O14924 (RGS12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 12
Short name=RGS12

Gene names

Name:

RGS12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1447 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Subunit structure	Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent By similarity.
Subcellular location	Nucleus.
Tissue specificity	Isoform 3 is brain specific.
Domain	The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3 By similarity.
Sequence similarities	Contains 1 GoLoco domain. Contains 1 PDZ (DHR) domain. Contains 1 PID domain. Contains 2 RBD (Ras-binding) domains. Contains 1 RGS domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Molecular function	Signal transduction inhibitor
PTM	Isopeptide bond Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of G-protein coupled receptor protein signaling pathway Traceable author statement Ref.2. Source: ProtInc termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	condensed nuclear chromosome Traceable author statement Ref.1. Source: ProtInc cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome receptor signaling protein activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14924-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14924-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ

Isoform 3 (identifier: O14924-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-647: Missing.
     648-666: RSFGRSKRFSITRSLDDLE → MNLGKELSNETHVSNDQQ

Isoform 4 (identifier: O14924-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1376: SGTH → TSRF
     1377-1447: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1447

1447

Regulator of G-protein signaling 12

PRO_0000204213

Regions

Domain

22 – 98

77

PDZ

Domain

228 – 340

113

PID

Domain

715 – 832

118

RGS

Domain

962 – 1032

71

RBD 1

Domain

1034 – 1104

71

RBD 2

Domain

1187 – 1209

23

GoLoco

Amino acid modifications

Cross-link

1115

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5

Natural variations

Alternative sequence

1 – 658

658

Missing in isoform 2.

VSP_005682

Alternative sequence

1 – 647

647

Missing in isoform 3.

VSP_005684

Alternative sequence

648 – 666

19

RSFGR…LDDLE → MNLGKELSNETHVSNDQQ in isoform 3.

VSP_005685

Alternative sequence

659 – 666

8

TRSLDDLE → MSLSLFFQ in isoform 2.

VSP_005683

Alternative sequence

1373 – 1376

4

SGTH → TSRF in isoform 4.

VSP_005686

Alternative sequence

1377 – 1447

71

Missing in isoform 4.

VSP_005687

Natural variant

225

1

I → V.
Corresponds to variant rs7679941 [ dbSNP | Ensembl ].

VAR_034451

Natural variant

277

1

M → L.
Corresponds to variant rs16844152 [ dbSNP | Ensembl ].

VAR_034452

Natural variant

1124

1

N → S.
Corresponds to variant rs2269497 [ dbSNP | Ensembl ].

VAR_020208

Secondary structure

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1447

Helix Strand Turn

Details...

