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Protein

Antizyme inhibitor 1

Gene

AZIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240).2 Publications

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • ornithine decarboxylase activator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processPolyamine biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-350562 Regulation of ornithine decarboxylase (ODC)

Names & Taxonomyi

Protein namesi
Recommended name:
Antizyme inhibitor 1
Short name:
AZI
Short name:
AZI1
Alternative name(s):
Ornithine decarboxylase antizyme inhibitor
Gene namesi
Name:AZIN1
Synonyms:OAZI, OAZIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000155096.13
HGNCiHGNC:16432 AZIN1
MIMi607909 gene
neXtProtiNX_O14977

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51582
OpenTargetsiENSG00000155096
PharmGKBiPA31887

Polymorphism and mutation databases

BioMutaiAZIN1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499921 – 448Antizyme inhibitor 1Add BLAST448

Post-translational modificationi

Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei69Not modifiedBy similarity1

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiO14977
PaxDbiO14977
PeptideAtlasiO14977
PRIDEiO14977
ProteomicsDBi48351

PTM databases

iPTMnetiO14977
PhosphoSitePlusiO14977

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Gene expression databases

BgeeiENSG00000155096
CleanExiHS_AZIN1
ExpressionAtlasiO14977 baseline and differential
GenevisibleiO14977 HS

Organism-specific databases

HPAiHPA027948

Interactioni

Subunit structurei

Monomer (PubMed:26305948). Interacts with OAZ1 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1 (Probable).1 Publication1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
OAZ3Q9UMX23EBI-1054824,EBI-10281601

Protein-protein interaction databases

BioGridi119621, 17 interactors
IntActiO14977, 6 interactors
STRINGi9606.ENSP00000321507

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZGZX-ray5.81A/C2-437[»]
ProteinModelPortaliO14977
SMRiO14977
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00390000011560
HOGENOMiHOG000274133
HOVERGENiHBG005456
InParanoidiO14977
OMAiNDKFSSG
OrthoDBiEOG091G0AJV
PhylomeDBiO14977
TreeFamiTF300760

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR031178 Azin1
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR11482:SF7 PTHR11482:SF7, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

O14977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK
60 70 80 90 100
KHSQWQNVVA QIKPFYTVKC NSAPAVLEIL AALGTGFACS SKNEMALVQE
110 120 130 140 150
LGVPPENIIY ISPCKQVSQI KYAAKVGVNI LTCDNEIELK KIARNHPNAK
160 170 180 190 200
VLLHIATEDN IGGEEGNMKF GTTLKNCRHL LECAKELDVQ IIGVKFHVSS
210 220 230 240 250
ACKESQVYVH ALSDARCVFD MAGEIGFTMN MLDIGGGFTG TEFQLEEVNH
260 270 280 290 300
VISPLLDIYF PEGSGVKIIS EPGSYYVSSA FTLAVNIIAK KVVENDKFPS
310 320 330 340 350
GVEKTGSDEP AFMYYMNDGV YGSFASKLSE DLNTIPEVHK KYKEDEPLFT
360 370 380 390 400
SSLWGPSCDE LDQIVESCLL PELNVGDWLI FDNMGADSFH EPSAFNDFQR
410 420 430 440
PAIYYMMSFS DWYEMQDAGI TSDSMMKNFF FVPSCIQLSQ EDSFSAEA
Length:448
Mass (Da):49,535
Last modified:August 15, 2003 - v2
Checksum:iDD26B22A993318E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20N → D in BAA23593 (PubMed:9349715).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88674 mRNA Translation: BAA23593.1
BT006858 mRNA Translation: AAP35504.1
CR456745 mRNA Translation: CAG33026.1
AP003354 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91851.1
BC013420 mRNA Translation: AAH13420.1
BC019279 mRNA Translation: AAH19279.1
AF070634 mRNA Translation: AAC25391.1
CCDSiCCDS6295.1
RefSeqiNP_056962.2, NM_015878.5
NP_680479.1, NM_148174.3
XP_011515428.1, XM_011517126.1
XP_011515429.1, XM_011517127.1
UniGeneiHs.459106

Genome annotation databases

EnsembliENST00000337198; ENSP00000337180; ENSG00000155096
ENST00000347770; ENSP00000321507; ENSG00000155096
GeneIDi51582
KEGGihsa:51582
UCSCiuc003ykx.4 human

Similar proteinsi

Entry informationi

Entry nameiAZIN1_HUMAN
AccessioniPrimary (citable) accession number: O14977
Secondary accession number(s): A6NCD5, Q6IBQ7, Q96D20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 15, 2003
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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