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Protein

Mitochondrial import inner membrane translocase subunit Tim23

Gene

TIMM23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

GO - Biological processi

  • protein import into mitochondrial matrix Source: GO_Central
  • protein targeting to mitochondrion Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138297-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim23
Gene namesi
Name:TIMM23
Synonyms:TIM23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17312. TIMM23.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei181 – 197HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

  • integral component of mitochondrial inner membrane Source: BHF-UCL
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrial inner membrane presequence translocase complex Source: BHF-UCL
  • mitochondrial intermembrane space Source: MGI
  • mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100287932.
OpenTargetsiENSG00000265354.
PharmGKBiPA38227.

Polymorphism and mutation databases

BioMutaiTIMM23.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002103021 – 209Mitochondrial import inner membrane translocase subunit Tim23Add BLAST209

Proteomic databases

EPDiO14925.
MaxQBiO14925.
PaxDbiO14925.
PeptideAtlasiO14925.
PRIDEiO14925.
TopDownProteomicsiO14925.

PTM databases

iPTMnetiO14925.
PhosphoSitePlusiO14925.
SwissPalmiO14925.

Expressioni

Gene expression databases

BgeeiENSG00000138297.
CleanExiHS_TIMM23.
GenevisibleiO14925. HS.

Organism-specific databases

HPAiHPA031408.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TIMM21Q9BVV73EBI-1047996,EBI-6570759

Protein-protein interaction databases

BioGridi939591. 34 interactors.
IntActiO14925. 24 interactors.
MINTiMINT-2998436.
STRINGi9606.ENSP00000260867.

Structurei

3D structure databases

ProteinModelPortaliO14925.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3324. Eukaryota.
COG5596. LUCA.
GeneTreeiENSGT00390000001094.
HOGENOMiHOG000166435.
HOVERGENiHBG057526.
InParanoidiO14925.
KOiK17794.
OMAiMSPISPY.
OrthoDBiEOG091G0NP6.
PhylomeDBiO14925.
TreeFamiTF106196.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

Sequencei

Sequence statusi: Complete.

O14925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP
60 70 80 90 100
RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL
110 120 130 140 150
KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG
160 170 180 190 200
AEDDLNTVAA GTMTGMLYKC TGGLRGIARG GLTGLTLTSL YALYNNWEHM

KGSLLQQSL
Length:209
Mass (Da):21,943
Last modified:January 1, 1998 - v1
Checksum:iC9A1BBEC703B6838
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27S → P in BAD97051 (Ref. 3) Curated1
Sequence conflicti62Missing in AAH62707 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030162 mRNA. Translation: AAB84060.1.
AY442341 mRNA. Translation: AAR14723.1.
AK223331 mRNA. Translation: BAD97051.1.
AL450342 Genomic DNA. Translation: CAI14480.1.
BC062707 mRNA. Translation: AAH62707.1.
BC066951 mRNA. Translation: AAH66951.1.
CCDSiCCDS73091.1.
RefSeqiNP_006318.1. NM_006327.3.
UniGeneiHs.524308.
Hs.661964.

Genome annotation databases

EnsembliENST00000580018; ENSP00000464522; ENSG00000265354.
GeneIDi100287932.
KEGGihsa:100287932.
UCSCiuc001jiu.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030162 mRNA. Translation: AAB84060.1.
AY442341 mRNA. Translation: AAR14723.1.
AK223331 mRNA. Translation: BAD97051.1.
AL450342 Genomic DNA. Translation: CAI14480.1.
BC062707 mRNA. Translation: AAH62707.1.
BC066951 mRNA. Translation: AAH66951.1.
CCDSiCCDS73091.1.
RefSeqiNP_006318.1. NM_006327.3.
UniGeneiHs.524308.
Hs.661964.

3D structure databases

ProteinModelPortaliO14925.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi939591. 34 interactors.
IntActiO14925. 24 interactors.
MINTiMINT-2998436.
STRINGi9606.ENSP00000260867.

PTM databases

iPTMnetiO14925.
PhosphoSitePlusiO14925.
SwissPalmiO14925.

Polymorphism and mutation databases

BioMutaiTIMM23.

Proteomic databases

EPDiO14925.
MaxQBiO14925.
PaxDbiO14925.
PeptideAtlasiO14925.
PRIDEiO14925.
TopDownProteomicsiO14925.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000580018; ENSP00000464522; ENSG00000265354.
GeneIDi100287932.
KEGGihsa:100287932.
UCSCiuc001jiu.5. human.

Organism-specific databases

CTDi100287932.
DisGeNETi100287932.
GeneCardsiTIMM23.
HGNCiHGNC:17312. TIMM23.
HPAiHPA031408.
MIMi605034. gene.
neXtProtiNX_O14925.
OpenTargetsiENSG00000265354.
PharmGKBiPA38227.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3324. Eukaryota.
COG5596. LUCA.
GeneTreeiENSGT00390000001094.
HOGENOMiHOG000166435.
HOVERGENiHBG057526.
InParanoidiO14925.
KOiK17794.
OMAiMSPISPY.
OrthoDBiEOG091G0NP6.
PhylomeDBiO14925.
TreeFamiTF106196.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138297-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Miscellaneous databases

GenomeRNAii100287932.
PROiO14925.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138297.
CleanExiHS_TIMM23.
GenevisibleiO14925. HS.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTIM23_HUMAN
AccessioniPrimary (citable) accession number: O14925
Secondary accession number(s): Q53FF8, Q5T1E6, Q6P5S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.