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Protein

Zinc finger protein 609

Gene

ZNF609

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri495 – 52026C2H2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 609
Gene namesi
Name:ZNF609
Synonyms:KIAA0295
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29003. ZNF609.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952302.

Polymorphism and mutation databases

BioMutaiZNF609.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14111411Zinc finger protein 609PRO_0000280422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei358 – 3581PhosphoserineCombined sources
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei379 – 3791PhosphoserineCombined sources
Modified residuei381 – 3811PhosphothreonineCombined sources
Modified residuei413 – 4131PhosphoserineCombined sources
Modified residuei433 – 4331PhosphoserineCombined sources
Modified residuei446 – 4461PhosphoserineCombined sources
Modified residuei452 – 4521PhosphoserineCombined sources
Modified residuei467 – 4671PhosphoserineCombined sources
Modified residuei470 – 4701PhosphoserineCombined sources
Modified residuei533 – 5331PhosphoserineBy similarity
Modified residuei576 – 5761PhosphoserineCombined sources
Modified residuei578 – 5781PhosphoserineCombined sources
Modified residuei743 – 7431PhosphoserineCombined sources
Modified residuei746 – 7461PhosphothreonineCombined sources
Modified residuei758 – 7581PhosphoserineCombined sources
Cross-linki789 – 789Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei804 – 8041PhosphoserineCombined sources
Modified residuei823 – 8231PhosphothreonineCombined sources
Modified residuei842 – 8421PhosphoserineCombined sources
Modified residuei846 – 8461PhosphoserineCombined sources
Modified residuei849 – 8491PhosphoserineCombined sources
Modified residuei1055 – 10551PhosphoserineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO15014.
MaxQBiO15014.
PaxDbiO15014.
PeptideAtlasiO15014.
PRIDEiO15014.

PTM databases

iPTMnetiO15014.
PhosphoSiteiO15014.

Expressioni

Gene expression databases

BgeeiENSG00000180357.
CleanExiHS_ZNF609.
ExpressionAtlasiO15014. baseline and differential.
GenevisibleiO15014. HS.

Organism-specific databases

HPAiHPA040742.
HPA040832.

Interactioni

Protein-protein interaction databases

BioGridi116695. 17 interactions.
DIPiDIP-50012N.
IntActiO15014. 9 interactions.
MINTiMINT-2870331.
STRINGi9606.ENSP00000316527.

Structurei

3D structure databases

ProteinModelPortaliO15014.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi725 – 73511Poly-LysAdd
BLAST
Compositional biasi952 – 9554Poly-Ser
Compositional biasi1333 – 13364Poly-Gly
Compositional biasi1366 – 13716Poly-His

