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O14976

- GAK_HUMAN

UniProt

O14976 - GAK_HUMAN

Protein

Cyclin-G-associated kinase

Gene

GAK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 2 (29 Aug 2001)
      Previous versions | rss
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    Functioni

    Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei173 – 1731Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein serine/threonine kinase activity Source: ProtInc

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.
    SignaLinkiO14976.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-G-associated kinase (EC:2.7.11.1)
    Gene namesi
    Name:GAK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:4113. GAK.

    Subcellular locationi

    Cytoplasmperinuclear region 1 Publication. Golgi apparatustrans-Golgi network 1 Publication. Cell junctionfocal adhesion 1 Publication
    Note: Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.

    GO - Cellular componenti

    1. focal adhesion Source: UniProtKB-SubCell
    2. Golgi apparatus Source: HPA
    3. intracellular membrane-bounded organelle Source: HPA
    4. membrane Source: UniProtKB
    5. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28528.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 13111310Cyclin-G-associated kinasePRO_0000085958Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei16 – 161Phosphoserine2 Publications
    Modified residuei456 – 4561Phosphoserine1 Publication
    Modified residuei770 – 7701Phosphoserine1 Publication
    Modified residuei826 – 8261Phosphoserine4 Publications
    Modified residuei829 – 8291Phosphoserine5 Publications
    Modified residuei834 – 8341Phosphoserine3 Publications
    Modified residuei939 – 9391Phosphoserine1 Publication
    Modified residuei1096 – 10961Phosphoserine1 Publication
    Modified residuei1176 – 11761Phosphoserine1 Publication
    Modified residuei1185 – 11851Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO14976.
    PaxDbiO14976.
    PRIDEiO14976.

    PTM databases

    PhosphoSiteiO14976.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highest in testis.

    Gene expression databases

    ArrayExpressiO14976.
    BgeeiO14976.
    CleanExiHS_GAK.
    GenevestigatoriO14976.

    Organism-specific databases

    HPAiHPA027405.
    HPA027459.
    HPA027463.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATP13A2Q9NQ112EBI-714707,EBI-6308763
    HSPA8P111425EBI-714707,EBI-351896
    LRRK2Q5S00710EBI-714707,EBI-5323863

    Protein-protein interaction databases

    BioGridi108853. 11 interactions.
    IntActiO14976. 10 interactions.
    MINTiMINT-5000432.
    STRINGi9606.ENSP00000314499.

    Structurei

    Secondary structure

    1
    1311
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni27 – 304
    Beta strandi32 – 354
    Beta strandi38 – 4710
    Beta strandi50 – 5910
    Turni60 – 623
    Beta strandi65 – 7511
    Helixi76 – 9217
    Beta strandi101 – 1077
    Turni109 – 1113
    Beta strandi115 – 12410
    Beta strandi127 – 1293
    Helixi130 – 1389
    Helixi145 – 16319
    Beta strandi165 – 1673
    Helixi176 – 1783
    Beta strandi179 – 1813
    Beta strandi187 – 1893
    Helixi208 – 22114
    Helixi224 – 2263
    Helixi229 – 2324
    Helixi242 – 25817
    Turni262 – 2654
    Helixi268 – 2725
    Helixi286 – 2883
    Helixi289 – 2957
    Helixi300 – 3023
    Helixi306 – 31914
    Helixi329 – 3324

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4C57X-ray2.55A/B14-351[»]
    4C58X-ray2.16A27-351[»]
    4C59X-ray2.80A14-351[»]
    4O38X-ray2.10A/B12-347[»]
    ProteinModelPortaliO14976.
    SMRiO14976. Positions 25-334, 400-746, 1139-1311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 314275Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini399 – 566168Phosphatase tensin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini572 – 710139C2 tensin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini1247 – 131165JPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi347 – 3504Poly-Pro

