 2050 2060 2070 2080 2090 2100 GATKGKEPAT QSLGGSSREG KGHSKSGPDV FPATPGSQNK ASDGIGQGEG GPSVPLHTDR 2110 2120 2130 2140 2150 2160 APLDAKPQPT SGGRPLEVLE KPVHLPRPGH PGPSEPADQK LSAVGEKQTL SPKHPKPSTV 2170 2180 2190 2200 2210 2220 KDCPTLCKQT DNRQTDKSPS QPAANTDRRA EGKKCTEALY APAEGDKLEA GLSFVHSENR 2230 2240 2250 2260 2270 2280 LKGAERPAAG VGKGFPEARG KGPGPQKPPT EADKPNGMKR SPSATGQSSF RSTALPEKSL 2290 2300 2310 2320 2330 2340 SCSSSFPETR AGVREASAAS SDTSSAKAAG GMLELPAPSN RDHRKAQPAG EGRTHMTKSD 2350 2360 2370 2380 2390 2400 SLPSFRVSTL PLESHHPDPN TMGGASHRDR ALSVTATVGE TKGKDPAPAQ PPPARKQNVG 2410 2420 2430 2440 RDVTKPSPAP NTDRPISLSN EKDFVVRQRR GKESLRSSPH KKAL
	Isoform 3 [UniParc]. Checksum: 7BE938C15BAA4014	FASTA	2,434	265,354
	10 20 30 40 50 60 MDESSILRRR GLQKELSLPR RGSLIDSQKW NCLVKRCRTS NRKSLIGNGQ SPALPRPHSP 70 80 90 100 110 120 LSAHAGNSPQ DSPRNFSPSA SAHFSFARRT DGRRWSLASL PSSGYGTNTP SSTVSSSCSS 130 140 150 160 170 180 QEKLHQLPYQ PTPDELHFLS KHFCTTESIA TENRCRNTPM RPRSRSLSPG RSPACCDHEI 190 200 210 220 230 240 IMMNHVYKER FPKATAQMEE RLKEIITSYS PDNVLPLADG VLSFTHHQII ELARDCLDKS 250 260 270 280 290 300 HQGLITSRYF LELQHKLDKL LQEAHDRSES GELAFIKQLV RKILIVIARP ARLLECLEFD 310 320 330 340 350 360 PEEFYYLLEA AEGHAKEGQG IKTDIPRYII SQLGLNKDPL EEMAHLGNYD SGTAETPETD 370 380 390 400 410 420 ESVSSSNASL KLRRKPRESD FETIKLISNG AYGAVYFVRH KESRQRFAMK KINKQNLILR 430 440 450 460 470 480 NQIQQAFVER DILTFAENPF VVSMYCSFET RRHLCMVMEY VEGGDCATLM KNMGPLPVDM 490 500 510 520 530 540 ARMYFAETVL ALEYLHNYGI VHRDLKPDNL LVTSMGHIKL TDFGLSKVGL MSMTTNLYEG 550 560 570 580 590 600 HIEKDAREFL DKQVCGTPEY IAPEVILRQG YGKPVDWWAM GIILYEFLVG CVPFFGDTPE 610 620 630 640 650 660 ELFGQVISDE INWPEKDEAP PPDAQDLITL LLRQNPLERL GTGGAYEVKQ HRFFRSLDWN 670 680 690 700 710 720 SLLRQKAEFI PQLESEDDTS YFDTRSEKYH HMETEEEDDT NDEDFNVEIR QFSSCSHRFS 730 740 750 760 770 780 KVFSSIDRIT QNSAEEKEDS VDKTKSTTLP STETLSWSSE YSEMQQLSTS NSSDTESNRH 790 800 810 820 830 840 KLSSGLLPKL AISTEGEQDE AASCPGDPHE EPGKPALPPE ECAQEEPEVT TPASTISSST 850 860 870 880 890 900 LSVGSFSEHL DQINGRSECV DSTDNSSKPS SEPASHMARQ RLESTEKKKI SGKVTKSLSA 910 920 930 940 950 960 SALSLMIPGD MFAVSPLGSP MSPHSLSSDP SSSRDSSPSR DSSAASASPH QPIVIHSSGK 970 980 990 1000 1010 1020 NYGFTIRAIR VYVGDSDIYT VHHIVWNVEE GSPACQAGLK AGDLITHING EPVHGLVHTE 1030 1040 1050 1060 1070 1080 VIELLLKSGN KVSITTTPFE NTSIKTGPAR RNSYKSRMVR RSKKSKKKES LERRRSLFKK 1090 1100 1110 1120 1130 1140 LAKQPSPLLH TSRSFSCLNR SLSSGESLPG SPTHSLSPRS PTPSYRSTPD FPSGTNSSQS 1150 1160 1170 1180 1190 1200 SSPSSSAPNS PAGSGHIRPS TLHGLAPKLG GQRYRSGRRK SAGNIPLSPL ARTPSPTPQP 1210 1220 1230 1240 1250 1260 TSPQRSPSPL LGHSLGNSKI AQAFPSKMHS PPTIVRHIVR PKSAEPPRSP LLKRVQSEEK 1270 1280 1290 1300 1310 1320 LSPSYGSDKK HLCSRKHSLE VTQEEVQREQ SQREAPLQSL DENVCDVPPL SRARPVEQGC 1330 1340 1350 1360 1370 1380 LKRPVSRKVG RQESVDDLDR DKLKAKVVVK KADGFPEKQE SHQKSHGPGS DLENFALFKL 1390 1400 1410 1420 1430 1440 EEREKKVYPK