O15013 (ARHGA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho guanine nucleotide exchange factor 10

Gene names

Name:	ARHGEF10
Synonyms:	KIAA0294

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1369 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in developmental myelination of peripheral nerves. Ref.7
Involvement in disease	Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. Ref.7
Sequence similarities	Contains 1 DH (DBL-homology) domain.
Sequence caution	The sequence AAH36809.1 differs from that shown. Reason: Probable cloning artifact. The sequence AAH40474.1 differs from that shown. Reason: Probable cloning artifact. The sequence BAA20754.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAH18365.1 differs from that shown. Reason: Erroneous termination at position 895. Translated as Lys.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Coiled coil
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	centrosome duplication Inferred from mutant phenotype. Source: BHF-UCL myelination in peripheral nervous system Inferred from mutant phenotype Ref.7. Source: BHF-UCL positive regulation of GTP catabolic process Inferred from direct assay. Source: BHF-UCL positive regulation of stress fiber assembly Inferred from mutant phenotype. Source: BHF-UCL regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro spindle assembly involved in mitosis Inferred from mutant phenotype. Source: BHF-UCL
Cellular component	centrosome Inferred from direct assay. Source: BHF-UCL cytosol Non-traceable author statement. Source: BHF-UCL soluble fraction Inferred from direct assay. Source: BHF-UCL
Molecular function	Rho guanyl-nucleotide exchange factor activity Inferred from direct assay. Source: BHF-UCL kinesin binding Inferred from physical interaction. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15013-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: O15013-6)

The sequence of this isoform differs from the canonical sequence as follows:
     545-545: Missing.

Isoform 3 (identifier: O15013-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     307-345: Missing.

Isoform 4 (identifier: O15013-4)

