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Protein

PDZ domain-containing protein 2

Gene

PDZD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein 2
Alternative name(s):
Activated in prostate cancer protein
PDZ domain-containing protein 3
Cleaved into the following chain:
Gene namesi
Name:PDZD2
Synonyms:AIPC, KIAA0300, PDZK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:18486. PDZD2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm 1 Publication
  • Endoplasmic reticulum 1 Publication

  • Note: At cell-cell contacts in lung epithelial cells.By similarity

GO - Cellular componenti

  • cell-cell junction Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • extracellular region Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33164.

Polymorphism and mutation databases

BioMutaiPDZD2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 28392839PDZ domain-containing protein 2PRO_0000058294Add
BLAST
Chaini?2493 – 2839347Processed PDZ domain-containing protein 2By similarityPRO_0000302756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei568 – 5681PhosphoserineBy similarity
Modified residuei944 – 9441PhosphoserineBy similarity
Modified residuei948 – 9481PhosphoserineBy similarity
Modified residuei1850 – 18501PhosphoserineBy similarity

Post-translational modificationi

A secreted form is produced by caspase-mediated proteolytic cleavage.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei2492 – 24932Cleavage; by caspasesBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15018.
MaxQBiO15018.
PaxDbiO15018.
PRIDEiO15018.

PTM databases

iPTMnetiO15018.
PhosphoSiteiO15018.

Expressioni

Tissue specificityi

Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.1 Publication

Gene expression databases

BgeeiO15018.
CleanExiHS_PDZD2.
ExpressionAtlasiO15018. baseline and differential.
GenevisibleiO15018. HS.

Organism-specific databases

HPAiCAB020784.
HPA036503.
HPA036504.
HPA064387.

Interactioni

Subunit structurei

Interacts with SCN10A, CTNND2 and PKP4.By similarity

Protein-protein interaction databases

BioGridi116676. 11 interactions.
IntActiO15018. 2 interactions.
STRINGi9606.ENSP00000282493.

Structurei

3D structure databases

ProteinModelPortaliO15018.
SMRiO15018. Positions 68-178, 332-416, 554-812, 2624-2834.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 18298PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini334 – 41986PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini586 – 67287PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini728 – 81386PDZ 4PROSITE-ProRule annotationAdd
BLAST
Domaini2622 – 270685PDZ 5PROSITE-ProRule annotationAdd
BLAST
Domaini2750 – 283586PDZ 6PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2139 – 219456Ser-richAdd
BLAST

Sequence similaritiesi

Contains 6 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
KOG3528. Eukaryota.
ENOG4110362. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000115486.
HOVERGENiHBG082116.
InParanoidiO15018.
OMAiHESTSFF.
OrthoDBiEOG79W94J.
PhylomeDBiO15018.
TreeFamiTF326303.

