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Protein

Hepatocyte growth factor-regulated tyrosine kinase substrate

Gene

HGS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 220FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein domain specific binding Source: UniProtKB
  • ubiquitin-like protein ligase binding Source: UniProtKB

GO - Biological processi

  • endosomal transport Source: Reactome
  • macroautophagy Source: ParkinsonsUK-UCL
  • membrane invagination Source: UniProtKB
  • membrane organization Source: Reactome
  • multivesicular body assembly Source: ParkinsonsUK-UCL
  • negative regulation of angiogenesis Source: BHF-UCL
  • negative regulation of cell proliferation Source: ProtInc
  • negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  • negative regulation of JAK-STAT cascade Source: HGNC
  • negative regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
  • negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  • positive regulation of exosomal secretion Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • protein deubiquitination Source: Reactome
  • protein localization to membrane Source: UniProtKB
  • protein targeting to lysosome Source: UniProtKB
  • regulation of MAP kinase activity Source: UniProtKB
  • regulation of protein catabolic process Source: HGNC
  • signal transduction Source: ProtInc

Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-182971 EGFR downregulation
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-5689880 Ub-specific processing proteases
R-HSA-6807004 Negative regulation of MET activity
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
SignaLinkiO14964
SIGNORiO14964

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factor-regulated tyrosine kinase substrate
Alternative name(s):
Hrs1 Publication
Protein pp110
Gene namesi
Name:HGS
Synonyms:HRS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000185359.12
HGNCiHGNC:4897 HGS
MIMi604375 gene
neXtProtiNX_O14964

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi266A → Q: Strongly reduced ubiquitin-binding. Reduced degradation of ubiquitinated EGFR. 1 Publication1
Mutagenesisi268A → Q: Strongly reduced ubiquitin-binding. Reduced degradation of ubiquitinated EGFR. 1 Publication1

Organism-specific databases

DisGeNETi9146
OpenTargetsiENSG00000185359
PharmGKBiPA29271

Chemistry databases

DrugBankiDB04272 Citric Acid

Polymorphism and mutation databases

BioMutaiHGS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000987081 – 777Hepatocyte growth factor-regulated tyrosine kinase substrateAdd BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207N6-acetyllysineCombined sources1
Modified residuei216PhosphotyrosineCombined sources1
Modified residuei308PhosphotyrosineBy similarity1
Modified residuei329PhosphotyrosineBy similarity1
Modified residuei334PhosphotyrosineBy similarity1
Modified residuei551N6-succinyllysineBy similarity1

Post-translational modificationi

Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.By similarity
Ubiquitinated (PubMed:25588945). Ubiquitinated by ITCH (PubMed:14602072, PubMed:24790097).3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO14964
MaxQBiO14964
PaxDbiO14964
PeptideAtlasiO14964
PRIDEiO14964

PTM databases

iPTMnetiO14964
PhosphoSitePlusiO14964

Expressioni

Tissue specificityi

Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000185359
CleanExiHS_HGS
ExpressionAtlasiO14964 baseline and differential
GenevisibleiO14964 HS