The sequence of this isoform differs from the canonical sequence as follows:
     897-925: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: O15013-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     185-185: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1369	1369	Rho guanine nucleotide exchange factor 10		PRO_0000080926
Regions
	Domain	421 – 608	188	DH
	Coiled coil	304 – 355	52	Potential
	Compositional bias	1271 – 1304	34	Ser-rich
Amino acid modifications
	Modified residue	379	1	Phosphoserine By similarity
	Modified residue	1284	1	Phosphoserine Ref.8
	Modified residue	1287	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 24	24	Missing in isoform 3 and isoform 5.		VSP_040754
	Alternative sequence	185	1	Missing in isoform 5.		VSP_040755
	Alternative sequence	307 – 345	39	Missing in isoform 3.		VSP_040756
	Alternative sequence	545	1	Missing in isoform 2.		VSP_040757
	Alternative sequence	897 – 925	29	Missing in isoform 4.		VSP_010704
	Natural variant	357	1	T → I in SNCV. Ref.7		VAR_019118
	Natural variant	700	1	V → I. Corresponds to variant rs2294039 [ dbSNP | Ensembl ].		VAR_038603
	Natural variant	725	1	V → I. Corresponds to variant rs2294039 [ dbSNP | Ensembl ].		VAR_057188
Experimental info
	Sequence conflict	395	1	L → F in AAI12927. Ref.5
	Sequence conflict	500	1	D → V in AAH40474. Ref.5
	Sequence conflict	1024	1	T → S in AAB71662. Ref.6
	Sequence conflict	1046	1	S → T in AAB71662. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 4. Checksum: 6F87869C7C6A5759	FASTA	1,369	151,612
	10 20 30 40 50 60 MRPPGFLSRA PSLNRAERGI WSCSMDQREP LPPAPAENEM KYDTNNNEEE EGEQFDFDSG 70 80 90 100 110 120 DEIPEADRQA PSAPETGGAG ASEAPAPTGG EDGAGAETTP VAEPTKLVLP MKVNPYSVID 130 140 150 160 170 180 ITPFQEDQPP TPVPSAEEEN VGLHVPCGYL VPVPCGYAVP SNLPLLLPAY SSPVIICATS 190 200 210 220 230 240 LDEEAETPEV TEDRQPNSLS SEEPPTSEDQ VGREDSALAR WAADPANTAW MENPEEAIYD 250 260 270 280 290 300 DVPRENSDSE PDEMIYDDVE NGDEGGNSSL EYGWSSSEFE SYEEQSDSEC KNGIPRSFLR 310 320 330 340 350 360 SNHKKQLSHD LTRLKEHYEK KMRDLMASTV GVVEIQQLRQ KHELKMQKLV KAAKDGTKDG 370 380 390 400 410 420 LERTRAAVKR GRSFIRTKSL IAQDHRSSLE EEQNLFIDVD CKHPEAILTP MPEGLSQQQV 430 440 450 460 470 480 VRRYILGSVV DSEKNYVDAL KRILEQYEKP LSEMEPKVLS ERKLKTVFYR VKEILQCHSL 490 500 510 520 530 540 FQIALASRVS EWDSVEMIGD VFVASFSKSM VLDAYSEYVN NFSTAVAVLK KTCATKPAFL 550 560 570 580 590 600 EFLKQEQEAS PDRTTLYSLM MKPIQRFPQF ILLLQDMLKN TSKGHPDRLP LQMALTELET 610 620 630 640 650 660 LAEKLNERKR DADQRCEVKQ IAKAINERYL NKLLSSGSRY LIRSDDMIET