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O14924 (RGS12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 12

Short name=RGS12
Gene names
Name:RGS12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1447 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Ref.8

Isoform 5:Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. Ref.8

Subunit structure

Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent By similarity.

Subcellular location

Nucleus Ref.1 Ref.8.

Isoform 5: Nucleus matrix. Note: Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains. Ref.1 Ref.8

Tissue specificity

Isoform 3 is brain specific.

Domain

The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3 By similarity.

Sequence similarities

Contains 1 GoLoco domain.

Contains 1 PDZ (DHR) domain.

Contains 1 PID domain.

Contains 2 RBD (Ras-binding) domains.

Contains 1 RGS domain.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   Molecular functionRepressor
Signal transduction inhibitor
   PTMIsopeptide bond
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpositive regulation of GTPase activity

Inferred from Biological aspect of Ancestor. Source: GOC

regulation of G-protein coupled receptor protein signaling pathway

Traceable author statement Ref.2. Source: ProtInc

regulation of catalytic activity

Inferred from direct assay Ref.2. Source: GOC

termination of G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcondensed nuclear chromosome

Traceable author statement Ref.1. Source: ProtInc

cytoplasm

Inferred from direct assay. Source: HPA

nuclear matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleolus

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay. Source: HPA

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionGTPase activator activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

GTPase regulator activity

Inferred from direct assay Ref.2. Source: UniProtKB

receptor signaling protein activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O14924-1)

Also known as: RGS12TS-L; TS; trans-spliced;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O14924-2)

Also known as: P; peripheral;

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ
Isoform 3 (identifier: O14924-3)

Also known as: B; brain;

The sequence of this isoform differs from the canonical sequence as follows:
     1-647: Missing.
     648-666: RSFGRSKRFSITRSLDDLE → MNLGKELSNETHVSNDQQ
Isoform 4 (identifier: O14924-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1376: SGTH → TSRF
     1377-1447: Missing.
Isoform 5 (identifier: O14924-5)

Also known as: RGS12TS-S;

The sequence of this isoform differs from the canonical sequence as follows:
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.
Isoform 6 (identifier: O14924-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MFRAGEASKRPLPGPSPPRVRSVEV → MKKHDFAENLPSSLLIIILVIFTLS
     26-627: Missing.
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.
Isoform 7 (identifier: O14924-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14471447Regulator of G-protein signaling 12
PRO_0000204213

Regions

Domain22 – 9877PDZ
Domain228 – 340113PID
Domain715 – 832118RGS
Domain962 – 103271RBD 1
Domain1034 – 110471RBD 2
Domain1187 – 120923GoLoco

Amino acid modifications

Cross-link1115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.9

Natural variations

Alternative sequence1 – 658658Missing in isoform 2 and isoform 7.
VSP_005682
Alternative sequence1 – 647647Missing in isoform 3.
VSP_005684
Alternative sequence1 – 2525MFRAG…RSVEV → MKKHDFAENLPSSLLIIILV IFTLS in isoform 6.
VSP_047741
Alternative sequence26 – 627602Missing in isoform 6.
VSP_047742
Alternative sequence648 – 66619RSFGR…LDDLE → MNLGKELSNETHVSNDQQ in isoform 3.
VSP_005685
Alternative sequence659 – 6668TRSLDDLE → MSLSLFFQ in isoform 2 and isoform 7.
VSP_005683
Alternative sequence1138 – 115720GEERT…GENGK → SFLSLFPKLRATEQMTNVGC in isoform 5, isoform 6 and isoform 7.
VSP_047743
Alternative sequence1158 – 1447290Missing in isoform 5, isoform 6 and isoform 7.
VSP_047744
Alternative sequence1373 – 13764SGTH → TSRF in isoform 4.
VSP_005686
Alternative sequence1377 – 144771Missing in isoform 4.
VSP_005687
Natural variant2251I → V.
Corresponds to variant rs7679941 [ dbSNP | Ensembl ].
VAR_034451
Natural variant2771M → L.
Corresponds to variant rs16844152 [ dbSNP | Ensembl ].
VAR_034452
Natural variant11241N → S.
Corresponds to variant rs2269497 [ dbSNP | Ensembl ].
VAR_020208

Experimental info

Sequence conflict9411A → V in AAI18595. Ref.7

Secondary structure

.................................... 1447
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (RGS12TS-L) (TS) (trans-spliced) [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 033CD7403DAD2725

FASTA1,447156,357
        10         20         30         40         50         60 
MFRAGEASKR PLPGPSPPRV RSVEVARGRA GYGFTLSGQA PCVLSCVMRG SPADFVGLRA 

        70         80         90        100        110        120 
GDQILAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGVG RFESCSSDEE GGLYEGKGWL 

       130        140        150        160        170        180 
KPKLDSKALG INRAERVVEE MQSGGIFNMI FENPSLCASN SEPLKLKQRS LSESAATRFD 

       190        200        210        220        230        240 
VGHESINNPN PNMLSKEEIS KVIHDDSVFS IGLESHDDFA LDASILNVAM IVGYLGSIEL 

