ID   QCR10_HUMAN             Reviewed;          56 AA.
AC   O14957; B2R542; D6W5Z4; Q9UEA3; Q9UPK4;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   24-JAN-2024, entry version 180.
DE   RecName: Full=Cytochrome b-c1 complex subunit 10;
DE   AltName: Full=Complex III subunit 10;
DE   AltName: Full=Complex III subunit XI;
DE   AltName: Full=Ubiquinol-cytochrome c reductase complex 6.4 kDa protein;
GN   Name=UQCR11; Synonyms=UQCR;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fibroblast;
RX   PubMed=9161705; DOI=10.1080/15216549700202191;
RA   Islam M.M., Suzuki H., Yoneda M., Tanaka M.;
RT   "Primary structure of the smallest (6.4-kDa) subunit of human and bovine
RT   ubiquinol-cytochrome c reductase deduced from cDNA sequences.";
RL   Biochem. Mol. Biol. Int. 41:1109-1116(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS) OF 1-52.
RX   PubMed=28844695; DOI=10.1016/j.cell.2017.07.050;
RA   Guo R., Zong S., Wu M., Gu J., Yang M.;
RT   "Architecture of human mitochondrial respiratory megacomplex I2III2IV2.";
RL   Cell 170:1247-1257(2017).
CC   -!- FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a
CC       multisubunit transmembrane complex that is part of the mitochondrial
CC       electron transport chain which drives oxidative phosphorylation. The
CC       respiratory chain contains 3 multisubunit complexes succinate
CC       dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase
CC       (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase
CC       (complex IV, CIV), that cooperate to transfer electrons derived from
CC       NADH and succinate to molecular oxygen, creating an electrochemical
CC       gradient over the inner membrane that drives transmembrane transport
CC       and the ATP synthase. The cytochrome b-c1 complex catalyzes electron
CC       transfer from ubiquinol to cytochrome c, linking this redox reaction to
CC       translocation of protons across the mitochondrial inner membrane, with
CC       protons being carried across the membrane as hydrogens on the quinol.
CC       In the process called Q cycle, 2 protons are consumed from the matrix,
CC       4 protons are released into the intermembrane space and 2 electrons are
CC       passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1
CC       stability. {ECO:0000250|UniProtKB:P37299}.
CC   -!- SUBUNIT: Component of the ubiquinol-cytochrome c oxidoreductase
CC       (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme
CC       composed of 11 subunits. The complex is composed of 3 respiratory
CC       subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core
CC       protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular
CC       weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8,
CC       UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske
CC       protein UQCRFS1 (By similarity). The complex exists as an obligatory
CC       dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC       membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC       cytochrome c oxidase (complex IV, CIV), resulting in different
CC       assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex
CC       MCI(2)III(2)IV(2)) (PubMed:28844695). {ECO:0000250|UniProtKB:P07552,
CC       ECO:0000269|PubMed:28844695}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P37299}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P37299}.
CC   -!- SIMILARITY: Belongs to the UQCR11/QCR10 family. {ECO:0000305}.
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DR   EMBL; D55636; BAA21748.1; -; mRNA.
DR   EMBL; AK312053; BAG34989.1; -; mRNA.
DR   EMBL; AC005321; AAC27374.1; -; Genomic_DNA.
DR   EMBL; AC005943; AAC72105.1; -; Genomic_DNA.
DR   EMBL; CH471139; EAW69474.1; -; Genomic_DNA.
DR   EMBL; CH471139; EAW69475.1; -; Genomic_DNA.
DR   EMBL; CH471139; EAW69476.1; -; Genomic_DNA.
DR   EMBL; BC000462; AAH00462.1; -; mRNA.
DR   EMBL; BC003594; AAH03594.1; -; mRNA.
DR   CCDS; CCDS12073.1; -.
DR   RefSeq; NP_006821.1; NM_006830.3.
DR   PDB; 5XTE; EM; 3.40 A; G/T=2-52.
DR   PDB; 5XTH; EM; 3.90 A; AG/AT=2-52.
DR   PDB; 5XTI; EM; 17.40 A; AG/AT=2-52.
DR   PDBsum; 5XTE; -.
DR   PDBsum; 5XTH; -.
DR   PDBsum; 5XTI; -.
DR   AlphaFoldDB; O14957; -.
DR   SMR; O14957; -.
DR   BioGRID; 116172; 52.
DR   ComplexPortal; CPX-560; Mitochondrial respiratory chain complex III.
DR   IntAct; O14957; 2.
DR   STRING; 9606.ENSP00000467262; -.
DR   DrugBank; DB07763; (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE.
DR   DrugBank; DB07778; (S)-famoxadone.
DR   DrugBank; DB08453; 2-Nonyl-4-quinolinol 1-oxide.
DR   DrugBank; DB04799; 6-Hydroxy-5-undecyl-4,7-benzothiazoledione.
