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Protein

Ras-related protein Rab-7L1

Gene

RAB29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi33 – 39GTPBy similarity7
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4
Nucleotide bindingi156 – 157GTPBy similarity2

GO - Molecular functioni

  • dynein binding Source: ParkinsonsUK-UCL
  • GDP binding Source: ParkinsonsUK-UCL
  • GTPase activity Source: ProtInc
  • GTP binding Source: ParkinsonsUK-UCL
  • kinesin binding Source: ParkinsonsUK-UCL
  • Rab GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • Golgi organization Source: UniProtKB
  • Golgi to endosome transport Source: InterPro
  • melanosome organization Source: GO_Central
  • mitochondrion organization Source: ParkinsonsUK-UCL
  • multi-organism toxin transport Source: ParkinsonsUK-UCL
  • negative regulation of neuron projection development Source: ParkinsonsUK-UCL
  • positive regulation of intracellular protein transport Source: UniProtKB
  • positive regulation of receptor recycling Source: ParkinsonsUK-UCL
  • positive regulation of T cell receptor signaling pathway Source: ParkinsonsUK-UCL
  • protein localization to ciliary membrane Source: ParkinsonsUK-UCL
  • protein localization to membrane Source: ParkinsonsUK-UCL
  • protein transport Source: UniProtKB-KW
  • regulation of neuron death Source: ParkinsonsUK-UCL
  • response to bacterium Source: ParkinsonsUK-UCL
  • retrograde transport, endosome to Golgi Source: UniProtKB
  • retrograde transport, plasma membrane to Golgi Source: InterPro
  • small GTPase mediated signal transduction Source: InterPro
  • synapse assembly Source: ParkinsonsUK-UCL
  • T cell activation Source: ParkinsonsUK-UCL
  • viral RNA genome replication Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Differentiation, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117280-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-7L1
Alternative name(s):
Rab-7-like protein 1
Ras-related protein Rab-29
Gene namesi
Name:RAB29
Synonyms:RAB7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9789. RAB29.

Subcellular locationi

  • Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
  • Cytoplasm 1 Publication
  • Cytoplasmperinuclear region 1 Publication
  • Golgi apparatus 1 Publication
  • Golgi apparatustrans-Golgi network 1 Publication
  • Vacuole 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (By similarity). Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847). Colocalizes with TGN46 at the trans-Golgi network (TGN) (PubMed:24788816). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery (PubMed:22042847).By similarity2 Publications

GO - Cellular componenti

  • cis-Golgi network Source: ParkinsonsUK-UCL
  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: GOC
  • early endosome Source: ParkinsonsUK-UCL
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: ParkinsonsUK-UCL
  • intracellular vesicle Source: ParkinsonsUK-UCL
  • melanosome Source: GO_Central
  • mitochondrion Source: ParkinsonsUK-UCL
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
  • recycling endosome Source: ParkinsonsUK-UCL
  • symbiont-containing vacuole Source: ParkinsonsUK-UCL
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Vacuole

Pathology & Biotechi

Organism-specific databases

DisGeNETi8934.
OpenTargetsiENSG00000117280.
PharmGKBiPA34151.

Polymorphism and mutation databases

BioMutaiRAB7L1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211271 – 203Ras-related protein Rab-7L1Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi202S-geranylgeranyl cysteineBy similarity1
Lipidationi203S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41 – 42Cleavage; by S.Typhimurium viral protease GtgE2

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiO14966.
PaxDbiO14966.
PeptideAtlasiO14966.
PRIDEiO14966.

PTM databases

iPTMnetiO14966.
PhosphoSitePlusiO14966.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000117280.
CleanExiHS_RAB7L1.
ExpressionAtlasiO14966. baseline and differential.
GenevisibleiO14966. HS.

Organism-specific databases

HPAiCAB020822.
HPA026303.

Interactioni

Subunit structurei

Interacts with LRRK2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0077EBI-372165,EBI-5323863

GO - Molecular functioni

  • dynein binding Source: ParkinsonsUK-UCL
  • kinesin binding Source: ParkinsonsUK-UCL
  • Rab GTPase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi114447. 15 interactors.
DIPiDIP-31215N.
IntActiO14966. 8 interactors.
STRINGi9606.ENSP00000235932.

Structurei

3D structure databases

ProteinModelPortaliO14966.
SMRiO14966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG4423. Eukaryota.
ENOG410YITC. LUCA.
GeneTreeiENSGT00760000119125.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiO14966.
KOiK07916.
OMAiQERFISM.
OrthoDBiEOG091G0K53.
PhylomeDBiO14966.
TreeFamiTF324491.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR030697. Rab29.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PANTHERiPTHR24073:SF315. PTHR24073:SF315. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14966-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSRDHLFKV LVVGDAAVGK TSLVQRYSQD SFSKHYKSTV GVDFALKVLQ
60 70 80 90 100
WSDYEIVRLQ LWDIAGQERF TSMTRLYYRD ASACVIMFDV TNATTFSNSQ
110 120 130 140 150
RWKQDLDSKL TLPNGEPVPC LLLANKCDLS PWAVSRDQID RFSKENGFTG
160 170 180 190 200
WTETSVKENK NINEAMRVLI EKMMRNSTED IMSLSTQGDY INLQTKSSSW

SCC
Length:203
Mass (Da):23,155
Last modified:January 1, 1998 - v1
Checksum:i40E7CAB02446DF97
GO
Isoform 2 (identifier: O14966-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-65: Missing.