       250        260        270        280        290        300 
PSTSSNLESD SLQAIRGCMR RLRAEQKIHS LVTMKIMHDC VQLSTDKAGV VAEYPAEKLA 

       310        320        330        340        350        360 
FSAVCPDDRR FFGLVTMQTN DDGSLAQEEE GALRTSCHVF MVDPDLFNHK IHQGIARRFG 

       370        380        390        400        410        420 
FECTADPDTN GCLEFPASSL PVLQFISVLY RDMGELIEGM RARAFLDGDA DAHQNNSTSS 

       430        440        450        460        470        480 
NSDSGIGNFH QEEKSNRVLV VDLGGSSSRH GPGGSAWDGV GGRGAQPWGA PWTGPFCPDP 

       490        500        510        520        530        540 
EGSPPFEAAH QTDRFWDLNK HLGPASPVEV PPASLRSSVP PSKRGTVGAG CGFNQRWLPV 

       550        560        570        580        590        600 
HVLREWQCGH TSDQDSYTDS TDGWSSINCG TLPPPMSKIP ADRYRVEGSF AQPPLNAPKR 

       610        620        630        640        650        660 
EWSRKAFGMQ SIFGPHRNVR KTKEDKKGSK FGRGTGLTQP SQRTSARRSF GRSKRFSITR 

       670        680        690        700        710        720 
SLDDLESATV SDGELTGADL KDCVSNNSLS SNASLPSVQS CRRLRERRVA SWAVSFERLL 

       730        740        750        760        770        780 
QDPVGVRYFS DFLRKEFSEE NILFWQACEY FNHVPAHDKK ELSYRAREIF SKFLCSKATT 

       790        800        810        820        830        840 
PVNIDSQAQL ADDVLRAPHP DMFKEQQLQI FNLMKFDSYT RFLKSPLYQE CILAEVEGRA 

       850        860        870        880        890        900 
LPDSQQVPSS PASKHSLGSD HSSVSTPKKL SGKSKSGRSL NEELGDEDSE KKRKGAFFSW 

       910        920        930        940        950        960 
SRTRSTGRSQ KKREHGDHAD DALHANGGLC RRESQGSVSS AGSLDLSEAC RTLAPEKDKA 

       970        980        990       1000       1010       1020 
TKHCCIHLPD GTSCVVAVKA GFSIKDILSG LCERHGINGA AADLFLVGGD KPLVLHQDSS 

      1030       1040       1050       1060       1070       1080 
ILESRDLRLE KRTLFRLDLV PINRSVGLKA KPTKPVTEVL RPVVARYGLD LSGLLVRLSG 

      1090       1100       1110       1120       1130       1140 
EKEPLDLGAP ISSLDGQRVV LEEKDPSRGK ASADKQKGVP VKQNTAVNSS SRNHSATGEE 

      1150       1160       1170       1180       1190       1200 
RTLGKSNSIK IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN 

      1210       1220       1230       1240       1250       1260 
RADDQRGLLR KEDLVLPEFL RLPPGSTELT LPTPAAVAKG FSKRSATGNG RESASQPGEQ 

      1270       1280       1290       1300       1310       1320 
WEPVQESSDS PSTSPGSASS PPGPPGTTPP GQKSPSGPFC TPQSPVSLAQ EGTAQIWKRQ 

      1330       1340       1350       1360       1370       1380 
SQEVEAGGIQ TVEDEHVAEL TLMGEGDISS PNSTLLPPPS TPQEVPGPSR PGSGTHGSRD 

      1390       1400       1410       1420       1430       1440 
LPVNRIIDVD LVTGSAPGRD GGIAGAQAGP GRSQASGGPP TSDLPGLGPV PGEPAKPKTS 


AHHATFV 

« Hide

Isoform 2 (P) (peripheral) [UniParc].

Checksum: EBFFA3BA3A575003
Show »

FASTA78984,894
Isoform 3 (B) (brain) [UniParc].

Checksum: 2B3DE78DBC475BE6
Show »

FASTA79985,966
Isoform 4 [UniParc].

Checksum: B16232931A795162
Show »

FASTA1,376149,593
Isoform 5 (RGS12TS-S) [UniParc].

Checksum: 008E7B25C0DF3E69
Show »

FASTA1,157126,372
Isoform 6 [UniParc].

Checksum: BBCE94518BABF917
Show »

FASTA55561,107
Isoform 7 [UniParc].

