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O15018 (PDZD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PDZ domain-containing protein 2
Alternative name(s):
Activated in prostate cancer protein
PDZ domain-containing protein 3

Cleaved into the following chain:

  1. Processed PDZ domain-containing protein 2
Gene names
Name:PDZD2
Synonyms:AIPC, KIAA0300, PDZK3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length2839 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with SCN10A, CTNND2 and PKP4 By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm. Endoplasmic reticulum. Note: At cell-cell contacts in lung epithelial cells By similarity. Ref.1

Processed PDZ domain-containing protein 2: Secreted By similarity Ref.1.

Tissue specificity

Isoform 2 is expressed (at protein level) in prostate and many prostate tumors. Ref.1

Post-translational modification

A secreted form is produced by caspase-mediated proteolytic cleavage By similarity.

Sequence similarities

Contains 6 PDZ (DHR) domains.

Sequence caution

The sequence BAA20760.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15018-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15018-2)

The sequence of this isoform differs from the canonical sequence as follows:
     375-555: Missing.
     803-817: Missing.
     909-911: THK → S
     1179-1179: K → KLCQ
     1228-1231: Missing.
Note: May be due to aberrant splicing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 28392839PDZ domain-containing protein 2
PRO_0000058294
Chain?2493 – 2839347Processed PDZ domain-containing protein 2 By similarity
PRO_0000302756

Regions

Domain85 – 18298PDZ 1
Domain334 – 41986PDZ 2
Domain586 – 67287PDZ 3
Domain728 – 81386PDZ 4
Domain2622 – 270685PDZ 5
Domain2750 – 283586PDZ 6
Compositional bias2139 – 219456Ser-rich

Sites

Site2492 – 24932Cleavage; by caspases By similarity

Natural variations

Alternative sequence375 – 555181Missing in isoform 2.
VSP_012369
Alternative sequence803 – 81715Missing in isoform 2.
VSP_012370
Alternative sequence909 – 9113THK → S in isoform 2.
VSP_012371
Alternative sequence11791K → KLCQ in isoform 2.
VSP_012372
Alternative sequence1228 – 12314Missing in isoform 2.
VSP_012373
Natural variant11781E → G.
Corresponds to variant rs57158698 [ dbSNP | Ensembl ].
VAR_061691
Natural variant12581Q → K.
Corresponds to variant rs3101878 [ dbSNP | Ensembl ].
VAR_031654
Natural variant12741T → A. Ref.2
Corresponds to variant rs157496 [ dbSNP | Ensembl ].
VAR_031655
Natural variant13431D → E.
Corresponds to variant rs12520467 [ dbSNP | Ensembl ].
VAR_031656
Natural variant14251T → M.
Corresponds to variant rs36097367 [ dbSNP | Ensembl ].
VAR_031657
Natural variant16491A → V.
Corresponds to variant rs3101873 [ dbSNP | Ensembl ].
VAR_031658
Natural variant22471R → Q.
Corresponds to variant rs10066063 [ dbSNP | Ensembl ].
VAR_031659

Experimental info

Sequence conflict2541P → A in AAK07661. Ref.1
Sequence conflict3261R → RQ in AAK07661. Ref.1
Sequence conflict25761N → K in AAK07661. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 17, 2007. Version 4.
Checksum: 4B1CB91A9CE96267

FASTA2,839301,641
        10         20         30         40         50         60 
MPITQDNAVL HLPLLYQWLQ NSLQEGGDGP EQRLCQAAIQ KLQEYIQLNF AVDESTVPPD 

        70         80         90        100        110        120 
HSPPEMEICT VYLTKELGDT ETVGLSFGNI PVFGDYGEKR RGGKKRKTHQ GPVLDVGCIW 

       130        140        150        160        170        180 
VTELRKNSPA GKSGKVRLRD EILSLNGQLM VGVDVSGASY LAEQCWNGGF IYLIMLRRFK 

       190        200        210        220        230        240 
HKAHSTYNGN SSNSSEPGET PTLELGDRTA KKGKRTRKFG VISRPPANKA PEESKGSAGC 

       250        260        270        280        290        300 
EVSSDPSTEL ENGPDPELGN GHVFQLENGP DSLKEVAGPH LERSEVDRGT EHRIPKTDAP 

       310        320        330        340        350        360 
LTTSNDKRRF SKGGKTDFQS SDCLAREEVG RIWKMELLKE SDGLGIQVSG GRGSKRSPHA 

       370        380        390        400        410        420 
IVVTQVKEGG AAHRDGRLSL GDELLVINGH LLVGLSHEEA VAILRSATGM VQLVVASKEN 

       430        440        450        460        470        480 
SAEDLLRLTS KSLPDLTSSV EDVSSWTDNE DQEADGEEDE GTSSSVQRAM PGTDEPQDVC 

       490        500        510        520        530        540 
GAEESKGNLE SPKQGSNKIK LKSRLSGGVH RLESVEEYNE LMVRNGDPRI RMLEVSRDGR 