AVERSSTFEN KASMQEAPPL GSLLKDALHK QASVRASEGA MSDGRVPAEH 1450 1460 1470 1480 1490 1500 RQGGGDFRRA PAPGTLQDGL CHSLDRGISG KGEGTEKSSQ AKELLRCEKL DSKLANIDYL 1510 1520 1530 1540 1550 1560 RKKMSLEDKE DNLCPVLKPK MTAGSHECLP GNPVRPTGGQ QEPPPASESR AFVSSTHAAQ 1570 1580 1590 1600 1610 1620 MSAVSFVPLK ALTGRVDSGT EKPGLVAPES PVRKSPSEYK LEGRSVSCLK PIEGTLDIAL 1630 1640 1650 1660 1670 1680 LSGPQASKTE LPSPESAQSP SPSGDVRASV PPVLPSSSGK KNDTTSAREL SPSSLKMNKS 1690 1700 1710 1720 1730 1740 YLLEPWFLPP SRGLQNSPAV SLPDPEFKRD RKGPHPTARS PGTVMESNPQ QREGSSPKHQ 1750 1760 1770 1780 1790 1800 DHTTDPKLLT CLGQNLHSPD LARPRCPLPP EASPSREKPG LRESSERGPP TARSERSAAR 1810 1820 1830 1840 1850 1860 ADTCREPSME LCFPETAKTS DNSKNLLSVG RTHPDFYTQT QAMEKAWAPG GKTNHKDGPG 1870 1880 1890 1900 1910 1920 EARPPPRDNS SLHSAGIPCE KELGKVRRGV EPKPEALLAR RSLQPPGIES EKSEKLSSFP 1930 1940 1950 1960 1970 1980 SLQKDGAKEP ERKEQPLQRH PSSIPPPPLT AKDLSSPAAR QHCSSPSHAS GREPGAKPST 1990 2000 2010 2020 2030 2040 AEPSSSPQDP PKPVAAHSES SSHKPRPGPD PGPPKTKHPD RSLSSQKPSV GATKGKEPAT 2050 2060 2070 2080 2090 2100 QSLGGSSREG KGHSKSGPDV FPATPGSQNK ASDGIGQGEG GPSVPLHTDR APLDAKPQPT 2110 2120 2130 2140 2150 2160 SGGRPLEVLE KPVHLPRPGH PGPSEPADQK LSAVGEKQTL SPKHPKPSTV KDCPTLCKQT 2170 2180 2190 2200 2210 2220 DNRQTDKSPS QPAANTDRRA EGKKCTEALY APAEGDKLEA GLSFVHSENR LKGAERPAAG 2230 2240 2250 2260 2270 2280 VGKGFPEARG KGPGPQKPPT EADKPNGMKR SPSATGQSSF RSTALPEKSL SCSSSFPETR 2290 2300 2310 2320 2330 2340 AGVREASAAS SDTSSAKAAG GMLELPAPSN RDHRKAQPAG EGRTHMTKSD SLPSFRVSTL 2350 2360 2370 2380 2390 2400 PLESHHPDPN TMGGASHRDR ALSVTATVGE TKGKDPAPAQ PPPARKQNVG RDVTKPSPAP 2410 2420 2430 NTDRPISLSN EKDFVVRQRR GKESLRSSPH KKAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family." Sun L., Gu S., Li X., Sun Y., Zheng D., Yu K., Ji C., Tang R., Xie Y., Mao Y. Mol. Biol. (Mosk.) 40:808-815(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Lung.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-681 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-666 (ISOFORM 2). Tissue: Brain and Thymus.
[5]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 490-2626 (ISOFORM 1). Tissue: Brain.
[6]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-923; TRP-1957; LEU-2201; CYS-2293 AND ASP-2470.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY830839 mRNA. Translation: AAW52510.1.
AC008872 Genomic DNA. No translation available.
AC008920 Genomic DNA. No translation available.
AC016634 Genomic DNA. No translation available.
AC034208 Genomic DNA. No translation available.
AC044799 Genomic DNA. No translation available.
AC092349 Genomic DNA. No translation available.
AC092373 Genomic DNA. No translation available.
AC113365 Genomic DNA. No translation available.
BC033215 mRNA. Translation: AAH33215.1.
AK057601 mRNA. Translation: BAB71532.1.
AK131421 mRNA. No translation available.
AB002301 mRNA. Translation: BAA20762.1.

