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O14964

- HGS_HUMAN

UniProt

O14964 - HGS_HUMAN

Protein

Hepatocyte growth factor-regulated tyrosine kinase substrate

Gene

HGS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri160 – 22061FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein domain specific binding Source: UniProtKB

    GO - Biological processi

    1. endosomal transport Source: UniProtKB
    2. endosome to lysosome transport Source: Ensembl
    3. epidermal growth factor receptor signaling pathway Source: Reactome
    4. intracellular protein transport Source: InterPro
    5. membrane organization Source: Reactome
    6. negative regulation of cell proliferation Source: ProtInc
    7. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
    8. negative regulation of JAK-STAT cascade Source: HGNC
    9. regulation of protein catabolic process Source: HGNC
    10. signal transduction Source: ProtInc

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12484. EGFR downregulation.
    REACT_27258. Endosomal Sorting Complex Required For Transport (ESCRT).
    SignaLinkiO14964.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatocyte growth factor-regulated tyrosine kinase substrate
    Alternative name(s):
    Hrs
    Protein pp110
    Gene namesi
    Name:HGS
    Synonyms:HRS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:4897. HGS.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. early endosome Source: HGNC
    4. early endosome membrane Source: UniProtKB-SubCell
    5. endosome Source: HGNC
    6. extracellular vesicular exosome Source: UniProt
    7. intracellular membrane-bounded organelle Source: HPA
    8. multivesicular body membrane Source: UniProtKB-SubCell
    9. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi266 – 2661A → Q: Strongly reduced ubiquitin-binding. Reduced degradation of ubiquitinated EGFR. 1 Publication
    Mutagenesisi268 – 2681A → Q: Strongly reduced ubiquitin-binding. Reduced degradation of ubiquitinated EGFR. 1 Publication

    Organism-specific databases

    PharmGKBiPA29271.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 777777Hepatocyte growth factor-regulated tyrosine kinase substratePRO_0000098708Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei207 – 2071N6-acetyllysine1 Publication
    Modified residuei216 – 2161Phosphotyrosine1 Publication
    Modified residuei308 – 3081PhosphotyrosineBy similarity
    Modified residuei329 – 3291PhosphotyrosineBy similarity
    Modified residuei334 – 3341PhosphotyrosineBy similarity
    Modified residuei551 – 5511N6-succinyllysineBy similarity

    Post-translational modificationi

    Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected By similarity. Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.By similarity1 Publication
    Ubiquitinated by ITCH.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO14964.
    PaxDbiO14964.
    PeptideAtlasiO14964.
    PRIDEiO14964.

    PTM databases

    PhosphoSiteiO14964.

    Expressioni

    Tissue specificityi

    Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.2 Publications

    Gene expression databases

    ArrayExpressiO14964.
    BgeeiO14964.
    CleanExiHS_HGS.
    GenevestigatoriO14964.

    Organism-specific databases

    HPAiHPA004872.
    HPA007728.

    Interactioni

    Subunit structurei

    Interacts with TRAK1. Interacts with TRAK2 By similarity. Interacts with TRAK1. Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 (or probably STAM) and EPS15. Interacts with STAM. Interacts with STAM2. Interacts with EPS15; the interaction is direct, calcium-dependent and inhibited by SNAP25. Interacts with NF2; the interaction is direct. Interacts with ubiquitin; the interaction is direct. Interacts with VPS37C. Interacts with SMAD1, SMAD2 and SMAD3. Interacts with TSG101; the interaction mediates the association with the ESCRT-I complex. Interacts with SNAP25; the interaction is direct and decreases with addition of increasing concentrations of free calcium. Interacts with SNX1; the interaction is direct. Component of a 550 kDa membrane complex at least composed of HGS and SNX1 but excluding EGFR. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3.By similarity8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    sh3rf1Q6NRD33EBI-740220,EBI-7734031From a different organism.
    UBBP0CG537EBI-740220,EBI-5333021From a different organism.