       550        560        570        580        590        600 
KHSLPQLLDS SSASQEYHIV KKSTRSLSTT QVESPWRLIR PSVISIIGLY KEKGKGLGFS 

       610        620        630        640        650        660 
IAGGRDCIRG QMGIFVKTIF PNGSAAEDGR LKEGDEILDV NGIPIKGLTF QEAIHTFKQI 

       670        680        690        700        710        720 
RSGLFVLTVR TKLVSPSLTP CSTPTHMSRS ASPNFNTSGG ASAGGSDEGS SSSLGRKTPG 

       730        740        750        760        770        780 
PKDRIVMEVT LNKEPRVGLG IGACCLALEN SPPGIYIHSL APGSVAKMES NLSRGDQILE 

       790        800        810        820        830        840 
VNSVNVRHAA LSKVHAILSK CPPGPVRLVI GRHPNPKVSE QEMDEVIARS TYQESKEANS 

       850        860        870        880        890        900 
SPGLGTPLKS PSLAKKDSLI SESELSQYFA HDVPGPLSDF MVAGSEDEDH PGSGCSTSEE 

       910        920        930        940        950        960 
GSLPPSTSTH KEPGKPRANS LVTLGSHRAS GLFHKQVTVA RQASLPGSPQ ALRNPLLRQR 

       970        980        990       1000       1010       1020 
KVGCYDANDA SDEEEFDREG DCISLPGALP GPIRPLSEDD PRRVSISSSK GMDVHNQEER 

      1030       1040       1050       1060       1070       1080 
PRKTLVSKAI SAPLLGSSVD LEESIPEGMV DAASYAANLT DSAEAPKGSP GSWWKKELSG 

      1090       1100       1110       1120       1130       1140 
SSSAPKLEYT VRTDTQSPTN TGSPSSPQQK SEGLGSRHRP VARVSPHCKR SEAEAKPSGS 

      1150       1160       1170       1180       1190       1200 
QTVNLTGRAN DPCDLDSRVQ ATSVKVTVAG FQPGGAVEKE SLGKLTTGDA CVSTSCELAS 

      1210       1220       1230       1240       1250       1260 
ALSHLDASHL TENLPKAASE LGQQPMTELD SSSDLISSPG KKGAAHPDPS KTSVDTGQVS 

      1270       1280       1290       1300       1310       1320 
RPENPSQPAS PRVTKCKARS PVRLPHEGSP SPGEKAAAPP DYSKTRSASE TSTPHNTRRV 

      1330       1340       1350       1360       1370       1380 
AALRGAGPGA EGMTPAGAVL PGDPLTSQEQ RQGAPGNHSK ALEMTGIHAP ESSQEPSLLE 

      1390       1400       1410       1420       1430       1440 
GADSVSSRAP QASLSMLPST DNTKEACGHV SGHCCPGGSR ESPVTDIDSF IKELDASAAR 

      1450       1460       1470       1480       1490       1500 
SPSSQTGDSG SQEGSAQGHP PAGAGGGSSC RAEPVPGGQT SSPRRAWAAG APAYPQWASQ 

      1510       1520       1530       1540       1550       1560 
PSVLDSINPD KHFTVNKNFL SNYSRNFSSF HEDSTSLSGL GDSTEPSLSS MYGDAEDSSS 

      1570       1580       1590       1600       1610       1620 
DPESLTEAPR ASARDGWSPP RSRVSLHKED PSESEEEQIE ICSTRGCPNP PSSPAHLPTQ 

      1630       1640       1650       1660       1670       1680 
AAICPASAKV LSLKYSTPRE SVASPREKAA CLPGSYTSGP DSSQPSSLLE MSSQEHETHA 

      1690       1700       1710       1720       1730       1740 
DISTSQNHRP SCAEETTEVT SASSAMENSP LSKVARHFHS PPIILSSPNM VNGLEHDLLD 

      1750       1760       1770       1780       1790       1800 
DETLNQYETS INAAASLSSF SVDVPKNGES VLENLHISES QDLDDLLQKP KMIARRPIMA 

      1810       1820       1830       1840       1850       1860 
WFKEINKHNQ GTHLRSKTEK EQPLMPARSP DSKIQMVSSS QKKGVTVPHS PPQPKTNLEN 

      1870       1880       1890       1900       1910       1920 
KDLSKKSPAE MLLTNGQKAK CGPKLKRLSL KGKAKVNSEA PAANAVKAGG TDHRKPLISP 

      1930       1940       1950       1960       1970       1980 
QTSHKTLSKA VSQRLHVADH EDPDRNTTAA PRSPQCVLES KPPLATSGPL KPSVSDTSIR 

      1990       2000       2010       2020       2030       2040 
TFVSPLTSPK PVPEQGMWSR FHMAVLSEPD RGCPTTPKSP KCRAEGRAPR ADSGPVSPAA 