Family and domain databases

Gene3Di2.30.42.10. 6 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 5 hits.
[Graphical view]
SMARTiSM00228. PDZ. 6 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 6 hits.
PROSITEiPS50106. PDZ. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15018-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPITQDNAVL HLPLLYQWLQ NSLQEGGDGP EQRLCQAAIQ KLQEYIQLNF
60 70 80 90 100
AVDESTVPPD HSPPEMEICT VYLTKELGDT ETVGLSFGNI PVFGDYGEKR
110 120 130 140 150
RGGKKRKTHQ GPVLDVGCIW VTELRKNSPA GKSGKVRLRD EILSLNGQLM
160 170 180 190 200
VGVDVSGASY LAEQCWNGGF IYLIMLRRFK HKAHSTYNGN SSNSSEPGET
210 220 230 240 250
PTLELGDRTA KKGKRTRKFG VISRPPANKA PEESKGSAGC EVSSDPSTEL
260 270 280 290 300
ENGPDPELGN GHVFQLENGP DSLKEVAGPH LERSEVDRGT EHRIPKTDAP
310 320 330 340 350
LTTSNDKRRF SKGGKTDFQS SDCLAREEVG RIWKMELLKE SDGLGIQVSG
360 370 380 390 400
GRGSKRSPHA IVVTQVKEGG AAHRDGRLSL GDELLVINGH LLVGLSHEEA
410 420 430 440 450
VAILRSATGM VQLVVASKEN SAEDLLRLTS KSLPDLTSSV EDVSSWTDNE
460 470 480 490 500
DQEADGEEDE GTSSSVQRAM PGTDEPQDVC GAEESKGNLE SPKQGSNKIK
510 520 530 540 550
LKSRLSGGVH RLESVEEYNE LMVRNGDPRI RMLEVSRDGR KHSLPQLLDS
560 570 580 590 600
SSASQEYHIV KKSTRSLSTT QVESPWRLIR PSVISIIGLY KEKGKGLGFS
610 620 630 640 650
IAGGRDCIRG QMGIFVKTIF PNGSAAEDGR LKEGDEILDV NGIPIKGLTF
660 670 680 690 700
QEAIHTFKQI RSGLFVLTVR TKLVSPSLTP CSTPTHMSRS ASPNFNTSGG
710 720 730 740 750
ASAGGSDEGS SSSLGRKTPG PKDRIVMEVT LNKEPRVGLG IGACCLALEN
760 770 780 790 800
SPPGIYIHSL APGSVAKMES NLSRGDQILE VNSVNVRHAA LSKVHAILSK
810 820 830 840 850
CPPGPVRLVI GRHPNPKVSE QEMDEVIARS TYQESKEANS SPGLGTPLKS
860 870 880 890 900
PSLAKKDSLI SESELSQYFA HDVPGPLSDF MVAGSEDEDH PGSGCSTSEE
910 920 930 940 950
GSLPPSTSTH KEPGKPRANS LVTLGSHRAS GLFHKQVTVA RQASLPGSPQ
960 970 980 990 1000
ALRNPLLRQR KVGCYDANDA SDEEEFDREG DCISLPGALP GPIRPLSEDD
1010 1020 1030 1040 1050
PRRVSISSSK GMDVHNQEER PRKTLVSKAI SAPLLGSSVD LEESIPEGMV
1060 1070 1080 1090 1100
DAASYAANLT DSAEAPKGSP GSWWKKELSG SSSAPKLEYT VRTDTQSPTN
1110 1120 1130 1140 1150
TGSPSSPQQK SEGLGSRHRP VARVSPHCKR SEAEAKPSGS QTVNLTGRAN
1160 1170 1180 1190 1200
DPCDLDSRVQ ATSVKVTVAG FQPGGAVEKE SLGKLTTGDA CVSTSCELAS
1210 1220 1230 1240 1250
ALSHLDASHL TENLPKAASE LGQQPMTELD SSSDLISSPG KKGAAHPDPS
1260 1270 1280 1290 1300
KTSVDTGQVS RPENPSQPAS PRVTKCKARS PVRLPHEGSP SPGEKAAAPP
1310 1320 1330 1340 1350
DYSKTRSASE TSTPHNTRRV AALRGAGPGA EGMTPAGAVL PGDPLTSQEQ
1360 1370 1380 1390 1400
RQGAPGNHSK ALEMTGIHAP ESSQEPSLLE GADSVSSRAP QASLSMLPST
1410 1420 1430 1440 1450
DNTKEACGHV SGHCCPGGSR ESPVTDIDSF IKELDASAAR SPSSQTGDSG
1460 1470 1480 1490 1500
SQEGSAQGHP PAGAGGGSSC RAEPVPGGQT SSPRRAWAAG APAYPQWASQ
1510 1520 1530 1540 1550
PSVLDSINPD KHFTVNKNFL SNYSRNFSSF HEDSTSLSGL GDSTEPSLSS
1560 1570 1580 1590 1600
MYGDAEDSSS DPESLTEAPR ASARDGWSPP RSRVSLHKED PSESEEEQIE
1610 1620 1630 1640 1650
ICSTRGCPNP PSSPAHLPTQ AAICPASAKV LSLKYSTPRE SVASPREKAA
1660 1670 1680 1690 1700
CLPGSYTSGP DSSQPSSLLE MSSQEHETHA DISTSQNHRP SCAEETTEVT
1710 1720 1730 1740 1750
SASSAMENSP LSKVARHFHS PPIILSSPNM VNGLEHDLLD DETLNQYETS
1760 1770 1780 1790 1800
INAAASLSSF SVDVPKNGES VLENLHISES QDLDDLLQKP KMIARRPIMA
1810 1820 1830 1840 1850
WFKEINKHNQ GTHLRSKTEK EQPLMPARSP DSKIQMVSSS QKKGVTVPHS
1860 1870 1880 1890 1900
PPQPKTNLEN KDLSKKSPAE MLLTNGQKAK CGPKLKRLSL KGKAKVNSEA
1910 1920 1930 1940 1950
PAANAVKAGG TDHRKPLISP QTSHKTLSKA VSQRLHVADH EDPDRNTTAA
1960 1970 1980 1990 2000
PRSPQCVLES KPPLATSGPL KPSVSDTSIR TFVSPLTSPK PVPEQGMWSR
2010 2020 2030 2040 2050
FHMAVLSEPD RGCPTTPKSP KCRAEGRAPR ADSGPVSPAA SRNGMSVAGN
2060 2070 2080 2090 2100
RQSEPRLASH VAADTAQPRP TGEKGGNIMA SDRLERTNQL KIVEISAEAV
2110 2120 2130 2140 2150
SETVCGNKPA ESDRRGGCLA QGNCQEKSEI RLYRQVAESS TSHPSSLPSH
2160 2170 2180 2190 2200
ASQAEQEMSR SFSMAKLASS SSSLQTAIRK AEYSQGKSSL MSDSRGVPRN
2210 2220 2230 2240 2250
SIPGGPSGED HLYFTPRPAT RTYSMPAQFS SHFGREGHPP HSLGRSRDSQ
2260 2270 2280 2290 2300
VPVTSSVVPE AKASRGGLPS LANGQGIYSV KPLLDTSRNL PATDEGDIIS
2310 2320 2330 2340 2350
VQETSCLVTD KIKVTRRHYC YEQNWPHEST SFFSVKQRIK SFENLANADR
2360 2370 2380 2390 2400
PVAKSGASPF LSVSSKPPIG RRSSGSIVSG SLGHPGDAAA RLLRRSLSSC
2410 2420 2430 2440 2450
SENQSEAGTL LPQMAKSPSI MTLTISRQNP PETSSKGSDS ELKKSLGPLG
2460 2470 2480 2490 2500
IPTPTMTLAS PVKRNKSSVR HTQPSPVSRS KLQELRALSM PDLDKLCSED
2510 2520 2530 2540 2550
YSAGPSAVLF KTELEITPRR SPGPPAGGVS CPEKGGNRAC PGGSGPKTSA
2560 2570 2580 2590 2600
AETPSSASDT GEAAQDLPFR RSWSVNLDQL LVSAGDQQRL QSVLSSVGSK
2610 2620 2630 2640 2650
STILTLIQEA KAQSENEEDV CFIVLNRKEG SGLGFSVAGG TDVEPKSITV
2660 2670 2680 2690 2700
HRVFSQGAAS QEGTMNRGDF LLSVNGASLA GLAHGNVLKV LHQAQLHKDA
2710 2720 2730 2740 2750
LVVIKKGMDQ PRPSARQEPP TANGKGLLSR KTIPLEPGIG RSVAVHDALC
2760 2770 2780 2790 2800
VEVLKTSAGL GLSLDGGKSS VTGDGPLVIK RVYKGGAAEQ AGIIEAGDEI
2810 2820 2830
LAINGKPLVG LMHFDAWNIM KSVPEGPVQL LIRKHRNSS
Length:2,839
Mass (Da):301,641
Last modified:April 17, 2007 - v4
Checksum:i4B1CB91A9CE96267
GO
Isoform 2 (identifier: O15018-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-555: Missing.
     803-817: Missing.
     909-911: THK → S
     1179-1179: K → KLCQ
     1228-1231: Missing.

