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O14960

- LECT2_HUMAN

UniProt

O14960 - LECT2_HUMAN

Protein

Leukocyte cell-derived chemotaxin-2

Gene

LECT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation.

    GO - Molecular functioni

    1. identical protein binding Source: IntAct

    GO - Biological processi

    1. chemotaxis Source: ProtInc
    2. negative regulation of Wnt signaling pathway Source: Ensembl
    3. skeletal system development Source: ProtInc

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukocyte cell-derived chemotaxin-2
    Short name:
    LECT-2
    Short name:
    hLECT2
    Gene namesi
    Name:LECT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6550. LECT2.

    Subcellular locationi

    Cytoplasm 1 Publication. Secreted 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30330.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 151133Leukocyte cell-derived chemotaxin-2PRO_0000017364Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 601 Publication
    Disulfide bondi36 ↔ 411 Publication
    Disulfide bondi99 ↔ 1421 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiO14960.
    PRIDEiO14960.

    PTM databases

    PhosphoSiteiO14960.

    Expressioni

    Tissue specificityi

    Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.

    Inductioni

    By phytohemagglutinin (PHA).

    Gene expression databases

    ArrayExpressiO14960.
    BgeeiO14960.
    CleanExiHS_LECT2.
    GenevestigatoriO14960.

    Organism-specific databases

    HPAiCAB026052.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-8307271,EBI-8307271

    Protein-protein interaction databases

    BioGridi110142. 2 interactions.
    MINTiMINT-8408923.
    STRINGi9606.ENSP00000274507.

    Structurei

    3D structure databases

    ProteinModelPortaliO14960.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LECT2/MIM-1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45864.
    HOGENOMiHOG000113312.
    HOVERGENiHBG052320.
    InParanoidiO14960.
    OMAiCQDEAMA.
    PhylomeDBiO14960.
    TreeFamiTF331097.

    Family and domain databases

    InterProiIPR008663. LECT2.
    IPR017381. LECT2_chordata.
    IPR016047. Peptidase_M23.
    [Graphical view]
    PANTHERiPTHR11329. PTHR11329. 1 hit.
    PfamiPF01551. Peptidase_M23. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038085. LECT3. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14960-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSTKALLLA GLISTALAGP WANICAGKSS NEIRTCDRHG CGQYSAQRSQ    50
    RPHQGVDILC SAGSTVYAPF TGMIVGQEKP YQNKNAINNG VRISGRGFCV 100
    KMFYIKPIKY KGPIKKGEKL GTLLPLQKVY PGIQSHVHIE NCDSSDPTAY 150
    L 151
    Length:151
    Mass (Da):16,390
    Last modified:January 11, 2011 - v2
    Checksum:i3C1DFCA1B4F8792F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti58 – 581I → V.6 Publications
    Corresponds to variant rs31517 [ dbSNP | Ensembl ].
    VAR_011386

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63521 mRNA. Translation: BAA23609.1.
    AB007546 Genomic DNA. Translation: BAA25669.1.
    AK314092 mRNA. Translation: BAG36787.1.
    AC004763 Genomic DNA. Translation: AAC17734.1.
    AC002428 Genomic DNA. Translation: AAB66905.1.
    BC093670 mRNA. Translation: AAH93670.1.
    BC101579 mRNA. Translation: AAI01580.1.
    CCDSiCCDS4190.1.
    RefSeqiNP_002293.2. NM_002302.2.
    UniGeneiHs.512580.

    Genome annotation databases

    EnsembliENST00000274507; ENSP00000274507; ENSG00000145826.
    GeneIDi3950.
    KEGGihsa:3950.
    UCSCiuc003lbe.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63521 mRNA. Translation: BAA23609.1 .
    AB007546 Genomic DNA. Translation: BAA25669.1 .
    AK314092 mRNA. Translation: BAG36787.1 .
    AC004763 Genomic DNA. Translation: AAC17734.1 .
    AC002428 Genomic DNA. Translation: AAB66905.1 .
    BC093670 mRNA. Translation: AAH93670.1 .
    BC101579 mRNA. Translation: AAI01580.1 .
    CCDSi CCDS4190.1.
    RefSeqi NP_002293.2. NM_002302.2.
    UniGenei Hs.512580.

    3D structure databases

    ProteinModelPortali O14960.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110142. 2 interactions.
    MINTi MINT-8408923.
    STRINGi 9606.ENSP00000274507.

    PTM databases

    PhosphoSitei O14960.

    Proteomic databases

    PaxDbi O14960.
    PRIDEi O14960.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274507 ; ENSP00000274507 ; ENSG00000145826 .
    GeneIDi 3950.
    KEGGi hsa:3950.
    UCSCi uc003lbe.1. human.

    Organism-specific databases

    CTDi 3950.
    GeneCardsi GC05M135310.
    H-InvDB HIX0032112.
    HGNCi HGNC:6550. LECT2.
    HPAi CAB026052.
    MIMi 602882. gene.
    neXtProti NX_O14960.
    PharmGKBi PA30330.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45864.
    HOGENOMi HOG000113312.
    HOVERGENi HBG052320.
    InParanoidi O14960.
    OMAi CQDEAMA.
    PhylomeDBi O14960.
    TreeFami TF331097.

    Miscellaneous databases

    GeneWikii LECT2.
    GenomeRNAii 3950.
    NextBioi 15497.
    PROi O14960.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14960.
    Bgeei O14960.
    CleanExi HS_LECT2.
    Genevestigatori O14960.

    Family and domain databases

    InterProi IPR008663. LECT2.
    IPR017381. LECT2_chordata.
    IPR016047. Peptidase_M23.
    [Graphical view ]
    PANTHERi PTHR11329. PTHR11329. 1 hit.
    Pfami PF01551. Peptidase_M23. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038085. LECT3. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver."
      Yamagoe S., Mizuno S., Suzuki K.
      Biochim. Biophys. Acta 1396:105-113(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-58.
      Tissue: Liver.
    2. "Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene."
      Yamagoe S., Kameoka Y., Hashimoto K., Mizuno S., Suzuki K.
      Genomics 48:324-329(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-58.
      Tissue: Peripheral blood.
    3. "Systemic expression of a newly recognized protein, LECT2, in the human body."
      Nagai H., Hamada T., Uchida T., Yamagoe S., Suzuki K.
      Pathol. Int. 48:882-886(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-58.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-58.
      Tissue: Liver.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-58.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-58.
      Tissue: Liver.
    7. "Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2."
      Yamagoe S., Yamakawa Y., Matsuo Y., Minowada J., Mizuno S., Suzuki K.
      Immunol. Lett. 52:9-13(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. "Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry."
      Okumura A., Suzuki T., Dohmae N., Okabe T., Hashimoto Y., Nakazato K., Ohno H., Miyazaki Y., Yamagoe S.
      Biosci. Trends 3:139-143(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.

    Entry informationi

    Entry nameiLECT2_HUMAN
    AccessioniPrimary (citable) accession number: O14960
    Secondary accession number(s): B2RA90, O14565, Q52M49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3