      2050       2060       2070       2080       2090       2100 
SRNGMSVAGN RQSEPRLASH VAADTAQPRP TGEKGGNIMA SDRLERTNQL KIVEISAEAV 

      2110       2120       2130       2140       2150       2160 
SETVCGNKPA ESDRRGGCLA QGNCQEKSEI RLYRQVAESS TSHPSSLPSH ASQAEQEMSR 

      2170       2180       2190       2200       2210       2220 
SFSMAKLASS SSSLQTAIRK AEYSQGKSSL MSDSRGVPRN SIPGGPSGED HLYFTPRPAT 

      2230       2240       2250       2260       2270       2280 
RTYSMPAQFS SHFGREGHPP HSLGRSRDSQ VPVTSSVVPE AKASRGGLPS LANGQGIYSV 

      2290       2300       2310       2320       2330       2340 
KPLLDTSRNL PATDEGDIIS VQETSCLVTD KIKVTRRHYC YEQNWPHEST SFFSVKQRIK 

      2350       2360       2370       2380       2390       2400 
SFENLANADR PVAKSGASPF LSVSSKPPIG RRSSGSIVSG SLGHPGDAAA RLLRRSLSSC 

      2410       2420       2430       2440       2450       2460 
SENQSEAGTL LPQMAKSPSI MTLTISRQNP PETSSKGSDS ELKKSLGPLG IPTPTMTLAS 

      2470       2480       2490       2500       2510       2520 
PVKRNKSSVR HTQPSPVSRS KLQELRALSM PDLDKLCSED YSAGPSAVLF KTELEITPRR 

      2530       2540       2550       2560       2570       2580 
SPGPPAGGVS CPEKGGNRAC PGGSGPKTSA AETPSSASDT GEAAQDLPFR RSWSVNLDQL 

      2590       2600       2610       2620       2630       2640 
LVSAGDQQRL QSVLSSVGSK STILTLIQEA KAQSENEEDV CFIVLNRKEG SGLGFSVAGG 

      2650       2660       2670       2680       2690       2700 
TDVEPKSITV HRVFSQGAAS QEGTMNRGDF LLSVNGASLA GLAHGNVLKV LHQAQLHKDA 

      2710       2720       2730       2740       2750       2760 
LVVIKKGMDQ PRPSARQEPP TANGKGLLSR KTIPLEPGIG RSVAVHDALC VEVLKTSAGL 

      2770       2780       2790       2800       2810       2820 
GLSLDGGKSS VTGDGPLVIK RVYKGGAAEQ AGIIEAGDEI LAINGKPLVG LMHFDAWNIM 

      2830 
KSVPEGPVQL LIRKHRNSS

« Hide

Isoform 2 [UniParc].

Checksum: 478AF0A0876DE2BE
Show »

FASTA2,640280,092

References

« Hide 'large scale' references
[1]"Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors."
Chaib H., Rubin M.A., Mucci N.R., Li L., Taylor J.M.G., Day M.L., Rhim J.S., Macoska J.A.
Cancer Res. 61:2390-2394(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-1274.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF338650 mRNA. Translation: AAK07661.1.
AB002298 mRNA. Translation: BAA20760.2. Different initiation.
IPIIPI00155647.
IPI00745746.
RefSeqNP_835260.2. NM_178140.2.
UniGeneHs.481819.

3D structure databases

ProteinModelPortalO15018.
ModBaseSearch...

Protein-protein interaction databases

IntActO15018. 2 interactions.
STRING9606.ENSP00000282493.

PTM databases

PhosphoSiteO15018.

Proteomic databases

PaxDbO15018.
PRIDEO15018.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000282493; ENSP00000282493; ENSG00000133401.
ENST00000438447; ENSP00000402033; ENSG00000133401.
GeneID23037.
KEGGhsa:23037.
UCSCuc003jhl.3. human.

Organism-specific databases

CTD23037.
GeneCardsGC05P031584.
H-InvDBHIX0004783.
HGNCHGNC:18486. PDZD2.
HPACAB020784.
MIM610697. gene.
neXtProtNX_O15018.
PharmGKBPA33164.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150595.
HOGENOMHOG000115486.
HOVERGENHBG082116.
InParanoidO15018.
OMAQNWPHES.
OrthoDBEOG4X6C7D.

Gene expression databases

ArrayExpressO15018.
BgeeO15018.
CleanExHS_PDZD2.
GenevestigatorO15018.

Family and domain databases

InterProIPR001478. PDZ.
[Graphical view]
PfamPF00595. PDZ. 5 hits.
[Graphical view]
SMARTSM00228. PDZ. 6 hits.
[Graphical view]
SUPFAMSSF50156. PDZ. 6 hits.
PROSITEPS50106. PDZ. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPDZD2. human.
GenomeRNAi23037.
NextBio44046.
SOURCESearch...

Entry information

Entry namePDZD2_HUMAN
AccessionPrimary (citable) accession number: O15018
Secondary accession number(s): Q9BXD4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: April 17, 2007
Last modified: May 1, 2013
This is version 98 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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