Natural cytotoxicity triggering receptor 3 precursor

Names and origin

Protein names

Recommended name:
Natural cytotoxicity triggering receptor 3

Alternative name(s):
Natural killer cell p30-related protein
Short name=NK-p30
Short name=NKp30
Activating natural killer receptor p30
CD_antigen=CD337

Gene names

Name:	NCR3
Synonyms:	1C7, LY117

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Ref.1
Subunit structure	Interacts with CD3Z. Ref.1 Ref.2
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. Ref.1 Ref.2
Polymorphism	A genetic variation in NCR3 is associated with mild malaria suceptibility [MIM:609148].
Sequence similarities	Belongs to the natural cytotoxicity receptor (NCR) family. Contains 1 Ig-like (immunoglobulin-like) domain.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell recognition Traceable author statement. Source: UniProtKB immune response Non-traceable author statement. Source: UniProtKB inflammatory response Non-traceable author statement. Source: UniProtKB positive regulation of natural killer cell mediated cytotoxicity Inferred from mutant phenotype. Source: UniProtKB
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14931-1) Also known as: 1C7a; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14931-2) Also known as: 1C7c; The sequence of this isoform differs from the canonical sequence as follows: 167-201: LTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG → HCHMGTHCHSSDGPRGVIPEPRCP

Isoform 3 (identifier: O14931-3) Also known as: 1C7b; The sequence of this isoform differs from the canonical sequence as follows: 166-201: CLTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG → YAKSTLSGFPQL

Isoform 4 (identifier: O14931-4) Also known as: 1C7e; The sequence of this isoform differs from the canonical sequence as follows: 66-90: Missing.
Note: No experimental confirmation available.

Isoform 5 (identifier: O14931-5) Also known as: 1C7f; The sequence of this isoform differs from the canonical sequence as follows: 66-90: Missing. 167-201: LTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG → HCHMGTHCHSSDGPRGVIPEPRCP
Note: No experimental confirmation available.

Isoform 6 (identifier: O14931-6) Also known as: 1C7d; The sequence of this isoform differs from the canonical sequence as follows: 66-90: Missing. 166-201: CLTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG → YAKSTLSGFPQL
Note: No experimental confirmation available.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 18

18

Potential

Chain

19 – 201

183

Natural cytotoxicity triggering receptor 3

PRO_0000015032

Regions

Topological domain

19 – 135

117

Extracellular Potential

Transmembrane

136 – 156

21

Potential

Topological domain

157 – 201

45

Cytoplasmic Potential

Domain

19 – 126

108

Ig-like

Amino acid modifications

Glycosylation

42

1

N-linked (GlcNAc...) Potential

Glycosylation

121

1

N-linked (GlcNAc...) Potential

Disulfide bond

39 ↔ 108

By similarity

Natural variations

Alternative sequence

66 – 90

25

Missing in isoform 4, isoform 5 and isoform 6.

VSP_010411

Alternative sequence

166 – 201

36

CLTWK…PVPGG → YAKSTLSGFPQL in isoform 3 and isoform 6.

VSP_010412

Alternative sequence

167 – 201

35

LTWKG…PVPGG → HCHMGTHCHSSDGPRGVIPE PRCP in isoform 2 and isoform 5.

VSP_010413

Natural variant

103

1

A → T: dbSNP rs11575840.

VAR_044114

Natural variant

174

1

R → S: dbSNP rs3179003.

