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O15016 (TRI66_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 66
Gene names
Name:TRIM66
Synonyms:C11orf29, KIAA0298
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1216 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association By similarity.

Subunit structure

Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif By similarity.

Subcellular location

Nucleus. Note: Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm By similarity.

Sequence similarities

Contains 2 B box-type zinc fingers.

Contains 1 bromo domain.

Contains 1 PHD-type zinc finger.

Sequence caution

The sequence BAA20758.2 differs from that shown. Reason: Frameshift at position 797.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainBromodomain
Coiled coil
Repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentaggresome

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay. Source: HPA

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15016-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15016-2)

The sequence of this isoform differs from the canonical sequence as follows:
     97-98: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12161216Tripartite motif-containing protein 66
PRO_0000220375

Regions

Domain1056 – 112873Bromo
Zinc finger1 – 4646B box-type 1; atypical
Zinc finger60 – 10142B box-type 2
Zinc finger970 – 101748PHD-type
Coiled coil130 – 20071 Potential
Motif860 – 8645PxVxL motif
Compositional bias384 – 571188Gln-rich
Compositional bias453 – 49947Pro-rich

Natural variations

Alternative sequence97 – 982Missing in isoform 2.
VSP_038386

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 24, 2009. Version 4.
Checksum: 5E0F4953230617D1

FASTA1,216134,663
        10         20         30         40         50         60 
MARNCSECKE KRAAHILCTY CNRWLCSSCT EEHRHSPVPG GPFFPRAQKG SPGVNGGPGD 

        70         80         90        100        110        120 
FTLYCPLHTQ EVLKLFCETC DMLTCHSCLV VEHKEHRCRH VEEVLQNQRM LLEGVTTQVA 

       130        140        150        160        170        180 
HKKSSLQTSA KQIEDRIFEV KHQHRKVENQ IKMAKMVLMN ELNKQANGLI EELEGITNER 

       190        200        210        220        230        240 
KRKLEQQLQS IMVLNRQFEH VQNFINWAVC SKTSVPFLFS KELIVFQMQR LLETSCNTDP 

       250        260        270        280        290        300 
GSPWSIRFTW EPNFWTKQLA SLGCITTEGG QMSRADAPAY GGLQGSSPFY QSHQSPVAQQ 

       310        320        330        340        350        360 
EALSHPSHKF QSPAVCSSSV CCSHCSPVSP SLKGQVPPPS IHPAHSFRQP PEMVPQQLGS 

       370        380        390        400        410        420 
LQCSALLPRE KELACSPHPP KLLQPWLETQ PPVEQESTSQ RLGQQLTSQP VCIVPPQDVQ 

       430        440        450        460        470        480 
QGAHAQPTLQ TPSIQVQFGH HQKLKLSHFQ QQPQQQLPPP PPPLPHPPPP LPPPPQQPHP 

       490        500        510        520        530        540 
PLPPSQHLAS SQHESPPGPA CSQNMDIMHH KFELEEMQKD LELLLQAQQP SLQLSQTKSP 

       550        560        570        580        590        600 
QHLQQTIVGQ INYIVRQPAP VQSQSQEETL QATDEPPASQ GSKPALPLDK NTAAALPQAS 

       610        620        630        640        650        660 
GEETPLSVPP VDSTIQHSSP NVVRKHSTSL SIMGFSNTLE MELSSTRLER PLEPQIQSVS 

       670        680        690        700        710        720 
NLTAGAPQAV PSLLSAPPKM VSSLTSVQNQ AMPSLTTSHL QTVPSLVHST FQSMPNLISD 

       730        740        750        760        770        780 
SPQAMASLAS DHPQAGPSLM SGHTQAVPSL ATCPLQSIPP VSDMQPETGS SSSSGRTSGS 

       790        800        810        820        830        840 
LCPRDGADPS LENALCKVKL EEPINLSVKK PPLAPVVSTS TALQQYQNPK ECENFEQGAL 

       850        860        870        880        890        900 
ELDAKENQSI RAFNSEHKIP YVRLERLKIC AASSGEMPVF KLKPQKNDQD GSFLLIIECG 

       910        920        930        940        950        960 
TESSSMSIKV SQDRLSEATQ APGLEGRKVT VTSLAGQRPP EVEGTSPEEH RLIPRTPGAK 

       970        980        990       1000       1010       1020 
KGPPAPIENE DFCAVCLNGG ELLCCDRCPK VFHLSCHVPA LLSFPGGEWV CTLCRSLTQP 

      1030       1040       1050       1060       1070       1080 
EMEYDCENAC YNQPGMRASP GLSMYDQKKC EKLVLSLCCN NLSLPFHEPV SPLARHYYQI 

      1090       1100       1110       1120       1130       1140 
IKRPMDLSII RRKLQKKDPA HYTTPEEVVS DVRLMFWNCA KFNYPDSEVA EAGRCLEVFF 

      1150       1160       1170       1180       1190       1200 
EGWLKEIYPE KRFAQPRQED SDSEEVSSES GCSTPQGFPW PPYMQEGIQP KRRRRHMENE 

      1210 
RAKRMSFRLA NSISQV 

« Hide

Isoform 2 [UniParc].

Checksum: A3973C0EA2D47C3A
Show »

FASTA1,214134,404

References

« Hide 'large scale' references
[1]"Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1).
[2]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-868 (ISOFORM 2).
Tissue: Brain.
[3]Nagase T., Ishikawa K., Seki N., Nakajima D., Ohira M., Miyajima N., Kotani H., Nomura N., Ohara O.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ400879 Genomic DNA. Translation: CAC35389.1.
AB002296 mRNA. Translation: BAA20758.2. Frameshift.
AC091053 Genomic DNA. No translation available.
AC104360 Genomic DNA. No translation available.
RefSeqNP_055633.1. NM_014818.1.
UniGeneHs.130836.
Hs.716965.

3D structure databases

ProteinModelPortalO15016.
SMRO15016. Positions 4-103, 969-1149.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000299550.

PTM databases

PhosphoSiteO15016.

Proteomic databases

PaxDbO15016.
PRIDEO15016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299550; ENSP00000299550; ENSG00000166436. [O15016-1]
GeneID9866.
KEGGhsa:9866.
UCSCuc010rbo.2. human. [O15016-1]

Organism-specific databases

CTD9866.
GeneCardsGC11M008595.
H-InvDBHIX0201585.
HGNCHGNC:29005. TRIM66.
HPAHPA027420.
MIM612000. gene.
neXtProtNX_O15016.
PharmGKBPA134954583.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5076.
HOGENOMHOG000074104.
HOVERGENHBG057849.
KOK12032.
PhylomeDBO15016.

Gene expression databases

ArrayExpressO15016.
BgeeO15016.
CleanExHS_TRIM66.
GenevestigatorO15016.

Family and domain databases

Gene3D1.20.920.10. 2 hits.
3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR003649. Bbox_C.
IPR001487. Bromodomain.
IPR019786. Zinc_finger_PHD-type_CS.
IPR000315. Znf_B-box.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTSM00502. BBC. 1 hit.
SM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view]
SUPFAMSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEPS50014. BROMODOMAIN_2. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9866.
NextBio37189.
PROO15016.
SOURCESearch...

Entry information

Entry nameTRI66_HUMAN
AccessionPrimary (citable) accession number: O15016
Secondary accession number(s): Q9BQQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 24, 2009
Last modified: April 16, 2014
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM