Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of G-protein signaling 12

Gene

RGS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.By similarity
Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: ProtInc
  • GTPase regulator activity Source: UniProtKB
  • signal transducer activity, downstream of receptor Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Repressor, Signal transduction inhibitor

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159788-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 12
Short name:
RGS12
Gene namesi
Name:RGS12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:9994. RGS12.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm By similarity
  • Cell projectiondendrite By similarity
  • Cell junctionsynapse By similarity
Isoform 5 :
  • Nucleus matrix 1 Publication

  • Note: Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains.1 Publication

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • condensed nuclear chromosome Source: ProtInc
  • cytoplasm Source: UniProtKB
  • dendrite Source: UniProtKB
  • nuclear matrix Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
  • plasma membrane Source: GO_Central
  • synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Nucleus, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi6002.
OpenTargetsiENSG00000159788.
PharmGKBiPA34364.

Chemistry databases

ChEMBLiCHEMBL1293276.

Polymorphism and mutation databases

BioMutaiRGS12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042131 – 1447Regulator of G-protein signaling 12Add BLAST1447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineBy similarity1
Modified residuei195PhosphoserineBy similarity1
Modified residuei524Omega-N-methylarginineCombined sources1
Modified residuei633Omega-N-methylarginineBy similarity1
Modified residuei661PhosphoserineBy similarity1
Modified residuei671PhosphoserineBy similarity1
Modified residuei850PhosphoserineBy similarity1
Modified residuei879PhosphoserineBy similarity1
Modified residuei943PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO14924.
MaxQBiO14924.
PaxDbiO14924.
PeptideAtlasiO14924.
PRIDEiO14924.
TopDownProteomicsiO14924-2. [O14924-2]

PTM databases

iPTMnetiO14924.
PhosphoSitePlusiO14924.

Expressioni

Tissue specificityi

Isoform 3 is brain specific.

Gene expression databases

BgeeiENSG00000159788.
CleanExiHS_RGS12.
ExpressionAtlasiO14924. baseline and differential.
GenevisibleiO14924. HS.

Interactioni

Subunit structurei

Interacts with GNAI1 (PubMed:18434541). Interacts with GNAI2 and GNAI3; the interactions are GDP-dependent (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi111934. 7 interactors.
IntActiO14924. 2 interactors.
MINTiMINT-154790.
STRINGi9606.ENSP00000339381.

Structurei

Secondary structure

11447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi20 – 25Combined sources6
Beta strandi39 – 41Combined sources3
Turni52 – 56Combined sources5
Beta strandi63 – 67Combined sources5
Helixi77 – 84Combined sources8
Beta strandi91 – 96Combined sources6
Helixi711 – 714Combined sources4
Helixi716 – 721Combined sources6
Helixi723 – 735Combined sources13
Helixi739 – 753Combined sources15
Helixi759 – 773Combined sources15
Beta strandi774 – 777Combined sources4
Helixi786 – 788Combined sources3
Helixi790 – 796Combined sources7
Helixi802 – 816Combined sources15
Helixi818 – 824Combined sources7
Helixi826 – 837Combined sources12
Turni844 – 846Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBZNMR-A705-852[»]
2KV8NMR-A18-100[»]
ProteinModelPortaliO14924.
SMRiO14924.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14924.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 98PDZPROSITE-ProRule annotationAdd BLAST77
Domaini228 – 340PIDPROSITE-ProRule annotationAdd BLAST113
Domaini715 – 832RGSPROSITE-ProRule annotationAdd BLAST118
Domaini962 – 1032RBD 1PROSITE-ProRule annotationAdd BLAST71
Domaini1034 – 1104RBD 2PROSITE-ProRule annotationAdd BLAST71
Domaini1187 – 1209GoLocoPROSITE-ProRule annotationAdd BLAST23

Domaini

The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3.By similarity

Sequence similaritiesi

Contains 1 GoLoco domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 PID domain.PROSITE-ProRule annotation
Contains 2 RBD (Ras-binding) domains.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000049111.
HOVERGENiHBG063299.
InParanoidiO14924.
KOiK16449.
OMAiLFHHKIH.
OrthoDBiEOG091G0BDG.
PhylomeDBiO14924.
TreeFamiTF328814.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR003109. GoLoco_motif.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR003116. RBD_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF02188. GoLoco. 1 hit.
PF00595. PDZ. 1 hit.
PF02196. RBD. 2 hits.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00390. GoLoco. 1 hit.
SM00228. PDZ. 1 hit.
SM00462. PTB. 1 hit.
SM00455. RBD. 2 hits.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50877. GOLOCO. 1 hit.
PS50106. PDZ. 1 hit.
PS01179. PID. 1 hit.
PS50898. RBD. 2 hits.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14924-1) [UniParc]FASTAAdd to basket
Also known as: RGS12TS-L, TS, trans-spliced