VYNDRGEIVK 670 680 690 700 710 720 TKERRVFMLN DVLMCATVSS RPSHDSRVMS SQRYLLKWSV PLGHVDAIEY GSSAGTGEHS 730 740 750 760 770 780 RHLAVHPPES LAVVANAKPN KVYMGPGQLY QDLQNLLHDL NVIGQITQLI GNLKGNYQNL 790 800 810 820 830 840 NQSVAHDWTS GLQRLILKKE DEIRAADCCR IQLQLPGKQD KSGRPTFFTA VFNTFTPAIK 850 860 870 880 890 900 ESWVNSLQMA KLALEEENHM GWFCVEDDGN HIKKEKHPLL VGHMPVMVAK QQEFKIECAA 910 920 930 940 950 960 YNPEPYLNNE SQPDSFSTAH GFLWIGSCTH QMGQIAIVSF QNSTPKVIEC FNVESRILCM 970 980 990 1000 1010 1020 LYVPVEEKRR EPGAPPDPET PAVRASDVPT ICVGTEEGSI SIYKSSQGSK KVRLQHFFTP 1030 1040 1050 1060 1070 1080 EKSTVMSLAC TSQSLYAGLV NGAVASYARA PDGSWDSEPQ KVIKLGVLPV RSLLMMEDTL 1090 1100 1110 1120 1130 1140 WAASGGQVFI ISVETHAVEG QLEAHQEEGM VISHMAVSGV GIWIAFTSGS TLRLFHTETL 1150 1160 1170 1180 1190 1200 KHLQDINIAT PVHNMLPGHQ RLSVTSLLVC HGLLMVGTSL GVLVALPVPR LQGIPKVTGR 1210 1220 1230 1240 1250 1260 GMVSYHAHNS PVKFIVLATA LHEKDKDKSR DSLAPGPEPQ DEDQKDALPS GGAGSSLSQG 1270 1280 1290 1300 1310 1320 DPDAAIWLGD SLGSMTQKSD LSSSSGSLSL SHGSSSLEHR SEDSTIYDLL KDPVSLRSKA 1330 1340 1350 1360 RRAKKAKASS ALVVCGGQGH RRVHRKARQP HQEELAPTVM VWQIPLLNI
	Isoform 2 [UniParc]. Checksum: DD1BB1820F4D85E4	FASTA	1,368	151,483
	10 20 30 40 50 60 MRPPGFLSRA PSLNRAERGI WSCSMDQREP LPPAPAENEM KYDTNNNEEE EGEQFDFDSG 70 80 90 100 110 120 DEIPEADRQA PSAPETGGAG ASEAPAPTGG EDGAGAETTP VAEPTKLVLP MKVNPYSVID 130 140 150 160 170 180 ITPFQEDQPP TPVPSAEEEN VGLHVPCGYL VPVPCGYAVP SNLPLLLPAY SSPVIICATS 190 200 210 220 230 240 LDEEAETPEV TEDRQPNSLS SEEPPTSEDQ VGREDSALAR WAADPANTAW MENPEEAIYD 250 260 270 280 290 300 DVPRENSDSE PDEMIYDDVE NGDEGGNSSL EYGWSSSEFE SYEEQSDSEC KNGIPRSFLR 310 320 330 340 350 360 SNHKKQLSHD LTRLKEHYEK KMRDLMASTV GVVEIQQLRQ KHELKMQKLV KAAKDGTKDG 370 380 390 400 410 420 LERTRAAVKR GRSFIRTKSL IAQDHRSSLE EEQNLFIDVD CKHPEAILTP MPEGLSQQQV 430 440 450 460 470 480 VRRYILGSVV DSEKNYVDAL KRILEQYEKP LSEMEPKVLS ERKLKTVFYR VKEILQCHSL 490 500 510 520 530 540 FQIALASRVS EWDSVEMIGD VFVASFSKSM VLDAYSEYVN NFSTAVAVLK KTCATKPAFL 550 560 570 580 590 600 EFLKEQEASP DRTTLYSLMM KPIQRFPQFI LLLQDMLKNT SKGHPDRLPL QMALTELETL 610 620 630 640 650 660 AEKLNERKRD ADQRCEVKQI AKAINERYLN KLLSSGSRYL IRSDDMIETV YNDRGEIVKT 670 680 690 700 710 720 KERRVFMLND VLMCATVSSR PSHDSRVMSS QRYLLKWSVP LGHVDAIEYG SSAGTGEHSR 730 740 750 760 770 780 HLAVHPPESL AVVANAKPNK VYMGPGQLYQ DLQNLLHDLN VIGQITQLIG NLKGNYQNLN 790 800 810 820 830 840 QSVAHDWTSG LQRLILKKED EIRAADCCRI QLQLPGKQDK SGRPTFFTAV FNTFTPAIKE 850 860 870 880 890 900 SWVNSLQMAK LALEEENHMG WFCVEDDGNH IKKEKHPLLV GHMPVMVAKQ QEFKIECAAY 910 920 930 940 950 960 NPEPYLNNES QPDSFSTAHG FLWIGSCTHQ MGQIAIVSFQ NSTPKVIECF NVESRILCML 970 980 990 1000 1010 1020 YVPVEEKRRE PGAPPDPETP AVRASDVPTI CVGTEEGSIS IYKSSQGSKK VRLQHFFTPE 1030 1040 1050 1060 1070 1080 KSTVMSLACT SQSLYAGLVN GAVASYARAP DGSWDSEPQK VIKLGVLPVR SLLMMEDTLW 1090 1100 1110 1120 1130 1140 AASGGQVFII SVETHAVEGQ LEAHQEEGMV ISHMAVSGVG IWIAFTSGST LRLFHTETLK 1150 1160 1170 1180 1190 1200 HLQDINIATP VHNMLPGHQR LSVTSLLVCH GLLMVGTSLG VLVALPVPRL QGIPKVTGRG 1210 1220 1230 1240 1250 1260 MVSYHAHNSP VKFIVLATAL HEKDKDKSRD SLAPGPEPQD EDQKDALPSG GAGSSLSQGD 1270 1280 1290 1300 1310 1320 PDAAIWLGDS LGSMTQKSDL SSSSGSLSLS HGSSSLEHRS EDSTIYDLLK DPVSLRSKAR 1330 1340 1350 1360 RAKKAKASSA LVVCGGQGHR RVHRKARQPH QEELAPTVMV WQIPLLNI
	Isoform 3 [UniParc]. Checksum: 051A631DCB20F225	FASTA	1,306	144,269
	10 20 30 40 50 60 MDQREPLPPA PAENEMKYDT NNNEEEEGEQ FDFDSGDEIP EADRQAPSAP ETGGAGASEA 70 80 90 100 110 120 PAPTGGEDGA GAETTPVAEP TKLVLPMKVN PYSVIDITPF QEDQPPTPVP SAEEENVGLH 130 140 150 160 170 180 VPCGYLVPVP CGYAVPSNLP LLLPAYSSPV IICATSLDEE AETPEVTEDR QPNSLSSEEP 190 200 210 220 230 240 PTSEDQVGRE DSALARWAAD PANTAWMENP EEAIYDDVPR ENSDSEPDEM IYDDVENGDE 250 260 270 280 290 300 GGNSSLEYGW SSSEFESYEE QSDSECKNGI PRSFLRSNHK KQMQKLVKAA KDGTKDGLER 310 320 330 340 350 360 TRAAVKRGRS FIRTKSLIAQ DHRSSLEEEQ NLFIDVDCKH PEAILTPMPE GLSQQQVVRR 370 380 390 400 410 420 YILGSVVDSE KNYVDALKRI LEQYEKPLSE MEPKVLSERK LKTVFYRVKE ILQCHSLFQI 430 440 450 460 470 480 ALASRVSEWD SVEMIGDVFV ASFSKSMVLD AYSEYVNNFS TAVAVLKKTC ATKPAFLEFL 490 500 510 520 530 540 KQEQEASPDR TTLYSLMMKP IQRFPQFILL LQDMLKNTSK GHPDRLPLQM ALTELETLAE 550 560 570 580 590 600 KLNERKRDAD QRCEVKQIAK AINERYLNKL LSSGSRYLIR SDDMIETVYN DRGEIVKTKE 610 620 630 640 650 660 RRVFMLNDVL MCATVSSRPS HDSRVMSSQR YLLKWSVPLG HVDAIEYGSS AGTGEHSRHL 670 680 690 700 710 720 AVHPPESLAV VANAKPNKVY MGPGQLYQDL QNLLHDLNVI GQITQLIGNL KGNYQNLNQS 730 740 750 760 770 780 VAHDWTSGLQ RLILKKEDEI RAADCCRIQL QLPGKQDKSG RPTFFTAVFN TFTPAIKESW 790 800 810 820 830 840 VNSLQMAKLA LEEENHMGWF CVEDDGNHIK KEKHPLLVGH MPVMVAKQQE FKIECAAYNP 850 860 870 880 890 900 EPYLNNESQP DSFSTAHGFL WIGSCTHQMG QIAIVSFQNS TPKVIECFNV ESRILCMLYV 910 920 930 940 950 960 PVEEKRREPG APPDPETPAV RASDVPTICV GTEEGSISIY KSSQGSKKVR LQHFFTPEKS 970 980 990 1000 1010 1020 TVMSLACTSQ SLYAGLVNGA VASYARAPDG SWDSEPQKVI KLGVLPVRSL LMMEDTLWAA 1030 1040 1050 1060 1070 1080 SGGQVFIISV ETHAVEGQLE AHQEEGMVIS HMAVSGVGIW IAFTSGSTLR LFHTETLKHL 1090 1100 1110 1120 1130 1140 QDINIATPVH NMLPGHQRLS VTSLLVCHGL LMVGTSLGVL VALPVPRLQG IPKVTGRGMV 1150 1160 1170 1180 1190 1200 SYHAHNSPVK FIVLATALHE KDKDKSRDSL APGPEPQDED QKDALPSGGA GSSLSQGDPD 1210 1220 1230 1240 1250 1260 AAIWLGDSLG SMTQKSDLSS SSGSLSLSHG SSSLEHRSED STIYDLLKDP VSLRSKARRA 1270 1280 1290 1300 KKAKASSALV VCGGQGHRRV HRKARQPHQE ELAPTVMVWQ IPLLNI
