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O14960 (LECT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukocyte cell-derived chemotaxin-2

Short name=LECT-2
Short name=hLECT2
Gene names
Name:LECT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length151 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation.

Subcellular location

Cytoplasm. Secreted Ref.7.

Tissue specificity

Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.

Induction

By phytohemagglutinin (PHA).

Sequence similarities

Belongs to the LECT2/MIM-1 family.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentCytoplasm
Secreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Traceable author statement Ref.7. Source: ProtInc

negative regulation of Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

skeletal system development

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentcytoplasm

Traceable author statement PubMed 9266841. Source: ProtInc

extracellular space

Traceable author statement PubMed 9266841. Source: ProtInc

   Molecular_functionidentical protein binding

Inferred from physical interaction PubMed 23352894. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself3EBI-8307271,EBI-8307271

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 151133Leukocyte cell-derived chemotaxin-2
PRO_0000017364

Amino acid modifications

Disulfide bond25 ↔ 60 Ref.8
Disulfide bond36 ↔ 41 Ref.8
Disulfide bond99 ↔ 142 Ref.8

Natural variations

Natural variant581I → V. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6
Corresponds to variant rs31517 [ dbSNP | Ensembl ].
VAR_011386

Sequences

Sequence LengthMass (Da)Tools
O14960 [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: 3C1DFCA1B4F8792F

FASTA15116,390
        10         20         30         40         50         60 
MFSTKALLLA GLISTALAGP WANICAGKSS NEIRTCDRHG CGQYSAQRSQ RPHQGVDILC 

        70         80         90        100        110        120 
SAGSTVYAPF TGMIVGQEKP YQNKNAINNG VRISGRGFCV KMFYIKPIKY KGPIKKGEKL 

       130        140        150 
GTLLPLQKVY PGIQSHVHIE NCDSSDPTAY L 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver."
Yamagoe S., Mizuno S., Suzuki K.
Biochim. Biophys. Acta 1396:105-113(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-58.
Tissue: Liver.
[2]"Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene."
Yamagoe S., Kameoka Y., Hashimoto K., Mizuno S., Suzuki K.
Genomics 48:324-329(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-58.
Tissue: Peripheral blood.
[3]"Systemic expression of a newly recognized protein, LECT2, in the human body."
Nagai H., Hamada T., Uchida T., Yamagoe S., Suzuki K.
Pathol. Int. 48:882-886(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-58.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-58.
Tissue: Liver.
[5]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-58.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-58.
Tissue: Liver.
[7]"Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2."
Yamagoe S., Yamakawa Y., Matsuo Y., Minowada J., Mizuno S., Suzuki K.
Immunol. Lett. 52:9-13(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[8]"Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry."
Okumura A., Suzuki T., Dohmae N., Okabe T., Hashimoto Y., Nakazato K., Ohno H., Miyazaki Y., Yamagoe S.
Biosci. Trends 3:139-143(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D63521 mRNA. Translation: BAA23609.1.
AB007546 Genomic DNA. Translation: BAA25669.1.
AK314092 mRNA. Translation: BAG36787.1.
AC004763 Genomic DNA. Translation: AAC17734.1.
AC002428 Genomic DNA. Translation: AAB66905.1.
BC093670 mRNA. Translation: AAH93670.1.
BC101579 mRNA. Translation: AAI01580.1.
CCDSCCDS4190.1.
RefSeqNP_002293.2. NM_002302.2.
UniGeneHs.512580.

3D structure databases

ProteinModelPortalO14960.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110142. 2 interactions.
MINTMINT-8408923.
STRING9606.ENSP00000274507.

PTM databases

PhosphoSiteO14960.

Proteomic databases

PaxDbO14960.
PRIDEO14960.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274507; ENSP00000274507; ENSG00000145826.
GeneID3950.
KEGGhsa:3950.
UCSCuc003lbe.1. human.

Organism-specific databases

CTD3950.
GeneCardsGC05M135310.
H-InvDBHIX0032112.
HGNCHGNC:6550. LECT2.
HPACAB026052.
MIM602882. gene.
neXtProtNX_O14960.
PharmGKBPA30330.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45864.
HOGENOMHOG000113312.
HOVERGENHBG052320.
InParanoidO14960.
OMACQDEAMA.
PhylomeDBO14960.
TreeFamTF331097.

Gene expression databases

ArrayExpressO14960.
BgeeO14960.
CleanExHS_LECT2.
GenevestigatorO14960.

Family and domain databases

InterProIPR008663. LECT2.
IPR017381. LECT2_chordata.
IPR016047. Peptidase_M23.
[Graphical view]
PANTHERPTHR11329. PTHR11329. 1 hit.
PfamPF01551. Peptidase_M23. 1 hit.
[Graphical view]
PIRSFPIRSF038085. LECT3. 1 hit.
ProtoNetSearch...

Other

GeneWikiLECT2.
GenomeRNAi3950.
NextBio15497.
PROO14960.
SOURCESearch...

Entry information

Entry nameLECT2_HUMAN
AccessionPrimary (citable) accession number: O14960
Secondary accession number(s): B2RA90, O14565, Q52M49
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM