Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O14925

- TIM23_HUMAN

UniProt

O14925 - TIM23_HUMAN

Protein

Mitochondrial import inner membrane translocase subunit Tim23

Gene

TIMM23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

    GO - Molecular functioni

    1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. protein targeting to mitochondrion Source: Reactome

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_118595. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim23
    Gene namesi
    Name:TIMM23
    Synonyms:TIM23
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:17312. TIMM23.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of mitochondrial inner membrane Source: BHF-UCL
    2. mitochondrial inner membrane Source: BHF-UCL
    3. mitochondrial inner membrane presequence translocase complex Source: BHF-UCL
    4. mitochondrial intermembrane space Source: MGI
    5. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38227.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Mitochondrial import inner membrane translocase subunit Tim23PRO_0000210302Add
    BLAST

    Proteomic databases

    MaxQBiO14925.
    PaxDbiO14925.
    PRIDEiO14925.

    PTM databases

    PhosphoSiteiO14925.

    Expressioni

    Gene expression databases

    ArrayExpressiO14925.
    BgeeiO14925.
    CleanExiHS_TIMM23.
    GenevestigatoriO14925.

    Organism-specific databases

    HPAiHPA031408.
    HPA047180.

    Interactioni

    Subunit structurei

    Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TIMM21Q9BVV73EBI-1047996,EBI-6570759

    Protein-protein interaction databases

    BioGridi939591. 3 interactions.
    IntActiO14925. 6 interactions.
    MINTiMINT-2998436.
    STRINGi9606.ENSP00000260867.

    Structurei

    3D structure databases

    ProteinModelPortaliO14925.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 19717HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tim17/Tim22/Tim23 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5596.
    HOGENOMiHOG000166435.
    HOVERGENiHBG057526.
    InParanoidiO14925.
    KOiK17794.
    OMAiLKETRDM.
    PhylomeDBiO14925.
    TreeFamiTF106196.

    Family and domain databases

    InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
    IPR005681. Tim23.
    [Graphical view]
    PfamiPF02466. Tim17. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O14925-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP    50
    RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL 100
    KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG 150
    AEDDLNTVAA GTMTGMLYKC TGGLRGIARG GLTGLTLTSL YALYNNWEHM 200
    KGSLLQQSL 209
    Length:209
    Mass (Da):21,943
    Last modified:January 1, 1998 - v1
    Checksum:iC9A1BBEC703B6838
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271S → P in BAD97051. 1 PublicationCurated
    Sequence conflicti62 – 621Missing in AAH62707. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030162 mRNA. Translation: AAB84060.1.
    AY442341 mRNA. Translation: AAR14723.1.
    AK223331 mRNA. Translation: BAD97051.1.
    AL450342 Genomic DNA. Translation: CAI14480.1.
    BC062707 mRNA. Translation: AAH62707.1.
    BC066951 mRNA. Translation: AAH66951.1.
    CCDSiCCDS7238.1.
    RefSeqiNP_006318.1. NM_006327.3.
    UniGeneiHs.524308.
    Hs.661964.

    Genome annotation databases

    GeneIDi100287932.
    KEGGihsa:100287932.
    UCSCiuc001jin.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030162 mRNA. Translation: AAB84060.1 .
    AY442341 mRNA. Translation: AAR14723.1 .
    AK223331 mRNA. Translation: BAD97051.1 .
    AL450342 Genomic DNA. Translation: CAI14480.1 .
    BC062707 mRNA. Translation: AAH62707.1 .
    BC066951 mRNA. Translation: AAH66951.1 .
    CCDSi CCDS7238.1.
    RefSeqi NP_006318.1. NM_006327.3.
    UniGenei Hs.524308.
    Hs.661964.

    3D structure databases

    ProteinModelPortali O14925.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 939591. 3 interactions.
    IntActi O14925. 6 interactions.
    MINTi MINT-2998436.
    STRINGi 9606.ENSP00000260867.

    PTM databases

    PhosphoSitei O14925.

    Proteomic databases

    MaxQBi O14925.
    PaxDbi O14925.
    PRIDEi O14925.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100287932.
    KEGGi hsa:100287932.
    UCSCi uc001jin.3. human.

    Organism-specific databases

    CTDi 100287932.
    GeneCardsi GC10M051591.
    HGNCi HGNC:17312. TIMM23.
    HPAi HPA031408.
    HPA047180.
    MIMi 605034. gene.
    neXtProti NX_O14925.
    PharmGKBi PA38227.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5596.
    HOGENOMi HOG000166435.
    HOVERGENi HBG057526.
    InParanoidi O14925.
    KOi K17794.
    OMAi LKETRDM.
    PhylomeDBi O14925.
    TreeFami TF106196.

    Enzyme and pathway databases

    Reactomei REACT_118595. Mitochondrial protein import.

    Miscellaneous databases

    GenomeRNAii 100287932.
    NextBioi 20777681.
    PROi O14925.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14925.
    Bgeei O14925.
    CleanExi HS_TIMM23.
    Genevestigatori O14925.

    Family and domain databases

    InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
    IPR005681. Tim23.
    [Graphical view ]
    Pfami PF02466. Tim17. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00983. 3a0801s02tim23. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genetic and structural characterization of the human mitochondrial inner membrane translocase."
      Bauer M.F., Gempel K., Reichert A.S., Rappold G.A., Lichtner P., Gerbitz K.-D., Neupert W., Brunner M., Hofmann S.
      J. Mol. Biol. 289:69-82(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of Homo sapiens translocase of inner mitochondrial membrane 23 (Tim23) mRNA."
      Cao X., Li Q., Jin K., Liu L., Dai S., Wu G., Dong C.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Testis.
    6. "Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death."
      Guo Y., Cheong N., Zhang Z., De Rose R., Deng Y., Farber S.A., Fernandes-Alnemri T., Alnemri E.S.
      J. Biol. Chem. 279:24813-24825(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TIMM50.
    7. "Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria."
      Schusdziarra C., Blamowska M., Azem A., Hell K.
      Hum. Mol. Genet. 22:1348-1357(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DNAJC15.

    Entry informationi

    Entry nameiTIM23_HUMAN
    AccessioniPrimary (citable) accession number: O14925
    Secondary accession number(s): Q53FF8, Q5T1E6, Q6P5S5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3