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O14931 (NCTR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Natural cytotoxicity triggering receptor 3
Alternative name(s):
Activating natural killer receptor p30
Natural killer cell p30-related protein
Short name=NK-p30
Short name=NKp30
CD_antigen=CD337
Gene names
Name:NCR3
Synonyms:1C7, LY117
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. Ref.1 Ref.10 Ref.13

Subunit structure

Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to B7H6. Interacts with and is activated by binding to BAG6. Ref.1 Ref.2 Ref.11 Ref.13 Ref.14 Ref.15 Ref.16

Subcellular location

Cell membrane; Single-pass type I membrane protein Ref.1.

Tissue specificity

Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. Ref.1 Ref.2

Polymorphism

A genetic variation in NCR3 is associated with mild malaria suceptibility [MIM:609148].

Sequence similarities

Belongs to the natural cytotoxicity receptor (NCR) family.

Contains 1 Ig-like (immunoglobulin-like) domain.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O14931-1)

Also known as: 1C7a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O14931-2)

Also known as: 1C7c;

The sequence of this isoform differs from the canonical sequence as follows:
     167-201: LTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG → HCHMGTHCHSSDGPRGVIPEPRCP
Isoform 3 (identifier: O14931-3)

Also known as: 1C7b;

The sequence of this isoform differs from the canonical sequence as follows:
     166-201: CLTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG → YAKSTLSGFPQL
Isoform 4 (identifier: O14931-4)

Also known as: 1C7e;

The sequence of this isoform differs from the canonical sequence as follows:
     66-90: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: O14931-5)

Also known as: 1C7f;

The sequence of this isoform differs from the canonical sequence as follows:
     66-90: Missing.
     167-201: LTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG → HCHMGTHCHSSDGPRGVIPEPRCP
Note: No experimental confirmation available.
Isoform 6 (identifier: O14931-6)

Also known as: 1C7d;

The sequence of this isoform differs from the canonical sequence as follows:
     66-90: Missing.
     166-201: CLTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG → YAKSTLSGFPQL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 201183Natural cytotoxicity triggering receptor 3
PRO_0000015032

Regions

Topological domain19 – 135117Extracellular Potential
Transmembrane136 – 15621Helical; Potential
Topological domain157 – 20145Cytoplasmic Potential
Domain19 – 126108Ig-like

Amino acid modifications

Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential
Disulfide bond39 ↔ 108 Ref.15 Ref.16

Natural variations

Alternative sequence66 – 9025Missing in isoform 4, isoform 5 and isoform 6.
VSP_010411
Alternative sequence166 – 20136CLTWK…PVPGG → YAKSTLSGFPQL in isoform 3 and isoform 6.
VSP_010412
Alternative sequence167 – 20135LTWKG…PVPGG → HCHMGTHCHSSDGPRGVIPE PRCP in isoform 2 and isoform 5.
VSP_010413
Natural variant1031A → T.
Corresponds to variant rs11575840 [ dbSNP | Ensembl ].
VAR_044114
Natural variant1741R → S.
Corresponds to variant rs3179003 [ dbSNP | Ensembl ].
VAR_044115

Secondary structure

1 ................. 201
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (1C7a) [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 2855AE4D6902D429

FASTA20121,593
        10         20         30         40         50         60 
MAWMLLLILI MVHPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV 

        70         80         90        100        110        120 
VPGKEVRNGT PEFRGRLAPL ASSRFLHDHQ AELHIRDVRG HDASIYVCRV EVLGLGVGTG 

       130        140        150        160        170        180 
NGTRLVVEKE HPQLGAGTVL LLRAGFYAVS FLSVAVGSTV YYQGKCLTWK GPRRQLPAVV 

       190        200 
PAPLPPPCGS SAHLLPPVPG G

« Hide

Isoform 2 (1C7c) [UniParc].

Checksum: 1FAC919E20A6B18A
Show »

FASTA19020,640
Isoform 3 (1C7b) [UniParc].

Checksum: DD5EC96F0AB2DCE6
Show »

FASTA17719,237
Isoform 4 (1C7e) [UniParc].

Checksum: 162BB775DA2BCD35
Show »

FASTA17618,749
Isoform 5 (1C7f) [UniParc].

Checksum: 0A3CA691CA3E1E7E
Show »

FASTA16517,796
Isoform 6 (1C7d) [UniParc].

Checksum: 42718746451F9ADC
Show »

FASTA15216,393

References

« Hide 'large scale' references
[1]"Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells."
Pende D., Parolini S., Pessino A., Sivori S., Augugliaro R., Morelli L., Marcenaro E., Accame L., Malaspina A., Biassoni R., Bottino C., Moretta L., Moretta A.
J. Exp. Med. 190:1505-1516(1999) [PubMed: 10562324] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CD3Z, FUNCTION.
Tissue: Lymphoid tissue.
[2]"Identificastion of two novel single nucleotide polymorphisms in the NKp30 gene in human natural killer cells."
Sato M., Yabe T., Ohashi J., Tsuchiya N., Hanaoka K., Tokunaga K., Juji T.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH CD3Z.
Tissue: Peripheral blood.
[3]"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
Neville M.J., Campbell R.D.
J. Immunol. 162:4745-4754(1999) [PubMed: 10202016] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6).
[4]"Genes in a 220-kb region spanning the TNF cluster in human MHC."
Nalabolu S.R., Shukla H., Nallur G., Parimoo S., Weissman S.M.
Genomics 31:215-222(1996) [PubMed: 8824804] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Spleen.
[5]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed: 14656967] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Blood.
[10]"NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor."
Vitale M., Della Chiesa M., Carlomagno S., Pende D., Arico M., Moretta L., Moretta A.
Blood 106:566-571(2005) [PubMed: 15784725] [Abstract]
Cited for: FUNCTION IN DENDRITIC CELLS MATURATION.
[11]"Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells."
Pogge von Strandmann E., Simhadri V.R., von Tresckow B., Sasse S., Reiners K.S., Hansen H.P., Rothe A., Boll B., Simhadri V.L., Borchmann P., McKinnon P.J., Hallek M., Engert A.
Immunity 27:965-974(2007) [PubMed: 18055229] [Abstract]
Cited for: INTERACTION WITH BAG6.
[12]"Association analyses of NCR3 polymorphisms with P. falciparum mild malaria."
Delahaye N.F., Barbier M., Fumoux F., Rihet P.
Microbes Infect. 9:160-166(2007) [PubMed: 17208487] [Abstract]
Cited for: INVOLVEMENT IN MILD MALARIA SUSCEPTIBILITY.
[13]"Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function."
Simhadri V.R., Reiners K.S., Hansen H.P., Topolar D., Simhadri V.L., Nohroudi K., Kufer T.A., Engert A., Pogge von Strandmann E.
PLoS ONE 3:E3377-E3377(2008) [PubMed: 18852879] [Abstract]
Cited for: FUNCTION IN DENDRITIC CELLS MATURATION, INTERACTION WITH BAG6.
[14]"The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans."
Brandt C.S., Baratin M., Yi E.C., Kennedy J., Gao Z., Fox B., Haldeman B., Ostrander C.D., Kaifu T., Chabannon C., Moretta A., West R., Xu W., Vivier E., Levin S.D.
J. Exp. Med. 206:1495-1503(2009) [PubMed: 19528259] [Abstract]
Cited for: INTERACTION WITH B7H6.
[15]"Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6."
Li Y., Wang Q., Mariuzza R.A.
J. Exp. Med. 208:703-714(2011) [PubMed: 21422170] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 19-135 IN COMPLEX WITH B7H6, SUBUNIT, DISULFIDE BOND.
[16]"Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site."
Joyce M.G., Tran P., Zhuravleva M.A., Jaw J., Colonna M., Sun P.D.
Proc. Natl. Acad. Sci. U.S.A. 108:6223-6228(2011) [PubMed: 21444796] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 18-130, INTERACTION WITH B7H6, SUBUNIT, DISULFIDE BOND.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ223153 mRNA. Translation: CAB54004.1.
AB055881 mRNA. Translation: BAB78472.1.
Y14768 Genomic DNA. Translation: CAA75063.1.
Y14768 Genomic DNA. Translation: CAA75064.1.
Y14768 Genomic DNA. Translation: CAA75065.1.
Y14768 Genomic DNA. Translation: CAA75066.1.
Y14768 Genomic DNA. Translation: CAA75067.1.
Y14768 Genomic DNA. Translation: CAA75068.1.
AF031136 mRNA. Translation: AAB86578.1.
AF031137 mRNA. Translation: AAB86579.1.
AF031138 mRNA. Translation: AAB86580.1.
AF129756 Genomic DNA. Translation: AAD18088.1.
BA000025 Genomic DNA. Translation: BAB63393.1.
AL662847 Genomic DNA. Translation: CAI17688.1.
AL662847 Genomic DNA. Translation: CAI17689.1.
AL662847 Genomic DNA. Translation: CAI17690.1.
AL662847 Genomic DNA. Translation: CAI17691.1.
AL662801 Genomic DNA. Translation: CAI18302.1.
AL662801 Genomic DNA. Translation: CAI18303.1.
AL662801 Genomic DNA. Translation: CAI18304.1.
AL662801 Genomic DNA. Translation: CAI18305.1.
AL929587 Genomic DNA. Translation: CAI18660.1.
AL929587 Genomic DNA. Translation: CAI18661.1.
AL929587 Genomic DNA. Translation: CAI18662.1.
AL929587 Genomic DNA. Translation: CAI18663.1.
BX248519 Genomic DNA. Translation: CAI41953.1.
BX248519 Genomic DNA. Translation: CAI41954.1.
BX248519 Genomic DNA. Translation: CAI41955.1.
BX248519 Genomic DNA. Translation: CAI41956.1.
CR753892 Genomic DNA. Translation: CAQ06951.1.
CR753892 Genomic DNA. Translation: CAQ06953.1.
CR753892 Genomic DNA. Translation: CAQ06954.1.
CR759886, CR759905 Genomic DNA. Translation: CAQ07224.1.
CR759886, CR759905 Genomic DNA. Translation: CAQ07226.1.
CR759886, CR759905 Genomic DNA. Translation: CAQ07227.1.
CR942185 Genomic DNA. Translation: CAQ07727.1.
CR942185 Genomic DNA. Translation: CAQ07729.1.
CR942185 Genomic DNA. Translation: CAQ07730.1.
CR759905, CR759886 Genomic DNA. Translation: CAQ08772.1.
CR759905, CR759886 Genomic DNA. Translation: CAQ08774.1.
CR759905, CR759886 Genomic DNA. Translation: CAQ08775.1.
BX927320 Genomic DNA. Translation: CAQ10009.1.
BX927320 Genomic DNA. Translation: CAQ10011.1.
BX927320 Genomic DNA. Translation: CAQ10012.1.
CH471081 Genomic DNA. Translation: EAX03439.1.
CH471081 Genomic DNA. Translation: EAX03440.1.
BC052582 mRNA. Translation: AAH52582.1.
IPIIPI00011558.
IPI00013125.
IPI00032121.
IPI00383788.
IPI00384964.
IPI00411498.
RefSeqNP_001138938.1. NM_001145466.1.
NP_001138939.1. NM_001145467.1.
NP_667341.1. NM_147130.2.
UniGeneHs.509513.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3NOIX-ray1.84A/B18-130[»]
3PV6X-ray2.30B19-135[»]
ProteinModelPortalO14931.
SMRO14931. Positions 18-166.
ModBaseSearch...

