O14921 (RGS13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 13
Short name=RGS13

Gene names

Name:

RGS13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha By similarity.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Signal transduction inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome cytosol Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 159	159	Regulator of G-protein signaling 13		PRO_0000204215
Regions
	Domain	34 – 150	117	RGS
Natural variations
	Natural variant	150	1	L → F. Ref.2 Corresponds to variant rs16834603 [ dbSNP | Ensembl ].		VAR_034453

Sequences

	Sequence		Length	Mass (Da)
	O14921 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: A7AEFD70DB8450C3	FASTA	159	19,135
	10 20 30 40 50 60 MSRRNCWICK MCRDESKRPP SNLTLEEVLQ WAQSFENLMA TKYGPVVYAA YLKMEHSDEN 70 80 90 100 110 120 IQFWMACETY KKIASRWSRI SRAKKLYKIY IQPQSPREIN IDSSTRETII RNIQEPTETC 130 140 150 FEEAQKIVYM HMERDSYPRF LKSEMYQKLL KTMQSNNSF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of human RGS13 cDNA." Chatterjee T.K., Fisher R.A. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-150. Tissue: Brain.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF030107 mRNA. Translation: AAB84000.1. AF493935 mRNA. Translation: AAM12649.1. AY562947 mRNA. Translation: AAS66360.1. BT006929 mRNA. Translation: AAP35575.1. CR536532 mRNA. Translation: CAG38769.1. AL136454, AL596119 Genomic DNA. Translation: CAI17062.1. AL596119, AL136454 Genomic DNA. Translation: CAH71773.1. BC016667 mRNA. Translation: AAH16667.1. BC056866 mRNA. Translation: AAH56866.2.
IPI	IPI00024710.
RefSeq	NP_002918.1. NM_002927.4. NP_658912.1. NM_144766.2.
UniGene	Hs.497220.
3D structure databases
ProteinModelPortal	O14921.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000247523.
PTM databases
PhosphoSite	O14921.
Proteomic databases
PaxDb	O14921.
PeptideAtlas	O14921.
PRIDE	O14921.
Protocols and materials databases
DNASU	6003.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000391995; ENSP00000375853; ENSG00000127074. ENST00000543215; ENSP00000442837; ENSG00000127074.
GeneID	6003.
KEGG	hsa:6003.
UCSC	uc001gsj.3. human.
Organism-specific databases
CTD	6003.
GeneCards	GC01P192605.
HGNC	HGNC:9995. RGS13.
HPA	HPA044952.
MIM	607190. gene.
neXtProt	NX_O14921.
PharmGKB	PA34365.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG279605.
HOGENOM	HOG000233513.
HOVERGEN	HBG013233.
InParanoid	O14921.
KO	K16449.
OMA	KLMATKY.
OrthoDB	EOG415GFK.
PhylomeDB	O14921.
Gene expression databases
Bgee	O14921.
CleanEx	HS_RGS13.
Genevestigator	O14921.
GermOnline	ENSG00000127074. Homo sapiens.
Family and domain databases
Gene3D	1.10.196.10. 2 hits.
InterPro	IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6003.
NextBio	23413.
SOURCE	Search...

Entry information

Entry name

RGS13_HUMAN

Accession

Primary (citable) accession number: O14921
Secondary accession number(s): Q6PGR2, Q8TD63, Q9BX45

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.