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O15016

- TRI66_HUMAN

UniProt

O15016 - TRI66_HUMAN

Protein

Tripartite motif-containing protein 66

Gene

TRIM66

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 4 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1 – 4646B box-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri60 – 10142B box-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri970 – 101748PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 66
    Gene namesi
    Name:TRIM66
    Synonyms:C11orf29, KIAA0298
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:29005. TRIM66.

    Subcellular locationi

    Nucleus
    Note: Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm.By similarity

    GO - Cellular componenti

    1. aggresome Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134954583.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12161216Tripartite motif-containing protein 66PRO_0000220375Add
    BLAST

    Proteomic databases

    PaxDbiO15016.
    PRIDEiO15016.

    PTM databases

    PhosphoSiteiO15016.

    Expressioni

    Gene expression databases

    ArrayExpressiO15016.
    BgeeiO15016.
    CleanExiHS_TRIM66.
    GenevestigatoriO15016.

    Organism-specific databases

    HPAiHPA027420.

    Interactioni

    Subunit structurei

    Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000299550.

    Structurei

    3D structure databases

    ProteinModelPortaliO15016.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1056 – 112873BromoPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili130 – 20071Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi860 – 8645PxVxL motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi384 – 571188Gln-richAdd
    BLAST
    Compositional biasi453 – 49947Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 bromo domain.PROSITE-ProRule annotation
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1 – 4646B box-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri60 – 10142B box-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri970 – 101748PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Bromodomain, Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5076.
    HOGENOMiHOG000074104.
    HOVERGENiHBG057849.
    KOiK12032.
    PhylomeDBiO15016.

    Family and domain databases

    Gene3Di1.20.920.10. 2 hits.
    3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR003649. Bbox_C.
    IPR001487. Bromodomain.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR000315. Znf_B-box.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00439. Bromodomain. 1 hit.
    PF00628. PHD. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    SMARTiSM00502. BBC. 1 hit.
    SM00297. BROMO. 1 hit.
    SM00249. PHD. 2 hits.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS50014. BROMODOMAIN_2. 1 hit.
    PS50119. ZF_BBOX. 2 hits.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15016-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARNCSECKE KRAAHILCTY CNRWLCSSCT EEHRHSPVPG GPFFPRAQKG     50
    SPGVNGGPGD FTLYCPLHTQ EVLKLFCETC DMLTCHSCLV VEHKEHRCRH 100
    VEEVLQNQRM LLEGVTTQVA HKKSSLQTSA KQIEDRIFEV KHQHRKVENQ 150
    IKMAKMVLMN ELNKQANGLI EELEGITNER KRKLEQQLQS IMVLNRQFEH 200
    VQNFINWAVC SKTSVPFLFS KELIVFQMQR LLETSCNTDP GSPWSIRFTW 250
    EPNFWTKQLA SLGCITTEGG QMSRADAPAY GGLQGSSPFY QSHQSPVAQQ 300
    EALSHPSHKF QSPAVCSSSV CCSHCSPVSP SLKGQVPPPS IHPAHSFRQP 350
    PEMVPQQLGS LQCSALLPRE KELACSPHPP KLLQPWLETQ PPVEQESTSQ 400
    RLGQQLTSQP VCIVPPQDVQ QGAHAQPTLQ TPSIQVQFGH HQKLKLSHFQ 450
    QQPQQQLPPP PPPLPHPPPP LPPPPQQPHP PLPPSQHLAS SQHESPPGPA 500
    CSQNMDIMHH KFELEEMQKD LELLLQAQQP SLQLSQTKSP QHLQQTIVGQ 550
    INYIVRQPAP VQSQSQEETL QATDEPPASQ GSKPALPLDK NTAAALPQAS 600
    GEETPLSVPP VDSTIQHSSP NVVRKHSTSL SIMGFSNTLE MELSSTRLER 650
    PLEPQIQSVS NLTAGAPQAV PSLLSAPPKM VSSLTSVQNQ AMPSLTTSHL 700
    QTVPSLVHST FQSMPNLISD SPQAMASLAS DHPQAGPSLM SGHTQAVPSL 750
    ATCPLQSIPP VSDMQPETGS SSSSGRTSGS LCPRDGADPS LENALCKVKL 800
    EEPINLSVKK PPLAPVVSTS TALQQYQNPK ECENFEQGAL ELDAKENQSI 850
    RAFNSEHKIP YVRLERLKIC AASSGEMPVF KLKPQKNDQD GSFLLIIECG 900
    TESSSMSIKV SQDRLSEATQ APGLEGRKVT VTSLAGQRPP EVEGTSPEEH 950
    RLIPRTPGAK KGPPAPIENE DFCAVCLNGG ELLCCDRCPK VFHLSCHVPA 1000
    LLSFPGGEWV CTLCRSLTQP EMEYDCENAC YNQPGMRASP GLSMYDQKKC 1050
    EKLVLSLCCN NLSLPFHEPV SPLARHYYQI IKRPMDLSII RRKLQKKDPA 1100
    HYTTPEEVVS DVRLMFWNCA KFNYPDSEVA EAGRCLEVFF EGWLKEIYPE 1150
    KRFAQPRQED SDSEEVSSES GCSTPQGFPW PPYMQEGIQP KRRRRHMENE 1200
    RAKRMSFRLA NSISQV 1216
    Length:1,216
    Mass (Da):134,663
    Last modified:November 24, 2009 - v4
    Checksum:i5E0F4953230617D1
    GO
    Isoform 2 (identifier: O15016-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         97-98: Missing.

