##gff-version 3 O14980 UniProtKB Chain 1 1071 . . . ID=PRO_0000204705;Note=Exportin-1 O14980 UniProtKB Domain 46 112 . . . Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115 O14980 UniProtKB Repeat 217 240 . . . Note=HEAT 1 O14980 UniProtKB Repeat 241 277 . . . Note=HEAT 2 O14980 UniProtKB Repeat 354 472 . . . Note=HEAT 3 O14980 UniProtKB Repeat 515 553 . . . Note=HEAT 4 O14980 UniProtKB Repeat 560 597 . . . Note=HEAT 5 O14980 UniProtKB Repeat 602 639 . . . Note=HEAT 6 O14980 UniProtKB Repeat 775 813 . . . Note=HEAT 7 O14980 UniProtKB Repeat 885 916 . . . Note=HEAT 8 O14980 UniProtKB Repeat 917 954 . . . Note=HEAT 9 O14980 UniProtKB Repeat 1002 1039 . . . Note=HEAT 10 O14980 UniProtKB Region 1 679 . . . Note=Necessary for HTLV-1 Rex-mediated mRNA export O14980 UniProtKB Region 327 450 . . . Note=Interaction with Ran and nuclear export complex formation O14980 UniProtKB Region 411 481 . . . Note=Interaction with RANBP3 O14980 UniProtKB Region 411 414 . . . Note=Necessary for HTLV-1 Rex multimerization O14980 UniProtKB Region 800 820 . . . Note=Interaction with HIV-1 Rev O14980 UniProtKB Modified residue 391 391 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 O14980 UniProtKB Modified residue 446 446 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 O14980 UniProtKB Modified residue 448 448 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80U96 O14980 UniProtKB Modified residue 450 450 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80U96 O14980 UniProtKB Modified residue 454 454 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80U96 O14980 UniProtKB Modified residue 693 693 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 O14980 UniProtKB Modified residue 1031 1031 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O14980 UniProtKB Mutagenesis 191 191 . . . Note=Does not abolish Rex-mediated mRNA export. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 284 284 . . . Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 334 334 . . . Note=Does not abolish Rex-mediated mRNA export. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 337 337 . . . Note=Does not abolish Rex-mediated mRNA export. I->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 346 346 . . . Note=Does not abolish Rex-mediated mRNA export. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 402 402 . . . Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 411 411 . . . Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 412 412 . . . Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 414 414 . . . Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 428 447 . . . Note=Abolishes Ran binding activity in absence of cargo and abolishes partially Ran binding activity in presence of cargo. EEVLVVENDQGEVVREFMKD->QQVLVVQNNQGQVVRQFMKN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 430 446 . . . Note=Partially restores Ran binding activity in presence of cargo. VLVVENDQGEVVREFMK->DEDEENDQGEDEEEDDD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 430 433 . . . Note=Abolishes Ran binding activity both in absence or presence of cargo. VLVV->DEDE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 454 454 . . . Note=Does not abolish Ran binding activity and nuclear export complex formation. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 474 474 . . . Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 481 481 . . . Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415 O14980 UniProtKB Mutagenesis 513 513 . . . Note=Abolishes Ran binding activity and nuclear export complex formation. Abolishes Ran binding activity and nuclear export complex formation%3B when associated with A-553 and A-554. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 525 525 . . . Note=Enhances Ran binding activity and does not abolish nuclear export complex formation. Does not abolish Ran binding activity and partially abolish nuclear export complex formation%3B when associated with A-561. Does not abolish Ran binding activity and partially abolish nuclear export complex formation%3B when associated with A-568 and A-572. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 550 550 . . . Note=Enhances Ran binding activity and does not abolish nuclear export complex formation%3B when associated with A-553 and A-590. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 553 553 . . . Note=Enhances Ran binding activity and does not abolish nuclear export complex formation%3B when associated with A-550 and A-590. Abolishes Ran binding activity and nuclear export complex formation%3B when associated with A-513 and A-554. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 554 554 . . . Note=Partially abolishes Ran binding activity and does not abolish nuclear export complex formation. Abolishes Ran binding activity and nuclear export complex formation%3B when associated with A-561. Abolishes Ran binding activity and nuclear export complex formation%3B when associated with A-553 and A-513. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 561 561 . . . Note=Abolishes Ran binding activity and nuclear export complex formation. Abolishes Ran binding activity and nuclear export complex formation%3B when associated with A-554. Does not abolish Ran binding activity and partially abolish nuclear export complex formation%3B when associated with A-525. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 568 568 . . . Note=Does not abolish Ran binding activity and partially abolish nuclear export complex formation%3B when associated with A-525 and A-572. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 572 572 . . . Note=Does not abolish Ran binding activity and partially abolish nuclear export complex formation%3B when associated with A-525 and A-568. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 583 583 . . . Note=Enhances Ran binding activity%3B when associated with A-590. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Mutagenesis 590 590 . . . Note=Enhances Ran binding activity and does not abolish nuclear export complex formation. Enhances Ran binding activity and does not abolish nuclear export complex formation%3B when associated with A-583. Enhances Ran binding activity and does not abolish nuclear export complex formation%3B when associated with A-550 and A-553. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574331;Dbxref=PMID:15574331 O14980 UniProtKB Sequence conflict 406 406 . . . Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 O14980 UniProtKB Sequence conflict 953 953 . . . Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 O14980 UniProtKB Sequence conflict 989 989 . . . Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 O14980 UniProtKB Helix 10 13 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 14 17 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Beta strand 19 21 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 25 37 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 40 55 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Beta strand 56 58 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TVO O14980 UniProtKB Helix 59 62 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 63 69 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 73 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 91 93 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 96 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 117 122 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 124 145 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 149 159 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 161 179 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Turn 183 185 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 188 200 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 202 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 219 232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Turn 233 235 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 238 242 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Beta strand 243 245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 246 253 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Turn 254 256 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 258 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 261 273 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 277 279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5DIS O14980 UniProtKB Helix 280 297 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 304 310 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 313 338 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 341 343 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 344 357 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 363 383 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 404 409 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Turn 410 412 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 413 423 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Beta strand 430 434 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Beta strand 436 438 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Beta strand 440 444 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 449 467 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 469 484 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Beta strand 485 488 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GB8 O14980 UniProtKB Helix 491 503 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Turn 504 506 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 510 530 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 534 549 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 552 557 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 559 572 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 580 595 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 596 599 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Beta strand 605 608 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GB8 O14980 UniProtKB Helix 610 615 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 618 621 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 627 642 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 647 657 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 659 674 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 676 680 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 682 702 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 704 706 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B51 O14980 UniProtKB Helix 711 713 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 714 735 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 738 741 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 743 764 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 769 775 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 777 789 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 793 795 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 799 811 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 812 818 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 819 834 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Turn 837 839 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 842 858 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 862 865 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 868 881 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Beta strand 884 886 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GB8 O14980 UniProtKB Helix 887 906 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 908 931 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Beta strand 932 934 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 936 938 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TVO O14980 UniProtKB Helix 939 954 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Beta strand 961 963 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5DIS O14980 UniProtKB Beta strand 964 966 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 970 985 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 991 1003 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Turn 1004 1006 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Helix 1008 1023 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Turn 1024 1026 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9C O14980 UniProtKB Turn 1028 1030 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GB8 O14980 UniProtKB Helix 1035 1047 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5DIS O14980 UniProtKB Helix 1053 1055 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GB8