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Protein

Leukocyte cell-derived chemotaxin-2

Gene

LECT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53ZincCombined sources1 Publication1
Metal bindingi57ZincCombined sources1 Publication1
Metal bindingi138ZincCombined sources1 Publication1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • chemotaxis Source: ProtInc
  • skeletal system development Source: ProtInc

Keywordsi

Biological processChemotaxis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte cell-derived chemotaxin-2
Short name:
LECT-2
Short name:
hLECT2
Gene namesi
Name:LECT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145826.8.
HGNCiHGNC:6550. LECT2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi104Y → H: No metalloendopeptidase activity. 1 Publication1

Organism-specific databases

DisGeNETi3950.
OpenTargetsiENSG00000145826.
PharmGKBiPA30330.

Polymorphism and mutation databases

BioMutaiLECT2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001736419 – 151Leukocyte cell-derived chemotaxin-2Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 60Combined sources2 Publications
Disulfide bondi36 ↔ 41Combined sources2 Publications
Disulfide bondi99 ↔ 142Combined sources2 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO14960.
PeptideAtlasiO14960.
PRIDEiO14960.

PTM databases

PhosphoSitePlusiO14960.

Expressioni

Tissue specificityi

Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.2 Publications

Inductioni

By phytohemagglutinin (PHA).1 Publication

Gene expression databases

BgeeiENSG00000145826.
CleanExiHS_LECT2.
ExpressionAtlasiO14960. baseline and differential.
GenevisibleiO14960. HS.

Organism-specific databases

HPAiHPA043883.

Interactioni

Subunit structurei

Interacts with MET.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-8307271,EBI-8307271

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

MINTiMINT-8408923.
STRINGi9606.ENSP00000274507.

Structurei

Secondary structure

1151
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi49 – 51Combined sources3
Beta strandi55 – 59Combined sources5
Beta strandi65 – 67Combined sources3
Beta strandi69 – 77Combined sources9
Beta strandi90 – 95Combined sources6
Beta strandi98 – 108Combined sources11
Beta strandi110 – 114Combined sources5
Beta strandi118 – 123Combined sources6
Helixi126 – 129Combined sources4
Beta strandi136 – 141Combined sources6
Helixi148 – 150Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B0HX-ray1.94A/B19-151[»]
ProteinModelPortaliO14960.
SMRiO14960.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LECT2/MIM-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ84. Eukaryota.
ENOG410XVAU. LUCA.
GeneTreeiENSGT00390000015484.
HOGENOMiHOG000113312.
HOVERGENiHBG052320.
InParanoidiO14960.
OMAiDSHGCGQ.
OrthoDBiEOG091G0B4B.
PhylomeDBiO14960.
TreeFamiTF331097.

Family and domain databases

InterProiView protein in InterPro
IPR008663. LECT2.
IPR017381. LECT2_chordata.
IPR016047. Peptidase_M23.
PANTHERiPTHR11329. PTHR11329. 1 hit.
PfamiView protein in Pfam
PF01551. Peptidase_M23. 1 hit.
PIRSFiPIRSF038085. LECT3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSTKALLLA GLISTALAGP WANICAGKSS NEIRTCDRHG CGQYSAQRSQ
60 70 80 90 100
RPHQGVDILC SAGSTVYAPF TGMIVGQEKP YQNKNAINNG VRISGRGFCV
110 120 130 140 150
KMFYIKPIKY KGPIKKGEKL GTLLPLQKVY PGIQSHVHIE NCDSSDPTAY

L
Length:151
Mass (Da):16,390
Last modified:January 11, 2011 - v2
Checksum:i3C1DFCA1B4F8792F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01138658I → V6 PublicationsCorresponds to variant dbSNP:rs31517Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63521 mRNA. Translation: BAA23609.1.
AB007546 Genomic DNA. Translation: BAA25669.1.
AK314092 mRNA. Translation: BAG36787.1.
AC004763 Genomic DNA. Translation: AAC17734.1.
AC002428 Genomic DNA. Translation: AAB66905.1.
BC093670 mRNA. Translation: AAH93670.1.
BC101579 mRNA. Translation: AAI01580.1.
CCDSiCCDS4190.1.
RefSeqiNP_002293.2. NM_002302.2.
UniGeneiHs.512580.

Genome annotation databases

EnsembliENST00000274507; ENSP00000274507; ENSG00000145826.
GeneIDi3950.
KEGGihsa:3950.
UCSCiuc003lbe.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLECT2_HUMAN
AccessioniPrimary (citable) accession number: O14960
Secondary accession number(s): B2RA90, O14565, Q52M49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2011
Last modified: September 27, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families