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O14924

- RGS12_HUMAN

UniProt

O14924 - RGS12_HUMAN

Protein

Regulator of G-protein signaling 12

Gene

RGS12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
    Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome
    2. GTPase regulator activity Source: UniProtKB
    3. receptor signaling protein activity Source: InterPro

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. regulation of catalytic activity Source: GOC
    3. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
    4. termination of G-protein coupled receptor signaling pathway Source: InterPro
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor, Signal transduction inhibitor

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    ReactomeiREACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 12
    Short name:
    RGS12
    Gene namesi
    Name:RGS12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:9994. RGS12.

    Subcellular locationi

    Nucleus 1 Publication
    Isoform 5 : Nucleus matrix 1 Publication
    Note: Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains.

    GO - Cellular componenti

    1. condensed nuclear chromosome Source: ProtInc
    2. cytoplasm Source: HPA
    3. nuclear matrix Source: UniProtKB-SubCell
    4. nucleolus Source: HPA
    5. nucleus Source: HPA
    6. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34364.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14471447Regulator of G-protein signaling 12PRO_0000204213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki1115 – 1115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiO14924.
    PaxDbiO14924.
    PRIDEiO14924.

    PTM databases

    PhosphoSiteiO14924.

    Expressioni

    Tissue specificityi

    Isoform 3 is brain specific.

    Gene expression databases

    ArrayExpressiO14924.
    BgeeiO14924.
    CleanExiHS_RGS12.
    GenevestigatoriO14924.

    Organism-specific databases

    HPAiHPA054646.

    Interactioni

    Subunit structurei

    Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent.By similarity

    Protein-protein interaction databases

    BioGridi111934. 7 interactions.
    MINTiMINT-154790.
    STRINGi9606.ENSP00000339381.

    Structurei

    Secondary structure

    1
    1447
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi20 – 256
    Beta strandi39 – 413
    Turni52 – 565
    Beta strandi63 – 675
    Helixi77 – 848
    Beta strandi91 – 966
    Helixi711 – 7144
    Helixi716 – 7216
    Helixi723 – 73513
    Helixi739 – 75315
    Helixi759 – 77315
    Beta strandi774 – 7774
    Helixi786 – 7883
    Helixi790 – 7967
    Helixi802 – 81615
    Helixi818 – 8247
    Helixi826 – 83712
    Turni844 – 8463

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EBZNMR-A705-852[»]
    2KV8NMR-A18-100[»]
    ProteinModelPortaliO14924.
    SMRiO14924. Positions 18-100, 705-852, 1025-1118, 1186-1221.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14924.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 9877PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini228 – 340113PIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini715 – 832118RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini962 – 103271RBD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1034 – 110471RBD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1187 – 120923GoLocoPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3.By similarity

    Sequence similaritiesi

    Contains 1 GoLoco domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 PID domain.PROSITE-ProRule annotation
    Contains 2 RBD (Ras-binding) domains.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG282424.
    HOVERGENiHBG063299.
    InParanoidiO14924.
    KOiK16449.
    OMAiLFHHKIH.
    OrthoDBiEOG7XDBF0.
    PhylomeDBiO14924.
    TreeFamiTF328814.

    Family and domain databases

    Gene3Di1.10.196.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR003109. GoLoco_motif.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR003116. Raf-like_ras-bd.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF02188. GoLoco. 1 hit.
    PF00595. PDZ. 1 hit.
    PF02196. RBD. 2 hits.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00390. GoLoco. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00462. PTB. 1 hit.
    SM00455. RBD. 2 hits.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 2 hits.
    PROSITEiPS50877. GOLOCO. 1 hit.
    PS50106. PDZ. 1 hit.
    PS01179. PID. 1 hit.
    PS50898. RBD. 2 hits.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14924-1) [UniParc]FASTAAdd to Basket

