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O15016

- TRI66_HUMAN

UniProt

O15016 - TRI66_HUMAN

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Protein

Tripartite motif-containing protein 66

Gene
TRIM66, C11orf29, KIAA0298
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 4646B box-type 1; atypicalAdd
BLAST
Zinc fingeri60 – 10142B box-type 2Add
BLAST
Zinc fingeri970 – 101748PHD-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 66
Gene namesi
Name:TRIM66
Synonyms:C11orf29, KIAA0298
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:29005. TRIM66.

Subcellular locationi

Nucleus
Note: Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm By similarity.

GO - Cellular componenti

  1. aggresome Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134954583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12161216Tripartite motif-containing protein 66PRO_0000220375Add
BLAST

Proteomic databases

PaxDbiO15016.
PRIDEiO15016.

PTM databases

PhosphoSiteiO15016.

Expressioni

Gene expression databases

ArrayExpressiO15016.
BgeeiO15016.
CleanExiHS_TRIM66.
GenevestigatoriO15016.

Organism-specific databases

HPAiHPA027420.

Interactioni

Subunit structurei

Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000299550.

Structurei

3D structure databases

ProteinModelPortaliO15016.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1056 – 112873BromoAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili130 – 20071 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi860 – 8645PxVxL motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi384 – 571188Gln-richAdd
BLAST
Compositional biasi453 – 49947Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 bromo domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 4646B box-type 1; atypicalAdd
BLAST
Zinc fingeri60 – 10142B box-type 2Add
BLAST
Zinc fingeri970 – 101748PHD-typeAdd
BLAST

Keywords - Domaini

Bromodomain, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000074104.
HOVERGENiHBG057849.
KOiK12032.
PhylomeDBiO15016.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR003649. Bbox_C.
IPR001487. Bromodomain.
IPR019786. Zinc_finger_PHD-type_CS.
IPR000315. Znf_B-box.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00502. BBC. 1 hit.
SM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50014. BROMODOMAIN_2. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15016-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MARNCSECKE KRAAHILCTY CNRWLCSSCT EEHRHSPVPG GPFFPRAQKG     50
SPGVNGGPGD FTLYCPLHTQ EVLKLFCETC DMLTCHSCLV VEHKEHRCRH 100
VEEVLQNQRM LLEGVTTQVA HKKSSLQTSA KQIEDRIFEV KHQHRKVENQ 150
IKMAKMVLMN ELNKQANGLI EELEGITNER KRKLEQQLQS IMVLNRQFEH 200
VQNFINWAVC SKTSVPFLFS KELIVFQMQR LLETSCNTDP GSPWSIRFTW 250
EPNFWTKQLA SLGCITTEGG QMSRADAPAY GGLQGSSPFY QSHQSPVAQQ 300
EALSHPSHKF QSPAVCSSSV CCSHCSPVSP SLKGQVPPPS IHPAHSFRQP 350
PEMVPQQLGS LQCSALLPRE KELACSPHPP KLLQPWLETQ PPVEQESTSQ 400
RLGQQLTSQP VCIVPPQDVQ QGAHAQPTLQ TPSIQVQFGH HQKLKLSHFQ 450
QQPQQQLPPP PPPLPHPPPP LPPPPQQPHP PLPPSQHLAS SQHESPPGPA 500
CSQNMDIMHH KFELEEMQKD LELLLQAQQP SLQLSQTKSP QHLQQTIVGQ 550
INYIVRQPAP VQSQSQEETL QATDEPPASQ GSKPALPLDK NTAAALPQAS 600
GEETPLSVPP VDSTIQHSSP NVVRKHSTSL SIMGFSNTLE MELSSTRLER 650
PLEPQIQSVS NLTAGAPQAV PSLLSAPPKM VSSLTSVQNQ AMPSLTTSHL 700
QTVPSLVHST FQSMPNLISD SPQAMASLAS DHPQAGPSLM SGHTQAVPSL 750
ATCPLQSIPP VSDMQPETGS SSSSGRTSGS LCPRDGADPS LENALCKVKL 800
EEPINLSVKK PPLAPVVSTS TALQQYQNPK ECENFEQGAL ELDAKENQSI 850
RAFNSEHKIP YVRLERLKIC AASSGEMPVF KLKPQKNDQD GSFLLIIECG 900
TESSSMSIKV SQDRLSEATQ APGLEGRKVT VTSLAGQRPP EVEGTSPEEH 950
RLIPRTPGAK KGPPAPIENE DFCAVCLNGG ELLCCDRCPK VFHLSCHVPA 1000
LLSFPGGEWV CTLCRSLTQP EMEYDCENAC YNQPGMRASP GLSMYDQKKC 1050
EKLVLSLCCN NLSLPFHEPV SPLARHYYQI IKRPMDLSII RRKLQKKDPA 1100
HYTTPEEVVS DVRLMFWNCA KFNYPDSEVA EAGRCLEVFF EGWLKEIYPE 1150
KRFAQPRQED SDSEEVSSES GCSTPQGFPW PPYMQEGIQP KRRRRHMENE 1200
RAKRMSFRLA NSISQV 1216
Length:1,216
Mass (Da):134,663
Last modified:November 24, 2009 - v4
Checksum:i5E0F4953230617D1
GO
Isoform 2 (identifier: O15016-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-98: Missing.