	Isoform 4 [UniParc]. Checksum: 80938B8E9F3189D1	FASTA	1,340	148,328
	10 20 30 40 50 60 MRPPGFLSRA PSLNRAERGI WSCSMDQREP LPPAPAENEM KYDTNNNEEE EGEQFDFDSG 70 80 90 100 110 120 DEIPEADRQA PSAPETGGAG ASEAPAPTGG EDGAGAETTP VAEPTKLVLP MKVNPYSVID 130 140 150 160 170 180 ITPFQEDQPP TPVPSAEEEN VGLHVPCGYL VPVPCGYAVP SNLPLLLPAY SSPVIICATS 190 200 210 220 230 240 LDEEAETPEV TEDRQPNSLS SEEPPTSEDQ VGREDSALAR WAADPANTAW MENPEEAIYD 250 260 270 280 290 300 DVPRENSDSE PDEMIYDDVE NGDEGGNSSL EYGWSSSEFE SYEEQSDSEC KNGIPRSFLR 310 320 330 340 350 360 SNHKKQLSHD LTRLKEHYEK KMRDLMASTV GVVEIQQLRQ KHELKMQKLV KAAKDGTKDG 370 380 390 400 410 420 LERTRAAVKR GRSFIRTKSL IAQDHRSSLE EEQNLFIDVD CKHPEAILTP MPEGLSQQQV 430 440 450 460 470 480 VRRYILGSVV DSEKNYVDAL KRILEQYEKP LSEMEPKVLS ERKLKTVFYR VKEILQCHSL 490 500 510 520 530 540 FQIALASRVS EWDSVEMIGD VFVASFSKSM VLDAYSEYVN NFSTAVAVLK KTCATKPAFL 550 560 570 580 590 600 EFLKQEQEAS PDRTTLYSLM MKPIQRFPQF ILLLQDMLKN TSKGHPDRLP LQMALTELET 610 620 630 640 650 660 LAEKLNERKR DADQRCEVKQ IAKAINERYL NKLLSSGSRY LIRSDDMIET VYNDRGEIVK 670 680 690 700 710 720 TKERRVFMLN DVLMCATVSS RPSHDSRVMS SQRYLLKWSV PLGHVDAIEY GSSAGTGEHS 730 740 750 760 770 780 RHLAVHPPES LAVVANAKPN KVYMGPGQLY QDLQNLLHDL NVIGQITQLI GNLKGNYQNL 790 800 810 820 830 840 NQSVAHDWTS GLQRLILKKE DEIRAADCCR IQLQLPGKQD KSGRPTFFTA VFNTFTPAIK 850 860 870 880 890 900 ESWVNSLQMA KLALEEENHM GWFCVEDDGN HIKKEKHPLL VGHMPVMVAK QQEFKIGSCT 910 920 930 940 950 960 HQMGQIAIVS FQNSTPKVIE CFNVESRILC MLYVPVEEKR REPGAPPDPE TPAVRASDVP 970 980 990 1000 1010 1020 TICVGTEEGS ISIYKSSQGS KKVRLQHFFT PEKSTVMSLA CTSQSLYAGL VNGAVASYAR 1030 1040 1050 1060 1070 1080 APDGSWDSEP QKVIKLGVLP VRSLLMMEDT LWAASGGQVF IISVETHAVE GQLEAHQEEG 1090 1100 1110 1120 1130 1140 MVISHMAVSG VGIWIAFTSG STLRLFHTET LKHLQDINIA TPVHNMLPGH QRLSVTSLLV 1150 1160 1170 1180 1190 1200 CHGLLMVGTS LGVLVALPVP RLQGIPKVTG RGMVSYHAHN SPVKFIVLAT ALHEKDKDKS 1210 1220 1230 1240 1250 1260 RDSLAPGPEP QDEDQKDALP SGGAGSSLSQ GDPDAAIWLG DSLGSMTQKS DLSSSSGSLS 1270 1280 1290 1300 1310 1320 LSHGSSSLEH RSEDSTIYDL LKDPVSLRSK ARRAKKAKAS SALVVCGGQG HRRVHRKARQ 1330 1340 PHQEELAPTV MVWQIPLLNI
	Isoform 5 [UniParc]. Checksum: E1BF9D9ACCB20E3A	FASTA	1,344	148,869