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
    Contains 1 J domain.PROSITE-ProRule annotation
    Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000034235.
    HOVERGENiHBG004322.
    InParanoidiO14976.
    KOiK08855.
    OMAiYMCDMMA.
    OrthoDBiEOG7WT40V.
    PhylomeDBiO14976.
    TreeFamiTF105165.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR001623. DnaJ_domain.
    IPR011009. Kinase-like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR014020. Tensin_C2-dom.
    IPR029023. Tensin_lipid_phosphatase_dom.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF10409. PTEN_C2. 1 hit.
    [Graphical view]
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51182. C2_TENSIN. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    PS51181. PPASE_TENSIN. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14976-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG     50
    FAFVYEAQDV GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ 100
    FCSAASIGKE ESDTGQAEFL LLTELCKGQL VEFLKKMESR GPLSCDTVLK 150
    IFYQTCRAVQ HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH 200
    YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI GEKQDIWALG 250
    CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP 300
    EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS ATLSRGPPPP 350
    VGPAGSGYSG GLALAEYDQP YGGFLDILRG GTERLFTNLK DTSSKVIQSV 400
    ANYAKGDLDI SYITSRIAVM SFPAEGVESA LKNNIEDVRL FLDSKHPGHY 450
    AVYNLSPRTY RPSRFHNRVS ECGWAARRAP HLHTLYNICR NMHAWLRQDH 500
    KNVCVVHCMD GRAASAVAVC SFLCFCRLFS TAEAAVYMFS MKRCPPGIWP 550
    SHKRYIEYMC DMVAEEPITP HSKPILVRAV VMTPVPLFSK QRSGCRPFCE 600
    VYVGDERVAS TSQEYDKMRD FKIEDGKAVI PLGVTVQGDV LIVIYHARST 650
    LGGRLQAKMA SMKMFQIQFH TGFVPRNATT VKFAKYDLDA CDIQEKYPDL 700
    FQVNLEVEVE PRDRPSREAP PWENSSMRGL NPKILFSSRE EQQDILSKFG 750
    KPELPRQPGS TAQYDAGAGS PEAEPTDSDS PPSSSADASR FLHTLDWQEE 800
    KEAETGAENA SSKESESALM EDRDESEVSD EGGSPISSEG QEPRADPEPP 850
    GLAAGLVQQD LVFEVETPAV LPEPVPQEDG VDLLGLHSEV GAGPAVPPQA 900
    CKAPSSNTDL LSCLLGPPEA ASQGPPEDLL SEDPLLLASP APPLSVQSTP 950
    RGGPPAAADP FGPLLPSSGN NSQPCSNPDL FGEFLNSDSV TVPPSFPSAH 1000
    SAPPPSCSAD FLHLGDLPGE PSKMTASSSN PDLLGGWAAW TETAASAVAP 1050
    TPATEGPLFS PGGQPAPCGS QASWTKSQNP DPFADLGDLS SGLQGSPAGF 1100
    PPGGFIPKTA TTPKGSSSWQ TSRPPAQGAS WPPQAKPPPK ACTQPRPNYA 1150
    SNFSVIGARE ERGVRAPSFA QKPKVSENDF EDLLSNQGFS SRSDKKGPKT 1200
    IAEMRKQDLA KDTDPLKLKL LDWIEGKERN IRALLSTLHT VLWDGESRWT 1250
    PVGMADLVAP EQVKKHYRRA VLAVHPDKAA GQPYEQHAKM IFMELNDAWS 1300
    EFENQGSRPL F 1311
    Length:1,311
    Mass (Da):143,191
    Last modified:August 29, 2001 - v2
    Checksum:i0ACE45DF57A5F981
    GO
    Isoform 2 (identifier: O14976-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         49-127: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,232
    Mass (Da):134,464
    Checksum:i483EE5F6B8416FDB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti607 – 6071R → C in AAH85005. (PubMed:15489334)Curated
    Sequence conflicti1113 – 11131P → A in BAA22623. (PubMed:9299234)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti144 – 1441S → L.1 Publication
    VAR_040505
    Natural varianti580 – 5801V → M.1 Publication
    Corresponds to variant rs34255232 [ dbSNP | Ensembl ].
    VAR_040506
    Natural varianti787 – 7871D → Y.1 Publication
    Corresponds to variant rs34585705 [ dbSNP | Ensembl ].
    VAR_040507
    Natural varianti877 – 8771Q → R.1 Publication
    Corresponds to variant rs149842313 [ dbSNP | Ensembl ].
    VAR_040508
    Natural varianti962 – 9621G → D in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
    VAR_040509
    Natural varianti1051 – 10511T → M.1 Publication
    Corresponds to variant rs35227944 [ dbSNP | Ensembl ].
    VAR_040510
    Natural varianti1120 – 11201Q → H.1 Publication
    Corresponds to variant rs55801437 [ dbSNP | Ensembl ].
    VAR_040511
    Natural varianti1137 – 11371P → L.1 Publication
    Corresponds to variant rs56169884 [ dbSNP | Ensembl ].
    VAR_040512
    Natural varianti1168 – 11681S → N.1 Publication
    Corresponds to variant rs56326341 [ dbSNP | Ensembl ].
    VAR_040513
    Natural varianti1265 – 12651K → R.1 Publication
    Corresponds to variant rs2306242 [ dbSNP | Ensembl ].
    VAR_040514
    Natural varianti1297 – 12971D → N.1 Publication
    Corresponds to variant rs1134921 [ dbSNP | Ensembl ].
    VAR_040515

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei49 – 12779Missing in isoform 2. 1 PublicationVSP_054479Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88435 mRNA. Translation: BAA22623.1.
    BC000816 mRNA. Translation: AAH00816.1.
    BC008668 mRNA. Translation: AAH08668.1.
    BC085005 mRNA. Translation: AAH85005.1.
    CCDSiCCDS3340.1. [O14976-1]
    RefSeqiNP_001273762.1. NM_001286833.1.
    NP_005246.2. NM_005255.2. [O14976-1]
    UniGeneiHs.369607.