Organism-specific databases

HPAiHPA004872
HPA007728

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 (or probably STAM) and EPS15 (PubMed:12551915). Interacts with STAM (PubMed:9407053). Interacts with STAM2 (By similarity). Interacts with EPS15; the interaction is direct, calcium-dependent and inhibited by SNAP25 (By similarity). Identified in a complex with STAM and LITAF (PubMed:23166352). Found in a complex with STAM and E3 ligase ITCH and DTX3L (PubMed:24790097). Interacts with E3 ligase DTX3L; the interaction brings together STAM and HSG, promotes their recruitment to early endosomes and decreases STAM and HGS ubiquitination by ITCH (PubMed:24790097). Interacts with NF2; the interaction is direct (PubMed:10861283). Interacts with ubiquitin; the interaction is direct (By similarity). Interacts with VPS37C (PubMed:15509564). Interacts with SMAD1, SMAD2 and SMAD3 (By similarity). Interacts with TSG101; the interaction mediates the association with the ESCRT-I complex (PubMed:21070952). Interacts with SNAP25; the interaction is direct and decreases with addition of increasing concentrations of free calcium (By similarity). Interacts with SNX1; the interaction is direct (By similarity). Component of a 550 kDa membrane complex at least composed of HGS and SNX1 but excluding EGFR (By similarity). Interacts with TRAK1 (PubMed:18675823). Interacts with TRAK2 (By similarity). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3 (PubMed:15772161). Interacts (via UIM domain) with UBQLN1 (via ubiquitin-like domain) (By similarity). Interacts with ARRDC3 (PubMed:23208550). Identified in a complex containing at least ARRDC4, AVPR2 and HGS (PubMed:23236378). Interacts with LAPTM4B; promotes HGS ubiquitination (PubMed:25588945).By similarity15 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-740220,EBI-743598
AESQ08117-25EBI-740220,EBI-11741437
ARFIP2P533653EBI-740220,EBI-638194
BCAS2O759343EBI-740220,EBI-1050106
C1orf94Q6P1W53EBI-740220,EBI-946029
CCDC103Q8IW403EBI-740220,EBI-10261970
CCDC114Q96M638EBI-740220,EBI-10173858
CCDC120Q96HB54EBI-740220,EBI-744556
CDR2Q018505EBI-740220,EBI-1181367
CEP55Q53EZ44EBI-740220,EBI-747776
CEP57L1Q8IYX8-23EBI-740220,EBI-10181988
CEP63Q96MT8-35EBI-740220,EBI-11522539
COG8Q96MW53EBI-740220,EBI-720875
CRXO431865EBI-740220,EBI-748171
CSTF2P332407EBI-740220,EBI-711360
CSTF2TQ9H0L43EBI-740220,EBI-747012
CTTNBP2NLQ9P2B43EBI-740220,EBI-1774273
DAZAP2Q150386EBI-740220,EBI-724310
EXOC5O004713EBI-740220,EBI-949824
EXOC7Q9UPT54EBI-740220,EBI-720048
FAM168AQ92567-25EBI-740220,EBI-11978259
FAM22FB7ZLH04EBI-740220,EBI-10220102
FANCGA0A0S2Z4A73EBI-740220,EBI-16433879
FCHSD2O94868-33EBI-740220,EBI-11958845
FIGNQ5HY924EBI-740220,EBI-12297985
GCD7P325023EBI-740220,EBI-6260From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
GOLGA2Q083793EBI-740220,EBI-618309
GOLGA6L9A6NEM14EBI-740220,EBI-5916454
HSFY2Q96LI63EBI-740220,EBI-3957665
ING5Q8WYH85EBI-740220,EBI-488533
INTS4Q96HW73EBI-740220,EBI-5663129
INTS4Q96HW7-23EBI-740220,EBI-16438029
JAKMIP2Q96AA83EBI-740220,EBI-752007
KRT13P136465EBI-740220,EBI-1223876
KRT15P190127EBI-740220,EBI-739566
KRT18P057838EBI-740220,EBI-297888
KRT19P087273EBI-740220,EBI-742756
KRT3P120354EBI-740220,EBI-2430095
KRT31Q153235EBI-740220,EBI-948001
KRT33BQ145255EBI-740220,EBI-1049638
KRT38O760155EBI-740220,EBI-1047263
KRT40Q6A1626EBI-740220,EBI-10171697
KRT6AP025386EBI-740220,EBI-702198
KRT76Q015464EBI-740220,EBI-2952745
KRTAP26-1Q6PEX33EBI-740220,EBI-3957672
LDOC1O9575111EBI-740220,EBI-740738
LITAFQ997327EBI-740220,EBI-725647
LURAP1Q96LR23EBI-740220,EBI-741355
MAGEB4O154813EBI-740220,EBI-751857
MAGED1Q9Y5V35EBI-740220,EBI-716006
MAPK1IP1LQ8NDC06EBI-740220,EBI-741424
MED7O435134EBI-740220,EBI-394632
MIF4GDA9UHW64EBI-740220,EBI-373498
MIF4GDA9UHW6-25EBI-740220,EBI-9118295
MRFAP1L1Q96HT85EBI-740220,EBI-748896
NDC80O147775EBI-740220,EBI-715849
NDC80P404603EBI-740220,EBI-25247From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
NEFLI6L9F63EBI-740220,EBI-10178578
NMIQ132879EBI-740220,EBI-372942
NUP54Q7Z3B45EBI-740220,EBI-741048
P4HA3Q7Z4N85EBI-740220,EBI-10181968
PEF1Q9UBV83EBI-740220,EBI-724639
PLA2G10O154964EBI-740220,EBI-726466
POGZQ7Z3K35EBI-740220,EBI-1389308
PPP1R32Q7Z5V6-24EBI-740220,EBI-12000762
RFX6Q8HWS33EBI-740220,EBI-746118
sh3rf1Q6NRD33EBI-740220,EBI-7734031From Xenopus laevis.
SNX7Q9UNH63EBI-740220,EBI-751422
SPATA12Q7Z6I54EBI-740220,EBI-10696971
SS18L1O75177-53EBI-740220,EBI-12035119
STAMQ927832EBI-740220,EBI-752333
STAMQ92783-15EBI-740220,EBI-15763634
STX11O755583EBI-740220,EBI-714135
SUMO1P631653EBI-740220,EBI-80140
TADA2AO754783EBI-740220,EBI-742268
TADA2AO75478-23EBI-740220,EBI-16433586
taxP034104EBI-740220,EBI-9676218From Human T-cell leukemia virus 2.
taxP140794EBI-740220,EBI-9675698From Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).
TEKT1Q969V45EBI-740220,EBI-10180409
THP2O135393EBI-740220,EBI-30898From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
TRAF4Q9BUZ45EBI-740220,EBI-3650647
TRIM17Q9Y5775EBI-740220,EBI-743894
TRIM69Q86WT6-27EBI-740220,EBI-11525489
TSG101Q998164EBI-740220,EBI-346882
TSG101Q99816-12EBI-740220,EBI-15891993
UBBP0CG537EBI-740220,EBI-5333021From Bos taurus.
UBCP0CG488EBI-740220,EBI-3390054
UBCP629902EBI-740220,EBI-413053From a different organism.
UBQLN2Q9UHD98EBI-740220,EBI-947187
USHBP1Q8N6Y04EBI-740220,EBI-739895
VPS37BQ9H9H45EBI-740220,EBI-4400866
VPS37CA5D8V63EBI-740220,EBI-2559305
VPS52Q8N1B43EBI-740220,EBI-2799833
WHAMMP3Q1A5X74EBI-740220,EBI-11956783
YPR123CO135663EBI-740220,EBI-29708From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • ubiquitin-like protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114593209 interactors.
CORUMiO14964
DIPiDIP-29050N
ELMiO14964
IntActiO14964 248 interactors.
MINTiO14964
STRINGi9606.ENSP00000331201