	10 20 30 40 50 60 MDQREPLPPA PAENEMKYDT NNNEEEEGEQ FDFDSGDEIP EADRQAPSAP ETGGAGASEA 70 80 90 100 110 120 PAPTGGEDGA GAETTPVAEP TKLVLPMKVN PYSVIDITPF QEDQPPTPVP SAEEENVGLH 130 140 150 160 170 180 VPCGYLVPVP CGYAVPSNLP LLLPAYSSPV IICATSLDEE ETPEVTEDRQ PNSLSSEEPP 190 200 210 220 230 240 TSEDQVGRED SALARWAADP ANTAWMENPE EAIYDDVPRE NSDSEPDEMI YDDVENGDEG 250 260 270 280 290 300 GNSSLEYGWS SSEFESYEEQ SDSECKNGIP RSFLRSNHKK QLSHDLTRLK EHYEKKMRDL 310 320 330 340 350 360 MASTVGVVEI QQLRQKHELK MQKLVKAAKD GTKDGLERTR AAVKRGRSFI RTKSLIAQDH 370 380 390 400 410 420 RSSLEEEQNL FIDVDCKHPE AILTPMPEGL SQQQVVRRYI LGSVVDSEKN YVDALKRILE 430 440 450 460 470 480 QYEKPLSEME PKVLSERKLK TVFYRVKEIL QCHSLFQIAL ASRVSEWDSV EMIGDVFVAS 490 500 510 520 530 540 FSKSMVLDAY SEYVNNFSTA VAVLKKTCAT KPAFLEFLKQ EQEASPDRTT LYSLMMKPIQ 550 560 570 580 590 600 RFPQFILLLQ DMLKNTSKGH PDRLPLQMAL TELETLAEKL NERKRDADQR CEVKQIAKAI 610 620 630 640 650 660 NERYLNKLLS SGSRYLIRSD DMIETVYNDR GEIVKTKERR VFMLNDVLMC ATVSSRPSHD 670 680 690 700 710 720 SRVMSSQRYL LKWSVPLGHV DAIEYGSSAG TGEHSRHLAV HPPESLAVVA NAKPNKVYMG 730 740 750 760 770 780 PGQLYQDLQN LLHDLNVIGQ ITQLIGNLKG NYQNLNQSVA HDWTSGLQRL ILKKEDEIRA 790 800 810 820 830 840 ADCCRIQLQL PGKQDKSGRP TFFTAVFNTF TPAIKESWVN SLQMAKLALE EENHMGWFCV 850 860 870 880 890 900 EDDGNHIKKE KHPLLVGHMP VMVAKQQEFK IECAAYNPEP YLNNESQPDS FSTAHGFLWI 910 920 930 940 950 960 GSCTHQMGQI AIVSFQNSTP KVIECFNVES RILCMLYVPV EEKRREPGAP PDPETPAVRA 970 980 990 1000 1010 1020 SDVPTICVGT EEGSISIYKS SQGSKKVRLQ HFFTPEKSTV MSLACTSQSL YAGLVNGAVA 1030 1040 1050 1060 1070 1080 SYARAPDGSW DSEPQKVIKL GVLPVRSLLM MEDTLWAASG GQVFIISVET HAVEGQLEAH 1090 1100 1110 1120 1130 1140 QEEGMVISHM AVSGVGIWIA FTSGSTLRLF HTETLKHLQD INIATPVHNM LPGHQRLSVT 1150 1160 1170 1180 1190 1200 SLLVCHGLLM VGTSLGVLVA LPVPRLQGIP KVTGRGMVSY HAHNSPVKFI VLATALHEKD 1210 1220 1230 1240 1250 1260 KDKSRDSLAP GPEPQDEDQK DALPSGGAGS SLSQGDPDAA IWLGDSLGSM TQKSDLSSSS 1270 1280 1290 1300 1310 1320 GSLSLSHGSS SLEHRSEDST IYDLLKDPVS LRSKARRAKK AKASSALVVC GGQGHRRVHR 1330 1340 KARQPHQEEL APTVMVWQIP LLNI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[2]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Duodenum, Prostate and Uterus.
[6]	"High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p." Ranta S., Lehesjoki A.-E., de Fatima Bonaldo M., Knowles J.A., Hirvasniemi A., Ross B., de Jong P.J., Soares M.B., de la Chapelle A., Gilliam T.C. Genome Res. 7:887-896(1997) [PubMed: 9314494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 353-1369 (ISOFORM 4). Tissue: Brain.