Checksum: 19D4E54B5D47C387
Show »

FASTA49954,909

References

« Hide 'large scale' references
[1]"Novel alternative splicing and nuclear localization of human RGS12 gene products."
Chatterjee T.K., Fisher R.A.
J. Biol. Chem. 275:29660-29671(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
Tissue: Lung.
[2]"GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain."
Snow B.E., Hall R.A., Krumins A.M., Brothers G.M., Bouchard D., Brothers C.A., Chung S., Mangion J., Gilman A.G., Lefkowitz R.J., Siderovski D.P.
J. Biol. Chem. 273:17749-17755(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
Tissue: Brain.
[3]"Novel amino terminal variant of RGS12TS-S."
Chatterjee T.K., Fisher R.A.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
Tissue: Synovium.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
[8]"RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression."
Chatterjee T.K., Fisher R.A.
Mol. Cell. Biol. 22:4334-4345(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORM 5), FUNCTION (ISOFORM 5), SUBCELLULAR LOCATION (ISOFORM 5).
[9]"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1115.
Tissue: Mammary cancer.
[10]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[11]"Solution structure of the RGS domain from human regulator of G-protein signaling 12 (RGS12)."
RIKEN structural genomics initiative (RSGI)
Submitted (MAR-2008) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 705-852.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030112 mRNA. Translation: AAB84187.1.
AF030111 mRNA. Translation: AAB84114.1.
AF030110 mRNA. Translation: AAB84007.1.
AF030109 mRNA. Translation: AAB84186.1.
AF030149 expand/collapse EMBL AC list , AF030151, AF030152, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96645.1.
AF030149 expand/collapse EMBL AC list , AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96646.1. Sequence problems.
AF030149 expand/collapse EMBL AC list , AF030134, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA. Translation: AAB96644.1.
AF035152 mRNA. Translation: AAC39835.1.
AF464737 mRNA. Translation: AAL69961.1.
AK301510 mRNA. Translation: BAH13500.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17750.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17751.1.
AL645949, AL590235 Genomic DNA. Translation: CAM17752.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21452.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21453.1.
AL590235, AL645949 Genomic DNA. Translation: CAM21454.1.
CH471131 Genomic DNA. Translation: EAW82465.1.
CH471131 Genomic DNA. Translation: EAW82468.1.
BC118594 mRNA. Translation: AAI18595.1.
CH471131 Genomic DNA. Translation: EAW82469.1.
CH471131 Genomic DNA. Translation: EAW82470.1.
CCDSCCDS3366.1. [O14924-1]
CCDS3367.1. [O14924-4]
CCDS3368.1. [O14924-3]
RefSeqNP_002917.1. NM_002926.3. [O14924-4]
NP_937870.1. NM_198227.1. [O14924-3]
NP_937872.1. NM_198229.2. [O14924-1]
XP_006713968.1. XM_006713905.1. [O14924-1]
XP_006713969.1. XM_006713906.1. [O14924-5]
XP_006713970.1. XM_006713907.1.
UniGeneHs.527061.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2EBZNMR-A705-852[»]
2KV8NMR-A18-100[»]
ProteinModelPortalO14924.
SMRO14924. Positions 18-100, 705-852, 1025-1118, 1186-1221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111934. 7 interactions.
MINTMINT-154790.
STRING9606.ENSP00000339381.

Chemistry

ChEMBLCHEMBL1293276.

PTM databases

PhosphoSiteO14924.

Proteomic databases

MaxQBO14924.
PaxDbO14924.
PRIDEO14924.

Protocols and materials databases

DNASU6002.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306648; ENSP00000304459; ENSG00000159788. [O14924-6]
ENST00000336727; ENSP00000338509; ENSG00000159788. [O14924-4]
ENST00000338806; ENSP00000342133; ENSG00000159788. [O14924-3]
ENST00000344733; ENSP00000339381; ENSG00000159788. [O14924-1]
ENST00000382788; ENSP00000372238; ENSG00000159788. [O14924-4]
ENST00000538395; ENSP00000438888; ENSG00000159788.
GeneID6002.
KEGGhsa:6002.
UCSCuc003ggu.2. human. [O14924-1]
uc003ggv.3. human. [O14924-4]
uc003ggz.3. human. [O14924-3]
uc003gha.3. human. [O14924-2]

Organism-specific databases

CTD6002.
GeneCardsGC04P003294.
H-InvDBHIX0164019.
HGNCHGNC:9994. RGS12.
HPAHPA054646.
MIM602512. gene.
neXtProtNX_O14924.
PharmGKBPA34364.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282424.
HOVERGENHBG063299.
InParanoidO14924.
KOK16449.
OMALFHHKIH.
OrthoDBEOG7XDBF0.
PhylomeDBO14924.
TreeFamTF328814.

Gene expression databases

ArrayExpressO14924.
BgeeO14924.
CleanExHS_RGS12.
GenevestigatorO14924.

Family and domain databases

Gene3D1.10.196.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProIPR003109. GoLoco_motif.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR003116. Raf-like_ras-bd.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF02188. GoLoco. 1 hit.
PF00595. PDZ. 1 hit.
PF02196. RBD. 2 hits.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00390. GoLoco. 1 hit.
SM00228. PDZ. 1 hit.
SM00462. PTB. 1 hit.
SM00455. RBD. 2 hits.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEPS50877. GOLOCO. 1 hit.
PS50106. PDZ. 1 hit.
PS01179. PID. 1 hit.
PS50898. RBD. 2 hits.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO14924.
GeneWikiRGS12.
GenomeRNAi6002.
NextBio23405.
PROO14924.
SOURCESearch...

Entry information

Entry nameRGS12_HUMAN
AccessionPrimary (citable) accession number: O14924
Secondary accession number(s): B1AQ30 expand/collapse secondary AC list , B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O43510, O75338, Q147X0, Q8WX95
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM