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Protein

Cytochrome b-c1 complex subunit 10

Gene

UQCR11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.
This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

GO - Molecular functioni

  • electron carrier activity Source: UniProtKB
  • ubiquinol-cytochrome-c reductase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 10
Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
Gene namesi
Name:UQCR11
Synonyms:UQCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30862. UQCR11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394505.

Polymorphism and mutation databases

BioMutaiUQCR11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5656Cytochrome b-c1 complex subunit 10PRO_0000193560Add
BLAST

Proteomic databases

MaxQBiO14957.
PaxDbiO14957.
PRIDEiO14957.

PTM databases

PhosphoSiteiO14957.

Expressioni

Gene expression databases

BgeeiO14957.
CleanExiHS_UQCR.
GenevisibleiO14957. HS.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

BioGridi116172. 4 interactions.
IntActiO14957. 1 interaction.
STRINGi9606.ENSP00000466420.

Structurei

3D structure databases

ProteinModelPortaliO14957.
SMRiO14957. Positions 1-53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR11/QCR10 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299371.
GeneTreeiENSGT00390000018299.
HOGENOMiHOG000030914.
HOVERGENiHBG105467.
InParanoidiO14957.
KOiK00420.
OMAiGMWGAVG.
PhylomeDBiO14957.
TreeFamiTF105034.

Family and domain databases

Gene3Di1.20.5.220. 1 hit.
InterProiIPR029027. Single_a-helix.
IPR015089. UQCR.
[Graphical view]
PANTHERiPTHR15420. PTHR15420. 1 hit.
PfamiPF08997. UCR_6-4kD. 1 hit.
[Graphical view]
SUPFAMiSSF81518. SSF81518. 1 hit.

Sequencei

Sequence statusi: Complete.

O14957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTRFLGPRY RELVKNWVPT AYTWGAVGAV GLVWATDWRL ILDWVPYING

KFKKDN
Length:56
Mass (Da):6,570
Last modified:January 1, 1998 - v1
Checksum:i0AE1CB90A205112C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55636 mRNA. Translation: BAA21748.1.
AK312053 mRNA. Translation: BAG34989.1.
AC005321 Genomic DNA. Translation: AAC27374.1.
AC005943 Genomic DNA. Translation: AAC72105.1.
CH471139 Genomic DNA. Translation: EAW69474.1.
CH471139 Genomic DNA. Translation: EAW69475.1.
CH471139 Genomic DNA. Translation: EAW69476.1.
BC000462 mRNA. Translation: AAH00462.1.
BC003594 mRNA. Translation: AAH03594.1.
CCDSiCCDS12073.1.
RefSeqiNP_006821.1. NM_006830.3.
UniGeneiHs.8372.

Genome annotation databases

EnsembliENST00000585671; ENSP00000466420; ENSG00000127540.
ENST00000589880; ENSP00000467555; ENSG00000127540.
ENST00000591899; ENSP00000467262; ENSG00000127540.
GeneIDi10975.
KEGGihsa:10975.
UCSCiuc002ltm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55636 mRNA. Translation: BAA21748.1.
AK312053 mRNA. Translation: BAG34989.1.
AC005321 Genomic DNA. Translation: AAC27374.1.
AC005943 Genomic DNA. Translation: AAC72105.1.
CH471139 Genomic DNA. Translation: EAW69474.1.
CH471139 Genomic DNA. Translation: EAW69475.1.
CH471139 Genomic DNA. Translation: EAW69476.1.
BC000462 mRNA. Translation: AAH00462.1.
BC003594 mRNA. Translation: AAH03594.1.
CCDSiCCDS12073.1.
RefSeqiNP_006821.1. NM_006830.3.
UniGeneiHs.8372.

3D structure databases

ProteinModelPortaliO14957.
SMRiO14957. Positions 1-53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116172. 4 interactions.
IntActiO14957. 1 interaction.
STRINGi9606.ENSP00000466420.

PTM databases

PhosphoSiteiO14957.

Polymorphism and mutation databases

BioMutaiUQCR11.

Proteomic databases

MaxQBiO14957.
PaxDbiO14957.
PRIDEiO14957.

Protocols and materials databases

DNASUi10975.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585671; ENSP00000466420; ENSG00000127540.
ENST00000589880; ENSP00000467555; ENSG00000127540.
ENST00000591899; ENSP00000467262; ENSG00000127540.
GeneIDi10975.
KEGGihsa:10975.
UCSCiuc002ltm.3. human.

Organism-specific databases

CTDi10975.
GeneCardsiGC19M001597.
HGNCiHGNC:30862. UQCR11.
MIMi609711. gene.
neXtProtiNX_O14957.
PharmGKBiPA165394505.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG299371.
GeneTreeiENSGT00390000018299.
HOGENOMiHOG000030914.
HOVERGENiHBG105467.
InParanoidiO14957.
KOiK00420.
OMAiGMWGAVG.
PhylomeDBiO14957.
TreeFamiTF105034.

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiUQCR11. human.
GenomeRNAii10975.
NextBioi41704.
PROiO14957.
SOURCEiSearch...

Gene expression databases

BgeeiO14957.
CleanExiHS_UQCR.
GenevisibleiO14957. HS.

Family and domain databases

Gene3Di1.20.5.220. 1 hit.
InterProiIPR029027. Single_a-helix.
IPR015089. UQCR.
[Graphical view]
PANTHERiPTHR15420. PTHR15420. 1 hit.
PfamiPF08997. UCR_6-4kD. 1 hit.
[Graphical view]
SUPFAMiSSF81518. SSF81518. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences."
    Islam M.M., Suzuki H., Yoneda M., Tanaka M.
    Biochem. Mol. Biol. Int. 41:1109-1116(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibroblast.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiQCR10_HUMAN
AccessioniPrimary (citable) accession number: O14957
Secondary accession number(s): B2R542
, D6W5Z4, Q9UEA3, Q9UPK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: July 22, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.