Proteomic databases

PRIDEO14931.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340027; ENSP00000342156; ENSG00000204475.
ENST00000383477; ENSP00000372969; ENSG00000206430.
ENST00000415123; ENSP00000416944; ENSG00000237103.
ENST00000420556; ENSP00000405306; ENSG00000236315.
ENST00000430599; ENSP00000416035; ENSG00000236979.
ENST00000435674; ENSP00000390131; ENSG00000225211.
ENST00000437517; ENSP00000398313; ENSG00000223833.
ENST00000447248; ENSP00000389071; ENSG00000237808.
GeneID259197.
KEGGhsa:259197.
UCSCuc003nuv.1. human.
uc003nux.1. human.

Organism-specific databases

CTD259197.
GeneCardsGC06M031557.
HGNCHGNC:19077. NCR3.
MIM609148. phenotype.
611550. gene.
neXtProtNX_O14931.
PharmGKBPA134883693.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11796.
GeneTreeENSGT00390000006603.
HOVERGENHBG052590.
InParanoidO14931.
OMAIGSVTWY.
OrthoDBEOG4NKBWQ.

Gene expression databases

GenevestigatorO14931.
GermOnlineENSG00000204475. Homo sapiens.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KOK06743.
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio93046.
SOURCESearch...

Entry information

Entry nameNCTR3_HUMAN
AccessionPrimary (citable) accession number: O14931
Secondary accession number(s): B0S8F2 expand/collapse secondary AC list , B0S8F4, B0S8F5, O14930, O14932, O95667, O95668, O95669, Q5ST89, Q5ST90, Q5ST91, Q5ST92, Q5STA3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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