Structurei

Secondary structure

1777
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 15Combined sources9
Helixi25 – 36Combined sources12
Helixi42 – 53Combined sources12
Helixi58 – 75Combined sources18
Helixi77 – 83Combined sources7
Helixi86 – 98Combined sources13
Helixi102 – 118Combined sources17
Turni119 – 121Combined sources3
Helixi123 – 125Combined sources3
Helixi126 – 138Combined sources13
Helixi147 – 150Combined sources4
Turni167 – 169Combined sources3
Turni183 – 185Combined sources3
Turni191 – 193Combined sources3
Beta strandi196 – 200Combined sources5
Helixi201 – 203Combined sources3
Beta strandi205 – 211Combined sources7
Helixi213 – 219Combined sources7
Helixi258 – 273Combined sources16
Helixi405 – 428Combined sources24
Helixi433 – 435Combined sources3
Helixi437 – 499Combined sources63

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D3GX-ray1.70P257-277[»]
3F1IX-ray2.30H404-501[»]
3OBQX-ray1.40B346-354[»]
3ZYQX-ray1.48A1-225[»]
4AVXX-ray1.68A1-225[»]
ProteinModelPortaliO14964
SMRiO14964
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14964

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 143VHSPROSITE-ProRule annotationAdd BLAST129
Domaini258 – 277UIMPROSITE-ProRule annotationAdd BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni225 – 543Interaction with SNX1By similarityAdd BLAST319
Regioni445 – 543Interaction with SNAP25 and TRAK2By similarityAdd BLAST99
Regioni454 – 572Interaction with STAMBy similarityAdd BLAST119
Regioni480 – 777Interaction with NF21 PublicationAdd BLAST298

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi346 – 394Pro-richAdd BLAST49
Compositional biasi505 – 772Gln-richAdd BLAST268