    Also known as: RGS12TS-L, TS, trans-spliced

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFRAGEASKR PLPGPSPPRV RSVEVARGRA GYGFTLSGQA PCVLSCVMRG     50
    SPADFVGLRA GDQILAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGVG 100
    RFESCSSDEE GGLYEGKGWL KPKLDSKALG INRAERVVEE MQSGGIFNMI 150
    FENPSLCASN SEPLKLKQRS LSESAATRFD VGHESINNPN PNMLSKEEIS 200
    KVIHDDSVFS IGLESHDDFA LDASILNVAM IVGYLGSIEL PSTSSNLESD 250
    SLQAIRGCMR RLRAEQKIHS LVTMKIMHDC VQLSTDKAGV VAEYPAEKLA 300
    FSAVCPDDRR FFGLVTMQTN DDGSLAQEEE GALRTSCHVF MVDPDLFNHK 350
    IHQGIARRFG FECTADPDTN GCLEFPASSL PVLQFISVLY RDMGELIEGM 400
    RARAFLDGDA DAHQNNSTSS NSDSGIGNFH QEEKSNRVLV VDLGGSSSRH 450
    GPGGSAWDGV GGRGAQPWGA PWTGPFCPDP EGSPPFEAAH QTDRFWDLNK 500
    HLGPASPVEV PPASLRSSVP PSKRGTVGAG CGFNQRWLPV HVLREWQCGH 550
    TSDQDSYTDS TDGWSSINCG TLPPPMSKIP ADRYRVEGSF AQPPLNAPKR 600
    EWSRKAFGMQ SIFGPHRNVR KTKEDKKGSK FGRGTGLTQP SQRTSARRSF 650
    GRSKRFSITR SLDDLESATV SDGELTGADL KDCVSNNSLS SNASLPSVQS 700
    CRRLRERRVA SWAVSFERLL QDPVGVRYFS DFLRKEFSEE NILFWQACEY 750
    FNHVPAHDKK ELSYRAREIF SKFLCSKATT PVNIDSQAQL ADDVLRAPHP 800
    DMFKEQQLQI FNLMKFDSYT RFLKSPLYQE CILAEVEGRA LPDSQQVPSS 850
    PASKHSLGSD HSSVSTPKKL SGKSKSGRSL NEELGDEDSE KKRKGAFFSW 900
    SRTRSTGRSQ KKREHGDHAD DALHANGGLC RRESQGSVSS AGSLDLSEAC 950
    RTLAPEKDKA TKHCCIHLPD GTSCVVAVKA GFSIKDILSG LCERHGINGA 1000
    AADLFLVGGD KPLVLHQDSS ILESRDLRLE KRTLFRLDLV PINRSVGLKA 1050
    KPTKPVTEVL RPVVARYGLD LSGLLVRLSG EKEPLDLGAP ISSLDGQRVV 1100
    LEEKDPSRGK ASADKQKGVP VKQNTAVNSS SRNHSATGEE RTLGKSNSIK 1150
    IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN 1200
    RADDQRGLLR KEDLVLPEFL RLPPGSTELT LPTPAAVAKG FSKRSATGNG 1250
    RESASQPGEQ WEPVQESSDS PSTSPGSASS PPGPPGTTPP GQKSPSGPFC 1300
    TPQSPVSLAQ EGTAQIWKRQ SQEVEAGGIQ TVEDEHVAEL TLMGEGDISS 1350
    PNSTLLPPPS TPQEVPGPSR PGSGTHGSRD LPVNRIIDVD LVTGSAPGRD 1400
    GGIAGAQAGP GRSQASGGPP TSDLPGLGPV PGEPAKPKTS AHHATFV 1447
    Length:1,447
    Mass (Da):156,357
    Last modified:January 1, 1998 - v1
    Checksum:i033CD7403DAD2725
    GO
    Isoform 2 (identifier: O14924-2) [UniParc]FASTAAdd to Basket

    Also known as: P, peripheral

    The sequence of this isoform differs from the canonical sequence as follows:
         1-658: Missing.
         659-666: TRSLDDLE → MSLSLFFQ

    Show »
    Length:789
    Mass (Da):84,894
    Checksum:iEBFFA3BA3A575003
    GO
    Isoform 3 (identifier: O14924-3) [UniParc]FASTAAdd to Basket

    Also known as: B, brain

    The sequence of this isoform differs from the canonical sequence as follows:
         1-647: Missing.
         648-666: RSFGRSKRFSITRSLDDLE → MNLGKELSNETHVSNDQQ

    Show »
    Length:799
    Mass (Da):85,966
    Checksum:i2B3DE78DBC475BE6
    GO
    Isoform 4 (identifier: O14924-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1373-1376: SGTH → TSRF
         1377-1447: Missing.

