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Protein

Leukocyte cell-derived chemotaxin-2

Gene

LECT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation.

GO - Molecular functioni

  1. identical protein binding Source: IntAct

GO - Biological processi

  1. chemotaxis Source: ProtInc
  2. negative regulation of Wnt signaling pathway Source: Ensembl
  3. skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte cell-derived chemotaxin-2
Short name:
LECT-2
Short name:
hLECT2
Gene namesi
Name:LECT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6550. LECT2.

Subcellular locationi

Cytoplasm 1 Publication. Secreted 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 151133Leukocyte cell-derived chemotaxin-2PRO_0000017364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 601 Publication
Disulfide bondi36 ↔ 411 Publication
Disulfide bondi99 ↔ 1421 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO14960.
PRIDEiO14960.

PTM databases

PhosphoSiteiO14960.

Expressioni

Tissue specificityi

Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.

Inductioni

By phytohemagglutinin (PHA).

Gene expression databases

BgeeiO14960.
CleanExiHS_LECT2.
ExpressionAtlasiO14960. baseline and differential.
GenevestigatoriO14960.

Organism-specific databases

HPAiHPA043883.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-8307271,EBI-8307271

Protein-protein interaction databases

BioGridi110142. 2 interactions.
MINTiMINT-8408923.
STRINGi9606.ENSP00000274507.

Structurei

3D structure databases

ProteinModelPortaliO14960.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LECT2/MIM-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45864.
GeneTreeiENSGT00390000015484.
HOGENOMiHOG000113312.
HOVERGENiHBG052320.
InParanoidiO14960.
OMAiPYKNKNA.
PhylomeDBiO14960.
TreeFamiTF331097.

Family and domain databases

InterProiIPR008663. LECT2.
IPR017381. LECT2_chordata.
IPR016047. Peptidase_M23.
[Graphical view]
PANTHERiPTHR11329. PTHR11329. 1 hit.
PfamiPF01551. Peptidase_M23. 1 hit.
[Graphical view]
PIRSFiPIRSF038085. LECT3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSTKALLLA GLISTALAGP WANICAGKSS NEIRTCDRHG CGQYSAQRSQ
60 70 80 90 100
RPHQGVDILC SAGSTVYAPF TGMIVGQEKP YQNKNAINNG VRISGRGFCV
110 120 130 140 150
KMFYIKPIKY KGPIKKGEKL GTLLPLQKVY PGIQSHVHIE NCDSSDPTAY

L
Length:151
Mass (Da):16,390
Last modified:January 11, 2011 - v2
Checksum:i3C1DFCA1B4F8792F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581I → V.6 Publications
Corresponds to variant rs31517 [ dbSNP | Ensembl ].
VAR_011386

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63521 mRNA. Translation: BAA23609.1.
AB007546 Genomic DNA. Translation: BAA25669.1.
AK314092 mRNA. Translation: BAG36787.1.
AC004763 Genomic DNA. Translation: AAC17734.1.
AC002428 Genomic DNA. Translation: AAB66905.1.
BC093670 mRNA. Translation: AAH93670.1.
BC101579 mRNA. Translation: AAI01580.1.
CCDSiCCDS4190.1.
RefSeqiNP_002293.2. NM_002302.2.
UniGeneiHs.512580.

Genome annotation databases

EnsembliENST00000274507; ENSP00000274507; ENSG00000145826.
GeneIDi3950.
KEGGihsa:3950.
UCSCiuc003lbe.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63521 mRNA. Translation: BAA23609.1.
AB007546 Genomic DNA. Translation: BAA25669.1.
AK314092 mRNA. Translation: BAG36787.1.
AC004763 Genomic DNA. Translation: AAC17734.1.
AC002428 Genomic DNA. Translation: AAB66905.1.
BC093670 mRNA. Translation: AAH93670.1.
BC101579 mRNA. Translation: AAI01580.1.
CCDSiCCDS4190.1.
RefSeqiNP_002293.2. NM_002302.2.
UniGeneiHs.512580.

3D structure databases

ProteinModelPortaliO14960.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110142. 2 interactions.
MINTiMINT-8408923.
STRINGi9606.ENSP00000274507.

PTM databases

PhosphoSiteiO14960.

Proteomic databases

PaxDbiO14960.
PRIDEiO14960.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274507; ENSP00000274507; ENSG00000145826.
GeneIDi3950.
KEGGihsa:3950.
UCSCiuc003lbe.1. human.

Organism-specific databases

CTDi3950.
GeneCardsiGC05M135310.
H-InvDBHIX0032112.
HGNCiHGNC:6550. LECT2.
HPAiHPA043883.
MIMi602882. gene.
neXtProtiNX_O14960.
PharmGKBiPA30330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45864.
GeneTreeiENSGT00390000015484.
HOGENOMiHOG000113312.
HOVERGENiHBG052320.
InParanoidiO14960.
OMAiPYKNKNA.
PhylomeDBiO14960.
TreeFamiTF331097.

Miscellaneous databases

GeneWikiiLECT2.
GenomeRNAii3950.
NextBioi15497.
PROiO14960.
SOURCEiSearch...

Gene expression databases

BgeeiO14960.
CleanExiHS_LECT2.
ExpressionAtlasiO14960. baseline and differential.
GenevestigatoriO14960.

Family and domain databases

InterProiIPR008663. LECT2.
IPR017381. LECT2_chordata.
IPR016047. Peptidase_M23.
[Graphical view]
PANTHERiPTHR11329. PTHR11329. 1 hit.
PfamiPF01551. Peptidase_M23. 1 hit.
[Graphical view]
PIRSFiPIRSF038085. LECT3. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver."
    Yamagoe S., Mizuno S., Suzuki K.
    Biochim. Biophys. Acta 1396:105-113(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-58.
    Tissue: Liver.
  2. "Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene."
    Yamagoe S., Kameoka Y., Hashimoto K., Mizuno S., Suzuki K.
    Genomics 48:324-329(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-58.
    Tissue: Peripheral blood.
  3. "Systemic expression of a newly recognized protein, LECT2, in the human body."
    Nagai H., Hamada T., Uchida T., Yamagoe S., Suzuki K.
    Pathol. Int. 48:882-886(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-58.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-58.
    Tissue: Liver.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-58.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-58.
    Tissue: Liver.
  7. "Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2."
    Yamagoe S., Yamakawa Y., Matsuo Y., Minowada J., Mizuno S., Suzuki K.
    Immunol. Lett. 52:9-13(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry."
    Okumura A., Suzuki T., Dohmae N., Okabe T., Hashimoto Y., Nakazato K., Ohno H., Miyazaki Y., Yamagoe S.
    Biosci. Trends 3:139-143(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.

Entry informationi

Entry nameiLECT2_HUMAN
AccessioniPrimary (citable) accession number: O14960
Secondary accession number(s): B2RA90, O14565, Q52M49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2011
Last modified: March 4, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.