IPI

IPI00788168.
IPI00827896.
IPI00893655.
IPI00894093.
IPI00914890.

RefSeq

NP_055998.1. NM_015183.2.
NP_942123.1. NM_198828.2.

UniGene

Hs.595458.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2W7R	X-ray	1.60	A/B	1143-1234	[»]

ProteinModelPortal

O15021.

ModBase

Search...

Protein-protein interaction databases

IntAct

O15021. 1 interaction.

MINT

MINT-1184694.

STRING

9606.ENSP00000384313.

PTM databases

PhosphoSite

O15021.

Proteomic databases

PaxDb

O15021.

PRIDE

O15021.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000261569; ENSP00000261569; ENSG00000069020.
ENST00000403666; ENSP00000384313; ENSG00000069020.
ENST00000406374; ENSP00000385088; ENSG00000069020.

GeneID

375449.

KEGG

hsa:375449.

UCSC

uc003jur.4. human.
uc003jut.2. human.
uc003juw.3. human.

Organism-specific databases

CTD

375449.

GeneCards

GC05P065892.

H-InvDB

HIX0004913.
HIX0164541.

HGNC

HGNC:19037. MAST4.

HPA

HPA000544.

neXtProt

NX_O15021.

PharmGKB

PA134920494.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0515.

HOGENOM

HOG000074100.

HOVERGEN

HBG108118.

KO

K08789.

OrthoDB

EOG4255S2.

Gene expression databases

ArrayExpress

O15021.

Bgee

O15021.

CleanEx

HS_MAST4.

Genevestigator

O15021.

GermOnline

ENSG00000069020. Homo sapiens.

Family and domain databases

Gene3D

1.20.1480.20. 1 hit.

InterPro

IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR015022. MA_Ser/Thr_Kinase_dom.
IPR023142. MAST_pre-PK_dom.
IPR001478. PDZ.
IPR000719. Prot_kinase_cat_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]

Pfam

PF08926. DUF1908. 1 hit.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]

SMART

SM00228. PDZ. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]

SUPFAM

SSF56112. Kinase_like. 1 hit.
SSF50156. PDZ. 1 hit.
SSF140482. SSF140482. 1 hit.

PROSITE

PS51285. AGC_KINASE_CTER. 1 hit.
PS50106. PDZ. 1 hit.
PS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

MAST4. human.

EvolutionaryTrace

O15021.

GenomeRNAi

375449.

NextBio

100512.

Entry information

Entry name

MAST4_HUMAN

Accession

Primary (citable) accession number: O15021
Secondary accession number(s): A6NL49 , B5ME48, Q05EE6, Q6ZN07, Q8N4X4, Q96LY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.