    Show »
    Length:1,214
    Mass (Da):134,404
    Checksum:iA3973C0EA2D47C3A
    GO

    Sequence cautioni

    The sequence BAA20758.2 differs from that shown. Reason: Frameshift at position 797.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei97 – 982Missing in isoform 2. 1 PublicationVSP_038386

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ400879 Genomic DNA. Translation: CAC35389.1.
    AB002296 mRNA. Translation: BAA20758.2. Frameshift.
    AC091053 Genomic DNA. No translation available.
    AC104360 Genomic DNA. No translation available.
    RefSeqiNP_055633.1. NM_014818.1. [O15016-1]
    UniGeneiHs.130836.
    Hs.716965.

    Genome annotation databases

    EnsembliENST00000299550; ENSP00000299550; ENSG00000166436. [O15016-1]
    GeneIDi9866.
    KEGGihsa:9866.
    UCSCiuc010rbo.2. human. [O15016-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ400879 Genomic DNA. Translation: CAC35389.1 .
    AB002296 mRNA. Translation: BAA20758.2 . Frameshift.
    AC091053 Genomic DNA. No translation available.
    AC104360 Genomic DNA. No translation available.
    RefSeqi NP_055633.1. NM_014818.1. [O15016-1 ]
    UniGenei Hs.130836.
    Hs.716965.

    3D structure databases

    ProteinModelPortali O15016.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000299550.

    PTM databases

    PhosphoSitei O15016.

    Proteomic databases

    PaxDbi O15016.
    PRIDEi O15016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299550 ; ENSP00000299550 ; ENSG00000166436 . [O15016-1 ]
    GeneIDi 9866.
    KEGGi hsa:9866.
    UCSCi uc010rbo.2. human. [O15016-1 ]

    Organism-specific databases

    CTDi 9866.
    GeneCardsi GC11M008595.
    H-InvDB HIX0201585.
    HGNCi HGNC:29005. TRIM66.
    HPAi HPA027420.
    MIMi 612000. gene.
    neXtProti NX_O15016.
    PharmGKBi PA134954583.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5076.
    HOGENOMi HOG000074104.
    HOVERGENi HBG057849.
    KOi K12032.
    PhylomeDBi O15016.

    Miscellaneous databases

    GenomeRNAii 9866.
    NextBioi 37189.
    PROi O15016.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15016.
    Bgeei O15016.
    CleanExi HS_TRIM66.
    Genevestigatori O15016.

    Family and domain databases

    Gene3Di 1.20.920.10. 2 hits.
    3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR003649. Bbox_C.
    IPR001487. Bromodomain.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR000315. Znf_B-box.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00439. Bromodomain. 1 hit.
    PF00628. PHD. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    SMARTi SM00502. BBC. 1 hit.
    SM00297. BROMO. 1 hit.
    SM00249. PHD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS50014. BROMODOMAIN_2. 1 hit.
    PS50119. ZF_BBOX. 2 hits.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
      Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
      Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1).
    2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-868 (ISOFORM 2).
      Tissue: Brain.
    3. Nagase T., Ishikawa K., Seki N., Nakajima D., Ohira M., Miyajima N., Kotani H., Nomura N., Ohara O.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTRI66_HUMAN
    AccessioniPrimary (citable) accession number: O15016
    Secondary accession number(s): Q9BQQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 111 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3