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O14957

- QCR10_HUMAN

UniProt

O14957 - QCR10_HUMAN

Protein

Cytochrome b-c1 complex subunit 10

Gene

UQCR11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.
    This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

    GO - Molecular functioni

    1. electron carrier activity Source: UniProtKB
    2. ubiquinol-cytochrome-c reductase activity Source: InterPro

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. generation of precursor metabolites and energy Source: ProtInc
    3. respiratory electron transport chain Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 10
    Alternative name(s):
    Complex III subunit 10
    Complex III subunit XI
    Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
    Gene namesi
    Name:UQCR11
    Synonyms:UQCR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30862. UQCR11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165394505.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5656Cytochrome b-c1 complex subunit 10PRO_0000193560Add
    BLAST

    Proteomic databases

    MaxQBiO14957.
    PaxDbiO14957.
    PRIDEiO14957.

    PTM databases

    PhosphoSiteiO14957.

    Expressioni

    Gene expression databases

    BgeeiO14957.
    CleanExiHS_UQCR.
    GenevestigatoriO14957.

    Interactioni

    Subunit structurei

    The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Protein-protein interaction databases

    BioGridi116172. 6 interactions.
    IntActiO14957. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO14957.
    SMRiO14957. Positions 1-53.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UQCR11/QCR10 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299371.
    HOGENOMiHOG000030914.
    HOVERGENiHBG105467.
    InParanoidiO14957.
    KOiK00420.
    OMAiLAKNWMP.
    PhylomeDBiO14957.
    TreeFamiTF105034.

    Family and domain databases

    Gene3Di1.20.5.220. 1 hit.
    InterProiIPR029027. Single_a-helix.
    IPR015089. UQCR.
    [Graphical view]
    PANTHERiPTHR15420. PTHR15420. 1 hit.
    PfamiPF08997. UCR_6-4kD. 1 hit.
    [Graphical view]
    SUPFAMiSSF81518. SSF81518. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O14957-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTRFLGPRY RELVKNWVPT AYTWGAVGAV GLVWATDWRL ILDWVPYING   50
    KFKKDN 56
    Length:56
    Mass (Da):6,570
    Last modified:January 1, 1998 - v1
    Checksum:i0AE1CB90A205112C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D55636 mRNA. Translation: BAA21748.1.
    AK312053 mRNA. Translation: BAG34989.1.
    AC005321 Genomic DNA. Translation: AAC27374.1.
    AC005943 Genomic DNA. Translation: AAC72105.1.
    CH471139 Genomic DNA. Translation: EAW69474.1.
    CH471139 Genomic DNA. Translation: EAW69475.1.
    CH471139 Genomic DNA. Translation: EAW69476.1.
    BC000462 mRNA. Translation: AAH00462.1.
    BC003594 mRNA. Translation: AAH03594.1.
    CCDSiCCDS12073.1.
    RefSeqiNP_006821.1. NM_006830.3.
    UniGeneiHs.8372.

    Genome annotation databases

    EnsembliENST00000585671; ENSP00000466420; ENSG00000127540.
    ENST00000589880; ENSP00000467555; ENSG00000127540.
    ENST00000591899; ENSP00000467262; ENSG00000127540.
    GeneIDi10975.
    KEGGihsa:10975.
    UCSCiuc002ltm.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D55636 mRNA. Translation: BAA21748.1 .
    AK312053 mRNA. Translation: BAG34989.1 .
    AC005321 Genomic DNA. Translation: AAC27374.1 .
    AC005943 Genomic DNA. Translation: AAC72105.1 .
    CH471139 Genomic DNA. Translation: EAW69474.1 .
    CH471139 Genomic DNA. Translation: EAW69475.1 .
    CH471139 Genomic DNA. Translation: EAW69476.1 .
    BC000462 mRNA. Translation: AAH00462.1 .
    BC003594 mRNA. Translation: AAH03594.1 .
    CCDSi CCDS12073.1.
    RefSeqi NP_006821.1. NM_006830.3.
    UniGenei Hs.8372.

    3D structure databases

    ProteinModelPortali O14957.
    SMRi O14957. Positions 1-53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116172. 6 interactions.
    IntActi O14957. 1 interaction.

    PTM databases

    PhosphoSitei O14957.

    Proteomic databases

    MaxQBi O14957.
    PaxDbi O14957.
    PRIDEi O14957.

    Protocols and materials databases

    DNASUi 10975.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000585671 ; ENSP00000466420 ; ENSG00000127540 .
    ENST00000589880 ; ENSP00000467555 ; ENSG00000127540 .
    ENST00000591899 ; ENSP00000467262 ; ENSG00000127540 .
    GeneIDi 10975.
    KEGGi hsa:10975.
    UCSCi uc002ltm.3. human.

    Organism-specific databases

    CTDi 10975.
    GeneCardsi GC19M001597.
    HGNCi HGNC:30862. UQCR11.
    MIMi 609711. gene.
    neXtProti NX_O14957.
    PharmGKBi PA165394505.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299371.
    HOGENOMi HOG000030914.
    HOVERGENi HBG105467.
    InParanoidi O14957.
    KOi K00420.
    OMAi LAKNWMP.
    PhylomeDBi O14957.
    TreeFami TF105034.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    ChiTaRSi UQCR11. human.
    GenomeRNAii 10975.
    NextBioi 41704.
    PROi O14957.
    SOURCEi Search...

    Gene expression databases

    Bgeei O14957.
    CleanExi HS_UQCR.
    Genevestigatori O14957.

    Family and domain databases

    Gene3Di 1.20.5.220. 1 hit.
    InterProi IPR029027. Single_a-helix.
    IPR015089. UQCR.
    [Graphical view ]
    PANTHERi PTHR15420. PTHR15420. 1 hit.
    Pfami PF08997. UCR_6-4kD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81518. SSF81518. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences."
      Islam M.M., Suzuki H., Yoneda M., Tanaka M.
      Biochem. Mol. Biol. Int. 41:1109-1116(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fibroblast.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiQCR10_HUMAN
    AccessioniPrimary (citable) accession number: O14957
    Secondary accession number(s): B2R542
    , D6W5Z4, Q9UEA3, Q9UPK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3