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O14924

- RGS12_HUMAN

UniProt

O14924 - RGS12_HUMAN

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Protein
Regulator of G-protein signaling 12
Gene
RGS12
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.1 Publication
Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome
  2. GTPase regulator activity Source: UniProtKB
  3. receptor signaling protein activity Source: InterPro

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
  3. regulation of catalytic activity Source: GOC
  4. termination of G-protein coupled receptor signaling pathway Source: InterPro
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor, Signal transduction inhibitor

Keywords - Biological processi

Transcription

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 12
Short name:
RGS12
Gene namesi
Name:RGS12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:9994. RGS12.

Subcellular locationi

Nucleus 2 Publications
Isoform 5 : Nucleus matrix
Note: Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains.2 Publications

GO - Cellular componenti

  1. condensed nuclear chromosome Source: ProtInc
  2. cytoplasm Source: HPA
  3. nuclear matrix Source: UniProtKB-SubCell
  4. nucleolus Source: HPA
  5. nucleus Source: HPA
  6. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34364.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14471447Regulator of G-protein signaling 12
PRO_0000204213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki1115 – 1115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiO14924.
PaxDbiO14924.
PRIDEiO14924.

PTM databases

PhosphoSiteiO14924.

Expressioni

Tissue specificityi

Isoform 3 is brain specific.

Gene expression databases

ArrayExpressiO14924.
BgeeiO14924.
CleanExiHS_RGS12.
GenevestigatoriO14924.

Organism-specific databases

HPAiHPA054646.

Interactioni

Subunit structurei

Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent By similarity.

Protein-protein interaction databases

BioGridi111934. 7 interactions.
MINTiMINT-154790.
STRINGi9606.ENSP00000339381.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi20 – 256
Beta strandi39 – 413
Turni52 – 565
Beta strandi63 – 675
Helixi77 – 848
Beta strandi91 – 966
Helixi711 – 7144
Helixi716 – 7216
Helixi723 – 73513
Helixi739 – 75315
Helixi759 – 77315
Beta strandi774 – 7774
Helixi786 – 7883
Helixi790 – 7967
Helixi802 – 81615
Helixi818 – 8247
Helixi826 – 83712
Turni844 – 8463

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EBZNMR-A705-852[»]
2KV8NMR-A18-100[»]
ProteinModelPortaliO14924.
SMRiO14924. Positions 18-100, 705-852, 1025-1118, 1186-1221.

Miscellaneous databases

EvolutionaryTraceiO14924.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 9877PDZ
Add
BLAST
Domaini228 – 340113PID
Add
BLAST
Domaini715 – 832118RGS
Add
BLAST
Domaini962 – 103271RBD 1
Add
BLAST
Domaini1034 – 110471RBD 2
Add
BLAST
Domaini1187 – 120923GoLoco
Add
BLAST

Domaini

The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3 By similarity.

Sequence similaritiesi

Contains 1 GoLoco domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PID domain.
Contains 1 RGS domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG282424.
HOVERGENiHBG063299.
InParanoidiO14924.
KOiK16449.
OMAiLFHHKIH.
OrthoDBiEOG7XDBF0.
PhylomeDBiO14924.
TreeFamiTF328814.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR003109. GoLoco_motif.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR003116. Raf-like_ras-bd.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF02188. GoLoco. 1 hit.
PF00595. PDZ. 1 hit.
PF02196. RBD. 2 hits.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00390. GoLoco. 1 hit.
SM00228. PDZ. 1 hit.
SM00462. PTB. 1 hit.
SM00455. RBD. 2 hits.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50877. GOLOCO. 1 hit.
PS50106. PDZ. 1 hit.
PS01179. PID. 1 hit.
PS50898. RBD. 2 hits.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14924-1) [UniParc]FASTAAdd to Basket

Also known as: RGS12TS-L, TS, trans-spliced

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFRAGEASKR PLPGPSPPRV RSVEVARGRA GYGFTLSGQA PCVLSCVMRG     50
SPADFVGLRA GDQILAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGVG 100
RFESCSSDEE GGLYEGKGWL KPKLDSKALG INRAERVVEE MQSGGIFNMI 150
FENPSLCASN SEPLKLKQRS LSESAATRFD VGHESINNPN PNMLSKEEIS 200
KVIHDDSVFS IGLESHDDFA LDASILNVAM IVGYLGSIEL PSTSSNLESD 250
SLQAIRGCMR RLRAEQKIHS LVTMKIMHDC VQLSTDKAGV VAEYPAEKLA 300
FSAVCPDDRR FFGLVTMQTN DDGSLAQEEE GALRTSCHVF MVDPDLFNHK 350
IHQGIARRFG FECTADPDTN GCLEFPASSL PVLQFISVLY RDMGELIEGM 400
RARAFLDGDA DAHQNNSTSS NSDSGIGNFH QEEKSNRVLV VDLGGSSSRH 450
GPGGSAWDGV GGRGAQPWGA PWTGPFCPDP EGSPPFEAAH QTDRFWDLNK 500
HLGPASPVEV PPASLRSSVP PSKRGTVGAG CGFNQRWLPV HVLREWQCGH 550
TSDQDSYTDS TDGWSSINCG TLPPPMSKIP ADRYRVEGSF AQPPLNAPKR 600
EWSRKAFGMQ SIFGPHRNVR KTKEDKKGSK FGRGTGLTQP SQRTSARRSF 650
GRSKRFSITR SLDDLESATV SDGELTGADL KDCVSNNSLS SNASLPSVQS 700
CRRLRERRVA SWAVSFERLL QDPVGVRYFS DFLRKEFSEE NILFWQACEY 750
FNHVPAHDKK ELSYRAREIF SKFLCSKATT PVNIDSQAQL ADDVLRAPHP 800
DMFKEQQLQI FNLMKFDSYT RFLKSPLYQE CILAEVEGRA LPDSQQVPSS 850
PASKHSLGSD HSSVSTPKKL SGKSKSGRSL NEELGDEDSE KKRKGAFFSW 900
SRTRSTGRSQ KKREHGDHAD DALHANGGLC RRESQGSVSS AGSLDLSEAC 950
RTLAPEKDKA TKHCCIHLPD GTSCVVAVKA GFSIKDILSG LCERHGINGA 1000
AADLFLVGGD KPLVLHQDSS ILESRDLRLE KRTLFRLDLV PINRSVGLKA 1050
KPTKPVTEVL RPVVARYGLD LSGLLVRLSG EKEPLDLGAP ISSLDGQRVV 1100
LEEKDPSRGK ASADKQKGVP VKQNTAVNSS SRNHSATGEE RTLGKSNSIK 1150
IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN 1200
RADDQRGLLR KEDLVLPEFL RLPPGSTELT LPTPAAVAKG FSKRSATGNG 1250
RESASQPGEQ WEPVQESSDS PSTSPGSASS PPGPPGTTPP GQKSPSGPFC 1300
TPQSPVSLAQ EGTAQIWKRQ SQEVEAGGIQ TVEDEHVAEL TLMGEGDISS 1350
PNSTLLPPPS TPQEVPGPSR PGSGTHGSRD LPVNRIIDVD LVTGSAPGRD 1400
GGIAGAQAGP GRSQASGGPP TSDLPGLGPV PGEPAKPKTS AHHATFV 1447
Length:1,447
Mass (Da):156,357
Last modified:January 1, 1998 - v1
Checksum:i033CD7403DAD2725
GO
Isoform 2 (identifier: O14924-2) [UniParc]FASTAAdd to Basket

Also known as: P, peripheral

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ

Show »
Length:789
Mass (Da):84,894
Checksum:iEBFFA3BA3A575003
GO
Isoform 3 (identifier: O14924-3) [UniParc]FASTAAdd to Basket

Also known as: B, brain

The sequence of this isoform differs from the canonical sequence as follows:
     1-647: Missing.
     648-666: RSFGRSKRFSITRSLDDLE → MNLGKELSNETHVSNDQQ

Show »
Length:799
Mass (Da):85,966
Checksum:i2B3DE78DBC475BE6
GO
Isoform 4 (identifier: O14924-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1376: SGTH → TSRF
     1377-1447: Missing.

Show »
Length:1,376
Mass (Da):149,593
Checksum:iB16232931A795162
GO
Isoform 5 (identifier: O14924-5) [UniParc]FASTAAdd to Basket

Also known as: RGS12TS-S

The sequence of this isoform differs from the canonical sequence as follows:
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Show »
Length:1,157
Mass (Da):126,372
Checksum:i008E7B25C0DF3E69
GO
Isoform 6 (identifier: O14924-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MFRAGEASKRPLPGPSPPRVRSVEV → MKKHDFAENLPSSLLIIILVIFTLS
     26-627: Missing.
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Show »
Length:555
Mass (Da):61,107
Checksum:iBBCE94518BABF917
GO
Isoform 7 (identifier: O14924-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Note: No experimental confirmation available.

Show »
Length:499
Mass (Da):54,909
Checksum:i19D4E54B5D47C387
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti225 – 2251I → V.
Corresponds to variant rs7679941 [ dbSNP | Ensembl ].
VAR_034451
Natural varianti277 – 2771M → L.
Corresponds to variant rs16844152 [ dbSNP | Ensembl ].
VAR_034452
Natural varianti1124 – 11241N → S.
Corresponds to variant rs2269497 [ dbSNP | Ensembl ].
VAR_020208

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 658658Missing in isoform 2 and isoform 7.
VSP_005682Add
BLAST
Alternative sequencei1 – 647647Missing in isoform 3.
VSP_005684Add
BLAST
Alternative sequencei1 – 2525MFRAG…RSVEV → MKKHDFAENLPSSLLIIILV IFTLS in isoform 6.
VSP_047741Add
BLAST
Alternative sequencei26 – 627602Missing in isoform 6.
VSP_047742Add
BLAST
Alternative sequencei648 – 66619RSFGR…LDDLE → MNLGKELSNETHVSNDQQ in isoform 3.
VSP_005685Add
BLAST
Alternative sequencei659 – 6668TRSLDDLE → MSLSLFFQ in isoform 2 and isoform 7.
VSP_005683
Alternative sequencei1138 – 115720GEERT…GENGK → SFLSLFPKLRATEQMTNVGC in isoform 5, isoform 6 and isoform 7.
VSP_047743Add
BLAST
Alternative sequencei1158 – 1447290Missing in isoform 5, isoform 6 and isoform 7.
VSP_047744Add
BLAST
Alternative sequencei1373 – 13764SGTH → TSRF in isoform 4.
VSP_005686
Alternative sequencei1377 – 144771Missing in isoform 4.
VSP_005687Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti941 – 9411A → V in AAI18595. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030112 mRNA. Translation: AAB84187.1.
AF030111 mRNA. Translation: AAB84114.1.
AF030110 mRNA. Translation: AAB84007.1.
AF030109 mRNA. Translation: AAB84186.1.
AF030149
, AF030151, AF030152, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96645.1.
AF030149
, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96646.1. Sequence problems.
AF030149
, AF030134, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96644.1.
AF035152 mRNA. Translation: AAC39835.1.
AF464737 mRNA. Translation: AAL69961.1.
AK301510 mRNA. Translation: BAH13500.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17750.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17751.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17752.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21452.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21453.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21454.1.
CH471131 Genomic DNA. Translation: EAW82465.1.
CH471131 Genomic DNA. Translation: EAW82468.1.
BC118594 mRNA. Translation: AAI18595.1.
CH471131 Genomic DNA. Translation: EAW82469.1.
CH471131 Genomic DNA. Translation: EAW82470.1.
CCDSiCCDS3366.1. [O14924-1]
CCDS3367.1. [O14924-4]
CCDS3368.1. [O14924-3]
RefSeqiNP_002917.1. NM_002926.3. [O14924-4]
NP_937870.1. NM_198227.1. [O14924-3]
NP_937872.1. NM_198229.2. [O14924-1]
XP_006713968.1. XM_006713905.1. [O14924-1]
XP_006713969.1. XM_006713906.1. [O14924-5]
XP_006713970.1. XM_006713907.1.
UniGeneiHs.527061.