    Show »
    Length:1,376
    Mass (Da):149,593
    Checksum:iB16232931A795162
    GO
    Isoform 5 (identifier: O14924-5) [UniParc]FASTAAdd to Basket

    Also known as: RGS12TS-S

    The sequence of this isoform differs from the canonical sequence as follows:
         1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
         1158-1447: Missing.

    Show »
    Length:1,157
    Mass (Da):126,372
    Checksum:i008E7B25C0DF3E69
    GO
    Isoform 6 (identifier: O14924-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-25: MFRAGEASKRPLPGPSPPRVRSVEV → MKKHDFAENLPSSLLIIILVIFTLS
         26-627: Missing.
         1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
         1158-1447: Missing.

    Show »
    Length:555
    Mass (Da):61,107
    Checksum:iBBCE94518BABF917
    GO
    Isoform 7 (identifier: O14924-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-658: Missing.
         659-666: TRSLDDLE → MSLSLFFQ
         1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
         1158-1447: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:499
    Mass (Da):54,909
    Checksum:i19D4E54B5D47C387
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti941 – 9411A → V in AAI18595. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti225 – 2251I → V.
    Corresponds to variant rs7679941 [ dbSNP | Ensembl ].
    VAR_034451
    Natural varianti277 – 2771M → L.
    Corresponds to variant rs16844152 [ dbSNP | Ensembl ].
    VAR_034452
    Natural varianti1124 – 11241N → S.
    Corresponds to variant rs2269497 [ dbSNP | Ensembl ].
    VAR_020208

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 658658Missing in isoform 2 and isoform 7. 2 PublicationsVSP_005682Add
    BLAST
    Alternative sequencei1 – 647647Missing in isoform 3. 1 PublicationVSP_005684Add
    BLAST
    Alternative sequencei1 – 2525MFRAG…RSVEV → MKKHDFAENLPSSLLIIILV IFTLS in isoform 6. 2 PublicationsVSP_047741Add
    BLAST
    Alternative sequencei26 – 627602Missing in isoform 6. 2 PublicationsVSP_047742Add
    BLAST
    Alternative sequencei648 – 66619RSFGR…LDDLE → MNLGKELSNETHVSNDQQ in isoform 3. 1 PublicationVSP_005685Add
    BLAST
    Alternative sequencei659 – 6668TRSLDDLE → MSLSLFFQ in isoform 2 and isoform 7. 2 PublicationsVSP_005683
    Alternative sequencei1138 – 115720GEERT…GENGK → SFLSLFPKLRATEQMTNVGC in isoform 5, isoform 6 and isoform 7. 3 PublicationsVSP_047743Add
    BLAST
    Alternative sequencei1158 – 1447290Missing in isoform 5, isoform 6 and isoform 7. 3 PublicationsVSP_047744Add
    BLAST
    Alternative sequencei1373 – 13764SGTH → TSRF in isoform 4. 1 PublicationVSP_005686
    Alternative sequencei1377 – 144771Missing in isoform 4. 1 PublicationVSP_005687Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030112 mRNA. Translation: AAB84187.1.
    AF030111 mRNA. Translation: AAB84114.1.
    AF030110 mRNA. Translation: AAB84007.1.
    AF030109 mRNA. Translation: AAB84186.1.
    AF030149
    , AF030151, AF030152, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96645.1.
    AF030149
    , AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96646.1. Sequence problems.
    AF030149
    , AF030134, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96644.1.
    AF035152 mRNA. Translation: AAC39835.1.
    AF464737 mRNA. Translation: AAL69961.1.
    AK301510 mRNA. Translation: BAH13500.1.
    AL645949, AL590235 Genomic DNA. Translation: CAM17750.1.
    AL645949, AL590235 Genomic DNA. Translation: CAM17751.1.
    AL645949, AL590235 Genomic DNA. Translation: CAM17752.1.
    AL590235, AL645949 Genomic DNA. Translation: CAM21452.1.
    AL590235, AL645949 Genomic DNA. Translation: CAM21453.1.
    AL590235, AL645949 Genomic DNA. Translation: CAM21454.1.
    CH471131 Genomic DNA. Translation: EAW82465.1.
    CH471131 Genomic DNA. Translation: EAW82468.1.
    BC118594 mRNA. Translation: AAI18595.1.
    CH471131 Genomic DNA. Translation: EAW82469.1.
    CH471131 Genomic DNA. Translation: EAW82470.1.
    CCDSiCCDS3366.1. [O14924-1]
    CCDS3367.1. [O14924-4]
    CCDS3368.1. [O14924-3]
    RefSeqiNP_002917.1. NM_002926.3. [O14924-4]
    NP_937870.1. NM_198227.1. [O14924-3]
    NP_937872.1. NM_198229.2. [O14924-1]
    XP_006713968.1. XM_006713905.1. [O14924-1]
    XP_006713969.1. XM_006713906.1. [O14924-5]
    XP_006713970.1. XM_006713907.1.
    UniGeneiHs.527061.