Show »
Length:1,214
Mass (Da):134,404
Checksum:iA3973C0EA2D47C3A
GO

Sequence cautioni

The sequence BAA20758.2 differs from that shown. Reason: Frameshift at position 797.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei97 – 982Missing in isoform 2. VSP_038386

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ400879 Genomic DNA. Translation: CAC35389.1.
AB002296 mRNA. Translation: BAA20758.2. Frameshift.
AC091053 Genomic DNA. No translation available.
AC104360 Genomic DNA. No translation available.
RefSeqiNP_055633.1. NM_014818.1. [O15016-1]
UniGeneiHs.130836.
Hs.716965.

Genome annotation databases

EnsembliENST00000299550; ENSP00000299550; ENSG00000166436. [O15016-1]
GeneIDi9866.
KEGGihsa:9866.
UCSCiuc010rbo.2. human. [O15016-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ400879 Genomic DNA. Translation: CAC35389.1 .
AB002296 mRNA. Translation: BAA20758.2 . Frameshift.
AC091053 Genomic DNA. No translation available.
AC104360 Genomic DNA. No translation available.
RefSeqi NP_055633.1. NM_014818.1. [O15016-1 ]
UniGenei Hs.130836.
Hs.716965.

3D structure databases

ProteinModelPortali O15016.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000299550.

PTM databases

PhosphoSitei O15016.

Proteomic databases

PaxDbi O15016.
PRIDEi O15016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299550 ; ENSP00000299550 ; ENSG00000166436 . [O15016-1 ]
GeneIDi 9866.
KEGGi hsa:9866.
UCSCi uc010rbo.2. human. [O15016-1 ]

Organism-specific databases

CTDi 9866.
GeneCardsi GC11M008595.
H-InvDB HIX0201585.
HGNCi HGNC:29005. TRIM66.
HPAi HPA027420.
MIMi 612000. gene.
neXtProti NX_O15016.
PharmGKBi PA134954583.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5076.
HOGENOMi HOG000074104.
HOVERGENi HBG057849.
KOi K12032.
PhylomeDBi O15016.

Miscellaneous databases

GenomeRNAii 9866.
NextBioi 37189.
PROi O15016.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15016.
Bgeei O15016.
CleanExi HS_TRIM66.
Genevestigatori O15016.

Family and domain databases

Gene3Di 1.20.920.10. 2 hits.
3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR003649. Bbox_C.
IPR001487. Bromodomain.
IPR019786. Zinc_finger_PHD-type_CS.
IPR000315. Znf_B-box.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
SMARTi SM00502. BBC. 1 hit.
SM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS50014. BROMODOMAIN_2. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
    Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
    Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-868 (ISOFORM 2).
    Tissue: Brain.
  3. Nagase T., Ishikawa K., Seki N., Nakajima D., Ohira M., Miyajima N., Kotani H., Nomura N., Ohara O.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTRI66_HUMAN
AccessioniPrimary (citable) accession number: O15016
Secondary accession number(s): Q9BQQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 24, 2009
Last modified: July 9, 2014
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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