DR   DrugBank; DB07401; Azoxystrobin.
DR   DrugBank; DB08330; METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE.
DR   DrugBank; DB08690; Ubiquinone Q2.
DR   BioMuta; UQCR11; -.
DR   EPD; O14957; -.
DR   jPOST; O14957; -.
DR   MassIVE; O14957; -.
DR   MaxQB; O14957; -.
DR   PaxDb; 9606-ENSP00000467262; -.
DR   PeptideAtlas; O14957; -.
DR   ProteomicsDB; 48334; -.
DR   Pumba; O14957; -.
DR   TopDownProteomics; O14957; -.
DR   Antibodypedia; 42255; 77 antibodies from 12 providers.
DR   DNASU; 10975; -.
DR   Ensembl; ENST00000585671.2; ENSP00000466420.1; ENSG00000127540.12.
DR   Ensembl; ENST00000589880.1; ENSP00000467555.1; ENSG00000127540.12.
DR   Ensembl; ENST00000591899.8; ENSP00000467262.1; ENSG00000127540.12.
DR   GeneID; 10975; -.
DR   KEGG; hsa:10975; -.
DR   MANE-Select; ENST00000591899.8; ENSP00000467262.1; NM_006830.4; NP_006821.1.
DR   UCSC; uc002ltm.4; human.
DR   AGR; HGNC:30862; -.
DR   CTD; 10975; -.
DR   DisGeNET; 10975; -.
DR   GeneCards; UQCR11; -.
DR   HGNC; HGNC:30862; UQCR11.
DR   HPA; ENSG00000127540; Tissue enhanced (heart muscle, skeletal muscle).
DR   MIM; 609711; gene.
DR   neXtProt; NX_O14957; -.
DR   OpenTargets; ENSG00000127540; -.
DR   PharmGKB; PA165394505; -.
DR   VEuPathDB; HostDB:ENSG00000127540; -.
DR   eggNOG; ENOG502S9FZ; Eukaryota.
DR   GeneTree; ENSGT00390000018299; -.
DR   HOGENOM; CLU_211742_0_0_1; -.
DR   InParanoid; O14957; -.
DR   OMA; LAKNWMP; -.
DR   OrthoDB; 5340959at2759; -.
DR   PhylomeDB; O14957; -.
DR   TreeFam; TF105034; -.
DR   BioCyc; MetaCyc:HS05111-MONOMER; -.
DR   PathwayCommons; O14957; -.
DR   Reactome; R-HSA-611105; Respiratory electron transport.
DR   SignaLink; O14957; -.
DR   SIGNOR; O14957; -.
DR   BioGRID-ORCS; 10975; 71 hits in 1151 CRISPR screens.
DR   ChiTaRS; UQCR11; human.
DR   GenomeRNAi; 10975; -.
DR   Pharos; O14957; Tbio.
DR   PRO; PR:O14957; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; O14957; Protein.
DR   Bgee; ENSG00000127540; Expressed in apex of heart and 148 other cell types or tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IDA:ComplexPortal.
DR   GO; GO:0005750; C:mitochondrial respiratory chain complex III; IPI:ComplexPortal.
DR   GO; GO:0009055; F:electron transfer activity; TAS:UniProtKB.
DR   GO; GO:0045333; P:cellular respiration; NAS:ComplexPortal.
DR   GO; GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
DR   GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; NAS:ComplexPortal.
DR   Gene3D; 1.20.5.220; -; 1.
DR   InterPro; IPR029027; Single_a-helix_sf.
DR   InterPro; IPR015089; UQCR.
DR   PANTHER; PTHR15420:SF2; CYTOCHROME B-C1 COMPLEX SUBUNIT 10; 1.
DR   PANTHER; PTHR15420; UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 6.4 KD PROTEIN; 1.
DR   Pfam; PF08997; UCR_6-4kD; 1.
DR   SUPFAM; SSF81518; Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase); 1.
DR   Genevisible; O14957; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Electron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..56
FT                   /note="Cytochrome b-c1 complex subunit 10"
FT                   /id="PRO_0000193560"
FT   TOPO_DOM        1..12
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000269|PubMed:28844695"
FT   TRANSMEM        13..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000269|PubMed:28844695"
FT   TOPO_DOM        36..56
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000269|PubMed:28844695"
FT   HELIX           3..5
FT                   /evidence="ECO:0007829|PDB:5XTE"
FT   HELIX           8..35
FT                   /evidence="ECO:0007829|PDB:5XTE"
FT   HELIX           39..42
FT                   /evidence="ECO:0007829|PDB:5XTE"
FT   STRAND          45..47
FT                   /evidence="ECO:0007829|PDB:5XTE"
SQ   SEQUENCE   56 AA;  6570 MW;  0AE1CB90A205112C CRC64;
     MVTRFLGPRY RELVKNWVPT AYTWGAVGAV GLVWATDWRL ILDWVPYING KFKKDN
//