    Genome annotation databases

    EnsembliENST00000336727; ENSP00000338509; ENSG00000159788. [O14924-4]
    ENST00000338806; ENSP00000342133; ENSG00000159788. [O14924-3]
    ENST00000344733; ENSP00000339381; ENSG00000159788. [O14924-1]
    ENST00000382788; ENSP00000372238; ENSG00000159788. [O14924-4]
    GeneIDi6002.
    KEGGihsa:6002.
    UCSCiuc003ggu.2. human. [O14924-1]
    uc003ggv.3. human. [O14924-4]
    uc003ggy.1. human.
    uc003ggz.3. human. [O14924-3]
    uc003gha.3. human. [O14924-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030112 mRNA. Translation: AAB84187.1 .
    AF030111 mRNA. Translation: AAB84114.1 .
    AF030110 mRNA. Translation: AAB84007.1 .
    AF030109 mRNA. Translation: AAB84186.1 .
    AF030149
    , AF030151 , AF030152 , AF030135 , AF030136 , AF030137 , AF030138 , AF030139 , AF030140 , AF030141 , AF030142 , AF030143 , AF030144 , AF030145 , AF030146 , AF030147 , AF030148 Genomic DNA. Translation: AAB96645.1 .
    AF030149
    , AF030135 , AF030136 , AF030137 , AF030138 , AF030139 , AF030140 , AF030141 , AF030142 , AF030143 , AF030144 , AF030145 , AF030146 , AF030147 , AF030148 Genomic DNA. Translation: AAB96646.1 . Sequence problems.
    AF030149
    , AF030134 , AF030135 , AF030136 , AF030137 , AF030138 , AF030139 , AF030140 , AF030141 , AF030142 , AF030143 , AF030144 , AF030145 , AF030146 , AF030147 , AF030148 Genomic DNA. Translation: AAB96644.1 .
    AF035152 mRNA. Translation: AAC39835.1 .
    AF464737 mRNA. Translation: AAL69961.1 .
    AK301510 mRNA. Translation: BAH13500.1 .
    AL645949 , AL590235 Genomic DNA. Translation: CAM17750.1 .
    AL645949 , AL590235 Genomic DNA. Translation: CAM17751.1 .
    AL645949 , AL590235 Genomic DNA. Translation: CAM17752.1 .
    AL590235 , AL645949 Genomic DNA. Translation: CAM21452.1 .
    AL590235 , AL645949 Genomic DNA. Translation: CAM21453.1 .
    AL590235 , AL645949 Genomic DNA. Translation: CAM21454.1 .
    CH471131 Genomic DNA. Translation: EAW82465.1 .
    CH471131 Genomic DNA. Translation: EAW82468.1 .
    BC118594 mRNA. Translation: AAI18595.1 .
    CH471131 Genomic DNA. Translation: EAW82469.1 .
    CH471131 Genomic DNA. Translation: EAW82470.1 .
    CCDSi CCDS3366.1. [O14924-1 ]
    CCDS3367.1. [O14924-4 ]
    CCDS3368.1. [O14924-3 ]
    RefSeqi NP_002917.1. NM_002926.3. [O14924-4 ]
    NP_937870.1. NM_198227.1. [O14924-3 ]
    NP_937872.1. NM_198229.2. [O14924-1 ]
    XP_006713968.1. XM_006713905.1. [O14924-1 ]
    XP_006713969.1. XM_006713906.1. [O14924-5 ]
    XP_006713970.1. XM_006713907.1.
    UniGenei Hs.527061.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EBZ NMR - A 705-852 [» ]
    2KV8 NMR - A 18-100 [» ]
    ProteinModelPortali O14924.
    SMRi O14924. Positions 18-100, 705-852, 1025-1118, 1186-1221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111934. 7 interactions.
    MINTi MINT-154790.
    STRINGi 9606.ENSP00000339381.