Note: May be due to aberrant splicing.
Show »
Length:2,640
Mass (Da):280,092
Checksum:i478AF0A0876DE2BE
GO

Sequence cautioni

The sequence BAA20760.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541P → A in AAK07661 (PubMed:11289102).Curated
Sequence conflicti326 – 3261R → RQ in AAK07661 (PubMed:11289102).Curated
Sequence conflicti2576 – 25761N → K in AAK07661 (PubMed:11289102).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1178 – 11781E → G.
Corresponds to variant rs57158698 [ dbSNP | Ensembl ].
VAR_061691
Natural varianti1258 – 12581Q → K.
Corresponds to variant rs3101878 [ dbSNP | Ensembl ].
VAR_031654
Natural varianti1274 – 12741T → A.1 Publication
Corresponds to variant rs157496 [ dbSNP | Ensembl ].
VAR_031655
Natural varianti1343 – 13431D → E.
Corresponds to variant rs12520467 [ dbSNP | Ensembl ].
VAR_031656
Natural varianti1425 – 14251T → M.
Corresponds to variant rs36097367 [ dbSNP | Ensembl ].
VAR_031657
Natural varianti1649 – 16491A → V.
Corresponds to variant rs3101873 [ dbSNP | Ensembl ].
VAR_031658
Natural varianti2247 – 22471R → Q.
Corresponds to variant rs10066063 [ dbSNP | Ensembl ].
VAR_031659