VAR_044115

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 (1C7a) [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 2855AE4D6902D429 Show »	FASTA	201	21,593
10 20 30 40 50 60 MAWMLLLILI MVHPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV 70 80 90 100 110 120 VPGKEVRNGT PEFRGRLAPL ASSRFLHDHQ AELHIRDVRG HDASIYVCRV EVLGLGVGTG 130 140 150 160 170 180 NGTRLVVEKE HPQLGAGTVL LLRAGFYAVS FLSVAVGSTV YYQGKCLTWK GPRRQLPAVV 190 200 PAPLPPPCGS SAHLLPPVPG G « Hide
Isoform 2 (1C7c). Checksum: 1FAC919E20A6B18A Show »	FASTA	190	20,640
10 20 30 40 50 60 MAWMLLLILI MVHPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV 70 80 90 100 110 120 VPGKEVRNGT PEFRGRLAPL ASSRFLHDHQ AELHIRDVRG HDASIYVCRV EVLGLGVGTG 130 140 150 160 170 180 NGTRLVVEKE HPQLGAGTVL LLRAGFYAVS FLSVAVGSTV YYQGKCHCHM GTHCHSSDGP 190 RGVIPEPRCP « Hide
Isoform 3 (1C7b). Checksum: DD5EC96F0AB2DCE6 Show »	FASTA	177	19,237
10 20 30 40 50 60 MAWMLLLILI MVHPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV 70 80 90 100 110 120 VPGKEVRNGT PEFRGRLAPL ASSRFLHDHQ AELHIRDVRG HDASIYVCRV EVLGLGVGTG 130 140 150 160 170 NGTRLVVEKE HPQLGAGTVL LLRAGFYAVS FLSVAVGSTV YYQGKYAKST LSGFPQL « Hide
Isoform 4 (1C7e). Checksum: 162BB775DA2BCD35 Show »	FASTA	176	18,749
10 20 30 40 50 60 MAWMLLLILI MVHPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV 70 80 90 100 110 120 VPGKEAELHI RDVRGHDASI YVCRVEVLGL GVGTGNGTRL VVEKEHPQLG AGTVLLLRAG 130 140 150 160 170 FYAVSFLSVA VGSTVYYQGK CLTWKGPRRQ LPAVVPAPLP PPCGSSAHLL PPVPGG « Hide
Isoform 5 (1C7f). Checksum: 0A3CA691CA3E1E7E Show »	FASTA	165	17,796
10 20 30 40 50 60 MAWMLLLILI MVHPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV 70 80 90 100 110 120 VPGKEAELHI RDVRGHDASI YVCRVEVLGL GVGTGNGTRL VVEKEHPQLG AGTVLLLRAG 130 140 150 160 FYAVSFLSVA VGSTVYYQGK CHCHMGTHCH SSDGPRGVIP EPRCP « Hide
Isoform 6 (1C7d). Checksum: 42718746451F9ADC Show »	FASTA	152	16,393
10 20 30 40 50 60 MAWMLLLILI MVHPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV 70 80 90 100 110 120 VPGKEAELHI RDVRGHDASI YVCRVEVLGL GVGTGNGTRL VVEKEHPQLG AGTVLLLRAG 130 140 150 FYAVSFLSVA VGSTVYYQGK YAKSTLSGFP QL « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells." Pende D., Parolini S., Pessino A., Sivori S., Augugliaro R., Morelli L., Marcenaro E., Accame L., Malaspina A., Biassoni R., Bottino C., Moretta L., Moretta A. J. Exp. Med. 190:1505-1516(1999) [PubMed: 10562324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH CD3Z, FUNCTION. Tissue: Lymphoid tissue.
[2]	"Identificastion of two novel single nucleotide polymorphisms in the NKp30 gene in human natural killer cells." Sato M., Yabe T., Ohashi J., Tsuchiya N., Hanaoka K., Tokunaga K., Juji T. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH CD3Z. Tissue: Peripheral blood.
[3]	"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC." Neville M.J., Campbell R.D. J. Immunol. 162:4745-4754(1999) [PubMed: 10202016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6).
[4]	"Genes in a 220-kb region spanning the TNF cluster in human MHC." Nalabolu S.R., Shukla H., Nallur G., Parimoo S., Weissman S.M. Genomics 31:215-222(1996) [PubMed: 8824804] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Spleen.
[5]	"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse." Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L. Genome Res. 13:2621-2636(2003) [PubMed: 14656967] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Blood.