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):20,252
Checksum:i977C65E0E5641A2E
GO
Isoform 3 (identifier: O14966-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.
Show »
Length:131
Mass (Da):14,964
Checksum:i2DB0B04E3DC55E38
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0450781 – 72Missing in isoform 3. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_04339142 – 65Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84488 mRNA. Translation: BAA22160.1.
AK308359 mRNA. No translation available.
AK303879 mRNA. Translation: BAG64815.1.
AC119673 Genomic DNA. No translation available.
BC002585 mRNA. Translation: AAH02585.1.
CCDSiCCDS1459.1. [O14966-1]
CCDS44301.1. [O14966-2]
CCDS44302.1. [O14966-3]
RefSeqiNP_001129134.1. NM_001135662.1. [O14966-1]
NP_001129135.1. NM_001135663.1. [O14966-2]
NP_001129136.1. NM_001135664.1. [O14966-3]
NP_003920.1. NM_003929.2. [O14966-1]
XP_005245626.1. XM_005245569.1. [O14966-1]
XP_005245627.1. XM_005245570.1. [O14966-1]
XP_005245628.1. XM_005245571.1. [O14966-1]
XP_006711668.1. XM_006711605.3. [O14966-3]
XP_006711669.1. XM_006711606.2. [O14966-3]
XP_016858237.1. XM_017002748.1. [O14966-2]
XP_016858238.1. XM_017002749.1. [O14966-2]
XP_016858239.1. XM_017002750.1. [O14966-2]
UniGeneiHs.115325.

Genome annotation databases

EnsembliENST00000235932; ENSP00000235932; ENSG00000117280. [O14966-1]
ENST00000367139; ENSP00000356107; ENSG00000117280. [O14966-1]
ENST00000414729; ENSP00000402910; ENSG00000117280. [O14966-1]
ENST00000437324; ENSP00000416613; ENSG00000117280. [O14966-3]
ENST00000446390; ENSP00000389899; ENSG00000117280. [O14966-2]
GeneIDi8934.
KEGGihsa:8934.
UCSCiuc009xbp.4. human. [O14966-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84488 mRNA. Translation: BAA22160.1.
AK308359 mRNA. No translation available.
AK303879 mRNA. Translation: BAG64815.1.
AC119673 Genomic DNA. No translation available.
BC002585 mRNA. Translation: AAH02585.1.
CCDSiCCDS1459.1. [O14966-1]
CCDS44301.1. [O14966-2]
CCDS44302.1. [O14966-3]
RefSeqiNP_001129134.1. NM_001135662.1. [O14966-1]
NP_001129135.1. NM_001135663.1. [O14966-2]
NP_001129136.1. NM_001135664.1. [O14966-3]
NP_003920.1. NM_003929.2. [O14966-1]
XP_005245626.1. XM_005245569.1. [O14966-1]
XP_005245627.1. XM_005245570.1. [O14966-1]
XP_005245628.1. XM_005245571.1. [O14966-1]
XP_006711668.1. XM_006711605.3. [O14966-3]
XP_006711669.1. XM_006711606.2. [O14966-3]
XP_016858237.1. XM_017002748.1. [O14966-2]
XP_016858238.1. XM_017002749.1. [O14966-2]
XP_016858239.1. XM_017002750.1. [O14966-2]
UniGeneiHs.115325.

3D structure databases

ProteinModelPortaliO14966.
SMRiO14966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114447. 15 interactors.
DIPiDIP-31215N.
IntActiO14966. 8 interactors.
STRINGi9606.ENSP00000235932.

PTM databases

iPTMnetiO14966.
PhosphoSitePlusiO14966.

Polymorphism and mutation databases

BioMutaiRAB7L1.

Proteomic databases

EPDiO14966.
PaxDbiO14966.
PeptideAtlasiO14966.
PRIDEiO14966.

Protocols and materials databases

DNASUi8934.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000235932; ENSP00000235932; ENSG00000117280. [O14966-1]
ENST00000367139; ENSP00000356107; ENSG00000117280. [O14966-1]
ENST00000414729; ENSP00000402910; ENSG00000117280. [O14966-1]
ENST00000437324; ENSP00000416613; ENSG00000117280. [O14966-3]
ENST00000446390; ENSP00000389899; ENSG00000117280. [O14966-2]
GeneIDi8934.
KEGGihsa:8934.
UCSCiuc009xbp.4. human. [O14966-1]

Organism-specific databases

CTDi8934.
DisGeNETi8934.
GeneCardsiRAB29.
HGNCiHGNC:9789. RAB29.
HPAiCAB020822.
HPA026303.
MIMi603949. gene.
neXtProtiNX_O14966.
OpenTargetsiENSG00000117280.
PharmGKBiPA34151.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4423. Eukaryota.
ENOG410YITC. LUCA.
GeneTreeiENSGT00760000119125.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiO14966.
KOiK07916.
OMAiQERFISM.
OrthoDBiEOG091G0K53.
PhylomeDBiO14966.
TreeFamiTF324491.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117280-MONOMER.

Miscellaneous databases

ChiTaRSiRAB7L1. human.
GenomeRNAii8934.
PROiO14966.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117280.
CleanExiHS_RAB7L1.
ExpressionAtlasiO14966. baseline and differential.
GenevisibleiO14966. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR030697. Rab29.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PANTHERiPTHR24073:SF315. PTHR24073:SF315. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB7L_HUMAN
AccessioniPrimary (citable) accession number: O14966
Secondary accession number(s): B4E1K3, C9JE77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.