    Protein-protein interaction databases

    BioGridi114593. 155 interactions.
    DIPiDIP-29050N.
    IntActiO14964. 49 interactions.
    MINTiMINT-234372.
    STRINGi9606.ENSP00000331201.

    Structurei

    Secondary structure

    1
    777
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 159
    Helixi25 – 3612
    Helixi42 – 5312
    Helixi58 – 7518
    Helixi77 – 837
    Helixi86 – 9813
    Helixi102 – 11817
    Turni119 – 1213
    Helixi123 – 1253
    Helixi126 – 13813
    Helixi147 – 1504
    Turni167 – 1693
    Turni183 – 1853
    Turni191 – 1933
    Beta strandi196 – 2005
    Helixi201 – 2033
    Beta strandi205 – 2117
    Helixi213 – 2197
    Helixi258 – 27316
    Helixi405 – 42824
    Helixi433 – 4353
    Helixi437 – 49963

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D3GX-ray1.70P257-277[»]
    3F1IX-ray2.30H404-501[»]
    3OBQX-ray1.40B346-354[»]
    3ZYQX-ray1.48A1-225[»]
    4AVXX-ray1.68A1-225[»]
    ProteinModelPortaliO14964.
    SMRiO14964. Positions 6-221, 404-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14964.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 143129VHSPROSITE-ProRule annotationAdd
    BLAST
    Repeati258 – 27720UIMAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni225 – 543319Interaction with SNX1By similarityAdd
    BLAST
    Regioni445 – 54399Interaction with SNAP25 and TRAK2By similarityAdd
    BLAST
    Regioni454 – 572119Interaction with STAM1By similarityAdd
    BLAST
    Regioni480 – 777298Interaction with NF2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi346 – 39449Pro-richAdd
    BLAST
    Compositional biasi505 – 772268Gln-richAdd
    BLAST

    Domaini

    Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix.
    The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions.

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 1 UIM (ubiquitin-interacting motif) repeat.PROSITE-ProRule annotation
    Contains 1 VHS domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri160 – 22061FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG257212.
    HOGENOMiHOG000044175.
    HOVERGENiHBG062917.
    InParanoidiO14964.
    KOiK12182.
    OMAiERMRQKS.
    OrthoDBiEOG7N37CN.
    PhylomeDBiO14964.
    TreeFamiTF314470.

    Family and domain databases

    Gene3Di1.25.40.90. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR008942. ENTH_VHS.
    IPR024641. HRS_helical.
    IPR017073. Ubi-bd_Hrs_VPS27.
    IPR003903. Ubiquitin-int_motif.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF12210. Hrs_helical. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036956. Hrs_Vps27. 1 hit.
    SMARTiSM00064. FYVE. 1 hit.
    SM00726. UIM. 1 hit.
    SM00288. VHS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS50330. UIM. 1 hit.
    PS50179. VHS. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14964-1) [UniParc]FASTAAdd to Basket

    Also known as: HRSi1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK    50
    KKVNDKNPHV ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV 100
    EVNVRNKILY LIQAWAHAFR NEPKYKVVQD TYQIMKVEGH VFPEFKESDA 150
    MFAAERAPDW VDAEECHRCR VQFGVMTRKH HCRACGQIFC GKCSSKYSTI 200
    PKFGIEKEVR VCEPCYEQLN RKAEGKATST TELPPEYLTS PLSQQSQLPP 250
    KRDETALQEE EELQLALALS QSEAEEKERL RQKSTYTSYP KAEPMPSASS 300
    APPASSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA 350
    PVPLTEPAAQ PGEGHAAPTN VVENPLPETD SQPIPPSGGP FSEPQFHNGE 400
    SEESHEQFLK ALQNAVTTFV NRMKSNHMRG RSITNDSAVL SLFQSINGMH 450
    PQLLELLNQL DERRLYYEGL QDKLAQIRDA RGALSALREE HREKLRRAAE 500
    EAERQRQIQL AQKLEIMRQK KQEYLEVQRQ LAIQRLQEQE KERQMRLEQQ 550
    KQTVQMRAQM PAFPLPYAQL QAMPAAGGVL YQPSGPASFP STFSPAGSVE 600
    GSPMHGVYMS QPAPAAGPYP SMPSTAADPS MVSAYMYPAG ATGAQAAPQA 650
    QAGPTASPAY SSYQPTPTAG YQNVASQAPQ SLPAISQPPQ SSTMGYMGSQ 700
    SVSMGYQPYN MQNLMTTLPS QDASLPPQQP YIAGQQPMYQ QMAPSGGPPQ 750
    QQPPVAQQPQ AQGPPAQGSE AQLISFD 777
    Length:777
    Mass (Da):86,192
    Last modified:January 1, 1998 - v1
    Checksum:iDD64167A19DCF030
    GO
    Isoform 2 (identifier: O14964-2) [UniParc]FASTAAdd to Basket