    Genome annotation databases

    EnsembliENST00000314167; ENSP00000314499; ENSG00000178950. [O14976-1]
    ENST00000511163; ENSP00000421361; ENSG00000178950. [O14976-2]
    GeneIDi2580.
    KEGGihsa:2580.
    UCSCiuc003gbm.4. human. [O14976-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88435 mRNA. Translation: BAA22623.1 .
    BC000816 mRNA. Translation: AAH00816.1 .
    BC008668 mRNA. Translation: AAH08668.1 .
    BC085005 mRNA. Translation: AAH85005.1 .
    CCDSi CCDS3340.1. [O14976-1 ]
    RefSeqi NP_001273762.1. NM_001286833.1.
    NP_005246.2. NM_005255.2. [O14976-1 ]
    UniGenei Hs.369607.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4C57 X-ray 2.55 A/B 14-351 [» ]
    4C58 X-ray 2.16 A 27-351 [» ]
    4C59 X-ray 2.80 A 14-351 [» ]
    4O38 X-ray 2.10 A/B 12-347 [» ]
    ProteinModelPortali O14976.
    SMRi O14976. Positions 25-334, 400-746, 1139-1311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108853. 11 interactions.
    IntActi O14976. 10 interactions.
    MINTi MINT-5000432.
    STRINGi 9606.ENSP00000314499.

    Chemistry

    BindingDBi O14976.
    ChEMBLi CHEMBL4355.
    GuidetoPHARMACOLOGYi 2027.

    PTM databases

    PhosphoSitei O14976.

    Proteomic databases

    MaxQBi O14976.
    PaxDbi O14976.
    PRIDEi O14976.

    Protocols and materials databases

    DNASUi 2580.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314167 ; ENSP00000314499 ; ENSG00000178950 . [O14976-1 ]
    ENST00000511163 ; ENSP00000421361 ; ENSG00000178950 . [O14976-2 ]
    GeneIDi 2580.
    KEGGi hsa:2580.
    UCSCi uc003gbm.4. human. [O14976-1 ]

    Organism-specific databases

    CTDi 2580.
    GeneCardsi GC04M000832.
    H-InvDB HIX0004007.
    HGNCi HGNC:4113. GAK.
    HPAi HPA027405.
    HPA027459.
    HPA027463.
    MIMi 602052. gene.
    neXtProti NX_O14976.
    PharmGKBi PA28528.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000034235.
    HOVERGENi HBG004322.
    InParanoidi O14976.
    KOi K08855.
    OMAi YMCDMMA.
    OrthoDBi EOG7WT40V.
    PhylomeDBi O14976.
    TreeFami TF105165.

    Enzyme and pathway databases

    Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.
    SignaLinki O14976.

    Miscellaneous databases

    ChiTaRSi GAK. human.
    GeneWikii GAK_(protein).
    GenomeRNAii 2580.
    NextBioi 10201.
    PROi O14976.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14976.
    Bgeei O14976.
    CleanExi HS_GAK.
    Genevestigatori O14976.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR001623. DnaJ_domain.
    IPR011009. Kinase-like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR014020. Tensin_C2-dom.
    IPR029023. Tensin_lipid_phosphatase_dom.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF10409. PTEN_C2. 1 hit.
    [Graphical view ]
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51182. C2_TENSIN. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    PS51181. PPASE_TENSIN. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, expression, and chromosomal localization of human GAK."
      Kimura S.H., Tsuruga H., Yabuta N., Endo Y., Nojima H.
      Genomics 44:179-187(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
      Tissue: Fibroblast.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 981-1311 (ISOFORM 1).
      Tissue: Ovary and Placenta.
    3. "Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells."
      Greener T., Zhao X., Nojima H., Eisenberg E., Greene L.E.
      J. Biol. Chem. 275:1365-1370(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-456; SER-770; SER-826; SER-829; SER-834 AND SER-1096, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826; SER-829 AND SER-834, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-826; SER-829; SER-834; SER-939; SER-1176 AND SER-1185, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826 AND SER-829, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-829, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Crystal structure of the human cyclin G associated kinase (GAK)."
      Midwest center for structural genomics (MCSG)
      Submitted (JUL-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 12-347.
    12. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-144; MET-580; TYR-787; ARG-877; ASP-962; MET-1051; HIS-1120; LEU-1137; ASN-1168; ARG-1265 AND ASN-1297.

    Entry informationi

    Entry nameiGAK_HUMAN
    AccessioniPrimary (citable) accession number: O14976
    Secondary accession number(s): Q5U4P5, Q9BVY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: August 29, 2001
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3