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri495 – 52026C2H2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQYG. Eukaryota.
ENOG410XRNB. LUCA.
GeneTreeiENSGT00390000008748.
HOGENOMiHOG000082539.
HOVERGENiHBG054557.
InParanoidiO15014.
OMAiLMSTHHH.
OrthoDBiEOG091G00Q9.
PhylomeDBiO15014.
TreeFamiTF329775.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSSGASGG KGVDANPVET YDSGDEWDIG VGNLIIDLDA DLEKDQQKLE
60 70 80 90 100
MSGSKEVGIP APNAVATLPD NIKFVTPVPG PQGKEGKSKS KRSKSGKDTS
110 120 130 140 150
KPTPGTSLFT PSEGAASKKE VQGRSGDGAN AGGLVAAIAP KGSEKAAKAS
160 170 180 190 200
RSVAGSKKEK ENSSSKSKKE RSEGVGTCSE KDPGVLQPVP LGGRGGQYDG
210 220 230 240 250
SAGVDTGAVE PLGSIAIEPG AALNPLGTKP EPEEGENECR LLKKVKSEKM
260 270 280 290 300
ESPVSTPAVL PIHLLVPVVN NDISSPCEQI MVRTRSVGVN TCDVALATEP
310 320 330 340 350
ECLGPCEPGT SVNLEGIVWQ ETEDGMLVVN VTWRNKTYVG TLLDCTRHDW
360 370 380 390 400
APPRFCDSPT SDLEMRNGRG RGKRMRPNSN TPVNETATAS DSKGTSNSSK
410 420 430 440 450
TRAGANSKGR RGSQNSSEHR PPASSTSEDV KASPSSANKR KNKPLSDMEL
460 470 480 490 500
NSSSEDSKGS KRVRTNSMGS ATGPLPGTKV EPTVLDRNCP SPVLIDCPHP
510 520 530 540 550
NCNKKYKHIN GLKYHQAHAH TDDDSKPEAD GDSEYGEEPI LHADLGSCNG
560 570 580 590 600
ASVSQKGSLS PARSATPKVR LVEPHSPSPS SKFSTKGLCK KKLSGEGDTD
610 620 630 640 650
LGALSNDGSD DGPSVMDETS NDAFDSLERK CMEKEKCKKP SSLKPEKIPS
660 670 680 690 700
KSLKSARPIA PAIPPQQIYT FQTATFTAAS PGSSSGLTAT VAQAMPNSPQ
710 720 730 740 750
LKPIQPKPTV MGEPFTVNPA LTPAKDKKKK DKKKKESSKE LESPLTPGKV
760 770 780 790 800
CRAEEGKSPF RESSGDGMKM EGLLNGSSDP HQSRLASIKA EADKIYSFTD
810 820 830 840 850
NAPSPSIGGS SRLENTTPTQ PLTPLHVVTQ NGAEASSVKT NSPAYSDISD
860 870 880 890 900
AGEDGEGKVD SVKSKDAEQL VKEGAKKTLF PPQPQSKDSP YYQGFESYYS
910 920 930 940 950
PSYAQSSPGA LNPSSQAGVE SQALKTKRDE EPESIEGKVK NDICEEKKPE
960 970 980 990 1000
LSSSSQQPSV IQQRPNMYMQ SLYYNQYAYV PPYGYSDQSY HTHLLSTNTA
1010 1020 1030 1040 1050
YRQQYEEQQK RQSLEQQQRG VDKKAEMGLK EREAALKEEW KQKPSIPPTL
1060 1070 1080 1090 1100
TKAPSLTDLV KSGPGKAKEP GADPAKSVII PKLDDSSKLP GQAPEGLKVK
1110 1120 1130 1140 1150
LSDASHLSKE ASEAKTGAEC GRQAEMDPIL WYRQEAEPRM WTYVYPAKYS
1160 1170 1180 1190 1200
DIKSEDERWK EERDRKLKEE RSRSKDSVPK EDGKESTSSD CKLPTSEESR
1210 1220 1230 1240 1250
LGSKEPRPSV HVPVSSPLTQ HQSYIPYMHG YSYSQSYDPN HPSYRSMPAV
1260 1270 1280 1290 1300
MMQNYPGSYL PSSYSFSPYG SKVSGGEDAD KARASPSVTC KSSSESKALD
1310 1320 1330 1340 1350
ILQQHASHYK SKSPTISDKT SQERDRGGCG VVGGGGSCSS VGGASGGERS
1360 1370 1380 1390 1400
VDRPRTSPSQ RLMSTHHHHH HLGYSLLPAQ YNLPYAAGLS STAIVASQQG
1410
STPSLYPPPR R
Length:1,411
Mass (Da):151,191
Last modified:March 20, 2007 - v2
Checksum:i63A32348BB5C678E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti766 – 7661D → N in BAA20755 (PubMed:9205841).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090543 Genomic DNA. No translation available.
AB002293 mRNA. Translation: BAA20755.1.
BC110401 mRNA. Translation: AAI10402.1.
CCDSiCCDS32270.1.
RefSeqiNP_055857.1. NM_015042.1.
XP_011519688.1. XM_011521386.2.
UniGeneiHs.595451.
Hs.696256.

Genome annotation databases

EnsembliENST00000326648; ENSP00000316527; ENSG00000180357.
GeneIDi23060.
KEGGihsa:23060.
UCSCiuc002ann.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090543 Genomic DNA. No translation available.
AB002293 mRNA. Translation: BAA20755.1.
BC110401 mRNA. Translation: AAI10402.1.
CCDSiCCDS32270.1.
RefSeqiNP_055857.1. NM_015042.1.
XP_011519688.1. XM_011521386.2.
UniGeneiHs.595451.
Hs.696256.

3D structure databases

ProteinModelPortaliO15014.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116695. 17 interactions.
DIPiDIP-50012N.
IntActiO15014. 9 interactions.
MINTiMINT-2870331.
STRINGi9606.ENSP00000316527.

PTM databases

iPTMnetiO15014.
PhosphoSiteiO15014.

Polymorphism and mutation databases

BioMutaiZNF609.

Proteomic databases

EPDiO15014.
MaxQBiO15014.
PaxDbiO15014.
PeptideAtlasiO15014.
PRIDEiO15014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326648; ENSP00000316527; ENSG00000180357.
GeneIDi23060.
KEGGihsa:23060.
UCSCiuc002ann.4. human.

Organism-specific databases

CTDi23060.
GeneCardsiZNF609.
HGNCiHGNC:29003. ZNF609.
HPAiHPA040742.
HPA040832.
neXtProtiNX_O15014.
PharmGKBiPA134952302.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQYG. Eukaryota.
ENOG410XRNB. LUCA.
GeneTreeiENSGT00390000008748.
HOGENOMiHOG000082539.
HOVERGENiHBG054557.
InParanoidiO15014.
OMAiLMSTHHH.
OrthoDBiEOG091G00Q9.
PhylomeDBiO15014.
TreeFamiTF329775.

Miscellaneous databases

ChiTaRSiZNF609. human.
GenomeRNAii23060.
PROiO15014.

Gene expression databases

BgeeiENSG00000180357.
CleanExiHS_ZNF609.
ExpressionAtlasiO15014. baseline and differential.
GenevisibleiO15014. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN609_HUMAN
AccessioniPrimary (citable) accession number: O15014
Secondary accession number(s): Q0D2I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.