    Also known as: HRSi2

    The sequence of this isoform differs from the canonical sequence as follows:
         518-604: Missing.

    Note: Dubious isoform produced through aberrant splice sites.

    Show »
    Length:690
    Mass (Da):76,376
    Checksum:i9266F872DB03A3E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti236 – 2361E → D in AAF82361. (PubMed:10861283)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71T → S.1 Publication
    VAR_054154
    Natural varianti400 – 4001E → D.
    Corresponds to variant rs34868130 [ dbSNP | Ensembl ].
    VAR_052981
    Natural varianti733 – 7331A → S.
    Corresponds to variant rs56058441 [ dbSNP | Ensembl ].
    VAR_061991

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei518 – 60487Missing in isoform 2. 1 PublicationVSP_036172Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43895 mRNA. Translation: AAC51929.1.
    D84064 mRNA. Translation: BAA23366.1.
    AF260566 mRNA. Translation: AAF82361.1.
    BT009754 mRNA. Translation: AAP88756.1.
    BC003565 mRNA. Translation: AAH03565.1.
    CCDSiCCDS11784.1. [O14964-1]
    RefSeqiNP_004703.1. NM_004712.4. [O14964-1]
    UniGeneiHs.661056.

    Genome annotation databases

    EnsembliENST00000329138; ENSP00000331201; ENSG00000185359. [O14964-1]
    GeneIDi9146.
    KEGGihsa:9146.
    UCSCiuc002kbg.3. human. [O14964-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43895 mRNA. Translation: AAC51929.1 .
    D84064 mRNA. Translation: BAA23366.1 .
    AF260566 mRNA. Translation: AAF82361.1 .
    BT009754 mRNA. Translation: AAP88756.1 .
    BC003565 mRNA. Translation: AAH03565.1 .
    CCDSi CCDS11784.1. [O14964-1 ]
    RefSeqi NP_004703.1. NM_004712.4. [O14964-1 ]
    UniGenei Hs.661056.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D3G X-ray 1.70 P 257-277 [» ]
    3F1I X-ray 2.30 H 404-501 [» ]
    3OBQ X-ray 1.40 B 346-354 [» ]
    3ZYQ X-ray 1.48 A 1-225 [» ]
    4AVX X-ray 1.68 A 1-225 [» ]
    ProteinModelPortali O14964.
    SMRi O14964. Positions 6-221, 404-501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114593. 155 interactions.
    DIPi DIP-29050N.
    IntActi O14964. 49 interactions.
    MINTi MINT-234372.
    STRINGi 9606.ENSP00000331201.

    PTM databases

    PhosphoSitei O14964.

    Proteomic databases

    MaxQBi O14964.
    PaxDbi O14964.
    PeptideAtlasi O14964.
    PRIDEi O14964.

    Protocols and materials databases

    DNASUi 9146.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329138 ; ENSP00000331201 ; ENSG00000185359 . [O14964-1 ]
    GeneIDi 9146.
    KEGGi hsa:9146.
    UCSCi uc002kbg.3. human. [O14964-1 ]

    Organism-specific databases

    CTDi 9146.
    GeneCardsi GC17P079651.
    HGNCi HGNC:4897. HGS.
    HPAi HPA004872.
    HPA007728.
    MIMi 604375. gene.
    neXtProti NX_O14964.
    PharmGKBi PA29271.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257212.
    HOGENOMi HOG000044175.
    HOVERGENi HBG062917.
    InParanoidi O14964.
    KOi K12182.
    OMAi ERMRQKS.
    OrthoDBi EOG7N37CN.
    PhylomeDBi O14964.
    TreeFami TF314470.

    Enzyme and pathway databases

    Reactomei REACT_12484. EGFR downregulation.
    REACT_27258. Endosomal Sorting Complex Required For Transport (ESCRT).
    SignaLinki O14964.

    Miscellaneous databases

    ChiTaRSi HGS. human.
    EvolutionaryTracei O14964.
    GeneWikii HGS_(gene).
    GenomeRNAii 9146.
    NextBioi 34307.
    PROi O14964.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14964.
    Bgeei O14964.
    CleanExi HS_HGS.
    Genevestigatori O14964.

    Family and domain databases

    Gene3Di 1.25.40.90. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR008942. ENTH_VHS.
    IPR024641. HRS_helical.
    IPR017073. Ubi-bd_Hrs_VPS27.
    IPR003903. Ubiquitin-int_motif.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF12210. Hrs_helical. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036956. Hrs_Vps27. 1 hit.
    SMARTi SM00064. FYVE. 1 hit.
    SM00726. UIM. 1 hit.
    SM00288. VHS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS50330. UIM. 1 hit.
    PS50179. VHS. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth."
      Asao H., Sasaki Y., Arita T., Tanaka N., Endo K., Kasai H., Takeshita T., Endo Y., Fujita T., Sugamura K.
      J. Biol. Chem. 272:32785-32791(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH STAM.
    2. "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17."
      Lu L., Komada M., Kitamura N.
      Gene 213:125-132(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Placenta.
    3. "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate."
      Scoles D.R., Huynh D.P., Chen M.S., Burke S.P., Gutmann D.H., Pulst S.-M.
      Hum. Mol. Genet. 9:1567-1574(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DOMAIN, INTERACTION WITH NF2, SUBCELLULAR LOCATION.
      Tissue: Brain.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    6. "Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes."
      Komada M., Masaki R., Yamamoto A., Kitamura N.
      J. Biol. Chem. 272:20538-20544(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4."
      Marchese A., Raiborg C., Santini F., Keen J.H., Stenmark H., Benovic J.L.
      Dev. Cell 5:709-722(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION BY ITCH.
    8. "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes."
      Bache K.G., Raiborg C., Mehlum A., Stenmark H.
      J. Biol. Chem. 278:12513-12521(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STAM; STAM2 AND EPS15, IDENTIFICATION IN A COMPLEX WITH STAM2 AND EPS15.
    9. Cited for: INTERACTION WITH HIV-1 GAG AND HGS, SELF-ASSOCIATION.
    10. "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding."
      Eastman S.W., Martin-Serrano J., Chung W., Zang T., Bieniasz P.D.
      J. Biol. Chem. 280:628-636(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH VPS37C.
    11. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking."
      Webber E., Li L., Chin L.S.
      J. Mol. Biol. 382:638-651(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAK1.
    14. "CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling."
      Yan Q., Sun W., Kujala P., Lotfi Y., Vida T.A., Bean A.J.
      Mol. Biol. Cell 16:2470-2482(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CART COMPLEX.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. Cited for: DOMAIN FYVE-TYPE ZINC-FINGER.
    18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting."
      Hirano S., Kawasaki M., Ura H., Kato R., Raiborg C., Stenmark H., Wakatsuki S.
      Nat. Struct. Mol. Biol. 13:272-277(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 257-277 IN COMPLEX WITH UBIQUITIN, MUTAGENESIS OF ALA-266 AND ALA-268.
    22. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-7.

    Entry informationi

    Entry nameiHGS_HUMAN
    AccessioniPrimary (citable) accession number: O14964
    Secondary accession number(s): Q9NR36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3