[10]	"Association analyses of NCR3 polymorphisms with P. falciparum mild malaria." Delahaye N.F., Barbier M., Fumoux F., Rihet P. Microbes Infect. 9:160-166(2007) [PubMed: 17208487] [Abstract] Cited for: INVOLVEMENT IN MILD MALARIA SUSCEPTIBILITY.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ223153 mRNA. Translation: CAB54004.1. AB055881 mRNA. Translation: BAB78472.1. Y14768 Genomic DNA. Translation: CAA75063.1. Y14768 Genomic DNA. Translation: CAA75064.1. Y14768 Genomic DNA. Translation: CAA75065.1. Y14768 Genomic DNA. Translation: CAA75066.1. Y14768 Genomic DNA. Translation: CAA75067.1. Y14768 Genomic DNA. Translation: CAA75068.1. AF031136 mRNA. Translation: AAB86578.1. AF031137 mRNA. Translation: AAB86579.1. AF031138 mRNA. Translation: AAB86580.1. AF129756 Genomic DNA. Translation: AAD18088.1. BA000025 Genomic DNA. Translation: BAB63393.1. AL662847 Genomic DNA. Translation: CAI17688.1. AL662847 Genomic DNA. Translation: CAI17689.1. AL662847 Genomic DNA. Translation: CAI17690.1. AL662847 Genomic DNA. Translation: CAI17691.1. AL662801 Genomic DNA. Translation: CAI18302.1. AL662801 Genomic DNA. Translation: CAI18303.1. AL662801 Genomic DNA. Translation: CAI18304.1. AL662801 Genomic DNA. Translation: CAI18305.1. AL929587 Genomic DNA. Translation: CAI18660.1. AL929587 Genomic DNA. Translation: CAI18661.1. AL929587 Genomic DNA. Translation: CAI18662.1. AL929587 Genomic DNA. Translation: CAI18663.1. BX248519 Genomic DNA. Translation: CAI41953.1. BX248519 Genomic DNA. Translation: CAI41954.1. BX248519 Genomic DNA. Translation: CAI41955.1. BX248519 Genomic DNA. Translation: CAI41956.1. CR753892 Genomic DNA. Translation: CAQ06951.1. CR753892 Genomic DNA. Translation: CAQ06953.1. CR753892 Genomic DNA. Translation: CAQ06954.1. CR759886, CR759905 Genomic DNA. Translation: CAQ07224.1. CR759886, CR759905 Genomic DNA. Translation: CAQ07226.1. CR759886, CR759905 Genomic DNA. Translation: CAQ07227.1. CR942185 Genomic DNA. Translation: CAQ07727.1. CR942185 Genomic DNA. Translation: CAQ07729.1. CR942185 Genomic DNA. Translation: CAQ07730.1. CR759905, CR759886 Genomic DNA. Translation: CAQ08772.1. CR759905, CR759886 Genomic DNA. Translation: CAQ08774.1. CR759905, CR759886 Genomic DNA. Translation: CAQ08775.1. BX927320 Genomic DNA. Translation: CAQ10009.1. BX927320 Genomic DNA. Translation: CAQ10011.1. BX927320 Genomic DNA. Translation: CAQ10012.1. CH471081 Genomic DNA. Translation: EAX03439.1. CH471081 Genomic DNA. Translation: EAX03440.1. BC052582 mRNA. Translation: AAH52582.1.
IPI	IPI00011558. IPI00013125. IPI00032121. IPI00383788. IPI00384964. IPI00411498.
RefSeq	NP_001138938.1. NP_001138939.1. NP_667341.1.
UniGene	Hs.509513
3D structure databases
SMR	O14931. Positions 18-133, 21-166.
ModBase	Search...
Protein-protein interaction databases
STRING	O14931.
Proteomic databases
PRIDE	O14931.
Genome annotation databases
Ensembl	ENST00000340027; ENSP00000342156; ENSG00000204475; Homo sapiens. [Genome view] ENST00000383477; ENSP00000372969; ENSG00000206430; Homo sapiens. [Genome view] ENST00000415123; ENSP00000416944; ENSG00000237103; Homo sapiens. [Genome view] ENST00000420556; ENSP00000405306; ENSG00000236315; Homo sapiens. [Genome view] ENST00000430599; ENSP00000416035; ENSG00000236979; Homo sapiens. [Genome view] ENST00000435674; ENSP00000390131; ENSG00000225211; Homo sapiens. [Genome view] ENST00000437517; ENSP00000398313; ENSG00000223833; Homo sapiens. [Genome view] ENST00000447248; ENSP00000389071; ENSG00000237808; Homo sapiens. [Genome view]
GeneID	259197.
KEGG	hsa:259197.
UCSC	uc003nuv.1. human. uc003nux.1. human.
Organism-specific databases
CTD	259197.
GeneCards	GC06M031664.
HGNC	HGNC:19077. NCR3.
MIM	609148. phenotype. 611550. gene.
PharmGKB	PA134883693.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11796.
HOVERGEN	HBG052590.
InParanoid	O14931.
OMA	GVYVCRV.
Gene expression databases
Genevestigator	O14931.
GermOnline	ENSG00000204475. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	93046.
SOURCE	Search...

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Entry information

Entry name

NCTR3_HUMAN

Accession

Primary (citable) accession number: O14931
Secondary accession number(s): B0S8F2

Q5STA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	January 1, 1998
Last modified:	March 2, 2010
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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