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Protein

Antizyme inhibitor 1

Gene

AZIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1.1 Publication

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • ornithine decarboxylase activator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Polyamine biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-350562. Regulation of ornithine decarboxylase (ODC).

Names & Taxonomyi

Protein namesi
Recommended name:
Antizyme inhibitor 1
Short name:
AZI
Alternative name(s):
Ornithine decarboxylase antizyme inhibitor
Gene namesi
Name:AZIN1
Synonyms:OAZI, OAZIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:16432. AZIN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31887.

Polymorphism and mutation databases

BioMutaiAZIN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Antizyme inhibitor 1PRO_0000149992Add
BLAST

Post-translational modificationi

Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei69 – 691Not modifiedBy similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiO14977.
PaxDbiO14977.
PeptideAtlasiO14977.
PRIDEiO14977.

PTM databases

iPTMnetiO14977.
PhosphoSiteiO14977.

Expressioni

Tissue specificityi

Expressed in liver.

Gene expression databases

BgeeiO14977.
CleanExiHS_AZIN1.
ExpressionAtlasiO14977. baseline and differential.
GenevisibleiO14977. HS.

Organism-specific databases

HPAiHPA027948.

Interactioni

Subunit structurei

Monomer. Interacts with OAZ1 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation.

Binary interactionsi

WithEntry#Exp.IntActNotes
OAZ3Q9UMX23EBI-1054824,EBI-10281601

Protein-protein interaction databases

BioGridi119621. 16 interactions.
IntActiO14977. 5 interactions.
STRINGi9606.ENSP00000321507.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ZGZX-ray5.81A/C2-437[»]
ProteinModelPortaliO14977.
SMRiO14977. Positions 10-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiO14977.
OMAiNDKFSSG.
OrthoDBiEOG73Z2T6.
PhylomeDBiO14977.
TreeFamiTF300760.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR031178. Azin1.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF7. PTHR11482:SF7. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK
60 70 80 90 100
KHSQWQNVVA QIKPFYTVKC NSAPAVLEIL AALGTGFACS SKNEMALVQE
110 120 130 140 150
LGVPPENIIY ISPCKQVSQI KYAAKVGVNI LTCDNEIELK KIARNHPNAK
160 170 180 190 200
VLLHIATEDN IGGEEGNMKF GTTLKNCRHL LECAKELDVQ IIGVKFHVSS
210 220 230 240 250
ACKESQVYVH ALSDARCVFD MAGEIGFTMN MLDIGGGFTG TEFQLEEVNH
260 270 280 290 300
VISPLLDIYF PEGSGVKIIS EPGSYYVSSA FTLAVNIIAK KVVENDKFPS
310 320 330 340 350
GVEKTGSDEP AFMYYMNDGV YGSFASKLSE DLNTIPEVHK KYKEDEPLFT
360 370 380 390 400
SSLWGPSCDE LDQIVESCLL PELNVGDWLI FDNMGADSFH EPSAFNDFQR
410 420 430 440
PAIYYMMSFS DWYEMQDAGI TSDSMMKNFF FVPSCIQLSQ EDSFSAEA
Length:448
Mass (Da):49,535
Last modified:August 15, 2003 - v2
Checksum:iDD26B22A993318E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201N → D in BAA23593 (PubMed:9349715).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88674 mRNA. Translation: BAA23593.1.
BT006858 mRNA. Translation: AAP35504.1.
CR456745 mRNA. Translation: CAG33026.1.
AP003354 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91851.1.
BC013420 mRNA. Translation: AAH13420.1.
BC019279 mRNA. Translation: AAH19279.1.
AF070634 mRNA. Translation: AAC25391.1.
CCDSiCCDS6295.1.
RefSeqiNP_056962.2. NM_015878.5.
NP_680479.1. NM_148174.3.
XP_011515428.1. XM_011517126.1.
XP_011515429.1. XM_011517127.1.
UniGeneiHs.459106.

Genome annotation databases

EnsembliENST00000337198; ENSP00000337180; ENSG00000155096.
ENST00000347770; ENSP00000321507; ENSG00000155096.
GeneIDi51582.
KEGGihsa:51582.
UCSCiuc003ykx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88674 mRNA. Translation: BAA23593.1.
BT006858 mRNA. Translation: AAP35504.1.
CR456745 mRNA. Translation: CAG33026.1.
AP003354 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91851.1.
BC013420 mRNA. Translation: AAH13420.1.
BC019279 mRNA. Translation: AAH19279.1.
AF070634 mRNA. Translation: AAC25391.1.
CCDSiCCDS6295.1.
RefSeqiNP_056962.2. NM_015878.5.
NP_680479.1. NM_148174.3.
XP_011515428.1. XM_011517126.1.
XP_011515429.1. XM_011517127.1.
UniGeneiHs.459106.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ZGZX-ray5.81A/C2-437[»]
ProteinModelPortaliO14977.
SMRiO14977. Positions 10-432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119621. 16 interactions.
IntActiO14977. 5 interactions.
STRINGi9606.ENSP00000321507.

PTM databases

iPTMnetiO14977.
PhosphoSiteiO14977.

Polymorphism and mutation databases

BioMutaiAZIN1.

Proteomic databases

MaxQBiO14977.
PaxDbiO14977.
PeptideAtlasiO14977.
PRIDEiO14977.

Protocols and materials databases

DNASUi51582.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337198; ENSP00000337180; ENSG00000155096.
ENST00000347770; ENSP00000321507; ENSG00000155096.
GeneIDi51582.
KEGGihsa:51582.
UCSCiuc003ykx.4. human.

Organism-specific databases

CTDi51582.
GeneCardsiAZIN1.
HGNCiHGNC:16432. AZIN1.
HPAiHPA027948.
MIMi607909. gene.
neXtProtiNX_O14977.
PharmGKBiPA31887.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiO14977.
OMAiNDKFSSG.
OrthoDBiEOG73Z2T6.
PhylomeDBiO14977.
TreeFamiTF300760.

Enzyme and pathway databases

ReactomeiR-HSA-350562. Regulation of ornithine decarboxylase (ODC).

Miscellaneous databases

ChiTaRSiAZIN1. human.
GeneWikiiAZIN1.
GenomeRNAii51582.
PROiO14977.
SOURCEiSearch...

Gene expression databases

BgeeiO14977.
CleanExiHS_AZIN1.
ExpressionAtlasiO14977. baseline and differential.
GenevisibleiO14977. HS.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR031178. Azin1.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF7. PTHR11482:SF7. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor."
    Koguchi K., Kobayashi S., Hayashi T., Matsufuji S., Murakami Y., Hayashi S.
    Biochim. Biophys. Acta 1353:209-216(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  7. Yu W., Gibbs R.A.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 273-448.
    Tissue: Brain.
  8. "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase."
    Kanerva K., Makitie L.T., Pelander A., Heiskala M., Andersson L.C.
    Biochem. J. 409:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, UBIQUITINATION.

Entry informationi

Entry nameiAZIN1_HUMAN
AccessioniPrimary (citable) accession number: O14977
Secondary accession number(s): A6NCD5, Q6IBQ7, Q96D20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 15, 2003
Last modified: July 6, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.