    Chemistry

    ChEMBLi CHEMBL1293276.

    PTM databases

    PhosphoSitei O14924.

    Proteomic databases

    MaxQBi O14924.
    PaxDbi O14924.
    PRIDEi O14924.

    Protocols and materials databases

    DNASUi 6002.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336727 ; ENSP00000338509 ; ENSG00000159788 . [O14924-4 ]
    ENST00000338806 ; ENSP00000342133 ; ENSG00000159788 . [O14924-3 ]
    ENST00000344733 ; ENSP00000339381 ; ENSG00000159788 . [O14924-1 ]
    ENST00000382788 ; ENSP00000372238 ; ENSG00000159788 . [O14924-4 ]
    GeneIDi 6002.
    KEGGi hsa:6002.
    UCSCi uc003ggu.2. human. [O14924-1 ]
    uc003ggv.3. human. [O14924-4 ]
    uc003ggy.1. human.
    uc003ggz.3. human. [O14924-3 ]
    uc003gha.3. human. [O14924-2 ]

    Organism-specific databases

    CTDi 6002.
    GeneCardsi GC04P003294.
    H-InvDB HIX0164019.
    HGNCi HGNC:9994. RGS12.
    HPAi HPA054646.
    MIMi 602512. gene.
    neXtProti NX_O14924.
    PharmGKBi PA34364.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282424.
    HOVERGENi HBG063299.
    InParanoidi O14924.
    KOi K16449.
    OMAi LFHHKIH.
    OrthoDBi EOG7XDBF0.
    PhylomeDBi O14924.
    TreeFami TF328814.

    Enzyme and pathway databases

    Reactomei REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    EvolutionaryTracei O14924.
    GeneWikii RGS12.
    GenomeRNAii 6002.
    NextBioi 23405.
    PROi O14924.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14924.
    Bgeei O14924.
    CleanExi HS_RGS12.
    Genevestigatori O14924.

    Family and domain databases

    Gene3Di 1.10.196.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR003109. GoLoco_motif.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR003116. Raf-like_ras-bd.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF02188. GoLoco. 1 hit.
    PF00595. PDZ. 1 hit.
    PF02196. RBD. 2 hits.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00390. GoLoco. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00462. PTB. 1 hit.
    SM00455. RBD. 2 hits.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 2 hits.
    PROSITEi PS50877. GOLOCO. 1 hit.
    PS50106. PDZ. 1 hit.
    PS01179. PID. 1 hit.
    PS50898. RBD. 2 hits.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel alternative splicing and nuclear localization of human RGS12 gene products."
      Chatterjee T.K., Fisher R.A.
      J. Biol. Chem. 275:29660-29671(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
      Tissue: Lung.
    2. "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain."
      Snow B.E., Hall R.A., Krumins A.M., Brothers G.M., Bouchard D., Brothers C.A., Chung S., Mangion J., Gilman A.G., Lefkowitz R.J., Siderovski D.P.
      J. Biol. Chem. 273:17749-17755(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
      Tissue: Brain.
    3. "Novel amino terminal variant of RGS12TS-S."
      Chatterjee T.K., Fisher R.A.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
      Tissue: Synovium.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    8. "RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression."
      Chatterjee T.K., Fisher R.A.
      Mol. Cell. Biol. 22:4334-4345(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM 5), FUNCTION (ISOFORM 5), SUBCELLULAR LOCATION (ISOFORM 5).
    9. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
      Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
      Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1115.
      Tissue: Mammary cancer.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    11. "Solution structure of the RGS domain from human regulator of G-protein signaling 12 (RGS12)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (MAR-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 705-852.

    Entry informationi

    Entry nameiRGS12_HUMAN
    AccessioniPrimary (citable) accession number: O14924
    Secondary accession number(s): B1AQ30
    , B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O43510, O75338, Q147X0, Q8WX95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3