Beta strand

20 – 25

6

Beta strand

39 – 41

3

Turn

52 – 56

5

Beta strand

63 – 67

5

Helix

77 – 84

8

Beta strand

91 – 96

6

Helix

711 – 714

4

Helix

716 – 721

6

Helix

723 – 735

13

Helix

739 – 753

15

Helix

759 – 773

15

Beta strand

774 – 777

4

Helix

786 – 788

3

Helix

790 – 796

7

Helix

802 – 816

15

Helix

818 – 824

7

Helix

826 – 837

12

Turn

844 – 846

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 033CD7403DAD2725	FASTA	1,447	156,357
	10 20 30 40 50 60 MFRAGEASKR PLPGPSPPRV RSVEVARGRA GYGFTLSGQA PCVLSCVMRG SPADFVGLRA 70 80 90 100 110 120 GDQILAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGVG RFESCSSDEE GGLYEGKGWL 130 140 150 160 170 180 KPKLDSKALG INRAERVVEE MQSGGIFNMI FENPSLCASN SEPLKLKQRS LSESAATRFD 190 200 210 220 230 240 VGHESINNPN PNMLSKEEIS KVIHDDSVFS IGLESHDDFA LDASILNVAM IVGYLGSIEL 250 260 270 280 290 300 PSTSSNLESD SLQAIRGCMR RLRAEQKIHS LVTMKIMHDC VQLSTDKAGV VAEYPAEKLA 310 320 330 340 350 360 FSAVCPDDRR FFGLVTMQTN DDGSLAQEEE GALRTSCHVF MVDPDLFNHK IHQGIARRFG 370 380 390 400 410 420 FECTADPDTN GCLEFPASSL PVLQFISVLY RDMGELIEGM RARAFLDGDA DAHQNNSTSS 430 440 450 460 470 480 NSDSGIGNFH QEEKSNRVLV VDLGGSSSRH GPGGSAWDGV GGRGAQPWGA PWTGPFCPDP 490 500 510 520 530 540 EGSPPFEAAH QTDRFWDLNK HLGPASPVEV PPASLRSSVP PSKRGTVGAG CGFNQRWLPV 550 560 570 580 590 600 HVLREWQCGH TSDQDSYTDS TDGWSSINCG TLPPPMSKIP ADRYRVEGSF AQPPLNAPKR 610 620 630 640 650 660 EWSRKAFGMQ SIFGPHRNVR KTKEDKKGSK FGRGTGLTQP SQRTSARRSF GRSKRFSITR 670 680 690 700 710 720 SLDDLESATV SDGELTGADL KDCVSNNSLS SNASLPSVQS CRRLRERRVA SWAVSFERLL 730 740 750 760 770 780 QDPVGVRYFS DFLRKEFSEE NILFWQACEY FNHVPAHDKK ELSYRAREIF SKFLCSKATT 790 800 810 820 830 840 PVNIDSQAQL ADDVLRAPHP DMFKEQQLQI FNLMKFDSYT RFLKSPLYQE CILAEVEGRA 850 860 870 880 890 900 LPDSQQVPSS PASKHSLGSD HSSVSTPKKL SGKSKSGRSL NEELGDEDSE KKRKGAFFSW 910 920 930 940 950 960 SRTRSTGRSQ KKREHGDHAD DALHANGGLC RRESQGSVSS AGSLDLSEAC RTLAPEKDKA 970 980 990 1000 1010 1020 TKHCCIHLPD GTSCVVAVKA GFSIKDILSG LCERHGINGA AADLFLVGGD KPLVLHQDSS 1030 1040 1050 1060 1070 1080 ILESRDLRLE KRTLFRLDLV PINRSVGLKA KPTKPVTEVL RPVVARYGLD LSGLLVRLSG 1090 1100 1110 1120 1130 1140 EKEPLDLGAP ISSLDGQRVV LEEKDPSRGK ASADKQKGVP VKQNTAVNSS SRNHSATGEE 1150 1160 1170 1180 1190 1200 RTLGKSNSIK IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN 1210 1220 1230 1240 1250 1260 RADDQRGLLR KEDLVLPEFL RLPPGSTELT LPTPAAVAKG FSKRSATGNG RESASQPGEQ 1270 1280 1290 1300 1310 1320 WEPVQESSDS PSTSPGSASS PPGPPGTTPP GQKSPSGPFC TPQSPVSLAQ EGTAQIWKRQ 1330 1340 1350 1360 1370 1380 SQEVEAGGIQ TVEDEHVAEL TLMGEGDISS PNSTLLPPPS TPQEVPGPSR PGSGTHGSRD 1390 1400 1410 1420 1430 1440 LPVNRIIDVD LVTGSAPGRD GGIAGAQAGP GRSQASGGPP TSDLPGLGPV PGEPAKPKTS AHHATFV
	Isoform 2 [UniParc]. Checksum: EBFFA3BA3A575003	FASTA	789	84,894
	10 20 30 40 50 60 MSLSLFFQSA TVSDGELTGA DLKDCVSNNS LSSNASLPSV QSCRRLRERR VASWAVSFER 70 80 90 100 110 120 LLQDPVGVRY FSDFLRKEFS EENILFWQAC EYFNHVPAHD KKELSYRARE IFSKFLCSKA 130 140 150 160 170 180 TTPVNIDSQA QLADDVLRAP HPDMFKEQQL QIFNLMKFDS YTRFLKSPLY QECILAEVEG 190 200 210 220 230 240 RALPDSQQVP SSPASKHSLG SDHSSVSTPK KLSGKSKSGR SLNEELGDED SEKKRKGAFF 250 260 270 280 290 300 SWSRTRSTGR SQKKREHGDH ADDALHANGG LCRRESQGSV SSAGSLDLSE ACRTLAPEKD 310 320 330 340 350 360 KATKHCCIHL PDGTSCVVAV KAGFSIKDIL SGLCERHGIN GAAADLFLVG GDKPLVLHQD 370 380 390 400 410 420 SSILESRDLR LEKRTLFRLD LVPINRSVGL KAKPTKPVTE VLRPVVARYG LDLSGLLVRL 430 440 450 460 470 480 SGEKEPLDLG APISSLDGQR VVLEEKDPSR GKASADKQKG VPVKQNTAVN SSSRNHSATG 490 500 510 520 530 540 EERTLGKSNS IKIKGENGKN ARDPRLSKRE ESIAKIGKKK YQKINLDEAE EFFELISKAQ 550 560 570 580 590 600 SNRADDQRGL LRKEDLVLPE FLRLPPGSTE LTLPTPAAVA KGFSKRSATG NGRESASQPG 610 620 630 640 650 660 EQWEPVQESS DSPSTSPGSA SSPPGPPGTT PPGQKSPSGP FCTPQSPVSL AQEGTAQIWK 670 680 690 700 710 720 RQSQEVEAGG IQTVEDEHVA ELTLMGEGDI SSPNSTLLPP PSTPQEVPGP SRPGSGTHGS 730 740 750 760 770 780 RDLPVNRIID VDLVTGSAPG RDGGIAGAQA GPGRSQASGG PPTSDLPGLG PVPGEPAKPK TSAHHATFV
	Isoform 3 [UniParc]. Checksum: 2B3DE78DBC475BE6	FASTA	799	85,966
	10 20 30 40 50 60 MNLGKELSNE THVSNDQQSA TVSDGELTGA DLKDCVSNNS LSSNASLPSV QSCRRLRERR 70 80 90 100 110 120 VASWAVSFER LLQDPVGVRY FSDFLRKEFS EENILFWQAC EYFNHVPAHD KKELSYRARE 130 140 150 160 170 180 IFSKFLCSKA TTPVNIDSQA QLADDVLRAP HPDMFKEQQL QIFNLMKFDS YTRFLKSPLY 190 200 210 220 230 240 QECILAEVEG RALPDSQQVP SSPASKHSLG SDHSSVSTPK KLSGKSKSGR SLNEELGDED 250 260 270 280 290 300 SEKKRKGAFF SWSRTRSTGR SQKKREHGDH ADDALHANGG LCRRESQGSV SSAGSLDLSE 310 320 330 340 350 360 ACRTLAPEKD KATKHCCIHL PDGTSCVVAV KAGFSIKDIL SGLCERHGIN GAAADLFLVG 370 380 390 400 410 420 GDKPLVLHQD SSILESRDLR LEKRTLFRLD LVPINRSVGL KAKPTKPVTE VLRPVVARYG 430 440 450 460 470 480 LDLSGLLVRL SGEKEPLDLG APISSLDGQR VVLEEKDPSR GKASADKQKG VPVKQNTAVN 490 500 510 520 530 540 SSSRNHSATG EERTLGKSNS IKIKGENGKN ARDPRLSKRE ESIAKIGKKK YQKINLDEAE 550 560 570 580 590 600 EFFELISKAQ SNRADDQRGL LRKEDLVLPE FLRLPPGSTE LTLPTPAAVA KGFSKRSATG 610 620 630 640 650 660 NGRESASQPG EQWEPVQESS DSPSTSPGSA SSPPGPPGTT PPGQKSPSGP FCTPQSPVSL 670 680 690 700 710 720 AQEGTAQIWK RQSQEVEAGG IQTVEDEHVA ELTLMGEGDI SSPNSTLLPP PSTPQEVPGP 730 740 750 760 770 780 SRPGSGTHGS RDLPVNRIID VDLVTGSAPG RDGGIAGAQA GPGRSQASGG PPTSDLPGLG 790 PVPGEPAKPK TSAHHATFV
	Isoform 4 [UniParc]. Checksum: B16232931A795162	FASTA	1,376	149,593
	10 20 30 40 50 60 MFRAGEASKR PLPGPSPPRV RSVEVARGRA GYGFTLSGQA PCVLSCVMRG SPADFVGLRA 70 80 90 100 110 120 GDQILAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGVG RFESCSSDEE GGLYEGKGWL 130 140 150 160 170 180 KPKLDSKALG INRAERVVEE MQSGGIFNMI FENPSLCASN SEPLKLKQRS LSESAATRFD 190 200 210 220 230 240 VGHESINNPN PNMLSKEEIS KVIHDDSVFS IGLESHDDFA LDASILNVAM IVGYLGSIEL 250 260 270 280 290 300 PSTSSNLESD SLQAIRGCMR RLRAEQKIHS LVTMKIMHDC VQLSTDKAGV VAEYPAEKLA 310 320 330 340 350 360 FSAVCPDDRR FFGLVTMQTN DDGSLAQEEE GALRTSCHVF MVDPDLFNHK IHQGIARRFG 370 380 390 400 410 420 FECTADPDTN GCLEFPASSL PVLQFISVLY RDMGELIEGM RARAFLDGDA DAHQNNSTSS 430 440 450 460 470 480 NSDSGIGNFH QEEKSNRVLV VDLGGSSSRH GPGGSAWDGV GGRGAQPWGA PWTGPFCPDP 490 500 510 520 530 540 EGSPPFEAAH QTDRFWDLNK HLGPASPVEV PPASLRSSVP PSKRGTVGAG CGFNQRWLPV 550 560 570 580 590 600 HVLREWQCGH TSDQDSYTDS TDGWSSINCG TLPPPMSKIP ADRYRVEGSF AQPPLNAPKR 610 620 630 640 650 660 EWSRKAFGMQ SIFGPHRNVR KTKEDKKGSK FGRGTGLTQP SQRTSARRSF GRSKRFSITR 670 680 690 700 710 720 SLDDLESATV SDGELTGADL KDCVSNNSLS SNASLPSVQS CRRLRERRVA SWAVSFERLL 730 740 750 760 770 780 QDPVGVRYFS DFLRKEFSEE NILFWQACEY FNHVPAHDKK ELSYRAREIF SKFLCSKATT 790 800 810 820 830 840 PVNIDSQAQL ADDVLRAPHP DMFKEQQLQI FNLMKFDSYT RFLKSPLYQE CILAEVEGRA 850 860 870 880 890 900 LPDSQQVPSS PASKHSLGSD HSSVSTPKKL SGKSKSGRSL NEELGDEDSE KKRKGAFFSW 910 920 930 940 950 960 SRTRSTGRSQ KKREHGDHAD DALHANGGLC RRESQGSVSS AGSLDLSEAC RTLAPEKDKA 970 980 990 1000 1010 1020 TKHCCIHLPD GTSCVVAVKA GFSIKDILSG LCERHGINGA AADLFLVGGD KPLVLHQDSS 1030 1040 1050 1060 1070 1080 ILESRDLRLE KRTLFRLDLV PINRSVGLKA KPTKPVTEVL RPVVARYGLD LSGLLVRLSG 1090 1100 1110 1120 1130 1140 EKEPLDLGAP ISSLDGQRVV LEEKDPSRGK ASADKQKGVP VKQNTAVNSS SRNHSATGEE 1150 1160 1170 1180 1190 1200 RTLGKSNSIK IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN 1210 1220 1230 1240 1250 1260 RADDQRGLLR KEDLVLPEFL RLPPGSTELT LPTPAAVAKG FSKRSATGNG RESASQPGEQ 1270 1280 1290 1300 1310 1320 WEPVQESSDS PSTSPGSASS PPGPPGTTPP GQKSPSGPFC TPQSPVSLAQ EGTAQIWKRQ 1330 1340 1350 1360 1370 SQEVEAGGIQ TVEDEHVAEL TLMGEGDISS PNSTLLPPPS TPQEVPGPSR PGTSRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel alternative splicing and nuclear localization of human RGS12 gene products." Chatterjee T.K., Fisher R.A. J. Biol. Chem. 275:29660-29671(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Lung.
[2]	"GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain." Snow B.E., Hall R.A., Krumins A.M., Brothers G.M., Bouchard D., Brothers C.A., Chung S., Mangion J., Gilman A.G., Lefkowitz R.J., Siderovski D.P. J. Biol. Chem. 273:17749-17755(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Brain.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1115, MASS SPECTROMETRY. Tissue: Mammary cancer.
[6]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[7]	"Solution structure of the RGS domain from human regulator of G-protein signaling 12 (RGS12)." RIKEN structural genomics initiative (RSGI) Submitted (MAR-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 705-852.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF030112 mRNA. Translation: AAB84187.1.
AF030111 mRNA. Translation: AAB84114.1.
AF030110 mRNA. Translation: AAB84007.1.
AF030109 mRNA. Translation: AAB84186.1.
AF030149 , AF030151, AF030152, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96645.1.
AF030149 , AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96646.1. Sequence problems.
AF030149 , AF030134, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96644.1.
AF035152 mRNA. Translation: AAC39835.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17750.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17751.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17752.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21452.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21453.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21454.1.
CH471131 Genomic DNA. Translation: EAW82468.1.
CH471131 Genomic DNA. Translation: EAW82469.1.
CH471131 Genomic DNA. Translation: EAW82470.1.

