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Protein

Zinc finger protein 263

Gene

ZNF263

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Might play an important role in basic cellular processes as a transcriptional repressor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri378 – 400C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri659 – 681C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006194-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.
SignaLinkiO14978.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 263
Alternative name(s):
Zinc finger protein FPM315
Zinc finger protein with KRAB and SCAN domains 12
Gene namesi
Name:ZNF263
Synonyms:FPM315, ZKSCAN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13056. ZNF263.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10127.
OpenTargetsiENSG00000006194.
PharmGKBiPA37634.

Polymorphism and mutation databases

BioMutaiZNF263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474911 – 683Zinc finger protein 263Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14978.
PaxDbiO14978.
PeptideAtlasiO14978.
PRIDEiO14978.

PTM databases

iPTMnetiO14978.
PhosphoSitePlusiO14978.

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.

Gene expression databases

BgeeiENSG00000006194.
CleanExiHS_ZNF263.
ExpressionAtlasiO14978. baseline and differential.
GenevisibleiO14978. HS.

Organism-specific databases

HPAiHPA035085.
HPA035086.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLK2P497603EBI-744493,EBI-750020
CLK3P497613EBI-744493,EBI-745579
GPATCH2LQ9NWQ43EBI-744493,EBI-5666657
SCAND1P570863EBI-744493,EBI-745846
TCAF1Q9Y4C23EBI-744493,EBI-750484
TRIM41Q8WV443EBI-744493,EBI-725997

Protein-protein interaction databases

BioGridi115431. 68 interactors.
IntActiO14978. 17 interactors.
MINTiMINT-1435246.
STRINGi9606.ENSP00000219069.

Structurei

3D structure databases

ProteinModelPortaliO14978.
SMRiO14978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 123SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini217 – 289KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri378 – 400C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri659 – 681C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiO14978.
KOiK09229.
OMAiFGGNPHF.
OrthoDBiEOG091G02UG.
PhylomeDBiO14978.
TreeFamiTF350829.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR030752. ZNF263.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23226:SF43. PTHR23226:SF43. 4 hits.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGPGSQER EGLLIVKLEE DCAWSQELPP PDPGPSPEAS HLRFRRFRFQ
60 70 80 90 100
EAAGPREALS RLQELCHGWL RPEMRTKEQI LELLVLEQFL TILPQEIQSR
110 120 130 140 150
VQELHPESGE EAVTLVEDMQ RELGRLRQQV TNHGRGTEVL LEEPLPLETA
160 170 180 190 200
RESPSFKLEP METERSPGPR LQELLGPSPQ RDPQAVKERA LSAPWLSLFP
210 220 230 240 250
PEGNMEDKEM TGPQLPESLE DVAMYISQEE WGHQDPSKRA LSRDTVQESY
260 270 280 290 300
ENVDSLESHI PSQEVPGTQV GQGGKLWDPS VQSCKEGLSP RGPAPGEEKF
310 320 330 340 350
ENLEGVPSVC SENIHPQVLL PDQARGEVPW SPELGRPHDR SQGDWAPPPE
360 370 380 390 400
GGMEQALAGA SSGRELGRPK ELQPKKLHLC PLCGKNFSNN SNLIRHQRIH
410 420 430 440 450
AAERLCMGVD CTEIFGGNPR FLSLHRAHLG EEAHKCLECG KCFSQNTHLT
460 470 480 490 500
RHQRTHTGEK PYQCNICGKC FSCNSNLHRH QRTHTGEKPY KCPECGEIFA
510 520 530 540 550
HSSNLLRHQR IHTGERPYKC PECGKSFSRS SHLVIHERTH ERERLYPFSE
560 570 580 590 600
CGEAVSDSTP FLTNHGAHKA EKKLFECLTC GKSFRQGMHL TRHQRTHTGE
610 620 630 640 650
KPYKCTLCGE NFSHRSNLIR HQRIHTGEKP YTCHECGDSF SHSSNRIRHL
660 670 680
RTHTGERPYK CSECGESFSR SSRLMSHQRT HTG
Length:683
Mass (Da):77,299
Last modified:October 25, 2002 - v2
Checksum:i1E02C862FCE69265
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118D → G in BAA21853 (PubMed:9256059).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052801310C → S.Corresponds to variant rs220379dbSNPEnsembl.1
Natural variantiVAR_052802534V → I.Corresponds to variant rs34236132dbSNPEnsembl.1
Natural variantiVAR_061943646R → Q.Corresponds to variant rs57710602dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88827 mRNA. Translation: BAA21853.1.
AK312421 mRNA. Translation: BAG35331.1.
AC004232 Genomic DNA. Translation: AAC24490.1.
CH471112 Genomic DNA. Translation: EAW85379.1.
BC008805 mRNA. Translation: AAH08805.1.
CCDSiCCDS10499.1.
RefSeqiNP_005732.2. NM_005741.4.
UniGeneiHs.611475.

Genome annotation databases

EnsembliENST00000219069; ENSP00000219069; ENSG00000006194.
GeneIDi10127.
KEGGihsa:10127.
UCSCiuc002cuq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88827 mRNA. Translation: BAA21853.1.
AK312421 mRNA. Translation: BAG35331.1.
AC004232 Genomic DNA. Translation: AAC24490.1.
CH471112 Genomic DNA. Translation: EAW85379.1.
BC008805 mRNA. Translation: AAH08805.1.
CCDSiCCDS10499.1.
RefSeqiNP_005732.2. NM_005741.4.
UniGeneiHs.611475.

3D structure databases

ProteinModelPortaliO14978.
SMRiO14978.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115431. 68 interactors.
IntActiO14978. 17 interactors.
MINTiMINT-1435246.
STRINGi9606.ENSP00000219069.

PTM databases

iPTMnetiO14978.
PhosphoSitePlusiO14978.

Polymorphism and mutation databases

BioMutaiZNF263.

Proteomic databases

MaxQBiO14978.
PaxDbiO14978.
PeptideAtlasiO14978.
PRIDEiO14978.

Protocols and materials databases

DNASUi10127.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219069; ENSP00000219069; ENSG00000006194.
GeneIDi10127.
KEGGihsa:10127.
UCSCiuc002cuq.4. human.

Organism-specific databases

CTDi10127.
DisGeNETi10127.
GeneCardsiZNF263.
HGNCiHGNC:13056. ZNF263.
HPAiHPA035085.
HPA035086.
MIMi604191. gene.
neXtProtiNX_O14978.
OpenTargetsiENSG00000006194.
PharmGKBiPA37634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiO14978.
KOiK09229.
OMAiFGGNPHF.
OrthoDBiEOG091G02UG.
PhylomeDBiO14978.
TreeFamiTF350829.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006194-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.
SignaLinkiO14978.

Miscellaneous databases

ChiTaRSiZNF263. human.
GenomeRNAii10127.
PROiO14978.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006194.
CleanExiHS_ZNF263.
ExpressionAtlasiO14978. baseline and differential.
GenevisibleiO14978. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR030752. ZNF263.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23226:SF43. PTHR23226:SF43. 4 hits.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN263_HUMAN
AccessioniPrimary (citable) accession number: O14978
Secondary accession number(s): B2R634, O43387, Q96H95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 25, 2002
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.