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O14957

- QCR10_HUMAN

UniProt

O14957 - QCR10_HUMAN

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Protein

Cytochrome b-c1 complex subunit 10

Gene

UQCR11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.
This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

GO - Molecular functioni

  1. electron carrier activity Source: UniProtKB
  2. ubiquinol-cytochrome-c reductase activity Source: InterPro

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. generation of precursor metabolites and energy Source: ProtInc
  3. respiratory electron transport chain Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 10
Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
Gene namesi
Name:UQCR11
Synonyms:UQCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:30862. UQCR11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5656Cytochrome b-c1 complex subunit 10PRO_0000193560Add
BLAST

Proteomic databases

MaxQBiO14957.
PaxDbiO14957.
PRIDEiO14957.

PTM databases

PhosphoSiteiO14957.

Expressioni

Gene expression databases

BgeeiO14957.
CleanExiHS_UQCR.
GenevestigatoriO14957.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

BioGridi116172. 6 interactions.
IntActiO14957. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO14957.
SMRiO14957. Positions 1-53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR11/QCR10 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299371.
GeneTreeiENSGT00390000018299.
HOGENOMiHOG000030914.
HOVERGENiHBG105467.
InParanoidiO14957.
KOiK00420.
OMAiLAKNWMP.
PhylomeDBiO14957.
TreeFamiTF105034.

Family and domain databases

Gene3Di1.20.5.220. 1 hit.
InterProiIPR029027. Single_a-helix.
IPR015089. UQCR.
[Graphical view]
PANTHERiPTHR15420. PTHR15420. 1 hit.
PfamiPF08997. UCR_6-4kD. 1 hit.
[Graphical view]
SUPFAMiSSF81518. SSF81518. 1 hit.

Sequencei

Sequence statusi: Complete.

O14957-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTRFLGPRY RELVKNWVPT AYTWGAVGAV GLVWATDWRL ILDWVPYING

KFKKDN
Length:56
Mass (Da):6,570
Last modified:January 1, 1998 - v1
Checksum:i0AE1CB90A205112C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55636 mRNA. Translation: BAA21748.1.
AK312053 mRNA. Translation: BAG34989.1.
AC005321 Genomic DNA. Translation: AAC27374.1.
AC005943 Genomic DNA. Translation: AAC72105.1.
CH471139 Genomic DNA. Translation: EAW69474.1.
CH471139 Genomic DNA. Translation: EAW69475.1.
CH471139 Genomic DNA. Translation: EAW69476.1.
BC000462 mRNA. Translation: AAH00462.1.
BC003594 mRNA. Translation: AAH03594.1.
CCDSiCCDS12073.1.
RefSeqiNP_006821.1. NM_006830.3.
UniGeneiHs.8372.

Genome annotation databases

EnsembliENST00000585671; ENSP00000466420; ENSG00000127540.
ENST00000585937; ENSP00000468614; ENSG00000267059.
ENST00000589880; ENSP00000467555; ENSG00000127540.
ENST00000591899; ENSP00000467262; ENSG00000127540.
GeneIDi10975.
KEGGihsa:10975.
UCSCiuc002ltm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55636 mRNA. Translation: BAA21748.1 .
AK312053 mRNA. Translation: BAG34989.1 .
AC005321 Genomic DNA. Translation: AAC27374.1 .
AC005943 Genomic DNA. Translation: AAC72105.1 .
CH471139 Genomic DNA. Translation: EAW69474.1 .
CH471139 Genomic DNA. Translation: EAW69475.1 .
CH471139 Genomic DNA. Translation: EAW69476.1 .
BC000462 mRNA. Translation: AAH00462.1 .
BC003594 mRNA. Translation: AAH03594.1 .
CCDSi CCDS12073.1.
RefSeqi NP_006821.1. NM_006830.3.
UniGenei Hs.8372.

3D structure databases

ProteinModelPortali O14957.
SMRi O14957. Positions 1-53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116172. 6 interactions.
IntActi O14957. 1 interaction.

PTM databases

PhosphoSitei O14957.

Proteomic databases

MaxQBi O14957.
PaxDbi O14957.
PRIDEi O14957.

Protocols and materials databases

DNASUi 10975.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000585671 ; ENSP00000466420 ; ENSG00000127540 .
ENST00000585937 ; ENSP00000468614 ; ENSG00000267059 .
ENST00000589880 ; ENSP00000467555 ; ENSG00000127540 .
ENST00000591899 ; ENSP00000467262 ; ENSG00000127540 .
GeneIDi 10975.
KEGGi hsa:10975.
UCSCi uc002ltm.3. human.

Organism-specific databases

CTDi 10975.
GeneCardsi GC19M001597.
HGNCi HGNC:30862. UQCR11.
MIMi 609711. gene.
neXtProti NX_O14957.
PharmGKBi PA165394505.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299371.
GeneTreei ENSGT00390000018299.
HOGENOMi HOG000030914.
HOVERGENi HBG105467.
InParanoidi O14957.
KOi K00420.
OMAi LAKNWMP.
PhylomeDBi O14957.
TreeFami TF105034.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSi UQCR11. human.
GenomeRNAii 10975.
NextBioi 41704.
PROi O14957.
SOURCEi Search...

Gene expression databases

Bgeei O14957.
CleanExi HS_UQCR.
Genevestigatori O14957.

Family and domain databases

Gene3Di 1.20.5.220. 1 hit.
InterProi IPR029027. Single_a-helix.
IPR015089. UQCR.
[Graphical view ]
PANTHERi PTHR15420. PTHR15420. 1 hit.
Pfami PF08997. UCR_6-4kD. 1 hit.
[Graphical view ]
SUPFAMi SSF81518. SSF81518. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences."
    Islam M.M., Suzuki H., Yoneda M., Tanaka M.
    Biochem. Mol. Biol. Int. 41:1109-1116(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibroblast.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiQCR10_HUMAN
AccessioniPrimary (citable) accession number: O14957
Secondary accession number(s): B2R542
, D6W5Z4, Q9UEA3, Q9UPK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3