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRAGEASKR PLPGPSPPRV RSVEVARGRA GYGFTLSGQA PCVLSCVMRG
60 70 80 90 100
SPADFVGLRA GDQILAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGVG
110 120 130 140 150
RFESCSSDEE GGLYEGKGWL KPKLDSKALG INRAERVVEE MQSGGIFNMI
160 170 180 190 200
FENPSLCASN SEPLKLKQRS LSESAATRFD VGHESINNPN PNMLSKEEIS
210 220 230 240 250
KVIHDDSVFS IGLESHDDFA LDASILNVAM IVGYLGSIEL PSTSSNLESD
260 270 280 290 300
SLQAIRGCMR RLRAEQKIHS LVTMKIMHDC VQLSTDKAGV VAEYPAEKLA
310 320 330 340 350
FSAVCPDDRR FFGLVTMQTN DDGSLAQEEE GALRTSCHVF MVDPDLFNHK
360 370 380 390 400
IHQGIARRFG FECTADPDTN GCLEFPASSL PVLQFISVLY RDMGELIEGM
410 420 430 440 450
RARAFLDGDA DAHQNNSTSS NSDSGIGNFH QEEKSNRVLV VDLGGSSSRH
460 470 480 490 500
GPGGSAWDGV GGRGAQPWGA PWTGPFCPDP EGSPPFEAAH QTDRFWDLNK
510 520 530 540 550
HLGPASPVEV PPASLRSSVP PSKRGTVGAG CGFNQRWLPV HVLREWQCGH
560 570 580 590 600
TSDQDSYTDS TDGWSSINCG TLPPPMSKIP ADRYRVEGSF AQPPLNAPKR
610 620 630 640 650
EWSRKAFGMQ SIFGPHRNVR KTKEDKKGSK FGRGTGLTQP SQRTSARRSF
660 670 680 690 700
GRSKRFSITR SLDDLESATV SDGELTGADL KDCVSNNSLS SNASLPSVQS
710 720 730 740 750
CRRLRERRVA SWAVSFERLL QDPVGVRYFS DFLRKEFSEE NILFWQACEY
760 770 780 790 800
FNHVPAHDKK ELSYRAREIF SKFLCSKATT PVNIDSQAQL ADDVLRAPHP
810 820 830 840 850
DMFKEQQLQI FNLMKFDSYT RFLKSPLYQE CILAEVEGRA LPDSQQVPSS
860 870 880 890 900
PASKHSLGSD HSSVSTPKKL SGKSKSGRSL NEELGDEDSE KKRKGAFFSW
910 920 930 940 950
SRTRSTGRSQ KKREHGDHAD DALHANGGLC RRESQGSVSS AGSLDLSEAC
960 970 980 990 1000
RTLAPEKDKA TKHCCIHLPD GTSCVVAVKA GFSIKDILSG LCERHGINGA
1010 1020 1030 1040 1050
AADLFLVGGD KPLVLHQDSS ILESRDLRLE KRTLFRLDLV PINRSVGLKA
1060 1070 1080 1090 1100
KPTKPVTEVL RPVVARYGLD LSGLLVRLSG EKEPLDLGAP ISSLDGQRVV
1110 1120 1130 1140 1150
LEEKDPSRGK ASADKQKGVP VKQNTAVNSS SRNHSATGEE RTLGKSNSIK
1160 1170 1180 1190 1200
IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN
1210 1220 1230 1240 1250
RADDQRGLLR KEDLVLPEFL RLPPGSTELT LPTPAAVAKG FSKRSATGNG
1260 1270 1280 1290 1300
RESASQPGEQ WEPVQESSDS PSTSPGSASS PPGPPGTTPP GQKSPSGPFC
1310 1320 1330 1340 1350
TPQSPVSLAQ EGTAQIWKRQ SQEVEAGGIQ TVEDEHVAEL TLMGEGDISS
1360 1370 1380 1390 1400
PNSTLLPPPS TPQEVPGPSR PGSGTHGSRD LPVNRIIDVD LVTGSAPGRD
1410 1420 1430 1440
GGIAGAQAGP GRSQASGGPP TSDLPGLGPV PGEPAKPKTS AHHATFV
Length:1,447
Mass (Da):156,357
Last modified:January 1, 1998 - v1
Checksum:i033CD7403DAD2725
GO
Isoform 2 (identifier: O14924-2) [UniParc]FASTAAdd to basket
Also known as: P, peripheral

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ

Show »
Length:789
Mass (Da):84,894
Checksum:iEBFFA3BA3A575003
GO
Isoform 3 (identifier: O14924-3) [UniParc]FASTAAdd to basket
Also known as: B, brain

The sequence of this isoform differs from the canonical sequence as follows:
     1-647: Missing.
     648-666: RSFGRSKRFSITRSLDDLE → MNLGKELSNETHVSNDQQ

Show »
Length:799
Mass (Da):85,966
Checksum:i2B3DE78DBC475BE6
GO
Isoform 4 (identifier: O14924-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1376: SGTH → TSRF
     1377-1447: Missing.

