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UniProtKB/Swiss-Prot O15018 (PDZD2_HUMAN)
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June 16, 2009.
Version 65.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: PDZ domain-containing protein 2 Alternative name(s): PDZ domain-containing protein 3 Activated in prostate cancer protein Cleaved into the following chain: 1- Recommended name: Processed PDZ domain-containing protein 2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 2839 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subunit structure | Interacts with SCN10A, CTNND2 and PKP4 By similarity. |
| Subcellular location | Nucleus By similarity. Cytoplasm. Endoplasmic reticulum. Note: At cell-cell contacts in lung epithelial cells By similarity. Processed PDZ domain-containing protein 2: Secreted By similarity. |
| Tissue specificity | Expressed (at protein level) in prostate and many prostate tumors. Ref.1 |
| Post-translational modification | A secreted form is produced by caspase-mediated proteolytic cleavage By similarity. |
| Involvement in disease | May be associated with the early promotion of prostate tumoregenesis. |
| Sequence similarities | Contains 6 PDZ (DHR) domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cytoplasm Endoplasmic reticulum Nucleus Secreted |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Repeat |
| Gene Ontology (GO) | |
| Biological process | cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cell-cell junction Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulumInferred from sequence or structural similarity. Source: UniProtKB extracellular regionInferred from sequence or structural similarity. Source: UniProtKB nucleusInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | protein binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: O15018-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: O15018-2) The sequence of this isoform differs from the canonical sequence as follows: 375-555: Missing. 803-817: Missing. 909-911: THK → S 1179-1179: K → KLCQ 1228-1231: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 2839 | 2839 | PDZ domain-containing protein 2 | PRO_0000058294 | |||||
| Chain | ?2493 – 2839 | 347 | Processed PDZ domain-containing protein 2 By similarity | PRO_0000302756 | |||||
Regions | |||||||||
| Domain | 85 – 182 | 98 | PDZ 1 | ||||||
| Domain | 334 – 419 | 86 | PDZ 2 | ||||||
| Domain | 586 – 672 | 87 | PDZ 3 | ||||||
| Domain | 728 – 813 | 86 | PDZ 4 | ||||||
| Domain | 2622 – 2706 | 85 | PDZ 5 | ||||||
| Domain | 2750 – 2835 | 86 | PDZ 6 | ||||||
| Compositional bias | 2139 – 2194 | 56 | Ser-rich | ||||||
Sites | |||||||||
| Site | 2492 – 2493 | 2 | Cleavage; by caspases By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 375 – 555 | 181 | Missing in isoform 2. | VSP_012369 | |||||
| Alternative sequence | 803 – 817 | 15 | Missing in isoform 2. | VSP_012370 | |||||
| Alternative sequence | 909 – 911 | 3 | THK → S in isoform 2. | VSP_012371 | |||||
| Alternative sequence | 1179 | 1 | K → KLCQ in isoform 2. | VSP_012372 | |||||
| Alternative sequence | 1228 – 1231 | 4 | Missing in isoform 2. | VSP_012373 | |||||
| Natural variant | 1258 | 1 | Q → K: dbSNP rs3101878. | VAR_031654 | |||||
| Natural variant | 1274 | 1 | T → A: dbSNP rs157496. Ref.2 | VAR_031655 | |||||
| Natural variant | 1343 | 1 | D → E: dbSNP rs12520467. | VAR_031656 | |||||
| Natural variant | 1425 | 1 | T → M: dbSNP rs36097367. | VAR_031657 | |||||
| Natural variant | 1649 | 1 | A → V: dbSNP rs3101873. | VAR_031658 | |||||
| Natural variant | 2247 | 1 | R → Q: dbSNP rs10066063. | VAR_031659 | |||||
Experimental info | |||||||||
| Sequence conflict | 254 | 1 | P → A in AAK07661. Ref.1 | ||||||
| Sequence conflict | 326 | 1 | R → RQ in AAK07661. Ref.1 | ||||||
| Sequence conflict | 2576 | 1 | N → K in AAK07661. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors." Chaib H., Rubin M.A., Mucci N.R., Li L., Taylor J.M.G., Day M.L., Rhim J.S., Macoska J.A. Cancer Res. 61:2390-2394(2001) [PubMed: 11289102] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INVOLVEMENT IN PROSTATE TUMORIGENESIS, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. |
| [2] | "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-1274. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF338650 mRNA. Translation: AAK07661.1. AB002298 mRNA. Translation: BAA20760.2. Different initiation. | |
| IPI | IPI00155647. IPI00745746. |
| RefSeq | NP_835260.2. |
| UniGene | Hs.481819 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1QLC based on UniProtKB P31016. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O15018. 1 interaction. |
PTM databases | |
| PhosphoSite | O15018. |
Proteomic databases | |
| PRIDE | O15018. |
Genome annotation databases | |
| Ensembl | ENSG00000133401. Homo sapiens. [Contig view] |
| GeneID | 23037. |
| KEGG | hsa:23037. |
Organism-specific databases | |
| GeneCards | GC05P031834. |
| H-InvDB | HIX0004783. |
| HGNC | HGNC:18486. PDZD2. |
| MIM | 610697. gene. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O15018. |
| HOVERGEN | O15018. |
| OMA | O15018. RASGLFH. |
Gene expression databases | |
| ArrayExpress | O15018. |
| Bgee | O15018. |
| CleanEx | HS_PDZD2. |
Family and domain databases | |
| InterPro | IPR001478. PDZ/DHR/GLGF. [Graphical view] |
| Pfam | PF00595. PDZ. 5 hits. [Graphical view] |
| SMART | SM00228. PDZ. 6 hits. [Graphical view] |
| PROSITE | PS50106. PDZ. 6 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 44046. |
| SOURCE | Search... |
Entry information
| Entry name | PDZD2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O15018 Secondary accession number(s): Q9BXD4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |
