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O14964

- HGS_HUMAN

UniProt

O14964 - HGS_HUMAN

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Protein

Hepatocyte growth factor-regulated tyrosine kinase substrate

Gene

HGS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 22061FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein domain specific binding Source: UniProtKB

GO - Biological processi

  1. endosomal transport Source: UniProtKB
  2. endosome to lysosome transport Source: Ensembl
  3. epidermal growth factor receptor signaling pathway Source: Reactome
  4. membrane invagination Source: UniProtKB
  5. membrane organization Source: Reactome
  6. negative regulation of cell proliferation Source: ProtInc
  7. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  8. negative regulation of JAK-STAT cascade Source: HGNC
  9. positive regulation of gene expression Source: UniProtKB
  10. protein localization to membrane Source: UniProtKB
  11. protein targeting to lysosome Source: UniProtKB
  12. regulation of protein catabolic process Source: HGNC
  13. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12484. EGFR downregulation.
REACT_27258. Endosomal Sorting Complex Required For Transport (ESCRT).
SignaLinkiO14964.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factor-regulated tyrosine kinase substrate
Alternative name(s):
Hrs
Protein pp110
Gene namesi
Name:HGS
Synonyms:HRS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:4897. HGS.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. early endosome Source: HGNC
  4. endosome Source: HGNC
  5. extracellular vesicular exosome Source: UniProt
  6. intracellular membrane-bounded organelle Source: HPA
  7. membrane Source: UniProtKB-KW
  8. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi266 – 2661A → Q: Strongly reduced ubiquitin-binding. Reduced degradation of ubiquitinated EGFR. 1 Publication
Mutagenesisi268 – 2681A → Q: Strongly reduced ubiquitin-binding. Reduced degradation of ubiquitinated EGFR. 1 Publication

Organism-specific databases

PharmGKBiPA29271.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 777777Hepatocyte growth factor-regulated tyrosine kinase substratePRO_0000098708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei207 – 2071N6-acetyllysine1 Publication
Modified residuei216 – 2161Phosphotyrosine1 Publication
Modified residuei308 – 3081PhosphotyrosineBy similarity
Modified residuei329 – 3291PhosphotyrosineBy similarity
Modified residuei334 – 3341PhosphotyrosineBy similarity
Modified residuei551 – 5511N6-succinyllysineBy similarity

Post-translational modificationi

Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.By similarity1 Publication
Ubiquitinated by ITCH.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO14964.
PaxDbiO14964.
PeptideAtlasiO14964.
PRIDEiO14964.

PTM databases

PhosphoSiteiO14964.

Expressioni

Tissue specificityi

Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.2 Publications

Gene expression databases

BgeeiO14964.
CleanExiHS_HGS.
ExpressionAtlasiO14964. baseline and differential.
GenevestigatoriO14964.

Organism-specific databases

HPAiHPA004872.
HPA007728.

Interactioni

Subunit structurei

Interacts with TRAK1. Interacts with TRAK2 (By similarity). Interacts with TRAK1. Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 (or probably STAM) and EPS15. Interacts with STAM. Interacts with STAM2. Interacts with EPS15; the interaction is direct, calcium-dependent and inhibited by SNAP25. Interacts with NF2; the interaction is direct. Interacts with ubiquitin; the interaction is direct. Interacts with VPS37C. Interacts with SMAD1, SMAD2 and SMAD3. Interacts with TSG101; the interaction mediates the association with the ESCRT-I complex. Interacts with SNAP25; the interaction is direct and decreases with addition of increasing concentrations of free calcium. Interacts with SNX1; the interaction is direct. Component of a 550 kDa membrane complex at least composed of HGS and SNX1 but excluding EGFR. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3.By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P140794EBI-740220,EBI-9675698From a different organism.
sh3rf1Q6NRD33EBI-740220,EBI-7734031From a different organism.
taxP034104EBI-740220,EBI-9676218From a different organism.
UBBP0CG537EBI-740220,EBI-5333021From a different organism.

Protein-protein interaction databases

BioGridi114593. 159 interactions.
DIPiDIP-29050N.
IntActiO14964. 51 interactions.
MINTiMINT-234372.
STRINGi9606.ENSP00000331201.

Structurei

Secondary structure

1
777
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 159Combined sources
Helixi25 – 3612Combined sources
Helixi42 – 5312Combined sources
Helixi58 – 7518Combined sources
Helixi77 – 837Combined sources
Helixi86 – 9813Combined sources
Helixi102 – 11817Combined sources
Turni119 – 1213Combined sources
Helixi123 – 1253Combined sources
Helixi126 – 13813Combined sources
Helixi147 – 1504Combined sources
Turni167 – 1693Combined sources
Turni183 – 1853Combined sources
Turni191 – 1933Combined sources
Beta strandi196 – 2005Combined sources
Helixi201 – 2033Combined sources
Beta strandi205 – 2117Combined sources
Helixi213 – 2197Combined sources
Helixi258 – 27316Combined sources
Helixi405 – 42824Combined sources
Helixi433 – 4353Combined sources
Helixi437 – 49963Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D3GX-ray1.70P257-277[»]
3F1IX-ray2.30H404-501[»]
3OBQX-ray1.40B346-354[»]
3ZYQX-ray1.48A1-225[»]
4AVXX-ray1.68A1-225[»]
ProteinModelPortaliO14964.
SMRiO14964. Positions 6-221, 404-501.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14964.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 143129VHSPROSITE-ProRule annotationAdd
BLAST
Repeati258 – 27720UIMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni225 – 543319Interaction with SNX1By similarityAdd
BLAST
Regioni445 – 54399Interaction with SNAP25 and TRAK2By similarityAdd
BLAST
Regioni454 – 572119Interaction with STAM1By similarityAdd
BLAST
Regioni480 – 777298Interaction with NF2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi346 – 39449Pro-richAdd
BLAST
Compositional biasi505 – 772268Gln-richAdd
BLAST

Domaini

Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix.
The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions.

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 UIM (ubiquitin-interacting motif) repeat.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 22061FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG257212.
GeneTreeiENSGT00670000098022.
HOGENOMiHOG000044175.
HOVERGENiHBG062917.
InParanoidiO14964.
KOiK12182.
OMAiERMRQKS.
OrthoDBiEOG7N37CN.
PhylomeDBiO14964.
TreeFamiTF314470.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR024641. HRS_helical.
IPR017073. Ubi-bd_Hrs_VPS27.
IPR003903. Ubiquitin-int_motif.
IPR002014. VHS.
IPR018205. VHS_subgr.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF12210. Hrs_helical. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036956. Hrs_Vps27. 1 hit.
SMARTiSM00064. FYVE. 1 hit.
SM00726. UIM. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14964-1) [UniParc]FASTAAdd to Basket

Also known as: HRSi1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK
60 70 80 90 100
KKVNDKNPHV ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV
110 120 130 140 150
EVNVRNKILY LIQAWAHAFR NEPKYKVVQD TYQIMKVEGH VFPEFKESDA
160 170 180 190 200
MFAAERAPDW VDAEECHRCR VQFGVMTRKH HCRACGQIFC GKCSSKYSTI
210 220 230 240 250
PKFGIEKEVR VCEPCYEQLN RKAEGKATST TELPPEYLTS PLSQQSQLPP
260 270 280 290 300
KRDETALQEE EELQLALALS QSEAEEKERL RQKSTYTSYP KAEPMPSASS
310 320 330 340 350
APPASSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA
360 370 380 390 400
PVPLTEPAAQ PGEGHAAPTN VVENPLPETD SQPIPPSGGP FSEPQFHNGE
410 420 430 440 450
SEESHEQFLK ALQNAVTTFV NRMKSNHMRG RSITNDSAVL SLFQSINGMH
460 470 480 490 500
PQLLELLNQL DERRLYYEGL QDKLAQIRDA RGALSALREE HREKLRRAAE
510 520 530 540 550
EAERQRQIQL AQKLEIMRQK KQEYLEVQRQ LAIQRLQEQE KERQMRLEQQ
560 570 580 590 600
KQTVQMRAQM PAFPLPYAQL QAMPAAGGVL YQPSGPASFP STFSPAGSVE
610 620 630 640 650
GSPMHGVYMS QPAPAAGPYP SMPSTAADPS MVSAYMYPAG ATGAQAAPQA
660 670 680 690 700
QAGPTASPAY SSYQPTPTAG YQNVASQAPQ SLPAISQPPQ SSTMGYMGSQ
710 720 730 740 750
SVSMGYQPYN MQNLMTTLPS QDASLPPQQP YIAGQQPMYQ QMAPSGGPPQ
760 770
QQPPVAQQPQ AQGPPAQGSE AQLISFD
Length:777
Mass (Da):86,192
Last modified:January 1, 1998 - v1
Checksum:iDD64167A19DCF030
GO
Isoform 2 (identifier: O14964-2) [UniParc]FASTAAdd to Basket

Also known as: HRSi2

The sequence of this isoform differs from the canonical sequence as follows:
     518-604: Missing.

Note: Dubious isoform produced through aberrant splice sites.

Show »
Length:690
Mass (Da):76,376
Checksum:i9266F872DB03A3E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361E → D in AAF82361. (PubMed:10861283)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71T → S.1 Publication
VAR_054154
Natural varianti400 – 4001E → D.
Corresponds to variant rs34868130 [ dbSNP | Ensembl ].
VAR_052981
Natural varianti733 – 7331A → S.
Corresponds to variant rs56058441 [ dbSNP | Ensembl ].
VAR_061991

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei518 – 60487Missing in isoform 2. 1 PublicationVSP_036172Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43895 mRNA. Translation: AAC51929.1.
D84064 mRNA. Translation: BAA23366.1.
AF260566 mRNA. Translation: AAF82361.1.
BT009754 mRNA. Translation: AAP88756.1.
BC003565 mRNA. Translation: AAH03565.1.
CCDSiCCDS11784.1. [O14964-1]
RefSeqiNP_004703.1. NM_004712.4. [O14964-1]
UniGeneiHs.661056.

Genome annotation databases

EnsembliENST00000329138; ENSP00000331201; ENSG00000185359. [O14964-1]
GeneIDi9146.
KEGGihsa:9146.
UCSCiuc002kbg.3. human. [O14964-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43895 mRNA. Translation: AAC51929.1 .
D84064 mRNA. Translation: BAA23366.1 .
AF260566 mRNA. Translation: AAF82361.1 .
BT009754 mRNA. Translation: AAP88756.1 .
BC003565 mRNA. Translation: AAH03565.1 .
CCDSi CCDS11784.1. [O14964-1 ]
RefSeqi NP_004703.1. NM_004712.4. [O14964-1 ]
UniGenei Hs.661056.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D3G X-ray 1.70 P 257-277 [» ]
3F1I X-ray 2.30 H 404-501 [» ]
3OBQ X-ray 1.40 B 346-354 [» ]
3ZYQ X-ray 1.48 A 1-225 [» ]
4AVX X-ray 1.68 A 1-225 [» ]
ProteinModelPortali O14964.
SMRi O14964. Positions 6-221, 404-501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114593. 159 interactions.
DIPi DIP-29050N.
IntActi O14964. 51 interactions.
MINTi MINT-234372.
STRINGi 9606.ENSP00000331201.

PTM databases

PhosphoSitei O14964.

Proteomic databases

MaxQBi O14964.
PaxDbi O14964.
PeptideAtlasi O14964.
PRIDEi O14964.

Protocols and materials databases

DNASUi 9146.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329138 ; ENSP00000331201 ; ENSG00000185359 . [O14964-1 ]
GeneIDi 9146.
KEGGi hsa:9146.
UCSCi uc002kbg.3. human. [O14964-1 ]

Organism-specific databases

CTDi 9146.
GeneCardsi GC17P079651.
HGNCi HGNC:4897. HGS.
HPAi HPA004872.
HPA007728.
MIMi 604375. gene.
neXtProti NX_O14964.
PharmGKBi PA29271.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257212.
GeneTreei ENSGT00670000098022.
HOGENOMi HOG000044175.
HOVERGENi HBG062917.
InParanoidi O14964.
KOi K12182.
OMAi ERMRQKS.
OrthoDBi EOG7N37CN.
PhylomeDBi O14964.
TreeFami TF314470.

Enzyme and pathway databases

Reactomei REACT_12484. EGFR downregulation.
REACT_27258. Endosomal Sorting Complex Required For Transport (ESCRT).
SignaLinki O14964.

Miscellaneous databases

ChiTaRSi HGS. human.
EvolutionaryTracei O14964.
GeneWikii HGS_(gene).
GenomeRNAii 9146.
NextBioi 34307.
PROi O14964.
SOURCEi Search...

Gene expression databases

Bgeei O14964.
CleanExi HS_HGS.
ExpressionAtlasi O14964. baseline and differential.
Genevestigatori O14964.

Family and domain databases

Gene3Di 1.25.40.90. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR008942. ENTH_VHS.
IPR024641. HRS_helical.
IPR017073. Ubi-bd_Hrs_VPS27.
IPR003903. Ubiquitin-int_motif.
IPR002014. VHS.
IPR018205. VHS_subgr.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
PF12210. Hrs_helical. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view ]
PIRSFi PIRSF036956. Hrs_Vps27. 1 hit.
SMARTi SM00064. FYVE. 1 hit.
SM00726. UIM. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view ]
SUPFAMi SSF48464. SSF48464. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth."
    Asao H., Sasaki Y., Arita T., Tanaka N., Endo K., Kasai H., Takeshita T., Endo Y., Fujita T., Sugamura K.
    J. Biol. Chem. 272:32785-32791(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH STAM.
  2. "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17."
    Lu L., Komada M., Kitamura N.
    Gene 213:125-132(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Placenta.
  3. "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate."
    Scoles D.R., Huynh D.P., Chen M.S., Burke S.P., Gutmann D.H., Pulst S.-M.
    Hum. Mol. Genet. 9:1567-1574(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DOMAIN, INTERACTION WITH NF2, SUBCELLULAR LOCATION.
    Tissue: Brain.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  6. "Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes."
    Komada M., Masaki R., Yamamoto A., Kitamura N.
    J. Biol. Chem. 272:20538-20544(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4."
    Marchese A., Raiborg C., Santini F., Keen J.H., Stenmark H., Benovic J.L.
    Dev. Cell 5:709-722(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION BY ITCH.
  8. "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes."
    Bache K.G., Raiborg C., Mehlum A., Stenmark H.
    J. Biol. Chem. 278:12513-12521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STAM; STAM2 AND EPS15, IDENTIFICATION IN A COMPLEX WITH STAM2 AND EPS15.
  9. Cited for: INTERACTION WITH HIV-1 GAG AND HGS, SELF-ASSOCIATION.
  10. "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding."
    Eastman S.W., Martin-Serrano J., Chung W., Zang T., Bieniasz P.D.
    J. Biol. Chem. 280:628-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VPS37C.
  11. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking."
    Webber E., Li L., Chin L.S.
    J. Mol. Biol. 382:638-651(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAK1.
  14. "CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling."
    Yan Q., Sun W., Kujala P., Lotfi Y., Vida T.A., Bean A.J.
    Mol. Biol. Cell 16:2470-2482(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CART COMPLEX.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: DOMAIN FYVE-TYPE ZINC-FINGER.
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting."
    Hirano S., Kawasaki M., Ura H., Kato R., Raiborg C., Stenmark H., Wakatsuki S.
    Nat. Struct. Mol. Biol. 13:272-277(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 257-277 IN COMPLEX WITH UBIQUITIN, MUTAGENESIS OF ALA-266 AND ALA-268.
  22. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-7.

Entry informationi

Entry nameiHGS_HUMAN
AccessioniPrimary (citable) accession number: O14964
Secondary accession number(s): Q9NR36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3