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei375 – 555181Missing in isoform 2. 1 PublicationVSP_012369Add
BLAST
Alternative sequencei803 – 81715Missing in isoform 2. 1 PublicationVSP_012370Add
BLAST
Alternative sequencei909 – 9113THK → S in isoform 2. 1 PublicationVSP_012371
Alternative sequencei1179 – 11791K → KLCQ in isoform 2. 1 PublicationVSP_012372
Alternative sequencei1228 – 12314Missing in isoform 2. 1 PublicationVSP_012373

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338650 mRNA. Translation: AAK07661.1.
AB002298 mRNA. Translation: BAA20760.2. Different initiation.
CCDSiCCDS34137.1. [O15018-1]
RefSeqiNP_835260.2. NM_178140.3. [O15018-1]
XP_011512297.1. XM_011513995.1. [O15018-1]
UniGeneiHs.481819.

Genome annotation databases

EnsembliENST00000438447; ENSP00000402033; ENSG00000133401. [O15018-1]
GeneIDi23037.
KEGGihsa:23037.
UCSCiuc003jhl.4. human. [O15018-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338650 mRNA. Translation: AAK07661.1.
AB002298 mRNA. Translation: BAA20760.2. Different initiation.
CCDSiCCDS34137.1. [O15018-1]
RefSeqiNP_835260.2. NM_178140.3. [O15018-1]
XP_011512297.1. XM_011513995.1. [O15018-1]
UniGeneiHs.481819.

3D structure databases

ProteinModelPortaliO15018.
SMRiO15018. Positions 68-178, 332-416, 554-812, 2624-2834.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116676. 11 interactions.
IntActiO15018. 2 interactions.
STRINGi9606.ENSP00000282493.

PTM databases

iPTMnetiO15018.
PhosphoSiteiO15018.

Polymorphism and mutation databases

BioMutaiPDZD2.

Proteomic databases

EPDiO15018.
MaxQBiO15018.
PaxDbiO15018.
PRIDEiO15018.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438447; ENSP00000402033; ENSG00000133401. [O15018-1]
GeneIDi23037.
KEGGihsa:23037.
UCSCiuc003jhl.4. human. [O15018-1]

Organism-specific databases

CTDi23037.
GeneCardsiPDZD2.
H-InvDBHIX0004783.
HGNCiHGNC:18486. PDZD2.
HPAiCAB020784.
HPA036503.
HPA036504.
HPA064387.
MIMi610697. gene.
neXtProtiNX_O15018.
PharmGKBiPA33164.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
KOG3528. Eukaryota.
ENOG4110362. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000115486.
HOVERGENiHBG082116.
InParanoidiO15018.
OMAiHESTSFF.
OrthoDBiEOG79W94J.
PhylomeDBiO15018.
TreeFamiTF326303.

Miscellaneous databases

ChiTaRSiPDZD2. human.
GeneWikiiPDZD2.
GenomeRNAii23037.
PROiO15018.
SOURCEiSearch...

Gene expression databases

BgeeiO15018.
CleanExiHS_PDZD2.
ExpressionAtlasiO15018. baseline and differential.
GenevisibleiO15018. HS.

Family and domain databases

Gene3Di2.30.42.10. 6 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 5 hits.
[Graphical view]
SMARTiSM00228. PDZ. 6 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 6 hits.
PROSITEiPS50106. PDZ. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors."
    Chaib H., Rubin M.A., Mucci N.R., Li L., Taylor J.M.G., Day M.L., Rhim J.S., Macoska J.A.
    Cancer Res. 61:2390-2394(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-1274.
    Tissue: Brain.

Entry informationi

Entry nameiPDZD2_HUMAN
AccessioniPrimary (citable) accession number: O15018
Secondary accession number(s): Q9BXD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.