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O14921

- RGS13_HUMAN

UniProt

O14921 - RGS13_HUMAN

Protein

Regulator of G-protein signaling 13

Gene

RGS13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: Ensembl
    2. positive regulation of GTPase activity Source: GOC
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 13
    Short name:
    RGS13
    Gene namesi
    Name:RGS13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:9995. RGS13.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytosol Source: Ensembl
    3. nucleus Source: Ensembl
    4. plasma membrane Source: RefGenome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34365.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 159159Regulator of G-protein signaling 13PRO_0000204215Add
    BLAST

    Proteomic databases

    MaxQBiO14921.
    PaxDbiO14921.
    PeptideAtlasiO14921.
    PRIDEiO14921.

    PTM databases

    PhosphoSiteiO14921.

    Expressioni

    Gene expression databases

    BgeeiO14921.
    CleanExiHS_RGS13.
    GenevestigatoriO14921.

    Organism-specific databases

    HPAiHPA044952.

    Interactioni

    Protein-protein interaction databases

    BioGridi111935. 5 interactions.
    STRINGi9606.ENSP00000247523.

    Structurei

    3D structure databases

    ProteinModelPortaliO14921.
    SMRiO14921. Positions 32-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 150117RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG279605.
    HOGENOMiHOG000233513.
    HOVERGENiHBG013233.
    InParanoidiO14921.
    KOiK16449.
    OMAiETGNDSI.
    OrthoDBiEOG7VHSZ5.
    PhylomeDBiO14921.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14921-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRNCWICK MCRDESKRPP SNLTLEEVLQ WAQSFENLMA TKYGPVVYAA    50
    YLKMEHSDEN IQFWMACETY KKIASRWSRI SRAKKLYKIY IQPQSPREIN 100
    IDSSTRETII RNIQEPTETC FEEAQKIVYM HMERDSYPRF LKSEMYQKLL 150
    KTMQSNNSF 159
    Length:159
    Mass (Da):19,135
    Last modified:January 1, 1998 - v1
    Checksum:iA7AEFD70DB8450C3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti150 – 1501L → F.1 Publication
    Corresponds to variant rs16834603 [ dbSNP | Ensembl ].
    VAR_034453

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030107 mRNA. Translation: AAB84000.1.
    AF493935 mRNA. Translation: AAM12649.1.
    AY562947 mRNA. Translation: AAS66360.1.
    BT006929 mRNA. Translation: AAP35575.1.
    CR536532 mRNA. Translation: CAG38769.1.
    AL136454, AL596119 Genomic DNA. Translation: CAI17062.1.
    AL596119, AL136454 Genomic DNA. Translation: CAH71773.1.
    BC016667 mRNA. Translation: AAH16667.1.
    BC056866 mRNA. Translation: AAH56866.2.
    CCDSiCCDS1376.1.
    RefSeqiNP_002918.1. NM_002927.4.
    NP_658912.1. NM_144766.2.
    UniGeneiHs.497220.

    Genome annotation databases

    EnsembliENST00000391995; ENSP00000375853; ENSG00000127074.
    ENST00000543215; ENSP00000442837; ENSG00000127074.
    GeneIDi6003.
    KEGGihsa:6003.
    UCSCiuc001gsj.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030107 mRNA. Translation: AAB84000.1 .
    AF493935 mRNA. Translation: AAM12649.1 .
    AY562947 mRNA. Translation: AAS66360.1 .
    BT006929 mRNA. Translation: AAP35575.1 .
    CR536532 mRNA. Translation: CAG38769.1 .
    AL136454 , AL596119 Genomic DNA. Translation: CAI17062.1 .
    AL596119 , AL136454 Genomic DNA. Translation: CAH71773.1 .
    BC016667 mRNA. Translation: AAH16667.1 .
    BC056866 mRNA. Translation: AAH56866.2 .
    CCDSi CCDS1376.1.
    RefSeqi NP_002918.1. NM_002927.4.
    NP_658912.1. NM_144766.2.
    UniGenei Hs.497220.

    3D structure databases

    ProteinModelPortali O14921.
    SMRi O14921. Positions 32-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111935. 5 interactions.
    STRINGi 9606.ENSP00000247523.

    PTM databases

    PhosphoSitei O14921.

    Proteomic databases

    MaxQBi O14921.
    PaxDbi O14921.
    PeptideAtlasi O14921.
    PRIDEi O14921.

    Protocols and materials databases

    DNASUi 6003.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391995 ; ENSP00000375853 ; ENSG00000127074 .
    ENST00000543215 ; ENSP00000442837 ; ENSG00000127074 .
    GeneIDi 6003.
    KEGGi hsa:6003.
    UCSCi uc001gsj.3. human.

    Organism-specific databases

    CTDi 6003.
    GeneCardsi GC01P192605.
    HGNCi HGNC:9995. RGS13.
    HPAi HPA044952.
    MIMi 607190. gene.
    neXtProti NX_O14921.
    PharmGKBi PA34365.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279605.
    HOGENOMi HOG000233513.
    HOVERGENi HBG013233.
    InParanoidi O14921.
    KOi K16449.
    OMAi ETGNDSI.
    OrthoDBi EOG7VHSZ5.
    PhylomeDBi O14921.
    TreeFami TF315837.

    Miscellaneous databases

    GeneWikii RGS13.
    GenomeRNAii 6003.
    NextBioi 23413.
    PROi O14921.
    SOURCEi Search...

    Gene expression databases

    Bgeei O14921.
    CleanExi HS_RGS13.
    Genevestigatori O14921.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of human RGS13 cDNA."
      Chatterjee T.K., Fisher R.A.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-150.
      Tissue: Brain.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.

    Entry informationi

    Entry nameiRGS13_HUMAN
    AccessioniPrimary (citable) accession number: O14921
    Secondary accession number(s): Q6PGR2, Q8TD63, Q9BX45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3