Show »
Length:1,376
Mass (Da):149,593
Checksum:iB16232931A795162
GO
Isoform 5 (identifier: O14924-5) [UniParc]FASTAAdd to basket
Also known as: RGS12TS-S

The sequence of this isoform differs from the canonical sequence as follows:
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Show »
Length:1,157
Mass (Da):126,372
Checksum:i008E7B25C0DF3E69
GO
Isoform 6 (identifier: O14924-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MFRAGEASKRPLPGPSPPRVRSVEV → MKKHDFAENLPSSLLIIILVIFTLS
     26-627: Missing.
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Show »
Length:555
Mass (Da):61,107
Checksum:iBBCE94518BABF917
GO
Isoform 7 (identifier: O14924-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):54,909
Checksum:i19D4E54B5D47C387
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti941A → V in AAI18595 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034451225I → V.Corresponds to variant rs7679941dbSNPEnsembl.1
Natural variantiVAR_034452277M → L.Corresponds to variant rs16844152dbSNPEnsembl.1
Natural variantiVAR_0202081124N → S.Corresponds to variant rs2269497dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0056821 – 658Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST658
Alternative sequenceiVSP_0056841 – 647Missing in isoform 3. 1 PublicationAdd BLAST647
Alternative sequenceiVSP_0477411 – 25MFRAG…RSVEV → MKKHDFAENLPSSLLIIILV IFTLS in isoform 6. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_04774226 – 627Missing in isoform 6. 2 PublicationsAdd BLAST602
Alternative sequenceiVSP_005685648 – 666RSFGR…LDDLE → MNLGKELSNETHVSNDQQ in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_005683659 – 666TRSLDDLE → MSLSLFFQ in isoform 2 and isoform 7. 2 Publications8
Alternative sequenceiVSP_0477431138 – 1157GEERT…GENGK → SFLSLFPKLRATEQMTNVGC in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST20
Alternative sequenceiVSP_0477441158 – 1447Missing in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST290
Alternative sequenceiVSP_0056861373 – 1376SGTH → TSRF in isoform 4. 1 Publication4
Alternative sequenceiVSP_0056871377 – 1447Missing in isoform 4. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030112 mRNA. Translation: AAB84187.1.
AF030111 mRNA. Translation: AAB84114.1.
AF030110 mRNA. Translation: AAB84007.1.
AF030109 mRNA. Translation: AAB84186.1.
AF030149
, AF030151, AF030152, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96645.1.
AF030149
, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96646.1. Sequence problems.
AF030149
, AF030134, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96644.1.
AF035152 mRNA. Translation: AAC39835.1.
AF464737 mRNA. Translation: AAL69961.1.
AK301510 mRNA. Translation: BAH13500.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17750.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17751.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17752.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21452.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21453.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21454.1.
CH471131 Genomic DNA. Translation: EAW82465.1.
CH471131 Genomic DNA. Translation: EAW82468.1.
BC118594 mRNA. Translation: AAI18595.1.
CH471131 Genomic DNA. Translation: EAW82469.1.
CH471131 Genomic DNA. Translation: EAW82470.1.
CCDSiCCDS3366.1. [O14924-1]
CCDS3367.1. [O14924-4]
CCDS3368.1. [O14924-3]
RefSeqiNP_002917.1. NM_002926.3. [O14924-4]
NP_937870.1. NM_198227.1. [O14924-3]
NP_937872.1. NM_198229.2. [O14924-1]
XP_006713968.1. XM_006713905.1. [O14924-1]
XP_006713969.1. XM_006713906.2. [O14924-5]
XP_006713970.1. XM_006713907.1.
XP_011511845.1. XM_011513543.2.
XP_016864018.1. XM_017008529.1. [O14924-1]
XP_016864020.1. XM_017008531.1.
XP_016864021.1. XM_017008532.1.
XP_016864022.1. XM_017008533.1.
UniGeneiHs.527061.

