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O14921

- RGS13_HUMAN

UniProt

O14921 - RGS13_HUMAN

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Protein
Regulator of G-protein signaling 13
Gene
RGS13
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: Ensembl
  2. positive regulation of GTPase activity Source: GOC
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 13
Short name:
RGS13
Gene namesi
Name:RGS13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:9995. RGS13.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. cytosol Source: Ensembl
  3. nucleus Source: Ensembl
  4. plasma membrane Source: RefGenome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Regulator of G-protein signaling 13
PRO_0000204215Add
BLAST

Proteomic databases

MaxQBiO14921.
PaxDbiO14921.
PeptideAtlasiO14921.
PRIDEiO14921.

PTM databases

PhosphoSiteiO14921.

Expressioni

Gene expression databases

BgeeiO14921.
CleanExiHS_RGS13.
GenevestigatoriO14921.

Organism-specific databases

HPAiHPA044952.

Interactioni

Protein-protein interaction databases

BioGridi111935. 5 interactions.
STRINGi9606.ENSP00000247523.

Structurei

3D structure databases

ProteinModelPortaliO14921.
SMRiO14921. Positions 32-146.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 150117RGS
Add
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG279605.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiO14921.
KOiK16449.
OMAiETGNDSI.
OrthoDBiEOG7VHSZ5.
PhylomeDBiO14921.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14921-1 [UniParc]FASTAAdd to Basket

« Hide

MSRRNCWICK MCRDESKRPP SNLTLEEVLQ WAQSFENLMA TKYGPVVYAA    50
YLKMEHSDEN IQFWMACETY KKIASRWSRI SRAKKLYKIY IQPQSPREIN 100
IDSSTRETII RNIQEPTETC FEEAQKIVYM HMERDSYPRF LKSEMYQKLL 150
KTMQSNNSF 159
Length:159
Mass (Da):19,135
Last modified:January 1, 1998 - v1
Checksum:iA7AEFD70DB8450C3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501L → F.1 Publication
Corresponds to variant rs16834603 [ dbSNP | Ensembl ].
VAR_034453

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030107 mRNA. Translation: AAB84000.1.
AF493935 mRNA. Translation: AAM12649.1.
AY562947 mRNA. Translation: AAS66360.1.
BT006929 mRNA. Translation: AAP35575.1.
CR536532 mRNA. Translation: CAG38769.1.
AL136454, AL596119 Genomic DNA. Translation: CAI17062.1.
AL596119, AL136454 Genomic DNA. Translation: CAH71773.1.
BC016667 mRNA. Translation: AAH16667.1.
BC056866 mRNA. Translation: AAH56866.2.
CCDSiCCDS1376.1.
RefSeqiNP_002918.1. NM_002927.4.
NP_658912.1. NM_144766.2.
UniGeneiHs.497220.

Genome annotation databases

EnsembliENST00000391995; ENSP00000375853; ENSG00000127074.
ENST00000543215; ENSP00000442837; ENSG00000127074.
GeneIDi6003.
KEGGihsa:6003.
UCSCiuc001gsj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030107 mRNA. Translation: AAB84000.1 .
AF493935 mRNA. Translation: AAM12649.1 .
AY562947 mRNA. Translation: AAS66360.1 .
BT006929 mRNA. Translation: AAP35575.1 .
CR536532 mRNA. Translation: CAG38769.1 .
AL136454 , AL596119 Genomic DNA. Translation: CAI17062.1 .
AL596119 , AL136454 Genomic DNA. Translation: CAH71773.1 .
BC016667 mRNA. Translation: AAH16667.1 .
BC056866 mRNA. Translation: AAH56866.2 .
CCDSi CCDS1376.1.
RefSeqi NP_002918.1. NM_002927.4.
NP_658912.1. NM_144766.2.
UniGenei Hs.497220.

3D structure databases

ProteinModelPortali O14921.
SMRi O14921. Positions 32-146.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111935. 5 interactions.
STRINGi 9606.ENSP00000247523.

PTM databases

PhosphoSitei O14921.

Proteomic databases

MaxQBi O14921.
PaxDbi O14921.
PeptideAtlasi O14921.
PRIDEi O14921.

Protocols and materials databases

DNASUi 6003.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000391995 ; ENSP00000375853 ; ENSG00000127074 .
ENST00000543215 ; ENSP00000442837 ; ENSG00000127074 .
GeneIDi 6003.
KEGGi hsa:6003.
UCSCi uc001gsj.3. human.

Organism-specific databases

CTDi 6003.
GeneCardsi GC01P192605.
HGNCi HGNC:9995. RGS13.
HPAi HPA044952.
MIMi 607190. gene.
neXtProti NX_O14921.
PharmGKBi PA34365.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279605.
HOGENOMi HOG000233513.
HOVERGENi HBG013233.
InParanoidi O14921.
KOi K16449.
OMAi ETGNDSI.
OrthoDBi EOG7VHSZ5.
PhylomeDBi O14921.
TreeFami TF315837.

Miscellaneous databases

GeneWikii RGS13.
GenomeRNAii 6003.
NextBioi 23413.
PROi O14921.
SOURCEi Search...

Gene expression databases

Bgeei O14921.
CleanExi HS_RGS13.
Genevestigatori O14921.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human RGS13 cDNA."
    Chatterjee T.K., Fisher R.A.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-150.
    Tissue: Brain.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.

Entry informationi

Entry nameiRGS13_HUMAN
AccessioniPrimary (citable) accession number: O14921
Secondary accession number(s): Q6PGR2, Q8TD63, Q9BX45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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