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O14925

- TIM23_HUMAN

UniProt

O14925 - TIM23_HUMAN

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Protein

Mitochondrial import inner membrane translocase subunit Tim23

Gene

TIMM23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_118595. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim23
Gene namesi
Name:TIMM23
Synonyms:TIM23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:17312. TIMM23.

Subcellular locationi

GO - Cellular componenti

  1. integral component of mitochondrial inner membrane Source: BHF-UCL
  2. mitochondrial inner membrane Source: BHF-UCL
  3. mitochondrial inner membrane presequence translocase complex Source: BHF-UCL
  4. mitochondrial intermembrane space Source: MGI
  5. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38227.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Mitochondrial import inner membrane translocase subunit Tim23PRO_0000210302Add
BLAST

Proteomic databases

MaxQBiO14925.
PaxDbiO14925.
PRIDEiO14925.

PTM databases

PhosphoSiteiO14925.

Expressioni

Gene expression databases

BgeeiO14925.
CleanExiHS_TIMM23.
GenevestigatoriO14925.

Organism-specific databases

HPAiHPA031408.
HPA047180.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TIMM21Q9BVV73EBI-1047996,EBI-6570759

Protein-protein interaction databases

BioGridi939591. 3 interactions.
IntActiO14925. 6 interactions.
MINTiMINT-2998436.
STRINGi9606.ENSP00000260867.

Structurei

3D structure databases

ProteinModelPortaliO14925.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 19717HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
GeneTreeiENSGT00390000001094.
HOGENOMiHOG000166435.
HOVERGENiHBG057526.
InParanoidiO14925.
KOiK17794.
OMAiLKETRDM.
PhylomeDBiO14925.
TreeFamiTF106196.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

Sequencei

Sequence statusi: Complete.

O14925-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP
60 70 80 90 100
RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL
110 120 130 140 150
KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG
160 170 180 190 200
AEDDLNTVAA GTMTGMLYKC TGGLRGIARG GLTGLTLTSL YALYNNWEHM

KGSLLQQSL
Length:209
Mass (Da):21,943
Last modified:January 1, 1998 - v1
Checksum:iC9A1BBEC703B6838
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271S → P in BAD97051. 1 PublicationCurated
Sequence conflicti62 – 621Missing in AAH62707. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030162 mRNA. Translation: AAB84060.1.
AY442341 mRNA. Translation: AAR14723.1.
AK223331 mRNA. Translation: BAD97051.1.
AL450342 Genomic DNA. Translation: CAI14480.1.
BC062707 mRNA. Translation: AAH62707.1.
BC066951 mRNA. Translation: AAH66951.1.
CCDSiCCDS73091.1.
RefSeqiNP_006318.1. NM_006327.3.
UniGeneiHs.524308.
Hs.661964.

Genome annotation databases

GeneIDi100287932.
KEGGihsa:100287932.
UCSCiuc001jin.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030162 mRNA. Translation: AAB84060.1 .
AY442341 mRNA. Translation: AAR14723.1 .
AK223331 mRNA. Translation: BAD97051.1 .
AL450342 Genomic DNA. Translation: CAI14480.1 .
BC062707 mRNA. Translation: AAH62707.1 .
BC066951 mRNA. Translation: AAH66951.1 .
CCDSi CCDS73091.1.
RefSeqi NP_006318.1. NM_006327.3.
UniGenei Hs.524308.
Hs.661964.

3D structure databases

ProteinModelPortali O14925.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 939591. 3 interactions.
IntActi O14925. 6 interactions.
MINTi MINT-2998436.
STRINGi 9606.ENSP00000260867.

PTM databases

PhosphoSitei O14925.

Proteomic databases

MaxQBi O14925.
PaxDbi O14925.
PRIDEi O14925.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100287932.
KEGGi hsa:100287932.
UCSCi uc001jin.3. human.

Organism-specific databases

CTDi 100287932.
GeneCardsi GC10M051591.
HGNCi HGNC:17312. TIMM23.
HPAi HPA031408.
HPA047180.
MIMi 605034. gene.
neXtProti NX_O14925.
PharmGKBi PA38227.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5596.
GeneTreei ENSGT00390000001094.
HOGENOMi HOG000166435.
HOVERGENi HBG057526.
InParanoidi O14925.
KOi K17794.
OMAi LKETRDM.
PhylomeDBi O14925.
TreeFami TF106196.

Enzyme and pathway databases

Reactomei REACT_118595. Mitochondrial protein import.

Miscellaneous databases

GenomeRNAii 100287932.
NextBioi 20777681.
PROi O14925.
SOURCEi Search...

Gene expression databases

Bgeei O14925.
CleanExi HS_TIMM23.
Genevestigatori O14925.

Family and domain databases

InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view ]
Pfami PF02466. Tim17. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00983. 3a0801s02tim23. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic and structural characterization of the human mitochondrial inner membrane translocase."
    Bauer M.F., Gempel K., Reichert A.S., Rappold G.A., Lichtner P., Gerbitz K.-D., Neupert W., Brunner M., Hofmann S.
    J. Mol. Biol. 289:69-82(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of Homo sapiens translocase of inner mitochondrial membrane 23 (Tim23) mRNA."
    Cao X., Li Q., Jin K., Liu L., Dai S., Wu G., Dong C.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  6. "Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death."
    Guo Y., Cheong N., Zhang Z., De Rose R., Deng Y., Farber S.A., Fernandes-Alnemri T., Alnemri E.S.
    J. Biol. Chem. 279:24813-24825(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TIMM50.
  7. "Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria."
    Schusdziarra C., Blamowska M., Azem A., Hell K.
    Hum. Mol. Genet. 22:1348-1357(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DNAJC15.

Entry informationi

Entry nameiTIM23_HUMAN
AccessioniPrimary (citable) accession number: O14925
Secondary accession number(s): Q53FF8, Q5T1E6, Q6P5S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3