Genome annotation databases

EnsembliENST00000306648; ENSP00000304459; ENSG00000159788. [O14924-6]
ENST00000336727; ENSP00000338509; ENSG00000159788. [O14924-4]
ENST00000338806; ENSP00000342133; ENSG00000159788. [O14924-3]
ENST00000344733; ENSP00000339381; ENSG00000159788. [O14924-1]
ENST00000382788; ENSP00000372238; ENSG00000159788. [O14924-4]
ENST00000538395; ENSP00000438888; ENSG00000159788.
GeneIDi6002.
KEGGihsa:6002.
UCSCiuc003ggu.2. human. [O14924-1]
uc003ggv.3. human. [O14924-4]
uc003ggy.1. human.
uc003ggz.3. human. [O14924-3]
uc003gha.3. human. [O14924-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030112 mRNA. Translation: AAB84187.1 .
AF030111 mRNA. Translation: AAB84114.1 .
AF030110 mRNA. Translation: AAB84007.1 .
AF030109 mRNA. Translation: AAB84186.1 .
AF030149
, AF030151 , AF030152 , AF030135 , AF030136 , AF030137 , AF030138 , AF030139 , AF030140 , AF030141 , AF030142 , AF030143 , AF030144 , AF030145 , AF030146 , AF030147 , AF030148 Genomic DNA. Translation: AAB96645.1 .
AF030149
, AF030135 , AF030136 , AF030137 , AF030138 , AF030139 , AF030140 , AF030141 , AF030142 , AF030143 , AF030144 , AF030145 , AF030146 , AF030147 , AF030148 Genomic DNA. Translation: AAB96646.1 . Sequence problems.
AF030149
, AF030134 , AF030135 , AF030136 , AF030137 , AF030138 , AF030139 , AF030140 , AF030141 , AF030142 , AF030143 , AF030144 , AF030145 , AF030146 , AF030147 , AF030148 Genomic DNA. Translation: AAB96644.1 .
AF035152 mRNA. Translation: AAC39835.1 .
AF464737 mRNA. Translation: AAL69961.1 .
AK301510 mRNA. Translation: BAH13500.1 .
AL645949 , AL590235 Genomic DNA. Translation: CAM17750.1 .
AL645949 , AL590235 Genomic DNA. Translation: CAM17751.1 .
AL645949 , AL590235 Genomic DNA. Translation: CAM17752.1 .
AL590235 , AL645949 Genomic DNA. Translation: CAM21452.1 .
AL590235 , AL645949 Genomic DNA. Translation: CAM21453.1 .
AL590235 , AL645949 Genomic DNA. Translation: CAM21454.1 .
CH471131 Genomic DNA. Translation: EAW82465.1 .
CH471131 Genomic DNA. Translation: EAW82468.1 .
BC118594 mRNA. Translation: AAI18595.1 .
CH471131 Genomic DNA. Translation: EAW82469.1 .
CH471131 Genomic DNA. Translation: EAW82470.1 .
CCDSi CCDS3366.1. [O14924-1 ]
CCDS3367.1. [O14924-4 ]
CCDS3368.1. [O14924-3 ]
RefSeqi NP_002917.1. NM_002926.3. [O14924-4 ]
NP_937870.1. NM_198227.1. [O14924-3 ]
NP_937872.1. NM_198229.2. [O14924-1 ]
XP_006713968.1. XM_006713905.1. [O14924-1 ]
XP_006713969.1. XM_006713906.1. [O14924-5 ]
XP_006713970.1. XM_006713907.1.
UniGenei Hs.527061.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EBZ NMR - A 705-852 [» ]
2KV8 NMR - A 18-100 [» ]
ProteinModelPortali O14924.
SMRi O14924. Positions 18-100, 705-852, 1025-1118, 1186-1221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111934. 7 interactions.
MINTi MINT-154790.
STRINGi 9606.ENSP00000339381.