IPI

IPI00024714.
IPI00219104.
IPI00219105.
IPI00219106.

RefSeq

NP_002917.1. NM_002926.3.
NP_937870.1. NM_198227.1.
NP_937872.1. NM_198229.2.

UniGene

Hs.527061.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EBZ	NMR	-	A	705-852	[»]
2KV8	NMR	-	A	18-100	[»]

ProteinModelPortal

O14924.

SMR

O14924. Positions 18-100, 705-852, 1025-1118, 1186-1221.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-154790.

STRING

9606.ENSP00000339381.

PTM databases

PhosphoSite

O14924.

Proteomic databases

PaxDb

O14924.

PRIDE

O14924.

Protocols and materials databases

DNASU

6002.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000336727; ENSP00000338509; ENSG00000159788.
ENST00000338806; ENSP00000342133; ENSG00000159788.
ENST00000344733; ENSP00000339381; ENSG00000159788.
ENST00000382788; ENSP00000372238; ENSG00000159788.

GeneID

6002.

KEGG

hsa:6002.

UCSC

uc003ggu.2. human.
uc003ggv.3. human.
uc003ggz.3. human.
uc003gha.3. human.

Organism-specific databases

CTD

6002.

GeneCards

GC04P003253.

H-InvDB

HIX0164019.

HGNC

HGNC:9994. RGS12.

MIM

602512. gene.

neXtProt

NX_O14924.

PharmGKB

PA34364.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG282424.

HOVERGEN

HBG063299.

InParanoid

O14924.

KO

K16449.

OMA

MVDPELF.

PhylomeDB

O14924.

Gene expression databases

ArrayExpress

O14924.

Bgee

O14924.

CleanEx

HS_RGS12.

Genevestigator

O14924.

GermOnline

ENSG00000159788. Homo sapiens.

Family and domain databases

Gene3D

1.10.196.10. 1 hit.
2.30.29.30. 1 hit.

InterPro

IPR003109. GoLoco_motif.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR006020. PTyr_interaction_dom.
IPR003116. Raf-like_ras-bd.
IPR000342. Regulat_G_prot_signal.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
[Graphical view]

Pfam

PF02188. GoLoco. 1 hit.
PF00595. PDZ. 1 hit.
PF02196. RBD. 2 hits.
PF00615. RGS. 1 hit.
[Graphical view]

PRINTS

PR01301. RGSPROTEIN.

SMART

SM00390. GoLoco. 1 hit.
SM00228. PDZ. 1 hit.
SM00462. PTB. 1 hit.
SM00455. RBD. 2 hits.
SM00315. RGS. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.
SSF48097. Regulat_G_prot_signal_superfam. 1 hit.

PROSITE

PS50877. GOLOCO. 1 hit.
PS50106. PDZ. 1 hit.
PS01179. PID. 1 hit.
PS50898. RBD. 2 hits.
PS50132. RGS. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL1293276.

EvolutionaryTrace

O14924.

GenomeRNAi

6002.

NextBio

23405.

SOURCE

Search...

Entry information

Entry name

RGS12_HUMAN

Accession

Primary (citable) accession number: O14924
Secondary accession number(s): B1AQ30 , B1AQ31, B1AQ32, O14922, O14923, O43510, O75338

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.