Genome annotation databases

EnsembliENST00000336727; ENSP00000338509; ENSG00000159788. [O14924-1]
ENST00000338806; ENSP00000342133; ENSG00000159788. [O14924-3]
ENST00000344733; ENSP00000339381; ENSG00000159788. [O14924-1]
ENST00000382788; ENSP00000372238; ENSG00000159788. [O14924-4]
GeneIDi6002.
KEGGihsa:6002.
UCSCiuc003ggw.4. human. [O14924-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030112 mRNA. Translation: AAB84187.1.
AF030111 mRNA. Translation: AAB84114.1.
AF030110 mRNA. Translation: AAB84007.1.
AF030109 mRNA. Translation: AAB84186.1.
AF030149
, AF030151, AF030152, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96645.1.
AF030149
, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96646.1. Sequence problems.
AF030149
, AF030134, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96644.1.
AF035152 mRNA. Translation: AAC39835.1.
AF464737 mRNA. Translation: AAL69961.1.
AK301510 mRNA. Translation: BAH13500.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17750.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17751.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17752.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21452.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21453.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21454.1.
CH471131 Genomic DNA. Translation: EAW82465.1.
CH471131 Genomic DNA. Translation: EAW82468.1.
BC118594 mRNA. Translation: AAI18595.1.
CH471131 Genomic DNA. Translation: EAW82469.1.
CH471131 Genomic DNA. Translation: EAW82470.1.
CCDSiCCDS3366.1. [O14924-1]
CCDS3367.1. [O14924-4]
CCDS3368.1. [O14924-3]
RefSeqiNP_002917.1. NM_002926.3. [O14924-4]
NP_937870.1. NM_198227.1. [O14924-3]
NP_937872.1. NM_198229.2. [O14924-1]
XP_006713968.1. XM_006713905.1. [O14924-1]
XP_006713969.1. XM_006713906.2. [O14924-5]
XP_006713970.1. XM_006713907.1.
XP_011511845.1. XM_011513543.2.
XP_016864018.1. XM_017008529.1. [O14924-1]
XP_016864020.1. XM_017008531.1.
XP_016864021.1. XM_017008532.1.
XP_016864022.1. XM_017008533.1.
UniGeneiHs.527061.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBZNMR-A705-852[»]
2KV8NMR-A18-100[»]
ProteinModelPortaliO14924.
SMRiO14924.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111934. 7 interactors.
IntActiO14924. 2 interactors.
MINTiMINT-154790.
STRINGi9606.ENSP00000339381.

Chemistry databases

ChEMBLiCHEMBL1293276.

PTM databases

iPTMnetiO14924.
PhosphoSitePlusiO14924.

Polymorphism and mutation databases

BioMutaiRGS12.

Proteomic databases

EPDiO14924.
MaxQBiO14924.
PaxDbiO14924.
PeptideAtlasiO14924.
PRIDEiO14924.
TopDownProteomicsiO14924-2. [O14924-2]

Protocols and materials databases

DNASUi6002.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336727; ENSP00000338509; ENSG00000159788. [O14924-1]
ENST00000338806; ENSP00000342133; ENSG00000159788. [O14924-3]
ENST00000344733; ENSP00000339381; ENSG00000159788. [O14924-1]
ENST00000382788; ENSP00000372238; ENSG00000159788. [O14924-4]
GeneIDi6002.
KEGGihsa:6002.
UCSCiuc003ggw.4. human. [O14924-1]

Organism-specific databases

CTDi6002.
DisGeNETi6002.
GeneCardsiRGS12.
H-InvDBHIX0164019.
HGNCiHGNC:9994. RGS12.
MIMi602512. gene.
neXtProtiNX_O14924.
OpenTargetsiENSG00000159788.
PharmGKBiPA34364.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000049111.
HOVERGENiHBG063299.
InParanoidiO14924.
KOiK16449.
OMAiLFHHKIH.
OrthoDBiEOG091G0BDG.
PhylomeDBiO14924.
TreeFamiTF328814.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159788-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiRGS12. human.
EvolutionaryTraceiO14924.
GeneWikiiRGS12.
GenomeRNAii6002.
PROiO14924.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159788.
CleanExiHS_RGS12.
ExpressionAtlasiO14924. baseline and differential.
GenevisibleiO14924. HS.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR003109. GoLoco_motif.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR003116. RBD_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF02188. GoLoco. 1 hit.
PF00595. PDZ. 1 hit.
PF02196. RBD. 2 hits.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00390. GoLoco. 1 hit.
SM00228. PDZ. 1 hit.
SM00462. PTB. 1 hit.
SM00455. RBD. 2 hits.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50877. GOLOCO. 1 hit.
PS50106. PDZ. 1 hit.
PS01179. PID. 1 hit.
PS50898. RBD. 2 hits.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS12_HUMAN
AccessioniPrimary (citable) accession number: O14924
Secondary accession number(s): B1AQ30
, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O43510, O75338, Q147X0, Q8WX95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.