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O14972 (DSCR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Down syndrome critical region protein 3
Alternative name(s):
Down syndrome critical region protein A
Gene names
Name:DSCR3
Synonyms:DCRA, DSCRA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Ubiquitously expressed.

Sequence similarities

Belongs to the VPS26 family.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from direct assay PubMed 16780588. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Down syndrome critical region protein 3
PRO_0000073016

Sequences

Sequence LengthMass (Da)Tools
O14972 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 5CE40FEE9E6664D5

FASTA29733,010
        10         20         30         40         50         60 
MGTALDIKIK RANKVYHAGE VLSGVVVISS KDSVQHQGVS LTMEGTVNLQ LSAKSVGVFE 

        70         80         90        100        110        120 
AFYNSVKPIQ IINSTIEMVK PGKFPSGKTE IPFEFPLHLK GNKVLYETYH GVFVNIQYTL 

       130        140        150        160        170        180 
RCDMKRSLLA KDLTKTCEFI VHSAPQKGKF TPSPVDFTIT PETLQNVKER ALLPKFLLRG 

       190        200        210        220        230        240 
HLNSTNCVIT QPLTGELVVE SSEAAIRSVE LQLVRVETCG CAEGYARDAT EIQNIQIADG 

       250        260        270        280        290 
DVCRGLSVPI YMVFPRLFTC PTLETTNFKV EFEVNIVVLL HPDHLITENF PLKLCRI 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of a novel human gene from the Down syndrome critical region of chromosome 21q22.2."
Nakamura A., Hattori M., Sakaki Y.
J. Biochem. 122:872-877(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87343 mRNA. Translation: BAA23225.1.
AK312707 mRNA. Translation: BAG35585.1.
CH471079 Genomic DNA. Translation: EAX09714.1.
BC110655 mRNA. Translation: AAI10656.1.
PIRJC5698.
RefSeqNP_006043.1. NM_006052.1.
UniGeneHs.369488.

3D structure databases

ProteinModelPortalO14972.
SMRO14972. Positions 15-279.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115596. 3 interactions.
DIPDIP-47317N.
IntActO14972. 2 interactions.
MINTMINT-8247532.
STRING9606.ENSP00000311399.

PTM databases

PhosphoSiteO14972.

Proteomic databases

PaxDbO14972.
PRIDEO14972.

Protocols and materials databases

DNASU10311.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309117; ENSP00000311399; ENSG00000157538.
GeneID10311.
KEGGhsa:10311.
UCSCuc002ywf.1. human.

Organism-specific databases

CTD10311.
GeneCardsGC21M038591.
H-InvDBHIX0022605.
HGNCHGNC:3044. DSCR3.
HPAHPA023288.
MIM605298. gene.
neXtProtNX_O14972.
PharmGKBPA27496.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG321080.
HOGENOMHOG000294089.
HOVERGENHBG051411.
InParanoidO14972.
OMAVHSAPQK.
OrthoDBEOG7C8GHX.
PhylomeDBO14972.
TreeFamTF323199.

Gene expression databases

ArrayExpressO14972.
BgeeO14972.
CleanExHS_DSCR3.
GenevestigatorO14972.

Family and domain databases

InterProIPR014756. Ig_E-set.
IPR028934. Vps26-related.
[Graphical view]
PfamPF03643. Vps26. 1 hit.
[Graphical view]
SUPFAMSSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

ChiTaRSDSCR3. human.
GenomeRNAi10311.
NextBio39075.
PROO14972.
SOURCESearch...

Entry information

Entry nameDSCR3_HUMAN
AccessionPrimary (citable) accession number: O14972
Secondary accession number(s): B2R6T8, D3DSH4, Q2TAY6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM