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Protein

Protocadherin-17

Gene

PCDH17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118946-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-17
Alternative name(s):
Protocadherin-68
Gene namesi
Name:PCDH17
Synonyms:PCDH68, PCH68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:14267. PCDH17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 707ExtracellularSequence analysisAdd BLAST690
Transmembranei708 – 728HelicalSequence analysisAdd BLAST21
Topological domaini729 – 1159CytoplasmicSequence analysisAdd BLAST431

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27253.
OpenTargetsiENSG00000118946.
PharmGKBiPA33001.

Polymorphism and mutation databases

BioMutaiPCDH17.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000400118 – 1159Protocadherin-17Add BLAST1142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Glycosylationi453N-linked (GlcNAc...)Sequence analysis1
Glycosylationi504N-linked (GlcNAc...)Sequence analysis1
Glycosylationi566N-linked (GlcNAc...)Sequence analysis1
Glycosylationi590N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO14917.
MaxQBiO14917.
PaxDbiO14917.
PeptideAtlasiO14917.
PRIDEiO14917.

PTM databases

iPTMnetiO14917.
PhosphoSitePlusiO14917.
SwissPalmiO14917.

Expressioni

Developmental stagei

During midgestation, enriched in the frontal and anterior temporal cortices. Expressed at high levels in the exterior margins of the thalamus, ventromedial striatal neuroepithelium and anterior cingulate.1 Publication

Gene expression databases

BgeeiENSG00000118946.
CleanExiHS_PCDH17.
ExpressionAtlasiO14917. baseline and differential.
GenevisibleiO14917. HS.

Organism-specific databases

HPAiHPA026817.

Interactioni

Protein-protein interaction databases

BioGridi118101. 8 interactors.
IntActiO14917. 5 interactors.
MINTiMINT-2872192.
STRINGi9606.ENSP00000367151.

Structurei

3D structure databases

ProteinModelPortaliO14917.
SMRiO14917.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 132Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini133 – 243Cadherin 2PROSITE-ProRule annotationAdd BLAST111
Domaini244 – 351Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini353 – 472Cadherin 4PROSITE-ProRule annotationAdd BLAST120
Domaini473 – 583Cadherin 5PROSITE-ProRule annotationAdd BLAST111
Domaini589 – 695Cadherin 6PROSITE-ProRule annotationAdd BLAST107

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi186 – 188Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi382 – 408Gly-richAdd BLAST27

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiO14917.
KOiK16499.
OMAiEQEPEEC.
OrthoDBiEOG091G00QD.
PhylomeDBiO14917.
TreeFamiTF352008.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030709. Protocadherin-17.
[Graphical view]
PANTHERiPTHR24028:SF41. PTHR24028:SF41. 2 hits.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14917-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYLSICCCFL LWAPALTLKN LNYSVPEEQG AGTVIGNIGR DARLQPGLPP
60 70 80 90 100
AERGGGGRSK SGSYRVLENS APHLLDVDAD SGLLYTKQRI DRESLCRHNA
110 120 130 140 150
KCQLSLEVFA NDKEICMIKV EIQDINDNAP SFSSDQIEMD ISENAAPGTR
160 170 180 190 200
FPLTSAHDPD AGENGLRTYL LTRDDHGLFG LDVKSRGDGT KFPELVIQKA
210 220 230 240 250
LDREQQNHHT LVLTALDGGE PPRSATVQIN VKVIDSNDNS PVFEAPSYLV
260 270 280 290 300
ELPENAPLGT VVIDLNATDA DEGPNGEVLY SFSSYVPDRV RELFSIDPKT
310 320 330 340 350
GLIRVKGNLD YEENGMLEID VQARDLGPNP IPAHCKVTVK LIDRNDNAPS
360 370 380 390 400
IGFVSVRQGA LSEAAPPGTV IALVRVTDRD SGKNGQLQCR VLGGGGTGGG
410 420 430 440 450
GGLGGPGGSV PFKLEENYDN FYTVVTDRPL DRETQDEYNV TIVARDGGSP
460 470 480 490 500
PLNSTKSFAI KILDENDNPP RFTKGLYVLQ VHENNIPGEY LGSVLAQDPD
510 520 530 540 550
LGQNGTVSYS ILPSHIGDVS IYTYVSVNPT NGAIYALRSF NFEQTKAFEF
560 570 580 590 600
KVLAKDSGAP AHLESNATVR VTVLDVNDNA PVIVLPTLQN DTAELQVPRN
610 620 630 640 650
AGLGYLVSTV RALDSDFGES GRLTYEIVDG NDDHLFEIDP SSGEIRTLHP
660 670 680 690 700
FWEDVTPVVE LVVKVTDHGK PTLSAVAKLI IRSVSGSLPE GVPRVNGEQH
710 720 730 740 750
HWDMSLPLIV TLSTISIILL AAMITIAVKC KRENKEIRTY NCRIAEYSHP
760 770 780 790 800
QLGGGKGKKK KINKNDIMLV QSEVEERNAM NVMNVVSSPS LATSPMYFDY
810 820 830 840 850
QTRLPLSSPR SEVMYLKPAS NNLTVPQGHA GCHTSFTGQG TNASETPATR
860 870 880 890 900
MSIIQTDNFP AEPNYMGSRQ QFVQSSSTFK DPERASLRDS GHGDSDQADS
910 920 930 940 950
DQDTNKGSCC DMSVREALKM KTTSTKSQPL EQEPEECVNC TDECRVLGHS
960 970 980 990 1000
DRCWMPQFPA ANQAENADYR TNLFVPTVEA NVETETYETV NPTGKKTFCT
1010 1020 1030 1040 1050
FGKDKREHTI LIANVKPYLK AKRALSPLLQ EVPSASSSPT KACIEPCTST
1060 1070 1080 1090 1100
KGSLDGCEAK PGALAEASSQ YLPTDSQYLS PSKQPRDPPF MASDQMARVF
1110 1120 1130 1140 1150
ADVHSRASRD SSEMGAVLEQ LDHPNRDLGR ESVDAEEVVR EIDKLLQDCR

GNDPVAVRK
Length:1,159
Mass (Da):126,229
Last modified:November 28, 2006 - v2
Checksum:iF687502B563B4013
GO
Isoform 2 (identifier: O14917-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-889: SSTFKDPERASLRD → ISVAPRLRTQKEPA
     890-1159: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:889
Mass (Da):96,570
Checksum:iE53D044E217A02CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139M → L in AAB84144 (Ref. 1) Curated1
Sequence conflicti256A → T in AAB84144 (Ref. 1) Curated1
Sequence conflicti330P → L in AAB84144 (Ref. 1) Curated1
Sequence conflicti430L → M in AAB84144 (Ref. 1) Curated1
Sequence conflicti489E → D in AAB84144 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021581876 – 889SSTFK…ASLRD → ISVAPRLRTQKEPA in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_021582890 – 1159Missing in isoform 2. 1 PublicationAdd BLAST270

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029343 mRNA. Translation: AAB84144.1.
AK289980 mRNA. Translation: BAF82669.1.
AL445216, AL445288 Genomic DNA. Translation: CAH71250.1.
AL445288, AL445216 Genomic DNA. Translation: CAI17092.1.
CH471124 Genomic DNA. Translation: EAW52060.1.
BC028165 mRNA. Translation: AAH28165.1.
CCDSiCCDS31986.1. [O14917-1]
PIRiT09055.
RefSeqiNP_001035519.1. NM_001040429.2. [O14917-1]
XP_005266414.1. XM_005266357.2. [O14917-1]
UniGeneiHs.106511.

Genome annotation databases

EnsembliENST00000377918; ENSP00000367151; ENSG00000118946. [O14917-1]
ENST00000484979; ENSP00000432899; ENSG00000118946. [O14917-2]
GeneIDi27253.
KEGGihsa:27253.
UCSCiuc001vhq.2. human. [O14917-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029343 mRNA. Translation: AAB84144.1.
AK289980 mRNA. Translation: BAF82669.1.
AL445216, AL445288 Genomic DNA. Translation: CAH71250.1.
AL445288, AL445216 Genomic DNA. Translation: CAI17092.1.
CH471124 Genomic DNA. Translation: EAW52060.1.
BC028165 mRNA. Translation: AAH28165.1.
CCDSiCCDS31986.1. [O14917-1]
PIRiT09055.
RefSeqiNP_001035519.1. NM_001040429.2. [O14917-1]
XP_005266414.1. XM_005266357.2. [O14917-1]
UniGeneiHs.106511.

3D structure databases

ProteinModelPortaliO14917.
SMRiO14917.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118101. 8 interactors.
IntActiO14917. 5 interactors.
MINTiMINT-2872192.
STRINGi9606.ENSP00000367151.

PTM databases

iPTMnetiO14917.
PhosphoSitePlusiO14917.
SwissPalmiO14917.

Polymorphism and mutation databases

BioMutaiPCDH17.

Proteomic databases

EPDiO14917.
MaxQBiO14917.
PaxDbiO14917.
PeptideAtlasiO14917.
PRIDEiO14917.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377918; ENSP00000367151; ENSG00000118946. [O14917-1]
ENST00000484979; ENSP00000432899; ENSG00000118946. [O14917-2]
GeneIDi27253.
KEGGihsa:27253.
UCSCiuc001vhq.2. human. [O14917-1]

Organism-specific databases

CTDi27253.
DisGeNETi27253.
GeneCardsiPCDH17.
HGNCiHGNC:14267. PCDH17.
HPAiHPA026817.
MIMi611760. gene.
neXtProtiNX_O14917.
OpenTargetsiENSG00000118946.
PharmGKBiPA33001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiO14917.
KOiK16499.
OMAiEQEPEEC.
OrthoDBiEOG091G00QD.
PhylomeDBiO14917.
TreeFamiTF352008.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118946-MONOMER.

Miscellaneous databases

ChiTaRSiPCDH17. human.
GeneWikiiPCDH17.
GenomeRNAii27253.
PROiO14917.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118946.
CleanExiHS_PCDH17.
ExpressionAtlasiO14917. baseline and differential.
GenevisibleiO14917. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030709. Protocadherin-17.
[Graphical view]
PANTHERiPTHR24028:SF41. PTHR24028:SF41. 2 hits.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCD17_HUMAN
AccessioniPrimary (citable) accession number: O14917
Secondary accession number(s): A8K1R5, Q5VVW9, Q5VVX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 28, 2006
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.