Chemistry

ChEMBLi CHEMBL1293276.

PTM databases

PhosphoSitei O14924.

Proteomic databases

MaxQBi O14924.
PaxDbi O14924.
PRIDEi O14924.

Protocols and materials databases

DNASUi 6002.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306648 ; ENSP00000304459 ; ENSG00000159788 . [O14924-6 ]
ENST00000336727 ; ENSP00000338509 ; ENSG00000159788 . [O14924-4 ]
ENST00000338806 ; ENSP00000342133 ; ENSG00000159788 . [O14924-3 ]
ENST00000344733 ; ENSP00000339381 ; ENSG00000159788 . [O14924-1 ]
ENST00000382788 ; ENSP00000372238 ; ENSG00000159788 . [O14924-4 ]
ENST00000538395 ; ENSP00000438888 ; ENSG00000159788 .
GeneIDi 6002.
KEGGi hsa:6002.
UCSCi uc003ggu.2. human. [O14924-1 ]
uc003ggv.3. human. [O14924-4 ]
uc003ggy.1. human.
uc003ggz.3. human. [O14924-3 ]
uc003gha.3. human. [O14924-2 ]

Organism-specific databases

CTDi 6002.
GeneCardsi GC04P003294.
H-InvDB HIX0164019.
HGNCi HGNC:9994. RGS12.
HPAi HPA054646.
MIMi 602512. gene.
neXtProti NX_O14924.
PharmGKBi PA34364.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282424.
HOVERGENi HBG063299.
InParanoidi O14924.
KOi K16449.
OMAi LFHHKIH.
OrthoDBi EOG7XDBF0.
PhylomeDBi O14924.
TreeFami TF328814.

Enzyme and pathway databases

Reactomei REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei O14924.
GeneWikii RGS12.
GenomeRNAii 6002.
NextBioi 23405.
PROi O14924.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14924.
Bgeei O14924.
CleanExi HS_RGS12.
Genevestigatori O14924.

Family and domain databases

Gene3Di 1.10.196.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR003109. GoLoco_motif.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR003116. Raf-like_ras-bd.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF02188. GoLoco. 1 hit.
PF00595. PDZ. 1 hit.
PF02196. RBD. 2 hits.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00390. GoLoco. 1 hit.
SM00228. PDZ. 1 hit.
SM00462. PTB. 1 hit.
SM00455. RBD. 2 hits.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEi PS50877. GOLOCO. 1 hit.
PS50106. PDZ. 1 hit.
PS01179. PID. 1 hit.
PS50898. RBD. 2 hits.
PS50132. RGS. 1 hit.
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Publicationsi

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  1. "Novel alternative splicing and nuclear localization of human RGS12 gene products."
    Chatterjee T.K., Fisher R.A.
    J. Biol. Chem. 275:29660-29671(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    Tissue: Lung.
  2. "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain."
    Snow B.E., Hall R.A., Krumins A.M., Brothers G.M., Bouchard D., Brothers C.A., Chung S., Mangion J., Gilman A.G., Lefkowitz R.J., Siderovski D.P.
    J. Biol. Chem. 273:17749-17755(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    Tissue: Brain.
  3. "Novel amino terminal variant of RGS12TS-S."
    Chatterjee T.K., Fisher R.A.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    Tissue: Synovium.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
  8. "RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression."
    Chatterjee T.K., Fisher R.A.
    Mol. Cell. Biol. 22:4334-4345(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM 5), FUNCTION (ISOFORM 5), SUBCELLULAR LOCATION (ISOFORM 5).
  9. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1115.
    Tissue: Mammary cancer.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  11. "Solution structure of the RGS domain from human regulator of G-protein signaling 12 (RGS12)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (MAR-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 705-852.

Entry informationi

Entry nameiRGS12_HUMAN
AccessioniPrimary (citable) accession number: O14924
Secondary accession number(s): B1AQ30
, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O43510, O75338, Q147X0, Q8WX95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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