[7]	"Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10." Verhoeven K., De Jonghe P., Van de Putte T., Nelis E., Zwijsen A., Verpoorten N., De Vriendt E., Jacobs A., Van Gerwen V., Francis A., Ceuterick C., Huylebroeck D., Timmerman V. Am. J. Hum. Genet. 73:926-932(2003) [PubMed: 14508709] [Abstract] Cited for: FUNCTION, VARIANT SNCV ILE-357.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1284 AND SER-1287, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR749570 mRNA. Translation: CAH18365.1. Different termination. AB002292 mRNA. Translation: BAA20754.2. Different initiation. AC019257 Genomic DNA. No translation available. BC036809 mRNA. Translation: AAH36809.1. Sequence problems. BC040474 mRNA. Translation: AAH40474.1. Sequence problems. BC112926 mRNA. Translation: AAI12927.1. AF009205 mRNA. Translation: AAB71662.1.
IPI	IPI00413517. IPI00419950. IPI00873672. IPI00979519. IPI00981196.
PIR	T03307.
RefSeq	NP_055444.2. NM_014629.2.
UniGene	Hs.98594.
3D structure databases
ProteinModelPortal	O15013.
SMR	O15013. Positions 413-709.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15013. 1 interaction.
STRING	O15013.
PTM databases
PhosphoSite	O15013.
Proteomic databases
PRIDE	O15013.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398564; ENSP00000381571; ENSG00000104728. ENST00000520359; ENSP00000427909; ENSG00000104728.
GeneID	9639.
KEGG	hsa:9639.
UCSC	uc003wpq.1. human. uc003wpv.2. human.
Organism-specific databases
CTD	9639.
GeneCards	GC08P001778.
HGNC	HGNC:14103. ARHGEF10.
HPA	HPA024649.
MIM	608136. gene. 608236. phenotype.
neXtProt	NX_O15013.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05187.
GeneTree	ENSGT00600000084097.
HOGENOM	HBG402923.
HOVERGEN	HBG050570.
InParanoid	O15013.
OMA	ILKKTCA.
PhylomeDB	O15013.
Gene expression databases
ArrayExpress	O15013.
Bgee	O15013.
CleanEx	HS_ARHGEF10.
Genevestigator	O15013.
GermOnline	ENSG00000104728. Homo sapiens.
Family and domain databases
InterPro	IPR000219. DH-domain. IPR015943. WD40/YVTN_repeat-like_dom. IPR011046. WD40_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:1.20.900.10. RhoGEF. 1 hit. G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00325. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	36183.
SOURCE	Search...

Entry information

Entry name

ARHGA_HUMAN

Accession

Primary (citable) accession number: O15013
Secondary accession number(s): O14665 , Q2KHR8, Q68D55, Q8IWD9, Q8IY77

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 95 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.