Domaini

Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix.
The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 220FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1818 Eukaryota
ENOG410XNRF LUCA
GeneTreeiENSGT00670000098022
HOGENOMiHOG000044175
HOVERGENiHBG062917
InParanoidiO14964
KOiK12182
OMAiYMYPAGA
OrthoDBiEOG091G06JJ
PhylomeDBiO14964
TreeFamiTF314470

Family and domain databases

Gene3Di1.25.40.901 hit
3.30.40.101 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR024641 HRS_helical
IPR017073 Ubi-bd_Hrs_VPS27
IPR003903 UIM_dom
IPR002014 VHS_dom
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF12210 Hrs_helical, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036956 Hrs_Vps27, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50330 UIM, 1 hit
PS50179 VHS, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14964-1) [UniParc]FASTAAdd to basket
Also known as: HRSi1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK
60 70 80 90 100
KKVNDKNPHV ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV
110 120 130 140 150
EVNVRNKILY LIQAWAHAFR NEPKYKVVQD TYQIMKVEGH VFPEFKESDA
160 170 180 190 200
MFAAERAPDW VDAEECHRCR VQFGVMTRKH HCRACGQIFC GKCSSKYSTI
210 220 230 240 250
PKFGIEKEVR VCEPCYEQLN RKAEGKATST TELPPEYLTS PLSQQSQLPP
260 270 280 290 300
KRDETALQEE EELQLALALS QSEAEEKERL RQKSTYTSYP KAEPMPSASS
310 320 330 340 350
APPASSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA
360 370 380 390 400
PVPLTEPAAQ PGEGHAAPTN VVENPLPETD SQPIPPSGGP FSEPQFHNGE
410 420 430 440 450
SEESHEQFLK ALQNAVTTFV NRMKSNHMRG RSITNDSAVL SLFQSINGMH
460 470 480 490 500
PQLLELLNQL DERRLYYEGL QDKLAQIRDA RGALSALREE HREKLRRAAE
510 520 530 540 550
EAERQRQIQL AQKLEIMRQK KQEYLEVQRQ LAIQRLQEQE KERQMRLEQQ
560 570 580 590 600
KQTVQMRAQM PAFPLPYAQL QAMPAAGGVL YQPSGPASFP STFSPAGSVE
610 620 630 640 650
GSPMHGVYMS QPAPAAGPYP SMPSTAADPS MVSAYMYPAG ATGAQAAPQA
660 670 680 690 700
QAGPTASPAY SSYQPTPTAG YQNVASQAPQ SLPAISQPPQ SSTMGYMGSQ
710 720 730 740 750
SVSMGYQPYN MQNLMTTLPS QDASLPPQQP YIAGQQPMYQ QMAPSGGPPQ
760 770
QQPPVAQQPQ AQGPPAQGSE AQLISFD
Length:777
Mass (Da):86,192
Last modified:January 1, 1998 - v1
Checksum:iDD64167A19DCF030
GO
Isoform 2 (identifier: O14964-2) [UniParc]FASTAAdd to basket
Also known as: HRSi2

The sequence of this isoform differs from the canonical sequence as follows:
     518-604: Missing.

Note: Dubious isoform produced through aberrant splice sites.
Show »
Length:690
Mass (Da):76,376
Checksum:i9266F872DB03A3E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236E → D in AAF82361 (PubMed:10861283).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0541547T → S1 PublicationCorresponds to variant dbSNP:rs753682847Ensembl.1
Natural variantiVAR_052981400E → D. Corresponds to variant dbSNP:rs34868130Ensembl.1
Natural variantiVAR_061991733A → S. Corresponds to variant dbSNP:rs56058441Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036172518 – 604Missing in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43895 mRNA Translation: AAC51929.1
D84064 mRNA Translation: BAA23366.1
AF260566 mRNA Translation: AAF82361.1
BT009754 mRNA Translation: AAP88756.1
BC003565 mRNA Translation: AAH03565.1
CCDSiCCDS11784.1 [O14964-1]
RefSeqiNP_004703.1, NM_004712.4 [O14964-1]
UniGeneiHs.661056

Genome annotation databases

EnsembliENST00000329138; ENSP00000331201; ENSG00000185359 [O14964-1]
GeneIDi9146
KEGGihsa:9146
UCSCiuc002kbg.4 human [O14964-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHGS_HUMAN
AccessioniPrimary (citable) accession number: O14964
Secondary accession number(s): Q9NR36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome